Activity of Antioxidant System Is Associated with Different Damages on Rice Seeds and Seedlings after Low Dose Heavy Ion Exposure

2010 ◽  
Author(s):  
Ye-Qing Sun ◽  
Jin-Ming Shi ◽  
Meng Zhang ◽  
Wen-Jian Li
Keyword(s):  
Antioxidant System ◽  
Low Dose ◽  
Heavy Ion ◽  
Rice Seeds

scholarly journals Akt Inhibition Enhanced the Growth Inhibition Effects of Low-Dose Heavy-Ion Radiation via the PI3K/Akt/p53 Signaling Pathway in C6 Glioblastoma Cells

2021 ◽  
Vol 11 ◽  
Author(s):  
Ke Huang ◽  
Wei Zhao ◽  
Xuqiao Wang ◽  
Yingfei Qiu ◽  
Zelin Liu ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Signaling Pathway ◽  
Low Dose ◽  
Ion Irradiation ◽  
Heavy Ion ◽  
C6 Cells ◽  
Carbon Ion ◽  
P53 Signaling ◽  
Heavy Ion Radiation ◽  
P53 Signaling Pathway

BackgroundGlioma has one of the highest mortality rates of all tumors of the nervous system and commonly used treatments almost always fail to achieve tumor control. Low-dose carbon-ion radiation can effectively target cancer and tumor cells, but the mechanisms of growth inhibition induced by heavy-ion radiation via the PI3K/Akt signaling pathway are unknown, and inhibition by heavy-ion radiation is minor in C6 cells.MethodsCarbon-ion radiation was used to investigate the effects of heavy-ion radiation on C6 cells, and suppression of Akt was performed using perifosine. MTT assays were used to investigate optimal perifosine treatment concentrations. Clone formation assays were used to investigate the growth inhibition effects of carbon-ion radiation and the effects of radiation with Akt inhibition. Lactate dehydrogenase release, superoxide dismutase activity, and malondialdehyde content were assessed to investigate oxidative stress levels. Expression levels of proteins in the PI3K/Akt/p53 signaling pathway were assessed via western blotting.ResultsThe 10% maximum inhibitory concentration of perifosine was 19.95 μM. In clone formation assays there was no significant inhibition of cell growth after treatment with heavy-ion irradiation, whereas perifosine enhanced inhibition. Heavy-ion radiation induced lactate dehydrogenase release, increased the level of malondialdehyde, and reduced superoxide dismutase activity. Akt inhibition promoted these processes. Heavy-ion radiation treatment downregulated Akt expression, and upregulated B-cell lymphoma-2 (Bcl-2) expression. p53 and Bcl-2 expression were significantly upregulated, and Bcl-2-associated X protein (Bax) expression was downregulated. The expression profiles of pAkt, Bcl-2, and Bax were reversed by perifosine treatment. Caspase 3 expression was upregulated in all radiation groups.ConclusionsThe growth inhibition effects of low-dose heavy-ion irradiation were not substantial in C6 cells, and Akt inhibition induced by perifosine enhanced the growth inhibition effects via proliferation inhibition, apoptosis, and oxidative stress. Akt inhibition enhanced the effects of heavy-ion radiation, and the PI3K/Akt/p53 signaling pathway may be a critical component involved in the process.

scholarly journals Strain-dependent structure and Raman behaviours in the heavy-ion irradiated manganite at extreme low dose

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Nam Nhat Hoang ◽  
Duc Huyen Yen Pham ◽  
The Nghia Nguyen
Keyword(s):  
Density Functional ◽  
Structural Changes ◽  
Low Dose ◽  
Blue Shift ◽  
Heavy Ion ◽  
Dynamic Calculation ◽  
Functional Theory ◽  
Lattice Dynamic Calculation ◽  
Strain Dependent ◽  
Shed Light

AbstractThe microstrains in heavy-ion irradiated manganite LaMnO3 can be managed in linear response of irradiation dose, and the corresponding internal pressure up to 8 GPa can be induced by varying doses. The response of structure under stress is studied by means of Density Functional Theory and Lattice Dynamic Calculation. All obtained Raman scattering lines are discussed in details to shed light onto structural changes during ion implantation. There appears new resonance peak at around 550 cm−1, which splits from broad features in the spectra, and attributes to the anti-symmetric vibrations of O6 cages. The blue shift of this peak scales to ~2.4 cm−1 per 1 GPa of stress. Another strong feature showing considerable blue shift is seen in the vicinity of 640 cm−1 and corresponds to one of rhombohedral distortion related soft modes. A weak mode, not frequently reported, is seen at around 420 cm−1 and corresponds to translation-like motions of fixed O6 cages.

scholarly journals Risks of cognitive detriments after low dose heavy ion and proton exposures

2019 ◽  
Vol 95 (7) ◽  
pp. 985-998 ◽  
Author(s):  
Francis A. Cucinotta ◽  
Eliedonna Cacao
Keyword(s):  
Low Dose ◽  
Heavy Ion

Defect clusters in heavy-ion irradiated nickel and nickel alloys

1978 ◽  
Vol 36 (1) ◽  
pp. 362-363
Author(s):  
T.M. Robinson ◽  
M.L. Jenkins
Keyword(s):  
Nickel Alloys ◽  
Low Dose ◽  
Ion Irradiation ◽  
Neutron Radiation ◽  
Heavy Ion ◽  
Heavy Ion Irradiation ◽  
Transmission Electron ◽  
Interstitial Component ◽  
Damage Structure ◽  
Consistent Picture

Low-dose (≲1012ions/cm2) heavy-ion irradiation gives a convenient method of studying some aspects of fast-neutron radiation damage and has now been studied using transmission electron microscopy in a wide variety of metals and alloys (e.g. see the reviews by Eyre 1973 and Wilkens 1975). From these studies a consistent picture of the development of the damage structure has emerged. In most cases small vacancy loops are observed, produced heterogeneously at the sites of displacement cascades by the collapse of vacancy-rich ‘depleted zones’. The interstitial component of the damage is usually lost to the foil surfaces and is not observed. There have been surprisingly few investigations of heavy-ion damage in materials of technological importance. However, it has been noted that cascade collapse appears to take place less readily in complex alloys such as steels than in pure metals such as copper (e.g. Williams and Eyre 1976) but few attempts have been reported to explore this effect systematically.

Cellular response in normal human cells exposed to chronically low-dose radiation in heavy-ion radiation field

2002 ◽  
Vol 1236 ◽  
pp. 323-326
Author(s):  
Masao Suzuki ◽  
Hiroshi Yasuda ◽  
Ryonfa Lee ◽  
Chisa Ohira ◽  
Hideyuki Majima ◽  
...  
Keyword(s):  
Radiation Field ◽  
Cellular Response ◽  
Low Dose ◽  
Heavy Ion ◽  
Human Cells ◽  
Low Dose Radiation ◽  
Normal Human ◽  
Heavy Ion Radiation ◽  
Normal Human Cells ◽  
Dose Radiation

Phase Transitions During Ion-Beam Irradiation of the Perovskite-structure Oxides

1997 ◽  
Vol 481 ◽  
Author(s):  
A. Meldrum ◽  
L. A. Boatner ◽  
R. C. Ewingt
Keyword(s):  
Perovskite Structure ◽  
Low Dose ◽  
Ion Irradiation ◽  
Ion Beam ◽  
Heavy Ion ◽  
Dislocation Loops ◽  
Ion Beam Irradiation ◽  
Melting Temperatures ◽  
Heavy Ion Irradiation ◽  
Domain Boundaries

ABSTRACTSeveral perovskite-structure oxide compounds, including CaTiO3, SrTiO3, BaTiO3, KNbO3, and KTaO3 were irradiated by 800 keV Kr+ ions in order to investigate and compare their response to heavy-ion irradiation. The critical amorphization temperature Tc, above which amorphization could not be induced, was found to increase in the order SrTiO3 → CaTiO3 → BaTiO3 → KNbO3 → KTaO3. No single physical parameter explains the observed sequence, although Tc correlates well with the melting temperatures. The well-known solid state phase transformations in these materials did not have a significant effect on the dose required for amorphization. Domain boundaries were observed in the pristine samples; however, after only a low dose, the boundaries became poorly defined and, with increasing dose, eventually disappeared. Dislocation loops were observed to aggregate at the domain boundaries.

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