Reasonable determination of indoor ventilation rates are the main content of residential ventilation designs, and can save consumption by air conditioners. Firstly, the energy saving potential of ventilation cooling technology in Guangzhou is analyzed in this paper. The cooling load of a residential building in Guangzhou with different air exchange rates is simulated by the DeST-h after indoor heating quantity of different rooms is set. The energy saving rate is analyzed, the functional relation between energy saving rate of ventilation and air exchange rate is obtained using the linear-regression analysis method. After a comprehensive consideration of various factors, including variation of energy efficiency, room volume, air outlet size, and that the maximum air exchange rates of different rooms are fixed.