Molecular Modeling and Evaluation of Novel Dibenzopyrrole Derivatives as Telomerase Inhibitors and Potential Drug for Cancer Therapy

2014 ◽  
Vol 11 (6) ◽  
pp. 1196-1207 ◽  
Author(s):  
Umesh Kalathiya ◽  
Monikaben Padariya ◽  
Maciej Baginski
Keyword(s):  
Molecular Modeling ◽  
Cancer Therapy ◽  
Potential Drug ◽  
Telomerase Inhibitors

scholarly journals Bioinformatic Analysis of the Nicotinamide Binding Site in Poly(ADP-Ribose) Polymerase Family Proteins

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1201
Author(s):  
Garri Manasaryan ◽  
Dmitry Suplatov ◽  
Sergey Pushkarev ◽  
Viktor Drobot ◽  
Alexander Kuimov ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Binding Site ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Bioinformatic Analysis ◽  
Parp Inhibitors ◽  
Functional Region ◽  
D Loop

The PARP family consists of 17 members with diverse functions, including those related to cancer cells’ viability. Several PARP inhibitors are of great interest as innovative anticancer drugs, but they have low selectivity towards distinct PARP family members and exert serious adverse effects. We describe a family-wide study of the nicotinamide (NA) binding site, an important functional region in the PARP structure, using comparative bioinformatic analysis and molecular modeling. Mutations in the NA site and D-loop mobility around the NA site were identified as factors that can guide the design of selective PARP inhibitors. Our findings are of particular importance for the development of novel tankyrase (PARPs 5a and 5b) inhibitors for cancer therapy.

Isolation and in silico prediction of potential drug-like compounds from Anethum sowa L. root extracts targeted towards cancer therapy

2019 ◽  
Vol 78 ◽  
pp. 242-259 ◽  
Author(s):  
Md. Moshfekus Saleh-e-In ◽  
Ayan Roy ◽  
Muhammad Abdullah Al-Mansur ◽  
Choudhury Mahmood Hasan ◽  
Md. Matiur Rahim ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
In Silico ◽  
Potential Drug ◽  
In Silico Prediction ◽  
Root Extracts ◽  
Anethum Sowa

scholarly journals Highlighted STAT3 as a potential drug target for cancer therapy

BMB Reports ◽  
2019 ◽  
Vol 52 (7) ◽  
pp. 415-423 ◽  
Author(s):  
Haeri Lee ◽  
Ae Jin Jeong ◽  
Sang-Kyu Ye
Keyword(s):  
Cancer Therapy ◽  
Drug Target ◽  
Potential Drug Target ◽  
Potential Drug

Self-assembled hyaluronic acid nanoparticles as a potential drug carrier for cancer therapy: synthesis, characterization, and in vivo biodistribution

2009 ◽  
Vol 19 (24) ◽  
pp. 4102 ◽  
Author(s):  
Ki Young Choi ◽  
Kyung Hyun Min ◽  
Jin Hee Na ◽  
Kuiwon Choi ◽  
Kwangmeyung Kim ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Drug Carrier ◽  
Potential Drug ◽  
In Vivo Biodistribution ◽  
Self Assembled
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