scholarly journals Temporal changes of noninvasive electrocardiographic risk factors for sudden cardiac death in post‐myocardial infarction patients with preserved ejection fraction: Insights from the PRESERVE‐EF study

2019 ◽  
Vol 25 (1) ◽  
Author(s):  
Iosif Xenogiannis ◽  
Konstantinos A. Gatzoulis ◽  
Panagiota Flevari ◽  
Ignatios Ikonomidis ◽  
Efstathios Iliodromitis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Sudden Cardiac Death ◽  
Ejection Fraction ◽  
Cardiac Death ◽  
Temporal Changes ◽  
Post Myocardial Infarction ◽  
Preserved Ejection Fraction

P-45 Risk factors for sudden cardiac death in young women after myocardial infarction

Resuscitation ◽  
1996 ◽  
Vol 31 (3) ◽  
pp. S32
Author(s):  
J. Kloś ◽  
S. Karczmarewicz ◽  
P. Kulakowski ◽  
J. Kociszewska ◽  
L. Ceremużyński
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Sudden Cardiac Death ◽  
Young Women ◽  
Cardiac Death

scholarly journals Osteopontin and LDLR Are Upregulated in Hearts of Sudden Cardiac Death Victims With Heart Failure With Preserved Ejection Fraction and Diabetes Mellitus

2020 ◽  
Vol 7 ◽  
Author(s):  
Mausam Patel ◽  
Daniela Rodriguez ◽  
Keyvan Yousefi ◽  
Krista John-Williams ◽  
Armando J. Mendez ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Sudden Cardiac Death ◽  
Ejection Fraction ◽  
Cardiac Death ◽  
Density Lipoprotein ◽  
Molecular Pathways ◽  
Preserved Ejection Fraction ◽  
Control Subjects ◽  
Increased Risk

Background: Diabetes mellitus (DM) is associated with increased risk of sudden cardiac death (SCD), particularly in patients with heart failure with preserved ejection fraction (HFpEF). However, there are no known biomarkers in the population with DM and HFpEF to predict SCD risk.Objectives: This study was designed to test the hypothesis that osteopontin (OPN) and some proteins previously correlated with OPN, low-density lipoprotein receptor (LDLR), dynamin 2 (DNM2), fibronectin-1 (FN1), and 2-oxoglutarate dehydrogenase-like (OGDHL), are potential risk markers for SCD, and may reflect modifiable molecular pathways in patients with DM and HFpEF.Methods: Heart tissues were obtained at autopsy from 9 SCD victims with DM and HFpEF and 10 age and gender-matched accidental death control subjects from a Finnish SCD registry and analyzed for the expression of OPN and correlated proteins, including LDLR, DNM2, FN1, and OGDHL by immunohistochemistry.Results: We observed a significant upregulation in the expression of OPN, LDLR, and FN1, and a marked downregulation of DNM2 in heart tissues of SCD victims with DM and HFpEF as compared to control subjects (p < 0.01).Conclusions: The dysregulated protein expression of OPN, LDLR, FN1, and DNM2 in patients with DM and HFpEF who experienced SCD provides novel potential modifiable molecular pathways that may be implicated in the pathogenesis of SCD in these patients. Since secreted OPN and soluble LDLR can be measured in plasma, these results support the value of further prospective studies to assess the predictive value of these plasma biomarkers and to determine whether tuning expression levels of OPN and LDLR alters SCD risk in patients with DM and HFpEF.

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