In this paper, signal integrity challenges for high speed serial link at 25 Gb/s, such as lossy channels and noisy environments are discussed. A few solution spaces to address those challenges are investigated, such as advanced equalization schemes, alternative signaling formats and forward error correction. It demonstrates that advanced signal processing enables long reach and extra long reach serial link performance at 25 Gb/s in next generation systems. Modeling methodologies used in SerDes behavioral models to ensure good correlation with transistor level circuit simulation are also discussed.