Body mass index predicts discontinuation due to ineffectiveness and female sex predicts discontinuation due to side-effects in patients with psoriasis treated with adalimumab, etanercept or ustekinumab in daily practice: a prospective, comparative, long-t

2016 ◽  
Vol 175 (2) ◽  
pp. 340-347 ◽  
Author(s):  
J. Zweegers ◽  
J.M.P.A. van den Reek ◽  
P.C.M. van de Kerkhof ◽  
M.E. Otero ◽  
A.L.A. Kuijpers ◽  
...  
Author(s):  
Camila de Assunção Peixoto ◽  
Maria Beatriz Guimarães Ferreira ◽  
Márcia Marques dos Santos Felix ◽  
Patrícia da Silva Pires ◽  
Elizabeth Barichello ◽  
...  

ABSTRACT Objectives: to evaluate and classify patients according to the Risk Assessment Scale for Perioperative Pressure Injuries; verify the association between sociodemographic and clinical variables and the risk score; and identify the occurrence of pressure injuries due to surgical positioning. Method: observational, longitudinal, prospective and quantitative study carried out in a teaching hospital with 278 patients submitted to elective surgeries. A sociodemographic and clinical characterization questionnaire and the Risk Assessment Scale for Perioperative Pressure Injuries were used. Descriptive, bivariate and logistic regression analyses were applied. Results: the majority of patients (56.5%) presented a high risk for perioperative pressure injury. Female sex, elderly group, and altered body mass index values were statistically significant (p < 0.05) for a higher risk of pressure injuries. In 77% of the patients, there were perioperative pressure injuries. Conclusion: most of the participants presented a high risk for development of perioperative decubitus ulcers. The female sex, elderly group, and altered body mass index were significant factors for increased risk. The Risk Assessment Scale for Perioperative Pressure Injuries allows the early identification of risk of injury, subsidizing the adoption of preventive strategies to ensure the quality of perioperative care.


2018 ◽  
Vol 70 (3) ◽  
pp. 361-368 ◽  
Author(s):  
Sarah Twigg ◽  
Elizabeth M. A. Hensor ◽  
Jane Freeston ◽  
Ai Lyn Tan ◽  
Paul Emery ◽  
...  

2021 ◽  
Vol 10 (19) ◽  
pp. 4607
Author(s):  
Masakazu Hori ◽  
Teruhiko Imamura ◽  
Nikhil Narang ◽  
Hiroshi Onoda ◽  
Shuhei Tanaka ◽  
...  

Background: Small dense LDL-cholesterol is an established risk factor for atherosclerosis but is not routinely measured in daily practice. The association between small dense LDL-cholesterol and triglyceride, which in turn is routinely measured, in patients with acute coronary syndrome remains unknown. Methods: Consecutive patients with acute coronary syndrome who were admitted to our institute were prospectively included, and serum samples were obtained on admission. The association between small dense LDL-cholesterol and triglyceride was investigated. Results: Among 55 patients (median 71 years old, 64% men), median (interquartile range) small dense LDL-cholesterol was 23.6 (17.0, 36.0) and triglyceride was 101 (60, 134) mg/dL. Triglyceride level correlated with small dense LDL-cholesterol (r = 0.67, p < 0.001) and was an independent determinant of small dense LDL-cholesterol together with body mass index (p = 0.010 and p = 0.008, respectively). Those with high triglyceride and high body mass index had a 3-fold level of small dense LDL-cholesterol compared with those with low triglyceride and low body mass index (45.8 [35.0, 54.0] mg/dL versus 15.0 [11.6, 23.7] mg/dL, p = 0.001). Conclusions: Triglyceride level was a major determinant of small dense LDL-cholesterol in patients with acute coronary syndrome. Triglyceride level might be a useful and practical biomarker for risk stratification for patients with acute coronary syndrome together with body mass index.


2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Socrates Pozo ◽  
Janet Gordillo ◽  
Gisella Sanclemente ◽  
Lilia Toral ◽  
Walter Gonzalez ◽  
...  

Abstract Objectives The aim of this study was to determine the effects on the nutritional status of the migrant Puruhá indigenous by changing their food pattern. Methods A cross-sectional descriptive study on the dietary habits and nutritional status. By means of convenience sampling, 230 indigenous persons were selected, 108 male and 122 female, with age over 18 years. The nutritional status was calculated using the body mass index (BMI), according to the classification of the World Health Organization. With a SECA 216 mechanical stadiometer, the height of the participant. The weight was measured on a SECA scale with an accuracy of 0.1 Kg. To determine abdominal obesity, its presence was considered if the waist circumference was greater than 90 cm in men and greater than 80 cm in women, according to the International Diabetes Federation. For the determination of food consumption, the frequency of consumption form was applied by food groups. For the statistical analysis, the data were tabulated and expressed in absolute frequencies, percentages and measures of descriptive statistics of central tendency and dispersion. The Chi square statistic was used, to determine the difference of data, with a level of significance of 5%, it was considered as statistically significant if the p value was <0.05. The results were exposed in tables and graphs using the Microsoft office excel program of Windows 10. Results The average age of the population was 46.85 + 23.99. The average body mass index was 25.56 + 3.10, and the distribution of the nutritional status was: 1% for underweight, 47% overweight, 16% obesity and 36% normal. This distribution according to gender , did not have a significant difference. The first three food groups of the population, consumes per day, and of the which obtain the highest caloric intake, were: sugary drinks and soda (male sex 350 + 7 ml; female sex 322 + 8 ml), bread and cereal ( male sex 285 + 3 g; female sex 220 + 7 g), and fruits and vegetables ( male sex 210 + 6 g; female sex 195 + 5 g).A higher percentage of overweight and obesity was found in indigenous migrants, in relation to non-migrants, a difference that was significant (p:0.003). Conclusions The population has a high frequency of overweight and obesity. In addition, the high incidence of abdominal obesity, found places them at risk for the development of diseases such as diabetes and cardiovascular. Funding Sources Not applicable. Supporting Tables, Images and/or Graphs


2011 ◽  
Vol 23 (6) ◽  
pp. 404-409 ◽  
Author(s):  
Vito Di Lernia ◽  
Laura Tasin ◽  
Riccardo Pellicano ◽  
Giuseppe Zumiani ◽  
Giuseppe Albertini

2021 ◽  
Vol 15 (5) ◽  
pp. 1564-1570
Author(s):  
A. Soltanifar ◽  
R. Lashkarnevis ◽  
M. Ziaee ◽  
R. Samadi ◽  
A. Soltanifar ◽  
...  

Introduction: Due to the high prevalence of Tourette’s disorder among children and adolescents and its negative consequences, an appropriate and effective medical treatment with minimal complications is necessary. Therefore, this study was conducted to compare the effects of Aripiprazole and Risperidone on Tourette’s disorders in both children and adolescents. Method: The statistical population of this clinical trial was children and adolescents aged from seven to eighteen years old. They were diagnosed with the Tourette’s disorders based on the DSM-V criteria by the clinical interview of a child and adolescent psychiatrist in the child Psychiatry clinic of Ibn-e-Sina's Psychiatric Hospital (Mashhad-Iran) in 2018. A total of forty participants were selected by the convenience sampling method, and they were randomly divided into two groups treated by medicines, named as Risperidone or Aripiprazole for two months. Then, the demographic information questionnaire was completed. The Y-GTSS Scale was completed. Clinical Effect Rating Scale (CGI-Tics Scale) was completed. Calculation of body mass index and medical side effects complications were completed. The evaluation was carried out both at the beginning and on second, fourth and eighth weeks, and the results were compared. The data were analyzed by SPSS software (version 14) through using descriptive statistics, chi-square, and variance analysis. Results: The two groups were homogeneous for demographic variables. There was no significant difference in BMI between the two groups. Despite the positive effect of both medicines, no significant difference was observed among the general scores of such disorders, the overall score of severity, Tourette’s recovery, and BMI of these two groups at the intervals and at the end of treatments. (p <0.05). Due to the low number of complications reported, statistical comparisons of the medical side effects were not done for us Conclusion: According to the results, it seems that the two medicines, Aripiprazole and Risperidone, were effective in improving the symptoms of Tourette’s disorders and its overall severity. However, there was no significant statistical differences between them. In terms of the medical side effects, the statistical comparison between the two medicines was not possible due to the small number of complications. Keywords: tic, Tourette’s syndrome, Aripiprazole, Risperidone


1998 ◽  
Vol 31 ◽  
pp. 166-167
Author(s):  
D. Berman ◽  
A. Iskandrian ◽  
M. Verani ◽  
D. Johnston ◽  
J. Parry ◽  
...  

2002 ◽  
Vol 57 (3) ◽  
pp. 98-102 ◽  
Author(s):  
Alfredo Halpern ◽  
Claudia Cozer Leite ◽  
Nathan Herszkowicz ◽  
Alfonso Barbato ◽  
Ana Paula Arruda Costa

This is a double-blind, placebo-controlled study of the efficacy, safety, and tolerability of sibutramine in the management of obese patients for a 6-month period. METHOD: Sixty-one obese patients (BMI >30, <40 kg/m2), aged 18-65 years were evaluated. In the first phase of the study (30 days), the patients were given a placebo. We monitored compliance with a low-calorie diet (1200 kcal/day) and to the placebo. In the next stage, the double-blind phase (6 months), we compared placebo and sibutramine (10 mg/day). The criteria for evaluating efficacy were weight loss, reduction in body mass index (BMI), and abdominal and hip circumferences. Tolerability was assessed based on reported side effects, variation in arterial blood pressure and heart rate, metabolic profile (fasting glucose, total cholesterol and its fractions, and triglycerides), laboratory tests (renal and hepatic functions), and flow Doppler echocardiogram. RESULTS: We observed a greater weight loss (7.3 kg, 8% vs 2.6 kg, 2.8%) and a reduction in body mass index (7.4% vs 2.1%) in the sibutramine group than in the placebo group. Classifying the patients into 4 subgroups according to weight loss (weight gain, loss <5%, loss of 5% to 9.9%, and loss >10%), we observed a weight loss of >5% in 40% of the patients on sibutramine compared with 12.9% in the placebo group. We also detected weight gain in 45.2% of the placebo group compared to 20% in the sibutramine group. The sibutramine group showed improvement in HDL- cholesterol values (increased by 17%) and triglyceride values (decreased by 12.8%). This group also showed an increase in systolic blood pressure (6.7%, 5 mmHg). There were no changes in echocardiograms comparing the beginning and end of follow-up, and side effects did not lead to discontinuation of treatment. DISCUSSION: Sibutramine proved to be effective for weight loss providing an 8% loss of the initial weight. Compliance to prolonged treatment was good, and side effects did not result in discontinuation of treatment. These data confirmed the good efficacy, tolerability, and safety profiles of sibutramine for treatment of obesity.


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