Vitamin D status is associated with muscular strength in a nationally representative sample of US youth

2020 ◽  
Vol 109 (12) ◽  
pp. 2755-2761
Author(s):  
Kelly R. Laurson ◽  
Jaime N. Thomas ◽  
Jennifer L. Barnes
Keyword(s):  
Vitamin D ◽  
Representative Sample ◽  
Muscular Strength ◽  
Vitamin D Status ◽  
Nationally Representative

scholarly journals Vitamin D status and pain: analysis from the Health Survey for England among English adults aged 65 years and over

2011 ◽  
Vol 107 (7) ◽  
pp. 1080-1084 ◽  
Author(s):  
Vasant Hirani
Keyword(s):  
Vitamin D ◽  
Older People ◽  
Representative Sample ◽  
Well Being ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
Wide Range ◽  
Direction Of Causation ◽  
Nationally Representative

Poor vitamin D status is common in older people and results in osteoporosis; osteomalacia is associated with a wide range of non-communicable diseases and has potential effects on poor health outcomes. Pain is also common in older people and can be substantially disabling. The aim of the present analysis is to investigate associations between serum 25-hydroxy vitamin D (25(OH)D) and self-reported current symptoms of pain in a cross-sectional, nationally representative sample of 2070 adults aged ≥ 65 years living in the community in England in 2005. Measurements included serum 25(OH)D, pain status and covariates, namely, age, sex, social class, season of examination, use of vitamin supplements and physical health status. Results show that the symptoms of moderate/extreme pain (present in 53 % of the sample) were associated with poor vitamin D status, independent of other covariates. Particular advantages of the present study were the presence of directly measured vitamin D levels and a large and nationally representative sample. Poor vitamin D status is common and an associated risk factor for pain in older people living in northern latitudes. The direction of causation cannot be inferred from a cross-sectional study and further prospective research is required to clarify this. Regardless of the direction of causation, the relationship is potentially of high public health importance because of the adverse impact of both states on well-being. It is important that older people in pain are screened for vitamin D status and provided with appropriate interventions.

scholarly journals Weight and skin colour as predictors of vitamin D status: results of an epidemiological investigation using nationally representative data

2016 ◽  
Vol 20 (10) ◽  
pp. 1857-1864 ◽  
Author(s):  
Sonali Rajan ◽  
Tom Weishaar ◽  
Bryan Keller
Keyword(s):  
Vitamin D ◽  
Body Weight ◽  
Skin Colour ◽  
Vitamin D Status ◽  
Epidemiological Investigation ◽  
Dietary Recommendations ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Nationally Representative ◽  
The Impact

AbstractObjectiveCurrent US dietary recommendations for vitamin D vary by age. Recent research suggests that body weight and skin colour are also major determinants of vitamin D status. The objective of the present epidemiological investigation was to clarify the role of age as a predictor of vitamin D status, while accounting for body weight and skin colour, among a nationally representative sample.DesignWe calculated the mean serum 25-hydroxyvitamin D levels for the US population by age and weight, as well as by weight and race/ethnicity group. Multiple regression analyses were utilized to evaluate age and weight as predictors of vitamin D status: serum 25-hydroxyvitamin D levels with age alone, age and body weight, and age, body weight and their two-way interaction were modelled for the entire sample and each age subgroup. Graphical data were developed using B-spline non-linear regression.SettingNational Health and Nutrition Examination Survey (31 934 unweighted cases).SubjectsIndividuals aged 1 year and older.ResultsThere were highly significant differences in mean vitamin D status among US residents by weight and skin colour, with those having darker skin colour or higher body weight having worse vitamin D status. Although a significant factor, the impact of age on vitamin D status was notably less than the impact of body weight.ConclusionsVitamin D status varied predominantly by body weight and skin colour. Recommendations by nutritionists for diet and supplementation needs should take this into account if vitamin D-related health disparities are to be meaningfully reduced across the USA.

scholarly journals Association of serum 25-hydroxyvitamin D concentrations with all-cause and cause-specific mortality among individuals with diabetes mellitus

2020 ◽  
Author(s):  
Zhenzhen Wan ◽  
Jingyu Guo ◽  
An Pan ◽  
Chen Chen ◽  
Liegang Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Vitamin D Status ◽  
Hydroxyvitamin D ◽  
All Cause Mortality ◽  
Specific Mortality ◽  
25 Hydroxyvitamin D ◽  
Nationally Representative ◽  
Reduced Risk ◽  
Cvd Mortality

<b>Objective: </b>The evidence regarding vitamin D status and mortality among diabetes is scarce. This study aimed to examine the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-cause and cause-specific mortality among adults with <a>diabetes mellitus</a>. <p><b>Research Design and Methods: </b>This study included 6329 adults with diabetes from the Third National Health and Nutrition Examination Survey (NHANES III) and NHANES 2001-2014. Death outcomes were ascertained by linkage to National Death Index records through 31 December 2015. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence (CIs) for mortality from all causes, cardiovascular disease (CVD), and cancer.</p> <p><b>Results:</b> The weighted mean (95% CI) level of serum 25(OH)D was 57.7 (56.6, 58.8) nmol/L, and 46.6% had deficient vitamin D (<50 nmol/L [20 ng/mL]). <a>Higher </a>serum 25(OH)D levels were significantly associated with lower levels of glucose, insulin, HOMA-IR, HbA1c, blood lipids, and C-reactive protein at baseline (all <i>P</i><sub>trend</sub><0.05). During 55126 person-years of follow-up, 2056 deaths were documented, including 605 CVD deaths and 309 cancer deaths. <a>After multivariate adjustment, higher </a>serum 25(OH)D levels were significantly and linearly associated with lower all-cause and CVD mortality: there was a 31% reduced risk of all-cause mortality and a 38% reduced risk of CVD mortality per one unit increment in natural log-transformed 25(OH)D (both <i>P</i><0.001). Compared with participants with 25(OH)D <25 nmol/L, the multivariate-adjusted HRs and 95% CI for participants with 25(OH)D >75 nmol/L were 0.59 (0.43, 0.83) for all-cause mortality (<i>P</i><sub>trend</sub>=0.003), 0.50 (0.29, 0.86) for CVD mortality (<i>P</i><sub>trend</sub>=0.02), and 0.49 (0.23, 1.04) for cancer mortality (<i>P</i><sub>trend</sub>=0.12). </p> <p><b>Conclusions: </b>In a nationally representative sample of US adults with diabetes, higher serum 25(OH)D levels were significantly associated with lower all-cause and CVD mortality. These findings suggest that maintaining adequate vitamin D status may lower mortality risk in individuals with diabetes.</p>

scholarly journals Association of serum inorganic phosphate with sex steroid hormones and vitamin D in a nationally representative sample of men

Andrology ◽  
2014 ◽  
Vol 2 (6) ◽  
pp. 967-976 ◽  
Author(s):  
W. Wulaningsih ◽  
M. Van Hemelrijck ◽  
K. Michaelsson ◽  
N. Kanarek ◽  
W. G. Nelson ◽  
...  
Keyword(s):  
Vitamin D ◽  
Steroid Hormones ◽  
Representative Sample ◽  
Inorganic Phosphate ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Nationally Representative ◽  
Serum Inorganic Phosphate

Prevalence and predictors of vitamin D deficiency in a nationally representative sample of Australian Aboriginal and Torres Strait Islander adults

2020 ◽  
pp. 1-9
Author(s):  
Lucinda J. Black ◽  
Eleanor Dunlop ◽  
Robyn M. Lucas ◽  
Glenn Pearson ◽  
Brad Farrant ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Representative Sample ◽  
Torres Strait Islander ◽  
Public Health Problem ◽  
Healthy Weight ◽  
Remote Areas ◽  
Australian Aboriginal ◽  
Torres Strait ◽  
Nationally Representative

Abstract Vitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D) concentration <50 nmol/l) is recognised as a public health problem globally. The present study details the prevalence and predictors of vitamin D deficiency in a nationally representative sample (n 3250) of Australian Aboriginal and Torres Strait Islander adults aged ≥18 years. We used data from the 2012–2013 Australian Aboriginal and Torres Strait Islander Health Survey (AATSIHS). Serum 25(OH)D concentrations were measured by liquid chromatography-tandem MS. Survey-weighted logistic regression models were used to determine the independent predictors of vitamin D deficiency. Approximately 27 % of adult AATSIHS participants were vitamin D deficient. Vitamin D deficiency was more prevalent in remote areas (39 %) than in non-remote areas (23 %). Independent predictors of vitamin D deficiency included assessment during winter (men, adjusted OR (aOR) 5·7; 95 % CI 2·2, 14·6; women, aOR 2·2; 95 % CI 1·3, 3·8) and spring (men, aOR 3·3; 95 % CI 1·4, 7·5; women, aOR 2·6; 95 % CI 1·5, 4·5) compared with summer, and obesity (men, aOR 2·6; 95 % CI 1·2, 5·4; women, aOR 4·3; 95 % CI 2·8, 6·8) compared with healthy weight. Statistically significant associations were evident for current smokers (men only, aOR 2·0; 95 % CI 1·2, 3·4), remote-dwelling women (aOR 2·0; 95 % CI 1·4, 2·9) and university-educated women (aOR 2·4; 95 % CI 1·2, 4·8). Given the high prevalence of vitamin D deficiency in this population, strategies to maintain adequate vitamin D status through safe sun exposure and dietary approaches are needed.

scholarly journals Vitamin D deficiency and associated factors in Jordan

2019 ◽  
Vol 7 ◽  
pp. 205031211987615
Author(s):  
Mohammed El-Khateeb ◽  
Yousef Khader ◽  
Anwer Batieha ◽  
Hashem Jaddou ◽  
Dana Hyassat ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Representative Sample ◽  
Associated Factors ◽  
Vitamin D Status ◽  
Face To Face ◽  
Low Level ◽  
Health Authorities ◽  
Low Levels ◽  
National Representative Sample

Background: In Jordan, many studies reported various rates of vitamin D deficiency and insufficiency among different groups. This study aimed to determine the prevalence of low vitamin D level among Jordanian adults and determine its association with selected variables. Methods: The vitamin D level was assessed in a national representative sample of 4056 subjects aged >17 years. The study involved face-to-face interviews with the subjects and measurement of serum 25(OH)D. Low vitamin D level was defined as 25(OH)D < 30 ng/mL. Deficiency was defined as 25(OH)D < 20 ng/mL, and insufficiency was defined as 25(OH)D level of 20–30 ng/mL. Results: The overall prevalence of low vitamin D status (25(OH)D < 30 ng/mL) was 89.7%, with higher prevalence in males (92.4%) than in females (88.6%). Vitamin D was sufficient in 7.6% of males, insufficient in 38.4% of males, and deficient in 54% of males. Among females, vitamin D was insufficient in 10.1% and deficient in 78.5%. The prevalence of vitamin D deficiency was much higher in females than in males ( p = 0.001). The only variables that were significantly associated with low level of vitamin D were gender, age, obesity, and employment. Conclusion: The prevalence of low vitamin D level is extremely high in Jordan. Age, gender, obesity, and unemployment were associated with low levels of vitamin D. Health authorities in Jordan need to increase the level of awareness about vitamin D deficiency and its prevention, particularly among women.

scholarly journals Significance of Serum 24,25-Dihydroxyvitamin D in the Assessment of Vitamin D Status: A Double-edged Sword?

2015 ◽  
Vol 61 (4) ◽  
pp. 636-645 ◽  
Author(s):  
Kevin D Cashman ◽  
Aoife Hayes ◽  
Karen Galvin ◽  
Joyce Merkel ◽  
Glenville Jones ◽  
...  
Keyword(s):  
Vitamin D ◽  
Representative Sample ◽  
Controlled Trial ◽  
Cross Reactivity ◽  
Vitamin D Supplementation ◽  
Positive Bias ◽  
Dihydroxyvitamin D ◽  
Spiking Experiment ◽  
Nationally Representative ◽  
The Impact

Abstract BACKGROUND 24,25-Dihydroxyvitamin D [24,25(OH)2D] in serum may be both a nuisance and nutritionally valuable. METHODS We investigated the impact of 24,25(OH)2D3 on the performance of commercially available immunoassays for serum total 25-hydroxyvitamin D [25(OH)D] using (a) serum from a nationally representative sample of adults, (b) serum from a spiking experiment, and (c) data from the UK Vitamin D External Quality Assurance Scheme (DEQAS). We also investigated the utility of the serum ratio of 24,25(OH)2D3 to 25(OH)D as an index of inactivation and of response to vitamin D supplementation using randomized controlled trial (RCT) data. Measurement of 24,25(OH)2D in sera by a LC-MS/MS method allowed for an investigation of its impact on immunoassay-derived serum 25(OH)D values as well as its clinical utility. We report data from a nationally representative sample of adults, a recent vitamin D RCT in older adults, and DEQAS. RESULTS 24,25(OH)2D3 contributed to the positive bias observed in some immunoassays relative to LC-MS/MS-derived estimates for total 25(OH)D. A spiking experiment showed that the degree of cross-reactivity with 24,25(OH)2D was high and may underpin this positive bias. Adjustment for 24,25(OH)2D3 concentration brought estimates closer to true values. Data from the vitamin D RCT showed that the ratio of 24,25(OH)2D3 to 25(OH)D was associated with serum 25(OH)D3 and with response of serum 25(OH)D to vitamin D supplementation. CONCLUSIONS Our findings highlight that the effect of 24,25(OH)2D3 in serum is a double-edged sword—an interferent for some immunoassays, yet potentially informative of nutritional status.

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