scholarly journals Sulforaphane prevents age‐associated cardiac and muscular dysfunction through Nrf2 signaling

Aging Cell ◽  
2020 ◽  
Vol 19 (11) ◽  
Author(s):  
Chhanda Bose ◽  
Ines Alves ◽  
Preeti Singh ◽  
Philip T. Palade ◽  
Eugenia Carvalho ◽  
...  
Keyword(s):  
Muscular Dysfunction

Features of phosphorus-calcium metabolism in children with neurogenic disorders of urination

2020 ◽  
Vol 24 (1) ◽  
pp. 45-50
Author(s):  
Yu. F. Lobanov ◽  
D. Y. Latyshev ◽  
Ya. F. Zverev ◽  
N. A. Tekuteva ◽  
N. M. Mikheeva
Keyword(s):  
Connective Tissue ◽  
Calcium Metabolism ◽  
Point System ◽  
Industry Standards ◽  
Muscular Dysfunction ◽  
Connective Tissue Dysplasia ◽  
Calcium And Phosphorus ◽  
Comparison Of The Results ◽  
Neurogenic Disorders

THE AIM: To study the characteristics of phosphorus-calcium metabolism in patients with neurogenic disorders of urination, taking into account the severity of the manifestations of connective tissue dysplasia. PATIENTS AND METHODS. The study included 90 children, including 60 children with neuro-muscular dysfunction of the bladder (NMDB) and 30 children with enuresis from the age of 5 to 15 years. The diagnosis was established based on a comprehensive examination and according to industry standards. Connective tissue dysplasia was diagnosed in children with the detection of 6 or more small external or visceral manifestations involving 3 or more organs from different systems. Assessment of the severity (severity) of connective tissue dysplasia was carried out according to the point system proposed by T.I. Kadurina et al. Each group was divided into subgroups depending on the severity of the manifestations of connective tissue dysplasia. The determination of the level of calcium and phosphorus in the blood and urine, as well as the calculation of the calcium-creatinine coefficient followed by a comparison of the results in these groups and subgroups. To assess the significance of differences, the Mann-Whitney test was calculated, p <0.05 was considered significant. RESULTS. he level of calcium and phosphorus in the urine was slightly higher in children with enuresis, especially in the morning portion of urine, where the concentration of calcium was 26% higher than in patients with NMDB. At the same time, the value of calcium /creatinine coefficient was significantly higher in the group of patients with enuresis and was 2 times higher than the normative indicators, which indicates the importance of hypercalciuria in the development of enuresis. СONCLUSION. According to the obtained data, the severity of calciuria, determined by the value of the calcium-creatinine coefficient, is significantly higher in patients with enuresis than with NMDB.

scholarly journals Evaluation of clinical practice guidelines (CPG) on the management of female chronic pelvic pain (CPP) using the AGREE II instrument

2021 ◽  
Author(s):  
Vishalli Ghai ◽  
Venkatesh Subramanian ◽  
Haider Jan ◽  
Jemina Loganathan ◽  
Stergios K. Doumouchtsis ◽  
...  
Keyword(s):  
Surgical Management ◽  
Guideline Development ◽  
Stakeholder Involvement ◽  
Professional Organizations ◽  
Agree Ii ◽  
Behavioural Interventions ◽  
Recommended Treatment ◽  
Muscular Dysfunction ◽  
Health Related

Abstract Introduction and hypothesis Variations in guidelines may result in differences in treatments and potentially poorer health-related outcomes. We aimed to systematically review and evaluate the quality of national and international guidelines and create an inventory of CPG recommendations on CPP. Methods We searched EMBASE and MEDLINE databases from inception till August 2020 as well as websites of professional organizations and societies. We selected national and international CPGs reporting on the diagnosis and management of female CPP. We included six CPGs. Five researchers independently assessed the quality of included guidelines using the AGREE II tool and extracted recommendations. Results Two hundred thirty-two recommendations were recorded and grouped into six categories: diagnosis, medical treatment, surgical management, behavioural interventions, complementary/alternative therapies and education/research. Thirty-nine (17.11%) recommendations were comparable including: a comprehensive pain history, a multi-disciplinary approach, attributing muscular dysfunction as a cause of CPP and an assessment of quality of life. Two guidelines acknowledged sexual dysfunction associated with CPP and recommended treatment with pelvic floor exercises and behavioural interventions. All guidelines recommended surgical management; however, there was no consensus regarding adhesiolysis, bilateral salpingo-oophorectomy during hysterectomy, neurectomy and laparoscopic uterosacral nerve ablation. Half of recommendations (106, 46.49%) were unreferenced or made in absence of good-quality evidence or supported by expert opinion. Based on the AGREE II assessment, two guidelines were graded as high quality and recommended without modifications (EAU and RCOG). Guidelines performed poorly in the “Applicability”, “Editorial Independence” and “Stakeholder Involvement” domains. Conclusion Majority of guidelines were of moderate quality with significant variation in recommendations and quality of guideline development.

Muscular dysfunction elicited by creep of lumbar viscoelastic tissue

2003 ◽  
Vol 13 (4) ◽  
pp. 381-396 ◽  
Author(s):  
M. Solomonow ◽  
R.V. Baratta ◽  
B.-H. Zhou ◽  
E. Burger ◽  
A. Zieske ◽  
...  
Keyword(s):  
Muscular Dysfunction

scholarly journals Effect of educational and self-care therapies on masticatory performance of women with painful temporomandibular disorder

2018 ◽  
Vol 47 (3) ◽  
pp. 143-148
Author(s):  
Gabriela GIRO ◽  
Danny Omar Mendoza MARIN ◽  
Marcela Dantas Dias da SILVA ◽  
Daniela Aparecida de Godoi GONÇALVES ◽  
Ana Carolina PERO
Keyword(s):  
Temporomandibular Disorder ◽  
Self Care ◽  
Treatment Modalities ◽  
Control Group ◽  
Masticatory Performance ◽  
Education Group ◽  
Muscular Dysfunction ◽  
Baseline Evaluation ◽  
Mandibular Movements ◽  
The Impact

Abstract Introduction Temporomandibular disorders (TMD) can compromise masticatory performance due to the presence of pain, muscular dysfunction and limitation of mandibular movements. Substantial improvements in TMD pain can be achieved through therapeutic approaches including education and self-care. Objective The aim of the present study was to investigate the impact of these treatment modalities in the masticatory performance of women with painful TMD. Material and method Fifty-two women were randomly divided into three groups: Control Group (CG); Education Group (received education about TMD) (EG); Self-Care and Education Group (received education about TMD and instructions self-care therapies) (SEG). The education instructions about TMD and self-care therapies were transmitted through a video and printed illustrative material. The masticatory performance was evaluated through the sieves method with natural tested foods in the evaluation periods: baseline evaluation, 30 days after and 60 days of follow-up. Data were analyzed and used with a one-way ANOVA parametric test for mean comparison of CG, EG and SEG groups (α = 0.05). Result The masticatory performance of the participants was similar, irrespective of the proposed treatments, at baseline (p=.604), 30 days (p=.450) and 60 days (p=.669). Conclusions The results indicated that treatment with educational and self-care therapies over a period of 60 days had no impact on the masticatory performance of women with painful TMD.

High-Resolution Computed Tomography of the Osseous Temporomandibular Joint

1984 ◽  
Vol 25 (6) ◽  
pp. 465-469 ◽  
Author(s):  
T. A. Larheim ◽  
A. Kolbenstvedt
Keyword(s):  
Rheumatoid Arthritis ◽  
Computed Tomography ◽  
Temporomandibular Joint ◽  
Ct Scanning ◽  
Diagnostic Information ◽  
Disc Displacement ◽  
High Resolution Computed Tomography ◽  
Neck Stiffness ◽  
Muscular Dysfunction ◽  
Axial Ct

A standardized CT procedure for examination of the temporomandibular joint (TMJ) with axial and coronal scanning as well as reformatted coronal and sagittal sections, was performed on 32 adults. These included subjects with normal TMJ and patients suffering from muscular dysfunction/disc displacement, arthrosis or rheumatoid arthritis. Some normal CT appearances simulating disease were presented. Axial CT scanning appeared to be the most useful method for demonstrating osseous abnormalities of the TMJ. The diagnostic information was occasionally supplemented by the coronal scanning, which may be difficult to perform on patients with neck stiffness. Reformatted coronal or sagittal sections mostly confirmed TMJ abnormality and supplemented the findings at axial scans in about one third of the patients.

scholarly journals Prevention of scoliotic spinal deformity in children with mild neuro-orthopedic pathology

2020 ◽  
Vol 37 (3) ◽  
pp. 103-109
Author(s):  
N. B. Schekolova ◽  
V. M. Ladeischikov ◽  
Ya. V. Nenakhova ◽  
L. V. Likhacheva
Keyword(s):  
Spinal Deformity ◽  
Total Efficiency ◽  
Complex Treatment ◽  
Therapeutic Program ◽  
Muscular Dysfunction ◽  
Prognostic Criterion ◽  
Functional Features ◽  
Degree Of Severity ◽  
Early Diagnostic

Objective. To describe in details the prevention of scoliotic spinal deformity in children with mild neuro-orthopedic pathology. Materials and methods. The health status of 125 children aged 3 to 15 years was studied. To investigate in details the neuro-orthopedic pathology and estimate the efficiency of treatment, the method of computed optic topography and electroneuromyography was used. Results. Clinical and functional features in children with mild neuro-orthopedic disorders were characterized by the combination of vegetative, topographic and electromyographic changes. Scoliosis and spinal deformity progressed in children, who were not treated. Computer-topographic method of diagnosis determines the degree of severity of spinal state. Electroneuromyographic study is the method that permits to assess and predict the muscular dysfunction degree. All the children had conservative complex treatment at ambulatory-polyclinic rehabilitation institutions. The total efficiency of treatment was 95 %. Conclusions. 1. Mild neuro-orthopedic pathology is formed and progresses against the background of neuro-muscular and vegetative disorders while a child is growing and developing. 2. Computed optic topography is a reliable early diagnostic and prognostic criterion for estimation of scoliosis in the therapeutic program. 3. Purposeful conservative treatment and follow-up of children and adolescents prevent the progression of neuro-orthopedic pathology.

scholarly journals Myopenia and Musculoskeletal Aging in Rheumatoid Arthritis

2020 ◽  
Author(s):  
Dan Xu ◽  
Jiake Xu ◽  
Lei Dai
Keyword(s):  
Rheumatoid Arthritis ◽  
Muscle Function ◽  
Inflammatory Arthritis ◽  
Muscle Wasting ◽  
Management Strategies ◽  
Chronic Inflammatory Disease ◽  
Muscular Dysfunction ◽  
Younger Age ◽  
High Prevalence

Rheumatoid arthritis (RA), the commonest inflammatory arthritis, is a debilitating disease leading to decreased functional capacity, social disability and reduced quality of life. RA affects multisystems with chronic inflammatory disease characterized by destructive synovitis and muscular dysfunction leading to premature musculoskeletal aging, which has been coined with many terms including myopenia, sarcopenia, cachexia, muscle failure and muscle wasting. Myopenia is described as the presence of clinically relevant muscle wasting due to any illness at any age, associated with impaired muscle function, increased morbidity and mortality. RA myopenia has significantly less muscle mass compared to the general population muscle loss showing preservation or slight increase in fat mass. RA myopenia is unique compared to chronic disease-related myopenia in cancer, chronic heart failure, kidney disease and chronic infection as it is rarely accompanied by a net weight loss. RA myopenia has younger-age onset compared to elderly primary sarcopenia, while higher-grade inflammation has been considered as the pathophysiology of muscle wasting. Research, however, indicates that inflammation itself cannot fully explain the high prevalence of muscle wasting in RA. This chapter aims to review the literature on the casual relationships among RA myopenia, premature musculoskeletal aging and management strategies to delay musculoskeletal aging.

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