scholarly journals Predicting the effect of decompression sickness on survival following submarine tower escape

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Geoff A.M. Loveman ◽  
Joel J.E. Edney
Keyword(s):  
Subject Matter ◽  
Decompression Sickness ◽  
Survival Rates ◽  
Weather Conditions ◽  
Subject Matter Expert ◽  
Content Type ◽  
Probability Of Survival ◽  
Predicted Probability ◽  
Standard Probability ◽  
Current Advice

Purpose The purpose of the present study was the development of a methodology for translating predicted rates of decompression sickness (DCS), following tower escape from a sunken submarine, into predicted probability of survival, a more useful statistic for making operational decisions. Design/methodology/approach Predictions were made, using existing models, for the probabilities of a range of DCS symptoms following submarine tower escape. Subject matter expert estimates of the effect of these symptoms on a submariner’s ability to survive in benign weather conditions on the sea surface until rescued were combined with the likelihoods of the different symptoms occurring using standard probability theory. Plots were generated showing the dependence of predicted probability of survival following escape on the escape depth and the pressure within the stricken submarine. Findings Current advice on whether to attempt tower escape is based on avoiding rates of DCS above approximately 5%–10%. Consideration of predicted survival rates, based on subject matter expert opinion, suggests that the current advice might be considered as conservative in the distressed submarine scenario, as DCS rates of 10% are not anticipated to markedly affect survival rates. Originality/value According to the authors’ knowledge, this study represents the first attempt to quantify the effect of different DCS symptoms on the probability of survival in submarine tower escape.

scholarly journals Evaluation of Immunogenicity and Efficacy of Anthrax Vaccine Adsorbed for Postexposure Prophylaxis

2013 ◽  
Vol 20 (7) ◽  
pp. 1016-1026 ◽  
Author(s):  
Boris Ionin ◽  
Robert J. Hopkins ◽  
Brett Pleune ◽  
Gloria S. Sivko ◽  
Frances M. Reid ◽  
...  
Keyword(s):  
Survival Rates ◽  
Neutralizing Antibody ◽  
Antimicrobial Treatment ◽  
The Body ◽  
Postexposure Prophylaxis ◽  
Lethal Challenge ◽  
Anthrax Vaccine ◽  
Content Type ◽  
Probability Of Survival ◽  
Preexposure Prophylaxis

ABSTRACTAntimicrobials administered postexposure can reduce the incidence or progression of anthrax disease, but they do not protect against the disease resulting from the germination of spores that may remain in the body after cessation of the antimicrobial regimen. Such additional protection may be achieved by postexposure vaccination; however, no anthrax vaccine is licensed for postexposure prophylaxis (PEP). In a rabbit PEP study, animals were subjected to lethal challenge with aerosolizedBacillus anthracisspores and then were treated with levofloxacin with or without concomitant intramuscular (i.m.) vaccination with anthrax vaccine adsorbed (AVA) (BioThrax; Emergent BioDefense Operations Lansing LLC, Lansing, MI), administered twice, 1 week apart. A significant increase in survival rates was observed among vaccinated animals compared to those treated with antibiotic alone. In preexposure prophylaxis studies in rabbits and nonhuman primates (NHPs), animals received two i.m. vaccinations 1 month apart and were challenged with aerosolized anthrax spores at day 70. Prechallenge toxin-neutralizing antibody (TNA) titers correlated with animal survival postchallenge and provided the means for deriving an antibody titer associated with a specific probability of survival in animals. In a clinical immunogenicity study, 82% of the subjects met or exceeded the prechallenge TNA value that was associated with a 70% probability of survival in rabbits and 88% probability of survival in NHPs, which was estimated based on the results of animal preexposure prophylaxis studies. The animal data provide initial information on protective antibody levels for anthrax, as well as support previous findings regarding the ability of AVA to provide added protection toB. anthracis-infected animals compared to antimicrobial treatment alone.

Medulloblastoma in childhood: an epidemiological study

1984 ◽  
Vol 61 (4) ◽  
pp. 657-664 ◽  
Author(s):  
Jacqueline R. Farwell ◽  
George J. Dohrmann ◽  
John T. Flannery
Keyword(s):  
Mortality Rate ◽  
Survival Rates ◽  
Female Ratio ◽  
Tumor Registry ◽  
Content Type ◽  
Probability Of Survival ◽  
Number Of Children ◽  
Male To Female ◽  
Fine Print

✓ The authors have reviewed 143 cases of medulloblastoma in children aged 19 years or younger who were treated in a 42-year period and reported in the Connecticut Tumor Registry. About 20 cases have occurred in each 5-year period since 1950, but 31 were seen between 1955 and 1959. Correspondingly, an excessive number of children born in the period 1954 to 1958 have developed medulloblastomas. A relationship to polio vaccine contaminated with SV40 virus may exist. Children with medulloblastomas had an increased number of immediate family members with brain tumors, leukemia, and childhood cancer when compared to controls. In this series, the male to female ratio was 1.33:1. Average age at diagnosis was 6½ years, with most children being diagnosed at 3 years old and fewer cases appearing in each successive hemidecade from birth to 20 years of age. Probability of survival at 6 months was 0.687; at 1 year, 0.444; at 2 years, 0.314; and at 5 years, 0.222. Survival probability was statistically significantly better in the years 1968 to 1977 than in previous decades, in part due to fewer autopsy diagnoses and lowered operative mortality, but also due to a decreased mortality rate in children several years after diagnosis. Fifty-one percent were treated with operation and irradiation, 17% with operation alone, 12% with irradiation alone, and 5% with operation, irradiation, and chemotherapy. Fifteen percent were not treated. One- and 5-year survival rates in patients with operation and irradiation were, respectively, 0.615 and 0.307; with operation, 0.125 and 0.042; with irradiation, 0.688 and 0.277; and with operation, irradiation, and chemotherapy, 0.857 and 0.643. All seven children who received chemotherapy were diagnosed after 1968, and five are still alive. Perhaps due to short follow-up time, the course and mortality rate of children treated with all three modalities were not statistically significantly different from those of children treated since 1968 with operation and radiation therapy.

The fast are eating the slow: mentoring for leadership development as a competitive method

2014 ◽  
Vol 46 (1) ◽  
pp. 29-33 ◽  
Author(s):  
Judy Corner
Keyword(s):  
Leadership Development ◽  
Case Studies ◽  
Subject Matter ◽  
Cost Effective ◽  
Subject Matter Expert ◽  
Formal Mentoring ◽  
Content Type ◽  
Development Method ◽  
Company Culture ◽  
Goals And Objectives

Purpose – The purpose of this paper is to posit formal mentoring as cost-effective strategy for both developing leaders within an organization, as well as increasing organizational competitive ability in today's economy. Design/methodology/approach – The paper presents two case studies originally presented in a webinar which the author, a US-based subject matter expert in the field of mentoring, cohosted with a UK-based subject matter expert in the field of leadership development. Findings – Formal mentoring offers a uniquely suited approach to leadership development because of its ability to capitalize on knowledge that is both internal and specific to the organization, develop as broad or as targeted a group as necessary, and be tailored to meet any organization's goals and objectives. Together, these points can be leveraged to make an organization more competitive – not only in strength of existing leadership, but in readiness of ability to develop leaders for the future. Research limitations/implications – These are two case studies that examine the success of mentoring as a leadership development method within two large organizations. Practical implications – Formal mentoring for the purposes of leadership development can be leveraged to great competitive advantage in large organizations. Social implications – Mentoring for leadership development has the effect of improving and solidifying company culture, as well as engaging employees through career and leadership development activities. Originality/value – While using mentoring as a leadership development method is not a new concept, these case studies provide examples of how it can be practically applied, and to what ends.

Influence of subject matter expert personality on job analysis ratings

2007 ◽  
Author(s):  
Shonna D. Waters ◽  
Richard N. Landers ◽  
Nicholas Brenckman
Keyword(s):  
Subject Matter ◽  
Job Analysis ◽  
Subject Matter Expert

The importance of public support in the implementation of green transportation in smart cities using smart vehicle bicycle communication transport

2020 ◽  
Vol 38 (5/6) ◽  
pp. 997-1011
Author(s):  
Ning Li ◽  
Parthasarathy R. ◽  
Harshila H. Padwal
Keyword(s):  
Smart Cities ◽  
Optimization Technique ◽  
Public Support ◽  
Weather Conditions ◽  
Transport Systems ◽  
Content Type ◽  
Signaling Systems ◽  
Traffic Conditions ◽  
Green Transportation ◽  
Smart Vehicle

Purpose Smart mobility is a major guideline in the development of Smart Cities’ transport systems and management. The issue of transition into green, secure and sustainable transport modes, such as using bicycles, should be implemented in this case, along with the subjectivism of management. Design/methodology/approach The proposed technology reflects the Smart Bicycle vehicle model, which tracks cyclists and weather conditions and turns to electric motors in critical circumstances. Findings This reduces the physical load and battery consumption of cyclists which affects the Smart Cities’ ecology positively. Originality/value In Smart Vehicle Bicycle Communication Transport, the vehicle movement optimization technique is used for traffic scenarios to analyze traffic signaling systems that give better results in variable and dense traffic conditions.

scholarly journals Effects of Tedizolid Phosphate on Survival Outcomes and Suppression of Production of Staphylococcal Toxins in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia

2017 ◽  
Vol 61 (4) ◽  
Author(s):  
Vien T. M. Le ◽  
Hoan N. Le ◽  
Marcos Gabriel Pinheiro ◽  
Kenneth J. Hahn ◽  
Mary L. Dinh ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Bacterial Production ◽  
Protective Efficacy ◽  
Survival Rates ◽  
Rabbit Model ◽  
Rank Test ◽  
Necrotizing Pneumonia ◽  
Time Curve ◽  
Content Type

ABSTRACT The protective efficacy of tedizolid phosphate, a novel oxazolidinone that potently inhibits bacterial protein synthesis, was compared to those of linezolid, vancomycin, and saline in a rabbit model of Staphylococcus aureus necrotizing pneumonia. Tedizolid phosphate was administered to rabbits at 6 mg/kg of body weight intravenously twice daily, which yielded values of the 24-h area under the concentration-time curve approximating those found in humans. The overall survival rate was 83% for rabbits treated with 6 mg/kg tedizolid phosphate twice daily and 83% for those treated with 50 mg/kg linezolid thrice daily (P = 0.66 by the log-rank test versus the results obtained with tedizolid phosphate). These survival rates were significantly greater than the survival rates of 17% for rabbits treated with 30 mg/kg vancomycin twice daily (P = 0.003) and 17% for rabbits treated with saline (P = 0.002). The bacterial count in the lungs of rabbits treated with tedizolid phosphate was significantly decreased compared to that in the lungs of rabbits treated with saline, although it was not significantly different from that in the lungs of rabbits treated with vancomycin or linezolid. The in vivo bacterial production of alpha-toxin and Panton-Valentine leukocidin, two key S. aureus-secreted toxins that play critical roles in the pathogenesis of necrotizing pneumonia, in the lungs of rabbits treated with tedizolid phosphate and linezolid was significantly inhibited compared to that in the lungs of rabbits treated with vancomycin or saline. Taken together, these results indicate that tedizolid phosphate is superior to vancomycin for the treatment of S. aureus necrotizing pneumonia because it inhibits the bacterial production of lung-damaging toxins at the site of infection.

Dealing with surprise attacks: decomposing ERM as a dynamic capability to handle crises

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Vishnu Chandar Venkatesh ◽  
Meeta Dasgupta ◽  
Anupama Prashar ◽  
Torben Juul Andersen
Keyword(s):  
Empirical Evidence ◽  
Small And Medium Enterprises ◽  
Survival Rates ◽  
Dynamic Capability ◽  
Expert Interviews ◽  
Content Type ◽  
Intelligence Gathering ◽  
Enterprise Risk ◽  
Medium Enterprises ◽  
Alliance Building

PurposeTurbulent hypercompetitive market conditions make small and medium enterprises (SMEs) vulnerable to abrupt crises caused by unexpected competitor moves. In these situations, enterprise risk management (ERM) can serve as a dynamic capability (DC) to overcome the impending crisis and improve SMEs' survival rates. To explore this capacity, which has only been vaguely addressed in prior research, we conduct an exploratory, abductive study to update the extant (ERM and DC) literature with empirical evidence from expert interviews.Design/methodology/approachWe conduct an exploratory, abductive study using empirical evidence from expert interviews.FindingsOur findings reveal ERM as a second-order DC in the micro-foundational components of competitive intelligence gathering, alliance building and integrative capabilities. We find that competitive intensity and government policy moderate the effects of these foundational capabilities. Finally, our study proposes a survivability model that provides new valuable knowledge of ERM as a DC for SMEs to deal with competition-driven crises.Originality/valueThis research survivability model shows how ERM as DC can facilitate the survivability of SMEs against competitive surprises. Although restricted to crises arising out of competitive surprises, this study provides valuable knowledge to the literature on what type of DCs are useful for specific situations. The study findings not only extended Teece's (2007) DCs framework to competitive crises but also placed it within a hierarchy of capabilities. The research findings indicate that an ERM culture in SMEs promote the growth and development of sensing, seizing and reconfiguring capabilities, vital for tiding competitive crises.

A new IR and sprinkler based embedded controller directed robotic arm for automatic cleaning of solar panel

2019 ◽  
Vol 18 (4) ◽  
pp. 905-921
Author(s):  
Manish Kumar Ghodki ◽  
Akhilesh Swarup ◽  
Yash Pal
Keyword(s):  
Pulse Width Modulation ◽  
Weather Conditions ◽  
Solar Panel ◽  
Performance Ratio ◽  
Robotic Arm ◽  
Pv System ◽  
Content Type ◽  
Average Value ◽  
Ir Sensor ◽  
Embedded Controller

Purpose The purpose of this paper is to design and develop an IR and sprinkler based embedded controller operated robotic arm for automatic dust removal system to mitigate the dust effect on the solar panel surface, since dust accumulation normally affected by real weather conditions is one of the serious concern for the deterioration of photovoltaic (PV) system output. Design/methodology/approach The system is a wet cleaning device which provides a cheap silicon rubber-based wiping operation controlled by the pulse width modulation-operated motors of robotic arm. The IEEE 1149.1-compliant mixed signal-embedded platform of C8051F226DK is involved to command the complete system. Findings A prototype of 30 WP system is capable of producing an inspiring average value of 11.26 per cent in energy increase, 13.63 per cent in PV module efficiency and 85.20 per cent in performance ratio of the system after 73 days of cleaning in summer season. In addition, a total of 1,617.93 W power; 1,0516.55 Wh energy; and 350.55 KWh/KWP final yield was found during the entire cleaning period. Originality/value A novel technique of the implementation of IR sensor and sprinkler in dust mitigation is proposed in this paper. The IR sensor is used as a versatile object which can manage the robotic arm setting and control the automatic switching between cleaning and charging, as well as identify the thermal condition of solar panel for overheating.

scholarly journals TREM-1 Promotes Survival during Klebsiella pneumoniae Liver Abscess in Mice

2014 ◽  
Vol 82 (3) ◽  
pp. 1335-1342 ◽  
Author(s):  
Yi-Tsung Lin ◽  
Kai-Yu Tseng ◽  
Yi-Chen Yeh ◽  
Fu-Chen Yang ◽  
Chang-Phone Fung ◽  
...  
Keyword(s):  
Small Intestine ◽  
Klebsiella Pneumoniae ◽  
Liver Abscess ◽  
Survival Rates ◽  
Bacterial Clearance ◽  
Mesenteric Lymph Nodes ◽  
Content Type ◽  
Cytokine Levels ◽  
Peptide Expression ◽  
Antimicrobial Peptide Expression

ABSTRACTKlebsiella pneumoniaeliver abscess (KPLA) is prevalent in East Asia. Liver abscess can develop after translocation ofK. pneumoniaefrom a patient's bowel into the liver via the portal circulation. TREM-1 (triggeringreceptorexpressed onmyeloid cells1) amplifies inflammatory signaling during infection, but its role in KPLA is poorly understood. We used an animal study to characterize the role of TREM-1 in KPLA. We compared survival rates, bacterial burdens in tissues, inflammatory cytokine levels, and histology findings between wild-type andTrem-1knockout (KO) mice after oral inoculation of capsular type K1K. pneumoniae. Translocation ofK. pneumoniaeto mesenteric lymph nodes and liver was examined, and intestinal permeability, antimicrobial peptide expression, and the clearance ofK. pneumoniaein the small intestine were determined. In the absence of TREM-1, KPLA model mice showed increasedK. pneumoniaedissemination, enhanced liver and systemic inflammation, and reduced survival. Impaired bacterial clearance in the small intestine causes enhancedK. pneumoniaetranslocation, which rendersTrem-1KO mice more susceptible toK. pneumoniaeoral infection. In conclusion, TREM-1-mediated bacterial clearance in the small intestine is an important immune response againstK. pneumoniae. TREM-1 deficiency enhancesK. pneumoniaetranslocation in the small intestine and increases mortality rates in mice with KPLA.

Vertical translocation: the enigma of the disappearing atlantodens interval in patients with myelopathy and rheumatoid arthritis. Part I. Clinical, radiological, and neuropathological features

1997 ◽  
Vol 87 (6) ◽  
pp. 856-862 ◽  
Author(s):  
Adrian T. H. Casey ◽  
H. Alan Crockard ◽  
Jennian F. Geddes ◽  
John Stevens
Keyword(s):  
Cervical Myelopathy ◽  
Survival Rates ◽  
Cord Compression ◽  
Atlantoaxial Subluxation ◽  
Lateral Mass ◽  
Progressive Decrease ◽  
Content Type ◽  
Statistical Comparison ◽  
High Cervical ◽  
Fine Print

✓ This statistical comparison between patients with cervical myelopathy secondary to horizontal atlantoaxial subluxation and those with vertical translocation is designed to elucidate the mechanisms responsible for cranial settling and the effect of translocation on the development of spinal cord compression. In a 10-year study of a cohort of 256 patients, 186 suffered from myelopathy and 116 (62%) of these exhibited vertical translocation according to the Redlund-Johnell criteria. Vertical translocation occurred after a significantly longer period of disease than atlantoaxial subluxation (p < 0.001). Translocation was characterized clinically by a high cervical myelopathy with features of a cruciate paralysis present in 35% of individuals compared with 26% who exhibited horizontal atlantoaxial subluxation (p = 0.29), but there was a surprising paucity of cranial nerve problems. The patients with vertical translocation had a greater degree of neurological disability (p = 0.002) and poorer survival rates (p = 0.04). Radiologically, vertical translocation was secondary to lateral mass collapse and associated with a progressive decrease in the atlantodens interval ([ADI], r = 0.4; p < 0.001) and pannus (p = 0.003). Thirty percent of patients exhibited an ADI of less than 5 mm. This phenomenon has been termed pseudostabilization. The authors' studies emphasize that the ADI (frequently featured in the literature) is totally unreliable as an indicator of neuraxial compromise in the presence of vertical translocation.

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