scholarly journals Transplanting cells from old but not young donors causes physical dysfunction in older recipients

Aging Cell ◽  
2020 ◽  
Vol 19 (3) ◽  
Author(s):  
Binsheng Wang ◽  
Zukai Liu ◽  
Vicky P. Chen ◽  
Lichao Wang ◽  
Christina L. Inman ◽  
...  
Nephrology ◽  
2021 ◽  
Author(s):  
Thomas J. Wilkinson ◽  
Eleanor F. Gore ◽  
Luke A. Baker ◽  
Emma L. Watson ◽  
Alice C. Smith

2019 ◽  
Vol 185 (24) ◽  
pp. 757-757 ◽  
Author(s):  
Sarah Stadig ◽  
B Duncan X Lascelles ◽  
Gorel Nyman ◽  
Anna Bergh

BackgroundFeline osteoarthritis (OA) is a common cause of long-standing pain and physical dysfunction. Performing a physical examination of a cat is often challenging. There is a need for disease-specific questionnaires or the so-called clinical metrology instruments (CMIs) to facilitate diagnosis and evaluation of treatment of feline OA. The CMI provides the owners an assessment of the cat’s behavioural and lifestyle changes in the home environment. The purpose of the study was to evaluate readability, internal consistency, reliability and discriminatory ability of four CMIs.MethodsThis is a prospective, cross-sectional study with 142 client-owned cats. Feline OA was diagnosed based on medical history, orthopaedic examination and radiography.ResultsThe results indicate that all four instruments have sound readability, internal consistency, are reliable over time and have good discriminatory ability. Preliminary cut-off values with optimal sensitivity and specificity were suggested for each instrument. The osteoarthritic cats showed significant changes in behavioural response to pain during orthopaedic examination, compared with sound cats.ConclusionThe results indicate that all four questionnaires make an important contribution in a clinical setting, and that the cat’s behavioural response to pain during physical examination should be a parameter to take into account as a possible indication of chronic pain.


2021 ◽  
Author(s):  
Masumeh Delgarmi ◽  
Hamed Heravi ◽  
Ali Rahimpour Jounghani ◽  
Abdullah Shahrezie ◽  
Afshin Ebrahimi ◽  
...  

AbstractStudying human postural structure is one of the challenging issues among scholars and physicians. The spine is known as the central axis of the body, and due to various genetic and environmental reasons, it could suffer from deformities that cause physical dysfunction and correspondingly reduce people’s quality of life. Radiography is the most common method for detecting these deformities and requires monitoring and follow-up until full treatment; however, it frequently exposes the patient to X-rays and ionization and as a result, cancer risk is increased in the patient and could be highly dangerous for children or pregnant women. To prevent this, several solutions have been proposed using topographic data analysis of the human back surface. The purpose of this research is to provide an entirely safe and non-invasive method to examine the spiral structure and its deformities. Hence, it is attempted to find the exact location of anatomical landmarks on the human back surface, which provides useful and practical information about the status of the human postural structure to the physician.In this study, using Microsoft Kinect sensor, the depth images from the human back surface of 105 people were recorded and, our proposed approach - Deep convolution neural network-was used as a model to estimate the location of anatomical landmarks. In network architecture, two learning processes, including landmark position and affinity between the two associated landmarks, are successively performed in two separate branches. This is a bottom-up approach; thus, the runtime complexity is considerably reduced, and then the resulting anatomical points are evaluated concerning manual landmarks marked by the operator as the benchmark. Our results showed that 86.9% of PDJ and 80% of PCK. According to the results, this study was more effective than other methods with more than thousands of training data.


2010 ◽  
Vol 22 (4) ◽  
pp. 514-522 ◽  
Author(s):  
Liat Ayalon ◽  
Daniela Fialová ◽  
Patricia A. Areán ◽  
Graziano Onder

ABSTRACTBackground: Home care for older adults is a common phenomenon worldwide because it allows older adults to remain in their home environment. Research has shown that depression is frequently found in older recipients of home care services. Nonetheless, it is often poorly recognized and treated. Untreated or poorly treated depression in older home care recipients has been associated with a variety of negative outcomes, including increased morbidity and mortality, greater likelihood of nursing home institutionalization and higher caregiver distress.Methods: The present review outlines some of the challenges associated with appropriate recognition and treatment of depression in older home care recipients.Results: Our review demonstrates that more aggressive management of depressive symptoms and the employment of an interdiciplinary team can result in beneficial outcomes.Conclusions: Further research is needed, especially in the area of psychotherapeutic interventions as these should be flexible enough to meet the unique and evolving needs of this frail population of older adults.


Author(s):  
Scott N. Drum ◽  
Bryanne N. Bellovary ◽  
Randall L. Jensen ◽  
Maggy T. Moore ◽  
Lars Donath

Author(s):  
John A. Sturgeon ◽  
Katherine T. Martucci

Psychological factors play a key role in the pain experience. Clinical and experimental research has highlighted altered behavioral, cognitive, and emotional responses as endemic in chronic pain populations, which contribute to physical dysfunction and to depression, anxiety, and other psychiatric disorders. Neuroimaging research has complemented the knowledge in this domain by identifying how neural structure and function are altered in chronic pain. Brain processes related to mental illness, emotion, memory, and cognition are distributed throughout the brain and modulate pain processing in both the acute and chronic states. These processes can be targeted both behaviorally and neurophysiologically through noninvasive and nonpharmacological psychological therapies, including cognitive behavioral therapy, acceptance and commitment therapy, and mindfulness-based stress reduction. Psychological therapies are further supported by emerging neuroimaging research that demonstrates changes in brain structure and function associated with positive changes in patients’ responses to pain and overall improved quality of life.


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