Normobaric oxygen may correct chronic cerebral ischemia‐mediated EEG anomalies

The purpose of the study. To study clinical and neuroimaging features of chronic cerebral ischemia (CCI) in polycythemia vera (PV).Materials and methods. 66 patients with PV were examined – the main group (43 men, 23 women; mean age 62.0 ± 3.4 years), of which 64 (97.0%) patients were diagnosed with CCI. The comparison group consisted of 85 patients with CCI (34 men, 51 women; mean age 67.7 ± 4.6 years), who developed against the background of cerebral vascular atherosclerosis and arterial hypertension. To identify cognitive disorders, we used Mini Mental State Examination (MMSE). Insomnia was studied in accordance with the criteria of the International Classification of Sleep ICDS‑22005. The quality of sleep was determined using a questionnaire from the Federal Somnological Center. Neuroimaging (MRI of the brain) was performed on Siemens Symphony 1.5 T and GE Signa 1.5 T tomographs.Results. Subjective symptoms CCI are characterized by a greater representation of asthenic and insomniac disorders. Transient ischemic attacks in patients with PV are significantly more common than in the comparison group, their frequency depends on the duration of PV. The revealed changes in MRI of the brain in the majority of PV patients with CCI are characteristic of multiinfarction vascular encephalopathy; in the comparison group, changes that characteristic for subcortical arteriosclerotic encephalopathy were more often recorded.

Download Full-text

Potential Protective Effect of Dl-3-n-Butylphthalide on Chronic Cerebral Ischemia Brain Injury

CNS & Neurological Disorders - Drug Targets ◽

10.2174/1871527321666211221160922 ◽

2021 ◽

Vol 21 ◽

Author(s):

Fangfang Zhao ◽

Yumin Luo

Keyword(s):

Oxidative Stress ◽

Cerebral Ischemia ◽

Brain Dysfunction ◽

Cerebrovascular Diseases ◽

Pathophysiological Mechanism ◽

Chronic Cerebral Ischemia ◽

Celery Seed ◽

Prevention And Treatment ◽

Ischemic Cerebrovascular Diseases ◽

The Common

: Chronic cerebral ischemia is one of the common ischemic cerebrovascular diseases. Chronic cerebral ischemia can lead to brain dysfunction, and its pathophysiological mechanism involves inflammation, blood-brain barrier destruction, oxidative stress, and other factors. Due to it being difficult to detect, it is easily overlooked, and it is often only observed following onset of cognitive dysfunction. At present, there are few drugs for this treatment. DL-3-N-BUTYLPHTHALIDE (NBP), a compound extracted from celery seed, may play an important role in protecting against brain damage caused by chronic cerebral ischemia. Therefore, we pay more attention to the prevention and treatment of NBP on chronic cerebral ischemia.

Download Full-text

Imaging of Central Benzodiazepine Receptors in Chronic Cerebral Ischemia

PET and SPECT of Neurobiological Systems ◽

10.1007/978-3-030-53176-8_9 ◽

2020 ◽

pp. 245-264

Author(s):

Hiroshi Yamauchi

Keyword(s):

Cerebral Ischemia ◽

Benzodiazepine Receptors ◽

Chronic Cerebral Ischemia ◽

Central Benzodiazepine Receptors

Download Full-text

Chronic cerebrovascular disease: the role of venous disorders and the possibility of pathogenetic correction

Russian Medical Inquiry ◽

10.32364/2587-6821-2020-4-9-544-551 ◽

2020 ◽

Vol 4 (9) ◽

pp. 544-551

Author(s):

I.A. Schukin ◽

◽

M.S. Fidler ◽

I.A. Koltsov ◽

◽

...

Keyword(s):

Cerebral Ischemia ◽

Cerebrovascular Disease ◽

Venous Insufficiency ◽

Main Group ◽

Duplex Scanning ◽

Control Group ◽

Chronic Cerebral Ischemia ◽

Venous Disorders ◽

Tinetti Test

Aim: to evaluate the efficacy and safety of the L-lysine escinate venotropic drug in the treatment of cephalgic, atactic and asthenic syndromes in patients with chronic cerebral ischemia, mainly caused by venous disorders. Patients and Methods: the study involved 60 patients with a diagnosis of chronic cerebral ischemia with signs of chronic venous insufficiency. All patients were randomly divided into two groups consisting of 30 people. Patients in the main group received L-lysine escinate, and the control group received Vinpocetine. The drugs were administered by intravenous drip for 10 days. A dynamic assessment was performed using a modified subjective scale of asthenia evaluation (MFI-20), 100 mm long visual analogue scale (VAS) for headache, subjective neurological impairment scale (SNIS), and Tinetti test. An ophthalmic examination with an assessment of the fundus vessels and an ultrasound duplex scanning of head vessels (veins) were also conducted. Results: it was shown that L-lysine escinate therapy showed a statistically more significant reduction in the severity of headache (according to VAS) and an improved stability measured by Tinetti test versus during Vinpocetine treatment. There were no significant differences in the level of asthenia (MFI-20), the severity of emotional disorders, and the SNIS score. Also, the number of patients with dilated fundus veins significantly decreased during treatment in the main group (p<0.05), which was not the case in the control group. According to ultrasound duplex scanning data, the venous flow velocity through the veins of Rosenthal and angular veins during L-lysine escinate therapy was significantly higher (p<0.05) than in patients receiving Vinpocetine. Conclusion: the inclusion of vasotropic drugs (in particular, the L-lysine escinate venotonic drug) in the treatment regimen of patients with chronic brain ischemia seems appropriate, especially if there are signs of venous insufficiency. KEYWORDS: systemic venous insufficiency, chronic cerebrovascular disease, venous dyscirculation, glymphatic system, L-lysine escinate, Vinpocetine. FOR CITATION: Schukin I.A., Fidler M.S., Koltsov I.A. Chronic cerebrovascular disease: the role of venous disorders and the possibility of pathogenetic correction. Russian Medical Inquiry. 2020;4(9):544–551. DOI: 10.32364/2587-6821-2020-4-9-544-551.

Download Full-text

Vascular cognitive impairment and chronic cerebral ischemia (dyscirculatory encephalopathy)

Neurology neuropsychiatry Psychosomatics ◽

10.14412/2074-2711-2019-3s-61-67 ◽

2019 ◽

Vol 11 (3S) ◽

pp. 61-67 ◽

Cited By ~ 8

Author(s):

V. A. Parfenov

Keyword(s):

Cognitive Impairment ◽

Cerebral Ischemia ◽

Emotional Disorders ◽

Blood Lipid ◽

Vascular Cognitive Impairment ◽

Considerable Proportion ◽

Secondary Headache ◽

Chronic Cerebral Ischemia ◽

Dyscirculatory Encephalopathy ◽

Blood Clots

The paper reviews the literature on vascular cognitive impairment (VCI), the diagnosis widely used in foreign neurological practice, as well as chronic cerebral ischemia (CCI) and dyscirculatory encephalopathy (DEP), the common diagnoses in Russian neurological practice. According to the etiology, risk factors, and manifestations, Stages I and II DEP largely corresponds to moderate VCI; Stage III DEP does to severe VCI. The results of the author’s studies show that a considerable proportion of patients followed up with a diagnosis of CCI, DEP, have no signs of chronic cerebrovascular disease (CVD), but suffer from primary or secondary headache, vertigo of various origins, emotional disorders, and other diseases. The diagnosis of CCI, DEP should be based on the presence of CCI, the reliable neuroimaging signs of chronic CVD, and the ruling out of other diseases. When treating and preventing VCI, CCI, and DEP, a premium is placed upon both non-drug (regular physical activity, smoking cessation, rational nutrition) and drug therapy aimed at normalizing blood pressure and blood lipid spectrum, preventing blood clots, and improving cognitive functions.

Download Full-text

Comparative proteome analysis of blood plasma of patients with early-stage chronic cerebral ischemia

Biomeditsinskaya Khimiya ◽

10.18097/pbmc20166205599 ◽

2016 ◽

Vol 62 (5) ◽

pp. 599-602 ◽

Cited By ~ 5

Author(s):

Y.S. Kisrieva ◽

N.A. Petushkova ◽

N.F. Samenkova ◽

G.P. Kuznetsova ◽

O.V. Larina ◽

...

Keyword(s):

Cerebral Ischemia ◽

Blood Plasma ◽

Early Stage ◽

Proteome Analysis ◽

Study Group ◽

Liquid Chromatography Mass Spectrometry ◽

Chronic Cerebral Ischemia ◽

Automatic Mode ◽

Proteome Changes ◽

Spectrometer Data

In the present study, we explored the technology of liquid chromatography-mass spectrometry (HPLC-MS/MS) for the proteome analysis of blood plasma of patients with early chronic cerebral ischemia. Analysis of mass-spectrometer data carried out in automatic mode using the software Progenesis LS-MS. As a result of this study identified 43 proteins. The differences identified in the study group compared with the control in 7 proteins. It was found that in the early stages of chronic cerebral ischemia proteome changes in blood plasma affect proteins related to the immune system, the system for the maintenance of hemostasis and lipid metabolism.

Download Full-text

Prevalence and severity of depression in patients with the consequences of ischemic strokes and in patients with chronic brain ischemia

Journal of Education, Health and Sport ◽

10.12775/jehs.2021.11.10.030 ◽

2021 ◽

Vol 11 (10) ◽

pp. 320-324

Author(s):

A. Babirad

Keyword(s):

Cerebral Ischemia ◽

Brain Ischemia ◽

Rating Scale ◽

Severe Depression ◽

Chronic Cerebral Ischemia ◽

Mild Depression ◽

Hamilton Depression Rating Scale ◽

Chronic Brain Ischemia ◽

Severity Of Depression

The aim of our study was to investigate the prevalence and severity of depression in patients with the consequences of ischemic strokes and in patients with chronic brain ischemia. Material and Methods. We examined 100 patients with consequences of ischemic strokes and 17 patients with chronic cerebral ischemia. The Hamilton Depression Rating Scale was used to assess the presence and degree of depression. Conclusions. Slightly less than half of the patients with chronic cerebral ischemia (47.1%) had no depression, 42.1% had mild depression, and only 11.8% of the patients had moderate and severe depression. A different situation was observed in the group of patients with the consequences of ischemic strokes. Among them, only 22.0% of patients had no depression, 44.0% had mild depression, and 34.0% of patients had moderate, severe, and extremely severe depression (p < 0.05).

Download Full-text

Psychoemotional status and vegetative resistance in patients with chronic cerebral ischemia on the background of angina pectoris

East European Journal of Neurology ◽

10.33444/2411-5797.2017.4(16).36-41 ◽

2017 ◽

pp. 36-41

Author(s):

N. Inhula

Keyword(s):

Cerebral Ischemia ◽

Angina Pectoris ◽

Autonomic Dysfunction ◽

Stable Angina ◽

Control Group ◽

Depression And Anxiety ◽

Chronic Cerebral Ischemia ◽

Stable Angina Pectoris ◽

Personal Anxiety ◽

High Level

The article presents the results of the study of the state of the autonomic nervous system and the psychoemotional state in patients with chronic cerebral ischemia (CCI) against the background of stable angina pectoris II and III FС. 90 subjects (61 men and 29 women) (mean age 60.6 ± 7.8 years) were examined in the main group and 30 persons (10 men and 20 women) (mean age 55.27 ± 5.5 years) control group aged 45 to 74 years. The analysis of data of the conducted research and conclusions are given. Based on the findings, it was found that a high level of anxiety causes an imbalance between sympathetic and parasympathetic activity. In the group of patients with CCI against the background of stable angina pectoris III FС revealed a high level of depression and anxiety, reactive and personal anxiety, which causes a pronounced autonomic dysfunction, which was manifested in insufficient vegetative provision and the predominance of sympathicotonia in these patients. We can assume that autonomic dysfunction is one of the mechanisms for the progression of stable angina pectoris in patients with CCI.

Download Full-text