Protective effect of alpha glucosyl hesperidin (G-hesperidin) on chronic vanadium induced testicular toxicity and sperm nuclear DNA damage in male Sprague Dawley rats

Andrologia ◽  
2014 ◽  
Vol 47 (5) ◽  
pp. 568-578 ◽  
Author(s):  
B. Vijaya Bharathi ◽  
G. Jaya Prakash ◽  
K. M. Krishna ◽  
C. H. Ravi Krishna ◽  
T. Sivanarayana ◽  
...  
Keyword(s):  
Dna Damage ◽  
Protective Effect ◽  
Nuclear Dna ◽  
Testicular Toxicity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Curcumin Reduces Neuroinflammation and Improves the Impairments of Anesthetics on Learning and Memory by Regulating the Expression of miR-181a-5p

2021 ◽  
pp. 1-9
Author(s):  
Guizhen Liu ◽  
Yuchuan Sun ◽  
Fei Liu
Keyword(s):  
Cognitive Impairment ◽  
Protective Effect ◽  
Learning And Memory ◽  
Cognitive Dysfunction ◽  
Inflammatory Cytokines ◽  
Neuroprotective Effect ◽  
Morris Water Maze Test ◽  
Sprague Dawley ◽  
Protein Levels ◽  
Sprague Dawley Rats

<b><i>Objective:</i></b> The purpose of this study was to explore the role of curcumin (Cur) in isoflurane (ISO)-induced learning and memory dysfunction in Sprague-Dawley rats and further elucidate the mechanism of the protective effect produced by Cur. <b><i>Methods:</i></b> Rat models of cognitive impairment were established by inhaling 3% ISO. The Morris water maze test was used to assess the cognitive function of rats. ELISA and qRT-PCR were used to analyze the protein levels of pro-inflammatory cytokines and expression levels of miR-181a-5p, respectively. <b><i>Results:</i></b> Cur significantly improved the ISO-induced cognitive dysfunction in rats and alleviated the ISO-induced neuroinflammation. miR-181a-5p was overexpressed in ISO-induced rats, while Cur treatment significantly reduced the expression of miR-181a-5p. Overexpression of miR-181a-5p promoted the cognitive impairment and the release of inflammatory cytokines and reversed the neuroprotective effect of Cur. <b><i>Conclusion:</i></b> Cur has a protective effect on ISO-induced cognitive dysfunction, which may be achieved by regulating the expression of miR-181a-5p.

scholarly journals Effects of TRPC6 Inactivation on Glomerulosclerosis and Renal Fibrosis in Aging Rats

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 856
Author(s):  
Eun Young Kim ◽  
Stuart E. Dryer
Keyword(s):  
Renal Function ◽  
Protective Effect ◽  
Renal Fibrosis ◽  
Transient Receptor Potential ◽  
Smooth Muscle Actin ◽  
Receptor Potential ◽  
Sprague Dawley ◽  
Age Related ◽  
Sprague Dawley Rats ◽  
Transient Receptor

Canonical transient receptor potential 6 (TRPC6) channels have been implicated in familial and acquired forms of focal and segmental glomerulosclerosis (FSGS) in patients and animal models, as well as in renal fibrosis following ureteral obstruction in mice. Aging also evokes declines in renal function owing to effects on almost every renal compartment in humans and rodents. Here, we have examined the role of TRPC6 in driving inflammation and fibrosis during aging in Sprague-Dawley rats. This was assessed in rats with non-functional TRPC6 channels owing to CRISPR-Cas9 deletion of a portion of the ankyrin repeat domain required for the assembly of functional TRPC6 channels (Trpc6del/del rats). Wild-type littermates (Trpc6wt/wt rats) were used as controls. Animals were evaluated at 2 months and 12 months of age. There was no sign of kidney disease at 2 months of age, regardless of genotype. However, by 12 months of age, all rats examined showed declines in renal function associated with albuminuria, azotemia and increased urine excretion of β2–microglobulin, a marker for proximal tubule pathology. These changes were equally severe in Trpc6wt/wt and Trpc6del/del rats. We also observed age-related increases in renal cortical expression of markers of fibrosis (α-smooth muscle actin and vimentin) and inflammation (NLRP3 and pro-IL−1β), and there was no detectable protective effect of TRPC6 inactivation. Tubulointerstitial fibrosis assessed from histology also appeared equally severe in Trpc6wt/wt and Trpc6del/del rats. By contrast, glomerular pathology, blindly scored from histological sections, suggested a significant protective effect of TRPC6 inactivation, but only within the glomerular compartment.

DEHP-induced testicular injury through gene methylation pathway and the protective effect of soybean isoflavones in Sprague–Dawley rats

2021 ◽  
pp. 109569
Author(s):  
Luchen Yang ◽  
Dongliang Lu ◽  
Bo Yang ◽  
Zhufeng Peng ◽  
Kun Fang ◽  
...  
Keyword(s):  
Protective Effect ◽  
Sprague Dawley ◽  
Gene Methylation ◽  
Soybean Isoflavones ◽  
Methylation Pathway ◽  
Sprague Dawley Rats ◽  
Testicular Injury

scholarly journals The effects of MOTILIPERM on cisplatin induced testicular toxicity in Sprague–Dawley rats

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Kiran Kumar Soni ◽  
Li Tao Zhang ◽  
Jae Hyung You ◽  
Sung Won Lee ◽  
Chul Young Kim ◽  
...  
Keyword(s):  
Testicular Toxicity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Cross-talk between ER stress and mitochondrial pathway mediated adriamycin-induced testicular toxicity and DA-9401 modulate adriamycin-induced apoptosis in Sprague–Dawley rats

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Keshab Kumar Karna ◽  
Bo Ram Choi ◽  
Jae Hyung You ◽  
Yu Seob Shin ◽  
Kiran Kumar Soni ◽  
...  
Keyword(s):  
Er Stress ◽  
Cross Talk ◽  
Mitochondrial Pathway ◽  
Testicular Toxicity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Induced Apoptosis

scholarly journals Anti-infertility significance of aqueous extract of I pomoea batatas (L.) Lam. against exposure of bisphenol A (BPA) promoted testicular toxicity in male Sprague Dawley rats

2013 ◽  
Vol 2 (4) ◽  
pp. 263-271
Author(s):  
Rajendran Revathy ◽  
Kulanthaivel Langeswaran ◽  
Subbaraj Gowtham kumar ◽  
Shanmugam Vijayaprakash ◽  
Peranandam Tamilselvan ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Aqueous Extract ◽  
Testicular Toxicity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Protective Effect of 3, 3-Diindolylmethane on Bisphenol A Activated GPR30, RAS, PI3K/Akt Estrogenic Signaling Pathway in Female Sprague-Dawley Rats

2017 ◽  
Vol 03 (01) ◽  
Author(s):  
Subbaiyan Thilagavathi ◽  
Pachaiappan Pugalendhi ◽  
Thangarasu Rajakumar ◽  
Krishnamoorthy Vasudevan
Keyword(s):  
Bisphenol A ◽  
Protective Effect ◽  
Signaling Pathway ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Acrylonitrile-Induced Oxidative Stress and Oxidative DNA Damage in Male Sprague-Dawley Rats

2009 ◽  
Vol 111 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Xinzhu Pu ◽  
Lisa M. Kamendulis ◽  
James E. Klaunig
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals The Protective Effect of Yi Shen Juan Bi Pill in Arthritic Rats with Castration-Induced Kidney Deficiency

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Hongyan Zhao ◽  
Jian Li ◽  
Xiaojuan He ◽  
Cheng Lu ◽  
Cheng Xiao ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Protective Effect ◽  
Androgen Deficiency ◽  
Sprague Dawley ◽  
Collagen Induced Arthritis ◽  
Common Pattern ◽  
Pharmacological Mechanism ◽  
Kidney Deficiency ◽  
Sprague Dawley Rats ◽  
Lipid Metabolites

Androgens have been linked to the onset, severity, and progression of rheumatoid arthritis (RA). In traditional Chinese medicine (TCM), the most common pattern in RA is kidney deficiency, which partly corresponds to a low sex hormone state. In this study, TCM kidney deficiency was induced in male Sprague-Dawley rats with castration surgery, and a TCM preparation, Yi Shen Juan Bi Pill (YJB), was used to treat collagen induced arthritis (CIA) rats with castration. Metabolomic technique was used to evaluate the pharmacological mechanism in castrated CIA rats treated by YJB. The results showed that castration significantly increased the severity of the arthritis in rats but was ameliorated by YJB. Its pharmacological mechanism was partially associated with lipid metabolites involving free fatty acid (FFA) and lysophosphatidylcholine (LPC).In conclusion, the experimental results demonstrate the protective effect of YJB on the TCM kidney deficiency pattern induced by androgen deficiency in CIA rats and support that YJB should be used for the clinical treatment of RA with TCM kidney deficiency pattern.

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