A comprehensive comparison between real population based tournament selection and virtual population based tournament selection

Author(s):  
Yi Hong ◽  
Sam Kwong ◽  
Qingsheng Ren ◽  
Xiong Wang
2020 ◽  
Vol 23 (3) ◽  
pp. 174-177
Author(s):  
Alan E. Stark

AbstractThe dynamics of rare X-linked recessive traits is explored by simulation. The model follows the prevalence of affected males and carrier females as separate but correlated variables. Different mutation rates and selection coefficients are introduced for males and females. A virtual population based on a published study of hemophilia B in the west of Scotland is followed at weekly intervals over many years. Speculative values of critical parameters to mimic the real population are proposed.


2018 ◽  
Author(s):  
Noriyuki Sumida ◽  
Emmanouil G Sifakis ◽  
Barbara A Scholz ◽  
Alejandro Fernandez-Woodbridge ◽  
Narsis A Kiani ◽  
...  

AbstractThe relationship between stochastic transcriptional bursts and dynamic 3D chromatin states is not well understood due to poor sensitivity and/or resolution of current chromatin structure-based assays. Consequently, it is not well established if enhancers operate individually and/or in clusters to coordinate gene transcription. In the current study, we introduce Nodewalk, which uniquely combines high sensitivity with high resolution to enable the analysis of chromatin networks in minute input material. The >10,000-fold increase in sensitivity over other many-to-all competing methods uncovered that active chromatin hubs identified in large input material, corresponding to 10 000 cells, flanking the MYC locus are primarily virtual. Thus, the close agreement between chromatin interactomes generated from aliquots corresponding to less than 10 cells with randomly re-sampled interactomes, we find that numerous distal enhancers positioned within flanking topologically associating domains (TADs) converge on MYC in largely mutually exclusive manners. Moreover, when comparing with several enhancer baits, the assignment of the MYC locus as the node with the highest dynamic importance index, indicates that it is MYC targeting its enhancers, rather than vice versa. Dynamic changes in the configuration of the boundary between TADs flanking MYC underlie numerous stochastic encounters with a diverse set of enhancers to depict the plasticity of its transcriptional regulation. Such an arrangement might increase the fitness of the cancer cell by increasing the probability of MYC transcription in response to a wide range of environmental cues encountered by the cell during the neoplastic process.


PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252143
Author(s):  
Tomas Solano ◽  
Rajat Mittal ◽  
Kourosh Shoele

The use of face masks by the general population during viral outbreaks such as the COVID-19 pandemic, although at times controversial, has been effective in slowing down the spread of the virus. The extent to which face masks mitigate the transmission is highly dependent on how well the mask fits each individual. The fit of simple cloth masks on the face, as well as the resulting perimeter leakage and face mask efficacy, are expected to be highly dependent on the type of mask and facial topology. However, this effect has, to date, not been adequately examined and quantified. Here, we propose a framework to study the efficacy of different mask designs based on a quasi-static mechanical model of the deployment of face masks onto a wide range of faces. To illustrate the capabilities of the proposed framework, we explore a simple rectangular cloth mask on a large virtual population of subjects generated from a 3D morphable face model. The effect of weight, age, gender, and height on the mask fit is studied. The Centers for Disease Control and Prevention (CDC) recommended homemade cloth mask design was used as a basis for comparison and was found not to be the most effective design for all subjects. We highlight the importance of designing masks accounting for the widely varying population of faces. Metrics based on aerodynamic principles were used to determine that thin, feminine, and young faces were shown to benefit from mask sizes smaller than that recommended by the CDC. Besides mask size, side-edge tuck-in, or pleating, of the masks as a design parameter was also studied and found to have the potential to cause a larger localized gap opening.


2005 ◽  
Vol 9 (17) ◽  
pp. 11-23
Author(s):  
Jean Raveneau

The density of agricultural population based on cleared land does not necessarily express the real population pressure in a given agricultural region. Two factors can upset the significance of this measure of density : (1) differences in the intensity of exploitation within a single territory ; and (2), variations in the proportion of part-time farmers. The author bas developed an index of the pressure of population on the land by making various calculations for jour counties in Québec, on the south shore of the St. Lawrence estuary. He bas found that the population pressure on the land varies in nearly direct proportion to the agricultural density based on cleared land, in spite of the lack of uniformity of the physical environment in question. The author concludes that the agricultural density retains its validity for expressing the population pressure on the land.


2020 ◽  
Author(s):  
Tomas Solano ◽  
Rajat Mittal ◽  
Kourosh Shoele

AbstractThe use of face masks by the general population during viral outbreaks such as the COVID-19 pandemic, although at times controversial, has been effective in slowing down the spread of the virus. The fit of simple cloth masks on the face as well as the resulting perimeter leakage and face mask efficacy are expected to be highly dependent on the type of mask and facial topology. However, this effect has to date, not been examined and quantified. Here, we study the leakage of a rectangular cloth mask on a large virtual population of subjects with diverse facial features, using computational mechanics modeling. The effect of weight, age, gender, and height on the leakage is studied. The Centers for Disease Control and Prevention (CDC) recommended mask size was used as a basis for comparison and was found not to be the most effective design for all subjects. Thin, feminine, and young faces benefit from mask sizes smaller than that recommended by the CDC. The results show that side-edge tuck-in of the masks could lead to a larger localized gap opening in many face categories, and is therefore not recommended for all. The perimeter leakage from the face mask worn by thin/feminine faces is mostly from the leakage area along the bottom edge of the mask and therefore, a tuck-in of the bottom edge of the mask or a mask smaller than the CDC recommended mask size are proposed as a more effective design. The leakage from the top edge of the mask is determined to be largely unaffected by mask size and tuck-in ratio, meaning that other mechanical alterations such as a nose wire strip are necessary to reduce the leakage at this site.


2015 ◽  
Vol 76 (3) ◽  
pp. 986-997 ◽  
Author(s):  
Manuel Murbach ◽  
Esra Neufeld ◽  
Eugenia Cabot ◽  
Earl Zastrow ◽  
Juan Córcoles ◽  
...  

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Pablo Rodríguez ◽  
◽  
Santiago Graña ◽  
Eva Elisa Alvarez-León ◽  
Manuela Battaglini ◽  
...  

AbstractWhile Digital contact tracing (DCT) has been argued to be a valuable complement to manual tracing in the containment of COVID-19, no empirical evidence of its effectiveness is available to date. Here, we report the results of a 4-week population-based controlled experiment that took place in La Gomera (Canary Islands, Spain) between June and July 2020, where we assessed the epidemiological impact of the Spanish DCT app Radar Covid. After a substantial communication campaign, we estimate that at least 33% of the population adopted the technology and further showed relatively high adherence and compliance as well as a quick turnaround time. The app detects about 6.3 close-contacts per primary simulated infection, a significant percentage being contacts with strangers, although the spontaneous follow-up rate of these notified cases is low. Overall, these results provide experimental evidence of the potential usefulness of DCT during an epidemic outbreak in a real population.


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