Research and Implementation of Simulation Interactive Technology Based on Parameter File with Variable Number of Parameters

Background:Obesity is a chronic condition associated with poorer cognitive functioning. Wisconsin Card Sorting Test (WCST) is a useful tool for evaluating executive functions. In this study, we assessed the association between dopaminergic gene polymorphisms: DAT1 (SLC6A3), COMTVal158Met, DRD4 (48-bp variable number of tandem repeats - VNTR) and WCST parameters to investigate the functions of the frontal lobes in obese individuals.Objective:To find the significant correlations between polymorphisms of DAT1, COMTVal158Met, DRD4 and executive functions in obese subjects.Methods:The analysis of the frequency of individual alleles was performed in 248 obese patients (179 women, 69 men). Evaluation of the prefrontal cortex function (operating memory and executive functions) was measured with the Wisconsin Card Sorting Test (WCST). Separate analyzes were performed in age subgroups to determine different activities and regulation of genes in younger and older participants.Results:Scores of WCST parameters were different in the subgroups of women and men and in the age subgroups. Regarding the COMT gene, patients with A/A and G/A polymorphisms showed significantly better WCST results in WCST_P, WCST_CC and WCST_1st. Regarding DAT1 men with L/L and L/S made less non-perseverative errors, which was statistically significant. In DRD4, significantly better WCST_1st results were found only in older women with S allele.Conclusion:Obtained results indicate the involvement of dopaminergic transmission in the regulation of prefrontal cortex function. Data analysis indicates that prefrontal cortex function may ensue, from different elements such as genetic factors, metabolic aspects of obesity, and hormonal activity (estrogen).

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Antifúngicos poliénicos. Mecanismo de acción y aplicaciones

Studies in the Economic History of Southern Africa ◽

10.22201/fm.24484865e.2020.63.2.02 ◽

2020 ◽

Vol 63 (2) ◽

pp. 7-17

Author(s):

Evelyn Rivera-Toledo ◽

Alan Uriel Jiménez-Delgadillo ◽

Patricia Manzano-Gayosso

Keyword(s):

Antifungal Activity ◽

Key Words ◽

Secondary Metabolism ◽

Amphotericin B ◽

Antifungal Agents ◽

Fungal Infections ◽

Variable Number ◽

Therapeutic Failure ◽

Morbidity And Mortality ◽

Clinical Use

The first compounds with specific antifungal activity were identified in the middle of the last century as a product of the secondary metabolism of bacteria of the order Actinomycetales, and their clinical use significantly diminished the morbidity and mortality associated with severe fungal infections. Many of such biosynthetic compounds are characterized by a chemical polygenic structure, with a variable number of carbon-carbon double bonds. Currently, besides polygenic antimycotics, there are other antifungal agents, such as the azole compounds, that have less toxicity in patients; however, cases of therapeutic failure with such compounds have been documented, therefore, the use of polygenics is still the best alternative in such cases. This review presents data about the properties and applications of antifungal-polygenic compounds using amphotericin B as a model. Key words: Amphotericin B; antifungal polyenes; ergosterol

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Characterisation of Plasticity Response for Reciprocating Sliding Wear Test of Ti-6Al-4V under Variables Number of Cycles

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.773-774.168 ◽

2015 ◽

Vol 773-774 ◽

pp. 168-172

Author(s):

D. Harun ◽

D. Nalatambi ◽

Ramdziah Md. Nasir ◽

Abdul Latif Mohd Tobi

Keyword(s):

Plastic Deformation ◽

Titanium Alloy ◽

Sliding Wear ◽

Wear Track ◽

Wear Test ◽

Optical Microscope ◽

Variable Number ◽

Reciprocating Sliding ◽

Number Of Cycles ◽

Reciprocating Sliding Wear

Reciprocating sliding wear test of uncoated titanium alloy, Ti-6Al-4V is investigated using pin-on-flat contact arrangement of Ti-6Al-4V/Ti-6Al-4V pair under variable number of cycles at low number of cycles. The worn surfaces of the titanium alloy specimens were analyzed with the use of optical microscope (2D and 3D OM) and Vickers Hardness analysis was carried on. The pattern of the wear scar characteristics determined and the finding at the end of wear track had been focus through the presence at the end of wear track. It is suggesting an evidence of plastic deformation with the increasing in hardness value. The increase in hardness value at the end of wear track indicates increase in the plastic deformation with increasing number of cycles.

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Modelling and Multi-Objective Optimization of the Sulphur Dioxide Oxidation Process

Processes ◽

10.3390/pr9061072 ◽

2021 ◽

Vol 9 (6) ◽

pp. 1072

Author(s):

Mohammad Reza Zaker ◽

Clémence Fauteux-Lefebvre ◽

Jules Thibault

Keyword(s):

Sulphuric Acid ◽

Sulphur Dioxide ◽

Variable Number ◽

Inlet Temperature ◽

Multi Objective Optimization ◽

Absorption Column ◽

Maximum Reaction Rate ◽

Multi Objective ◽

Maximum Reaction

Sulphuric acid (H2SO4) is one of the most produced chemicals in the world. The critical step of the sulphuric acid production is the oxidation of sulphur dioxide (SO2) to sulphur trioxide (SO3) which takes place in a multi catalytic bed reactor. In this study, a representative kinetic rate equation was rigorously selected to develop a mathematical model to perform the multi-objective optimization (MOO) of the reactor. The objectives of the MOO were the SO2 conversion, SO3 productivity, and catalyst weight, whereas the decisions variables were the inlet temperature and the length of each catalytic bed. MOO studies were performed for various design scenarios involving a variable number of catalytic beds and different reactor configurations. The MOO process was mainly comprised of two steps: (1) the determination of Pareto domain via the determination a large number of non-dominated solutions, and (2) the ranking of the Pareto-optimal solutions based on preferences of a decision maker. Results show that a reactor comprised of four catalytic beds with an intermediate absorption column provides higher SO2 conversion, marginally superior to four catalytic beds without an intermediate SO3 absorption column. Both scenarios are close to the ideal optimum, where the reactor temperature would be adjusted to always be at the maximum reaction rate. Results clearly highlight the compromise existing between conversion, productivity and catalyst weight.

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