The relationship between dietary inflammatory index and metabolic syndrome in patients with rheumatoid arthritis

Purpose Inflammation plays a significant role in incidence of metabolic syndrome (MetS), whose risk can be reduced through modifying the diet. Considering the importance of incidence of MetS among patients with rheumatoid arthritis (RA), this study aims to determine the relationship between dietary inflammatory index (DII) and MetS in these patients. Design/methodology/approach This study was performed on 261 adults 35–65 years of age suffering from RA. The patients were among the participants in Ravansar non-communicable disease prospective study. DII was calculated based on food frequency questionnaire. The components of MetS were measured according to the protocol of prospective epidemiological research studies in Iran cohort. Data analysis was carried out using univariate and multivariate logistic regression model by modifying the confounding variables. Findings In patients with RA, prevalence of MetS was 37.5%. The mean of DII in RA patients with MetS and without MetS was −2.3 ± 1.5 and −2.2 ± 1.6, respectively, with no significant difference between two groups. After modifying the variables of age and gender, the odds of increasing waist circumference (WC) were near 1.9 times greater in the fourth quartile (pro-inflammatory diet) compared to the first quartile of DII (anti-inflammatory diet) (P = 0.03). The odds of developing hypertension was approximately 1.3 times greater in the fourth compared to the first quartile of DII (P = 0.034). The odds of developing MetS increased by 27% in the fourth quartile in comparison to the first one, though this increase was not statistically significant. Originality/value In RA patients, with increase in DII score, the WC and blood pressure had increased. The DII had no significant relationship with MetS. Further studies are essential across larger populations to confirm the findings.

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Is there a relationship between the dietary inflammatory index and metabolic syndrome among adolescents?

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2019-0409 ◽

2020 ◽

Vol 33 (4) ◽

pp. 495-502

Author(s):

Nilgun Seremet Kurklu ◽

Nimet Karatas Torun ◽

Ikbal Ozen Kucukcetin ◽

Aslı Akyol

Keyword(s):

Metabolic Syndrome ◽

Dietary Inflammatory Index ◽

Inflammation Markers ◽

Necrosis Factor Alpha ◽

Inflammatory Index ◽

Inflammatory Score ◽

Increased Risk ◽

Tnf Α ◽

Significant Difference ◽

Metabolic Syndrome Components

AbstractBackgroundDietary patterns have a crucial role in modulating chronic inflammation. This study aimed to determine the relationship between the Dietary Inflammatory Index (DII) and inflammation markers and metabolic syndrome components in adolescents (n = 343).MethodsFasting glucose, fasting insulin and lipid profile were analyzed and blood pressures were measured. Analysis of inflammation markers such as sedimentation, leukocyte, C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) was also performed. The DII scores were calculated based on the adolescent’s 3-day food consumption records.ResultsThe dietary inflammatory score varied between 1.04 and 5.11 (3.6 ± 0.82). There was no significant difference in leukocyte and CRP levels between quartiles (p > 0.05). Those in the fourth quartile were observed to have higher levels of TNF-α and IL-6 compared to the others (p < 0.05). In the multiple regression analysis, a positive correlation existed only between IL-6 and DII, independent of other inflammatory markers (β = 0.272; p < 0.05). The DII was associated with glucose intolerance (odds ratio [OR] for DII quartile 4 compared to 1 = 3.5, 95% confidence interval [CI] = 1.2–10.4) and dyslipidemia (OR for DII quartile 4 compared to 1 = 5.3, 95% CI = 1.7–16.8).ConclusionsThese data suggest that a higher DII score was significantly associated with an increased risk of metabolic syndrome and some metabolic syndrome components in adolescents. Hence, DII can be used to determine the inflammatory potential of a diet and a healthy diet with anti-inflammatory properties that may be conducive to the prevention of metabolic disorders.

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The Relationship Between the Dietary Inflammatory Index and Metabolic Syndrome in Ravansar Cohort Study

Diabetes Metabolic Syndrome and Obesity Targets and Therapy ◽

10.2147/dmso.s240641 ◽

2020 ◽

Vol Volume 13 ◽

pp. 477-487

Author(s):

Hadi Abdollahzad ◽

Yahya Pasdar ◽

Seyed Mostafa Nachvak ◽

Shahab Rezaeian ◽

Amir Saber ◽

...

Keyword(s):

Metabolic Syndrome ◽

Cohort Study ◽

Dietary Inflammatory Index ◽

Inflammatory Index ◽

The Relationship

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Change in dietary inflammatory index score is associated with control of long-term rheumatoid arthritis disease activity in a Japanese cohort: the TOMORROW study

Arthritis Research & Therapy ◽

10.1186/s13075-021-02478-y ◽

2021 ◽

Vol 23 (1) ◽

Author(s):

Yoshinari Matsumoto ◽

Nitin Shivappa ◽

Yuko Sugioka ◽

Masahiro Tada ◽

Tadashi Okano ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Disease Activity ◽

Quantitative Measure ◽

Inflammatory Change ◽

Multivariable Logistic Regression Analysis ◽

Dietary Inflammatory Index ◽

Low Disease Activity ◽

Inflammatory Index ◽

Rheumatoid Arthritis Disease ◽

Anti Inflammatory

Abstract Background The dietary inflammatory index (DII®), a quantitative measure of the inflammatory potential of daily food and nutrient intake, and associations between a variety of health outcomes have been reported. However, the association between DII score and disease activity of rheumatoid arthritis (RA) is unclear. Therefore, this study was designed to test whether higher DII score contributes to disease activity and as a corollary, whether reducing DII score helps to achieve or maintain low disease activity or remission in patients with RA. Methods We performed a cross-sectional and longitudinal analysis using 6 years of data (from 2011 to 2017) in TOMORROW, a cohort study consisting of 208 RA patients and 205 gender- and age-matched controls started in 2010. Disease activity of RA patients was assessed annually using DAS28-ESR (disease activity score 28 joints and the erythrocyte sedimentation rate) as a composite measure based on arthritic symptoms in 28 joints plus global health assessment and ESR. Dietary data were collected in 2011 and 2017 using the brief-type self-administered diet history questionnaire (BDHQ). Energy-adjusted DII (E-DII™) score was calculated using 26 nutrients derived from the BDHQ. Data were analyzed with two-group comparisons, correlation analysis, and multivariable logistic regression analysis. Results One hundred and seventy-seven RA patients and 183 controls, for whom clinical and dietary survey data were available, were analyzed. RA patients had significantly higher E-DII (pro-inflammatory) score compared to controls both in 2011 and 2017 (p < 0.05). In RA patients, E-DII score was not a factor associated with significant change in disease activity. However, anti-inflammatory change in E-DII score was associated maintaining low disease activity (DAS28-ESR ≤ 3.2) or less for 6 years (OR 3.46, 95% CI 0.33–8.98, p = 0.011). Conclusions The diets of RA patients had a higher inflammatory potential than controls. Although E-DII score was not a factor associated with significant disease activity change, anti-inflammatory change in E-DII score appeared to be associated with maintaining low disease activity in patients with RA. Trial registration UMIN Clinical Trials Registry, UMIN000003876. Registered 7 Aug 2010—retrospectively registered.

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THU0521 EVALUATION OF LIVER FIBROSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS UNDER METHOTREXATE TREATMENT. UTILITY OF FIBROSCAN AND BIOMARKERS IN ROUTINE CLINICAL PRACTICE.

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.5808 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 499.2-500

Author(s):

A. De Diego Sola ◽

M. Vaamonde Lorenzo ◽

A. Castiella Eguzkiza ◽

M. J. Sánchez Iturri ◽

N. Alcorta Lorenzo ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Metabolic Syndrome ◽

Liver Fibrosis ◽

Controlled Study ◽

Type I ◽

Concomitant Treatment ◽

Duration Of Treatment ◽

Significant Difference ◽

Apri Score ◽

The Mean

Background:Despite therapeutic advances in recent years, methotrexate (MTX) remains the gold standard for the treatment of rheumatoid arthritis (RA). Among the side effects that have been blamed on it are liver fibrosis (LF) and cirrhosis, although late studies have failed to show such a relation1,2. The only validated test in the diagnosis of LF is biopsy. Given the relevance of MTX in the treatment of RA, it is important to evaluate non-invasive diagnostic options for LF such as transitional elastography (FibroScan, FS).Objectives:To evaluate the percentage of LF in RA patients treated with MTX. Secondly, to assess the correlation between altered liver function, RA activity, and LF. To determine whether dose and/or duration of treatment with MTX may affect the development of LF in such patients.Methods:We did a prospective study between February 2019 and January 2020. Patients affected of RA treated with MTX were included. Patients with basal liver disease (hepatitis B, hepatitis C and steatohepatitis), alcohol consumption, type I diabetes mellitus, chronic renal failure, heart failure, obesity and concomitant treatment with leflunomide or antiretrovirals were excluded. Demographic, clinical, analytical and therapeutic variables were collected. Liver fibrosis was assessed by FS in kilopascals (kpa) and using the APRI score. RA activity was assessed by DAS28 score. Continuous variables are described with mean and standard deviation (SD), and qualitative variables are shown with absolute value and percentage. Spearman’s and Mann-Whitney’s U tests were used for the bivariate analysis.Results:Fifty patients were included (Table 1 and 2). Of these, 38 were women (76%) with mean age of 61.8 years (SD 11.7) and mean RA evolution time of 13.7 years (SD 8.2). The mean DAS28 at the visit was 2.39 (SD 1.1). The FS showed an average of 4.8 kpa (SD 2). The mean duration of treatment with MTX was 85.8 months (SD 93.3) and that of AD-MTX was 5414.6mg (SD 5011). Patients were divided into those with DA-MTX greater than 4000mg (21, 42%) and less than 4000mg (29, 58%) and no significant differences were found in terms of LF in FS (p 0.637) or APRI scale (p 0.806). No significant differences were found in terms of treatment duration either. Six patients (12%) had elevated aspartate aminotransferase (AST) and 9 (18%) had elevated alanine aminotransferase (ALT). No significant difference was found in FS values in relation to ALT, but it was with elevated AST (p 0.021). Similarly, differences were found in APRI based on AST (p 0.045). Metabolic syndrome was collected in 4 patients (8%) without significant differences with FS or APRI values. There were no significant differences in LF depending on gamma-glutamyl transpeptidase (GGT) values.Conclusion:FS and APRI score are useful for the determination of LF in RA patients treated with MTX. There is no evidence of a relationship between AD-MTX and LF by FS or APRI. AST values may be related to the presence of fibrosis as determined by FS or APRI. and the presence of the metabolic syndrome are not.References:[1]G.L. Erre, et al. Methotrexate therapy is not associated with increased liver stiffness and significant liver fibrosis in rheumatoid arthritis patients: A cross-sectional controlled study with real-time two-dimensional shear wave elastography. European Journal of Internal Medicine 69 (2019) 57–63. Internet.[2]R. Conway et al. Risk of liver injury among methotrexate users: a meta-analysis of randomised controlled trials. Semin Arthritis Rheum 2015 Oct;45(2):156–62. Internet.Disclosure of Interests:None declared

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Associations of dietary inflammatory index, serum levels of MCP-1 and body composition in Iranian overweight and obese women: a cross-sectional study

10.21203/rs.3.rs-47523/v3 ◽

2020 ◽

Author(s):

Nasim Ghodoosi ◽

Atieh Mirzababaei ◽

Elahe Rashidbeygi ◽

Negin Badrooj ◽

Seyedeh Forough Sajjadi ◽

...

Keyword(s):

Fat Mass ◽

Communicable Disease ◽

Diet Group ◽

Fat Free Mass ◽

Dietary Inflammatory Index ◽

Obese Women ◽

Cross Sectional ◽

Monocyte Chemoattractant Protein 1 ◽

Inflammatory Index ◽

Anti Inflammatory

Abstract Objective: Although, several studies have illustrated that there is a relation between the between dietary inflammatory index (DII) with obesity-related parameters, and inflammation, their results were controversial results. This study aimed to investigate this relationship among Iranian women. Results: Multivariable linear regression showed that fat mass was 0.14 kg lower in the anti-inflammatory diet group, with respect to the pro-inflammatory group, after adjusting covariates such as age, physical activity, economic and job status (β = -0.142, 95% CI -4.44, -1.71, P = 0.03). Fat-free mass (FFM) was 1.5 kg more in the anti-inflammatory diet group, compared to the pro-inflammatory diet group, after adjusting for potentials cofounders (β = 1.50, 95% CI 0, 3.01, p = 0.05). Furthermore, after adjusting for potentials cofounders, it was revealed that the subjects with lower DII had lower monocyte chemoattractant protein-1 (MCP-1) levels in serum (β = -18.81, 95% CI -35.84, -1.79, p = 0.03). These findings suggest an inverse and significant relationship between DII and FFM and also DII is directly related to Fat mass and the level of MCP-1. This finding can be used for developing interventions that aim to promote healthy eating to prevent inflammation and non-communicable disease development among obese female.

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Dietary inflammatory index does not modulate the association of Western diet with metabolic syndrome

European Journal of Public Health ◽

10.1093/eurpub/ckw172.063 ◽

2016 ◽

Vol 26 (suppl_1) ◽

Author(s):

F Naja ◽

N Shivappa ◽

L Nasreddine ◽

L Itani ◽

N Hwalla ◽

...

Keyword(s):

Metabolic Syndrome ◽

Western Diet ◽

Dietary Inflammatory Index ◽

Inflammatory Index

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Visitation and quality of life among older adults in jail

International Journal of Prisoner Health ◽

10.1108/ijph-06-2021-0058 ◽

2021 ◽

Vol ahead-of-print (ahead-of-print) ◽

Author(s):

Stephanie Grace Prost ◽

Meghan A. Novisky

Keyword(s):

Quality Of Life ◽

Older Adults ◽

Social Relationships ◽

Developmental Theory ◽

Cross Sectional ◽

Younger Adults ◽

Content Type ◽

Significant Difference ◽

The Relationship

Purpose The purpose of this paper aims to examine differences in measures of and relationships between visitation and quality of life (QOL) among older and younger jailed adults. The authors also explored the contribution of visitation to QOL among adults in this setting. The authors anticipated fewer visits and lower QOL among older adults. Framed by psychosocial developmental theory, the authors also anticipated a larger effect in the relationship between visitation and QOL among older rather than younger adults and that visitation would contribute most readily to psychological QOL. Design/methodology/approach Cross-sectional data from a large US jail were used (n = 264). The authors described the sample regarding visitation and QOL measures among older (≥45) and younger adults (≤44) and examined differences in measures of and relationships between visitation and QOL using independent sample t-tests and bivariate analyses. The authors explored the contribution of visitation to psychological, social relationships, physical and environmental QOL among jailed adults using hierarchical multiple linear regression. Findings Older adults had fewer family visits and lower physical QOL than younger adults, disparities were moderate in effect (d range = 0.33–0.35). A significant difference also emerged between groups regarding the visitation and environmental QOL relationship (z = 1.66, p <0.05). Visitation contributed to variation in physical and social relationships QOL among jailed adults (Beta range = 0.19–0.24). Originality/value Limited research exists among jailed older adults and scholars have yet to examine the relationship between visitation and QOL among persons in these settings.

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The impact of technological innovation upon servitization

Journal of Manufacturing Technology Management ◽

10.1108/jmtm-08-2018-0242 ◽

2019 ◽

Vol 30 (7) ◽

pp. 1097-1114 ◽

Cited By ~ 2

Author(s):

Bang-Ning Hwang ◽

Mu-Yen Hsu

Keyword(s):

Service Delivery ◽

Technological Innovation ◽

Large Scale ◽

Manufacturing Firms ◽

Multivariate Logistic Regression Model ◽

Technological Innovations ◽

Manufacturing Firm ◽

Content Type ◽

The Impact ◽

The Relationship

Purpose For most manufacturing firms, technological innovations are usually the key strategies to gain their competitive advantages. However, competing strategically through service provision is becoming an important strategy for most industries. A growing demand for packaged product and service delivery is blurring the traditional boundaries between manufacturing and service firms. This trend is called “servitization.” Prior research had different perspectives on the relationship between technological innovations and servitization. Some argued that as servitization exerts the innovative convergence of products and services, the possession of appropriate readiness and absorption capacity through technological innovations for a manufacturing firm is critical to the success of servitization. In contrast, some argued that the knowledge gained from developing technological innovations cannot be applied to the creation of services due to the fundamental difference between technology and service. These contradicting arguments motivated the authors to study the relationship between technological innovations and servitization a step further. The paper aims to discuss these issues. Design/methodology/approach To address the research gap, the authors conducted an empirical study based on the large-scale samples from the second Taiwan Community Innovation Survey (Taiwan CIS). A multivariate logistic regression model was applied in the research. Findings The authors found that different types of technological innovations, namely product innovation and process innovation, have different impacts on servitization. The innovativeness level of the technological innovation moderates the relationship between technological innovation and servitization. Based on the above findings, this research specifically explains the causes of the contradictory results of the prior research. Originality/value The values of this research are twofold. Its academic contribution rests on bridging the literature of innovation and servitization, and on providing a model to clarify the relationships among technological innovation type, level of innovativeness and servitization. Its practical contribution lies in its establishment of a guideline that illuminates manufacturing firms reinforcing service delivery through their existing technological innovation trajectory.

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The relationship between CSR disclosure and competitive advantage

Sustainability Accounting Management and Policy Journal ◽

10.1108/sampj-11-2016-0086 ◽

2017 ◽

Vol 8 (5) ◽

pp. 547-570 ◽

Cited By ~ 19

Author(s):

Hui-Cheng Yu ◽

Lopin Kuo ◽

Mao-Feng Kao

Keyword(s):

Competitive Advantage ◽

Signaling Theory ◽

Content Type ◽

Csr Strategies ◽

Significant Difference ◽

Strategic Csr ◽

Environmentally Sensitive ◽

The Difference ◽

Csr Disclosure ◽

The Relationship

Purpose This study aims to apply signaling theory to examine whether corporate social responsibility (CSR) disclosure can deliver effective signals to stakeholders to increase a firm’s competitive advantage in China. Whether ownership patterns or environmental sensitivity causes a significant difference in the relationship between a firm’s CSR disclosure and competitive advantage is also examined. Design/methodology/approach Data analysis is based on a regression model. Content analysis is performed to convert qualitative CSR information of Chinese firms into quantitative data, while intellectual capital (IC) is used as a proxy variable for competitive advantage. Findings The difference in competitive advantage impairment between environmentally sensitive industries (ESIs) and non-environmentally sensitive industries (NESIs) is significant. Further comparisons on the relationship between overall CSR disclosure and competitive advantage among state-owned enterprises, privately owned enterprises, ESIs and NESIs suggest that the relationship is negative. Research limitations/implications The study extends research of strategic CSR to signaling theory and competitive advantage. In particular, a research using IC as a proxy for competitive advantage is rare. It also contributes to the literature on competitive advantage and strategic CSR by examining the effects of both CSR disclosure and IC. Originality/value This paper provides evidence related to stakeholders’ reaction to managers’ various CSR strategies in China. The contribution of this study is that it confirms that different CSR initiatives have different effects on the competitiveness of enterprises in China.

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