scholarly journals Role of mTOR‐regulated autophagy in spine pruning defects and memory impairments induced by binge‐like ethanol treatment in adolescent mice

2020 ◽  
Author(s):  
María Pascual ◽  
Rosa López‐Hidalgo ◽  
Sandra Montagud‐Romero ◽  
Juan R. Ureña‐Peralta ◽  
Marta Rodríguez‐Arias ◽  
...  
Keyword(s):  
Ethanol Treatment ◽  
Memory Impairments ◽  
Spine Pruning

scholarly journals Neuropsychological rehabilitation of memory in post-stroke patients with brain nonspecific structure injury

2021 ◽  
Vol 101 ◽  
pp. 03023
Author(s):  
Tatiana Aleksandrovna Mardasova ◽  
Pavel Rafaelevich Iusupov
Keyword(s):  
Life Expectancy ◽  
Management System ◽  
Social Activity ◽  
Stroke Patients ◽  
Neuropsychological Rehabilitation ◽  
Memory Impairments ◽  
Post Stroke

The relevance of the study of the neuropsychological rehabilitation of memory impairments in stroke and the increasing role of the development of the rehabilitation direction to build a competent management system for such patients suggests good conditions for improving the health of the population, increasing the life expectancy and social activity of people.

Frontal lobe contributions to recognition and recall: Linking basic research with clinical evaluation and remediation

2006 ◽  
Vol 12 (2) ◽  
pp. 210-223 ◽  
Author(s):  
PATRICK S. R. DAVIDSON ◽  
ANGELA K. TROYER ◽  
MORRIS MOSCOVITCH
Keyword(s):  
Decision Making ◽  
Episodic Memory ◽  
Clinical Evaluation ◽  
Basic Research ◽  
Frontal Lobes ◽  
Focal Lesion ◽  
Memory Encoding ◽  
Memory Impairments ◽  
Memory Problems

The role of the human frontal lobes in episodic memory is becoming better understood, thanks mainly to focal lesion and neuroimaging studies. Here we review some recent findings from basic research on the frontal lobes in memory encoding, search, and decision-making at retrieval. For each of these processes, researchers have uncovered cases in which frontal memory impairments can be attenuated by various task manipulations. We suggest ways in which these findings may inform clinical evaluation and rehabilitation of memory problems following frontal damage. (JINS, 2006,12, 210–223.)

scholarly journals The role of hepatic and splenic macrophages in E. coli-induced memory impairments in aged rats

2015 ◽  
Vol 43 ◽  
pp. 60-67 ◽  
Author(s):  
Ruth M. Barrientos ◽  
Vanessa M. Thompson ◽  
T. Hayes Arnold ◽  
Matthew G. Frank ◽  
Linda R. Watkins ◽  
...  
Keyword(s):  
Aged Rats ◽  
Memory Impairments ◽  
E Coli ◽  
Splenic Macrophages

scholarly journals Memory deficits in males and females long after subchronic immune challenge

2018 ◽  
Author(s):  
Daria Tchessalova ◽  
Natalie C. Tronson
Keyword(s):  
Object Recognition ◽  
Memory Deficits ◽  
Poly I:C ◽  
Immune Challenge ◽  
Memory Decline ◽  
Memory Impairments ◽  
Increased Risk ◽  
Brain Barrier Permeability ◽  
Major Illness

ABSTRACTMemory impairments and cognitive decline persist long after recovery from major illness or injury, and correlate with increased risk of later dementia. Here we developed a subchronic peripheral immune challenge model to examine delayed and persistent memory impairments in females and in males. We show that intermittent injections of either lipopolysaccharide or Poly I:C cause memory decline in both sexes that are evident eight weeks after the immune challenge. Importantly, we observed sex-specific patterns of deficits. Females showed impairments in object recognition one week after challenge that persisted for at least eight weeks. In contrast, males had intact memory one week after the immune challenge but exhibited broad impairments in memory tasks including object recognition, and both context and tone fear conditioning several months later. The differential patterns of memory deficits in males and in females were observed without sustained microglial activation or changes in blood-brain barrier permeability. Together, these data suggest that transient neuroimmune activity results in differential vulnerabilities of females and males to memory decline after immune challenge. This model will be an important tool for determining the mechanisms in both sexes that contribute to memory impairments that develop over the weeks and months after recovery from illness. Future studies using this model will provide new insights into the role of chronic inflammation in the pathogenesis of long-lasting memory decline and dementias.

Protective role of adiponectin against ethanol-induced gastric injury in mice

2012 ◽  
Vol 302 (8) ◽  
pp. G773-G780 ◽  
Author(s):  
Shunsuke Yamamoto ◽  
Kenji Watabe ◽  
Hiroshi Araki ◽  
Yoshihiro Kamada ◽  
Motohiko Kato ◽  
...  
Keyword(s):  
Wound Repair ◽  
Mucosal Injury ◽  
Protective Role ◽  
Gastric Mucosal Injury ◽  
Serum Adiponectin ◽  
Gastric Injury ◽  
Prostaglandin E ◽  
Ethanol Treatment ◽  
Cox 2

Adiponectin is an anti-inflammatory molecule released from adipocytes, and serum adiponectin concentrations are reduced in obesity. We previously reported that gastric erosion occurs in association with obesity and low serum adiponectin levels. In the present study, we examined adiponectin-knockout (APN-KO) mice to elucidate the role of adiponectin in gastric mucosal injury. Gastric injury was induced by oral administration of ethanol in wild-type (WT) and APN-KO mice. Ethanol treatment induced severe gastric injury in APN-KO mice compared with WT mice. In APN-KO mice, increased apoptotic cells and decreased expression of prostaglandin E2 (PGE2) were detected in the injured stomach. We next assessed the effect of adiponectin on the cellular response to ethanol treatment and wound repair in rat gastric mucosal cells (RGM1). Adiponectin induced the expression of PGE2 and cyclooxygenase 2 (COX-2) in ethanol-treated RGM1 cells. RGM1 cells exhibited efficient wound repair accompanied by increased PGE2 expression in the presence of adiponectin. Coadministration of adiponectin with celecoxib, a COX-2 inhibitor, inhibited efficient wound repair. These findings indicate that adiponectin has a protective role against ethanol-induced gastric mucosal injury in mice. This effect may be partially mediated by the efficient wound repair of epithelial cells via increased PGE2 expression.

scholarly journals The role of dopamine D1 receptors in MDMA-induced memory impairments

2020 ◽  
Vol 176 ◽  
pp. 107322
Author(s):  
Hanna Squire ◽  
Jiun Youn ◽  
Bart A. Ellenbroek ◽  
David N. Harper
Keyword(s):  
D1 Receptors ◽  
Dopamine D1 Receptors ◽  
Memory Impairments
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