Cannabinoid dependence induces sustained changes in GABA release in the globus pallidus without affecting dopamine release in the dorsal striatum: A dual microdialysis probe study

2018 ◽  
Vol 23 (6) ◽  
pp. 1251-1261
Author(s):  
Margarita Moreno ◽  
Juan Decara ◽  
Francisco Javier Pavon ◽  
David G. Stouffer ◽  
Scott Edwards ◽  
...  
Keyword(s):  
Globus Pallidus ◽  
Dopamine Release ◽  
Dorsal Striatum ◽  
Gaba Release ◽  
Microdialysis Probe

scholarly journals Value Encoding in the Globus Pallidus: fMRI reveals an interaction effect between reward and dopamine drive

2017 ◽  
Author(s):  
Vincenzo G. Fiore ◽  
Tobias Nolte ◽  
Francesco Rigoli ◽  
Peter Smittenaar ◽  
Xiaosi Gu ◽  
...  
Keyword(s):  
Globus Pallidus ◽  
Dopamine Release ◽  
Dorsal Striatum ◽  
Neural Model ◽  
Neural Dynamics ◽  
Dopamine Antagonist ◽  
Core Nucleus ◽  
External Part ◽  
Fmri Analysis ◽  
New Perspective

AbstractThe external part of the globus pallidus (GPe) is a core nucleus of the basal ganglia (BG) whose activity is disrupted under conditions of low dopamine release, as in Parkinson’s disease. Current models assume decreased dopamine release in the dorsal striatum results in deactivation of dorsal GPe, which in turn affects motor expression via a regulatory effect on other nuclei of the BG. However, recent studies in healthy and pathological animal models have reported neural dynamics that do not match with this view of the GPe as a relay in the BG circuit. Thus, the computational role of the GPe in the BG is still to be determined. We previously proposed a neural model that revisits the functions of the nuclei of the BG, and this model predicts that GPe encodes values which are amplified under a condition of low striatal dopaminergic drive. To test this prediction, we used an fMRI paradigm involving a within-subject placebo-controlled design, using the dopamine antagonist risperidone, wherein healthy volunteers performed a motor selection and maintenance task under low and high reward conditions. ROI-based fMRI analysis revealed an interaction between reward and dopamine drive manipulations, with increased BOLD activity in GPe in a high compared to low reward condition, and under risperidone compared to placebo. These results confirm the core prediction of our computational model, and provide a new perspective on neural dynamics in the BG and their effects on motor selection and motor disorders.

scholarly journals The tectonigral pathway regulates appetitive locomotion in predatory hunting in mice

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Meizhu Huang ◽  
Dapeng Li ◽  
Xinyu Cheng ◽  
Qing Pei ◽  
Zhiyong Xie ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Superior Colliculus ◽  
Dopamine Release ◽  
Dorsal Striatum ◽  
Dopamine Neurons ◽  
Substantia Nigra Pars Compacta ◽  
Neuronal Circuitry ◽  
Locomotion Speed ◽  
Brain Circuit ◽  
Goal Directed Behavior

AbstractAppetitive locomotion is essential for animals to approach rewards, such as food and prey. The neuronal circuitry controlling appetitive locomotion is unclear. In a goal-directed behavior—predatory hunting, we show an excitatory brain circuit from the superior colliculus (SC) to the substantia nigra pars compacta (SNc) to enhance appetitive locomotion in mice. This tectonigral pathway transmits locomotion-speed signals to dopamine neurons and triggers dopamine release in the dorsal striatum. Synaptic inactivation of this pathway impairs appetitive locomotion but not defensive locomotion. Conversely, activation of this pathway increases the speed and frequency of approach during predatory hunting, an effect that depends on the activities of SNc dopamine neurons. Together, these data reveal that the SC regulates locomotion-speed signals to SNc dopamine neurons to enhance appetitive locomotion in mice.

scholarly journals In vivo evidence for the unique kinetics of evoked dopamine release in the patch and matrix compartments of the striatum

2021 ◽  
Author(s):  
Andrea Jaquins-Gerstl ◽  
Kathryn M. Nesbitt ◽  
Adrian C. Michael
Keyword(s):  
Dopamine Release ◽  
Spatial Organization ◽  
Dorsal Striatum ◽  
Immunohistochemical Analysis ◽  
Extensive Literature ◽  
Fast Scan Cyclic Voltammetry ◽  
Medial Dorsal ◽  
The Matrix ◽  
Slow Kinetic

AbstractThe neurochemical transmitter dopamine (DA) is implicated in a number of diseases states, including Parkinson’s disease, schizophrenia, and drug abuse. DA terminal fields in the dorsal striatum and core region of the nucleus accumbens in the rat brain are organized as heterogeneous domains exhibiting fast and slow kinetic of DA release. The rates of dopamine release are significantly and substantially faster in the fast domains relative to the slow domains. The striatum is composed of a mosaic of spatial compartments known as the striosomes (patches) and the matrix. Extensive literature exists on the spatial organization of the patch and matrix compartments and their functions. However, little is known about these compartments as they relate to fast and slow kinetic DA domains observed by fast scan cyclic voltammetry (FSCV). Thus, we combined high spatial resolution of FSCV with detailed immunohistochemical analysis of these architectural compartments (patch and matrix) using fluorescence microscopy. Our findings demonstrated a direct correlation between patch compartments with fast domain DA kinetics and matrix compartments to slow domain DA kinetics. We also investigated the kinetic domains in two very distinct sub-regions in the striatum, the lateral dorsal striatum (LDS) and the medial dorsal striatum (MDS). The lateral dorsal striatum as opposed to the medial dorsal striatum is mainly governed by fast kinetic DA domains. These finding are highly relevant as they may hold key promise in unraveling the fast and slow kinetic DA domains and their physiological significance. Graphical abstract

scholarly journals Calbindin-D28K Limits Dopamine Release in Ventral but Not Dorsal Striatum by Regulating Ca2+ Availability and Dopamine Transporter Function

2019 ◽  
Vol 10 (8) ◽  
pp. 3419-3426 ◽  
Author(s):  
Katherine R. Brimblecombe ◽  
Stefania Vietti-Michelina ◽  
Nicola J. Platt ◽  
Rahel Kastli ◽  
Ahmad Hnieno ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Dopamine Release ◽  
Dorsal Striatum ◽  
Calbindin D28k

2.406 Enhanced GABA release in the medial globus pallidus in a rat model of L-DOPA-induced dyskinesia

2007 ◽  
Vol 13 ◽  
pp. S129
Author(s):  
M. Tomiyama ◽  
A. Arai ◽  
G. Zhu ◽  
T. Kimura ◽  
T. Kawarabayashi ◽  
...  
Keyword(s):  
Globus Pallidus ◽  
Rat Model ◽  
Gaba Release

Frequency-dependent effects of electrical stimulation in the globus pallidus of dystonia patients

2012 ◽  
Vol 108 (1) ◽  
pp. 5-17 ◽  
Author(s):  
Liu D. Liu ◽  
Ian A. Prescott ◽  
Jonathan O. Dostrovsky ◽  
Mojgan Hodaie ◽  
Andres M. Lozano ◽  
...  
Keyword(s):  
Globus Pallidus ◽  
High Frequency ◽  
Gaba Release ◽  
Neuronal Firing ◽  
High Frequency Stimulation ◽  
Low Frequencies ◽  
Clinical Benefits ◽  
Frequency Stimulation ◽  
Train Length ◽  
Additional Support

Deep brain stimulation (DBS) in the globus pallidus internus (GPi) has been shown to improve dystonia, a movement disorder of repetitive twisting movements and postures. DBS at frequencies above 60 Hz improves dystonia, but the mechanisms underlying this frequency dependence are unclear. In patients undergoing dual-microelectrode mapping of the GPi, microstimulation has been shown to reduce neuronal firing, presumably due to synaptic GABA release. This study examined the effects of different microstimulation frequencies (1–100 Hz) and train length (0.5–20 s), with and without prior high-frequency stimulation (HFS) on neuronal firing and evoked field potentials (fEPs) in 13 dystonia patients. Pre-HFS, the average firing decreased as stimulation frequency increased and was silenced above 50 Hz. The average fEP amplitudes increased up to frequencies of 20–30 Hz but then declined and at 50 Hz, were only at 75% of baseline. In some cases, short latency fiber volleys and antidromic-like spikes were observed and followed high frequencies. Post-HFS, overall firing was reduced compared with pre-HFS, and the fEP amplitudes were enhanced at low frequencies, providing evidence of inhibitory synaptic plasticity in the GPi. In a patient with DBS electrodes already implanted in the GPi, recordings from four neurons in the subthalamic nucleus showed almost complete inhibition of firing with clinically effective but not clinically ineffective stimulation parameters. These data provide additional support for the hypothesis of stimulation-evoked GABA release from afferent synaptic terminals and reduction of neuronal firing during DBS and additionally, implicate excitation of GPi axon fibers and neurons and enhancement of inhibitory synaptic transmission by high-frequency GPi DBS as additional putative mechanisms underlying the clinical benefits of DBS in dystonia.

Synaptically Released GABA Activates Both Pre- and Postsynaptic GABAB Receptors in the Rat Globus Pallidus

2005 ◽  
Vol 94 (2) ◽  
pp. 1104-1114 ◽  
Author(s):  
Katsuyuki Kaneda ◽  
Hitoshi Kita
Keyword(s):  
Globus Pallidus ◽  
Reversal Potential ◽  
Gaba Release ◽  
Gabab Receptors ◽  
Equilibrium Potential ◽  
Postsynaptic Currents ◽  
Gabaergic Synapses ◽  
Rat Brain Slice ◽  
Whole Cell Recordings ◽  
Local Stimulation

The globus pallidus (GP) contains abundant GABAergic synapses and GABAB receptors. To investigate whether synaptically released GABA can activate pre- and postsynaptic GABAB receptors in the GP, physiological recordings were performed using rat brain slice preparations. Cell-attached recordings from GABAA antagonist-treated preparations revealed that repetitive local stimulation induced a GABAB antagonist-sensitive pause in spontaneous firings of GP neurons. Whole cell recordings revealed that the repetitive stimulation evoked fast excitatory postsynaptic potentials followed by a slow inhibitory postsynaptic potential (IPSP) in GP neurons. The slow IPSP was insensitive to a GABAA receptor antagonist, increased in amplitude with the application of ionotropic glutamate receptor antagonists, and was suppressed by the GABAB antagonist CGP55845 . The reversal potential of the slow IPSP was close to the potassium equilibrium potential. These results suggest that synaptically released GABA activated postsynaptic GABAB receptors and induced the pause and the slow IPSP. On the other hand, in the neurons that were treated to block postsynaptic GABAB responses, CGP55845 increased the amplitudes of repetitive local stimulation-induced GABAA-mediated inhibitory postsynaptic currents (IPSCs) but not the ionotropic glutamate-mediated excitatory postsynaptic currents. Moreover, the GABAB receptor specific agonist baclofen reduced the frequency of miniature IPSCs without altering their amplitude distributions. These results suggest that synaptically released GABA also activated presynaptic GABAB autoreceptors, resulting in decreased GABA release in the GP. Together, we infer that both pre- and postsynaptic GABAB receptors may play crucial roles in the control of GP neuronal activity.

Facilitation of gaba release by neurotensin is associated with a reduction of dopamine release in rat nucleus accumbens

Neuroscience ◽  
1994 ◽  
Vol 60 (3) ◽  
pp. 649-657 ◽  
Author(s):  
S. Tanganelli ◽  
W.T. O'connor ◽  
L. Ferraro ◽  
C. Bianchi ◽  
L. Beani ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Gaba Release ◽  
Rat Nucleus Accumbens

scholarly journals A review of the effects of FSCV and microdialysis measurements on dopamine release in the surrounding tissue

The Analyst ◽  
2015 ◽  
Vol 140 (11) ◽  
pp. 3696-3708 ◽  
Author(s):  
Andrea Jaquins-Gerstl ◽  
Adrian C. Michael
Keyword(s):  
Dopamine Release ◽  
Surrounding Tissue ◽  
Microdialysis Probe

We review the work of “voltammetry next to a microdialysis probe” as measured by dopamine and the surrounding tissue.

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