scholarly journals Chronic cerebrovascular disease: the role of venous disorders and the possibility of pathogenetic correction

2020 ◽  
Vol 4 (9) ◽  
pp. 544-551
Author(s):  
I.A. Schukin ◽  
◽  
M.S. Fidler ◽  
I.A. Koltsov ◽  
◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Cerebrovascular Disease ◽  
Venous Insufficiency ◽  
Main Group ◽  
Duplex Scanning ◽  
Control Group ◽  
Chronic Cerebral Ischemia ◽  
Venous Disorders ◽  
Tinetti Test

Aim: to evaluate the efficacy and safety of the L-lysine escinate venotropic drug in the treatment of cephalgic, atactic and asthenic syndromes in patients with chronic cerebral ischemia, mainly caused by venous disorders. Patients and Methods: the study involved 60 patients with a diagnosis of chronic cerebral ischemia with signs of chronic venous insufficiency. All patients were randomly divided into two groups consisting of 30 people. Patients in the main group received L-lysine escinate, and the control group received Vinpocetine. The drugs were administered by intravenous drip for 10 days. A dynamic assessment was performed using a modified subjective scale of asthenia evaluation (MFI-20), 100 mm long visual analogue scale (VAS) for headache, subjective neurological impairment scale (SNIS), and Tinetti test. An ophthalmic examination with an assessment of the fundus vessels and an ultrasound duplex scanning of head vessels (veins) were also conducted. Results: it was shown that L-lysine escinate therapy showed a statistically more significant reduction in the severity of headache (according to VAS) and an improved stability measured by Tinetti test versus during Vinpocetine treatment. There were no significant differences in the level of asthenia (MFI-20), the severity of emotional disorders, and the SNIS score. Also, the number of patients with dilated fundus veins significantly decreased during treatment in the main group (p<0.05), which was not the case in the control group. According to ultrasound duplex scanning data, the venous flow velocity through the veins of Rosenthal and angular veins during L-lysine escinate therapy was significantly higher (p<0.05) than in patients receiving Vinpocetine. Conclusion: the inclusion of vasotropic drugs (in particular, the L-lysine escinate venotonic drug) in the treatment regimen of patients with chronic brain ischemia seems appropriate, especially if there are signs of venous insufficiency. KEYWORDS: systemic venous insufficiency, chronic cerebrovascular disease, venous dyscirculation, glymphatic system, L-lysine escinate, Vinpocetine. FOR CITATION: Schukin I.A., Fidler M.S., Koltsov I.A. Chronic cerebrovascular disease: the role of venous disorders and the possibility of pathogenetic correction. Russian Medical Inquiry. 2020;4(9):544–551. DOI: 10.32364/2587-6821-2020-4-9-544-551.

scholarly journals The experience of using iodine-bromine baths and ozone therapy at the stage of health resort treatment of patients with chronic cerebral ischemia

2020 ◽  
Vol 17 (5) ◽  
pp. 263-271
Author(s):  
Lyubov A. Cherevaschenko ◽  
L. YU. Dadova ◽  
Nikolay N. Kulikov ◽  
Anatolii T. Tereshin ◽  
Igor A. Cherevashchenko
Keyword(s):  
Cerebral Ischemia ◽  
Comparison Group ◽  
Main Group ◽  
Control Group ◽  
High Plasticity ◽  
Chronic Cerebral Ischemia ◽  
Ozone Therapy ◽  
Health Resort ◽  
Treatment Groups ◽  
The Brain

Background. Treatment of chronic cerebral ischemia should be aimed both to the main etiological factor and to the pathogenetic mechanisms of cerebral ischemia and hypoxia. The action of ozone therapy is characterized with a multilateral positive effect on the main aspects of chronic cerebral ischemia pathogenesis, such as chronic cerebral hypoxia, impaired microcirculation, rheological disorders, and activation of lipid peroxidation. The use of iodine-bromine baths in chronic cerebral ischemia has been proved to be accompanied by an improvement in cerebral circulation, normalization of the brain bioelectric processes, an initially impaired condition of the autonomic nervous system, and an increase in the level of adaptive capabilities of the body. Aim: to develop effective pathogenetically substantiated methods for the combined use of iodine-bromine baths and ozone therapy in patients with chronic cerebral ischemia to increase the effectiveness of health resort treatment. Methods. In accordance with the tasks set in the work, 90 patients with chronic cerebral ischemia of the degree 1, who were randomized into three treatment groups, were examined and treated. Patients of the control group (n = 30) received iodine-bromine baths, patients of the comparison group (n = 30) received ozone therapy, patients of the main group (n = 30) received iodine-bromine baths and ozone therapy. Examination of patients included Doppler ultrasound, electroencephalography, rheoencephalography, сardiointervalography, lipid metabolism studies, fibrinogen content studies. Results. As a result of treatment, the improvement of clinical symptoms and the normalization of biochemical and neurophysiological parameters were noted in patients of all treatment groups. Overall efficiency (improvement and significant improvement) was 53.3% in the control group, in the comparison group it was 63.3%, and 73.3% in the main group. Conclusion. The authors proved the practicability of rehabilitative treatment of early forms of vascular diseases of the brain at the stage of sanatorium and resort rehabilitation, which is due to significant compensatory reserves and high plasticity of the structural and functional formations of the brain with preserved ability to develop nonspecific elements of the nervous tissue and restore reversibly damaged structures.

scholarly journals Function and role of system enzyme therapy in rehabilitation of patients with acute and chronic cerebral ischemia

2008 ◽  
Vol 7 (5-1) ◽  
pp. 135-140
Author(s):  
V. V. Yefremov ◽  
Yu. I. Sternin ◽  
V. S. Sergienko
Keyword(s):  
Cerebral Ischemia ◽  
Serum Concentration ◽  
Blood Serum ◽  
Control Group ◽  
Enzyme Therapy ◽  
Chronic Cerebral Ischemia ◽  
Tnf Α ◽  
Complex Therapy ◽  
Main Effects

Main effects of system enzyme therapy (SET) are antiinflammatory, fibrinolythic and immunomodulating. Combination of these effects proved to be important in the treatment of 30 patients with stroke and 30 patients with ischemic cerebrovascular diseas. The use of polyfermental preparation flogenzyme in complex therapy allowed to normalize the state of thrombocytic hemostasis and to improve the indexes of plasmatic hemostasis and rheology of blood, serum concentration of proinflamatory cytokines (TNF-α, IL-1β, IL-4) to a considerably greater degree than in control group (39 patients) and impaired velocity and reactivity parameters (33 control). Thus, SET medications are necessary and very important pathogenetically in the complex therapy of patients with acute and chronic cerebral ischemia.

scholarly journals Psychoemotional status and vegetative resistance in patients with chronic cerebral ischemia on the background of angina pectoris

2017 ◽  
pp. 36-41
Author(s):  
N. Inhula
Keyword(s):  
Cerebral Ischemia ◽  
Angina Pectoris ◽  
Autonomic Dysfunction ◽  
Stable Angina ◽  
Control Group ◽  
Depression And Anxiety ◽  
Chronic Cerebral Ischemia ◽  
Stable Angina Pectoris ◽  
Personal Anxiety ◽  
High Level

The article presents the results of the study of the state of the autonomic nervous system and the psychoemotional state in patients with chronic cerebral ischemia (CCI) against the background of stable angina pectoris II and III FС. 90 subjects (61 men and 29 women) (mean age 60.6 ± 7.8 years) were examined in the main group and 30 persons (10 men and 20 women) (mean age 55.27 ± 5.5 years) control group aged 45 to 74 years. The analysis of data of the conducted research and conclusions are given. Based on the findings, it was found that a high level of anxiety causes an imbalance between sympathetic and parasympathetic activity. In the group of patients with CCI against the background of stable angina pectoris III FС revealed a high level of depression and anxiety, reactive and personal anxiety, which causes a pronounced autonomic dysfunction, which was manifested in insufficient vegetative provision and the predominance of sympathicotonia in these patients. We can assume that autonomic dysfunction is one of the mechanisms for the progression of stable angina pectoris in patients with CCI.

Prevalence of allelic and genotypic variants of the rs1143627 polymorphism in the IL1β gene among patients with typhoid

2020 ◽  
Vol 18 (3) ◽  
pp. 126-130
Author(s):  
D.B. Mirzajonova ◽  
◽  
H.Ya. Karimov ◽  
G.K. Abdukhalilova ◽  
K.T. Boboev ◽  
...  
Keyword(s):  
Typhoid Fever ◽  
Key Words ◽  
Main Group ◽  
Minor Allele ◽  
Control Group ◽  
Healthy Individuals ◽  
Allele Detection ◽  
Generic Structure

Objective. To evaluatethe role of allelic and genotypic variants of gene IL1β polymorphism rs1143627 in susceptibility to typhoid fever (TF). Materials and methods. 41 patients with TF and 84 chronic carriers of S. typhi were endrolled in the study. Control group included 91 healthy individuals, All of the individuals under study were Uzbeks. DNA samples were isolated from peripheric blood with the kit Ribo-sorb (AmpliSens®, Russia). Genotyping of polymorphism rs1143627 of gene IL1β was carried out by the standard PCR using kits “SNP-Express” (LLC NPF “LITECH”, Russia) according to the instruction of manufacturer. Results. The domination of allele 31T was found in the main group (patients and carriers). Its frequency was significantly lower in comparison with the control group (51.2% and 67.0%, respectively; χ2 = 10.8; p = 0.001). Minor allele -31С cytokine IL1β, on the contrary was detected more frequently in patients with TF (48.8%), than in the control group (33.0%) in χ2 = 10.8 and p = 0.001. Calculated relative chance of this allele detection in the main group in comparison with control group was OR = 1.9 in 95% CI 1.304-2.88. Conclusion. Genotypic variant C/C of polymorphism rs1143627 of the gene IL1β made a certain contribution into forming of generic structure of susceptibility to S. typhi. Risk of susceptibility of macro organism to pathogen in the presence of this genotype is higher more than 2.5 times (χ2 = 4.3; p = 0.04; CI 95% 1.037–7.359). Key words: Typhoid fever, bacteria carrier, bacteria S. typhi, polymorphism rs1143627 of the gene IL1β

Effects and Comparison of Curcumin on Morphology Changes of Chronic Cerebral Hypoperfusion in Young and Aged Rats

2015 ◽  
Vol 1120-1121 ◽  
pp. 842-846
Author(s):  
Dan Li ◽  
Yue Xiang ◽  
Xiong Zhang ◽  
Yu Li
Keyword(s):  
Cerebral Ischemia ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Control Group ◽  
Age Difference ◽  
Dependent Manner ◽  
Aged Rats ◽  
Pathological Changes ◽  
Chronic Cerebral Ischemia ◽  
Ca1 Region

To observe the effect of curcumin on the morphology of the hippocampus in young and aged rats with vascular dementia (VD) induced by chronic cerebral hypoperfusion, then further investigate whether the effect of curcumin have any differences in age. Both young and aged Male Sprague-Dawley rats were randomly divided into normal control group, sham-operated group, 2VO group, 2VO+curcumin 50mg/Kg group and 2VO+curcumin 100mg/Kg goup. Permanent occlusion of bilateral common carotid arteries ligation (2VO) method was used to establish chronic cerebral ischemia model. The rats were injected intraperitoneally with curcumin or DMSO once daily for 30d. The pathological changes of CA1 region of the hippocampus were measured by HE staining and Nissl staining. Chronic cerebral ischemia led to pathological changes of young and aged rats, but no significant differences were found between the two ages of rats (t=0.658，P=0.523). Furthermore, curcumin could reduce the pathological injury of CA1 region of the hippocampus in young and aged VD rats, no significant differences were found between the two ages of rats (P=0.384，P=0.380). Curcumin can reduce the brain damage in young and aged VD rats in dose-dependent manner but without age difference. Our study suggests that the pathological injury of the hippocampus might be one of the mechanisms of curcumin’s protection effect of VD rats.

scholarly journals Features of neuroimaging data in patients with chronic cerebral ischemia on the background of angina pectoris

2018 ◽  
pp. 38-42
Author(s):  
N. Inhula
Keyword(s):  
Cerebral Ischemia ◽  
Stable Angina ◽  
Control Group ◽  
Chronic Cerebral Ischemia ◽  
Resonance Imaging ◽  
Bioelectric Activity ◽  
Acute Cerebrovascular Accident ◽  
Neuroimaging Data ◽  
The Brain ◽  
Neuroimaging Techniques

In the article the features of bioelectric activity and magnetic resonance imaging of the brain in patients with chronic cerebral ischemia (CCI) are exposed on the background of stable angina of the voltage ІІ and ІІІ ФК. 90 subjects (61 men and 29 women) (mean age 60.6 ± 7.8 years) were examined in the main group and 30 persons (10 men and 20 women) (mean age 55.2.6 ± 5.5 years) control group aged 45 to 74 years. The analysis of data of the conducted complex neuroimaging examination of patients with ССI on the background of stable angina was collected and provided. Based on the data obtained using neuroimaging techniques, it has been established that in patients with CCI, against the background of stable angina, the course of the disease is associated with the risk of development of the acute cerebrovascular accident.

scholarly journals Optimization of pharmacotherapy of patients with prostate adenoma with hormonal and metabolic disordes: correction of vitamin D deficiency with “Aquadetrim”

2019 ◽  
Vol 5 (4) ◽  
pp. 57-67
Author(s):  
Oleg I. Bratchikov ◽  
Igor A. Tyuzikov ◽  
Sergey O. Artishchev
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Metabolic Disorders ◽  
Main Group ◽  
Integrative Approach ◽  
Control Group ◽  
Practical Algorithms ◽  
Prostate Adenoma ◽  
Local Parameters

Introduction: Modern studies demonstrate an epidemiological and pathogenetic role of systemic hormonal and metabolic disorders in men with prostate adenoma (PA), so it is obvious that a pharmacotherapeutic correction of these disorders can increase the efficacy of the traditional therapy of the disease. Aim of study: To investigate the frequency, relationships among themselves and with PA local parameters of key systemic hormonal and metabolic disorders (obesity, insulin resistance, testosterone deficiency, vitamin D deficiency) and to develop practical algorithms for optimizing diagnosis and management based on an integrative approach. Material and Methods: The results of a comprehensive examination of 160 patients with PA (main group; average age 62.3 ± 4.2 years) and 30 healthy men without PA of the same age (control group), including: collection of anamnesis and complaints; questionnaires; physical, hormonal and sonographic studies, – are presented. Pharmacotherapeutic correction methods were tested in some patients of the main group. The data was processed using descriptive and comparative statistics. Results and Discussion: In the patients with PA, a significantly higher frequency of concomitant systemic hormonal and metabolic disorders formed at a younger age was established, compared to the men without PA, and significantly worse local characteristics of PA compared to the patients with PA without such (p &lt; 0.05). Reliable connections of some studied systemic hormonal and metabolic disorders with one another and with local parameters of PA (p &lt; 0.05) were revealed. A more severe vitamin D deficiency in the patients with PA compared to the control group was revealed, and the safety and a significant positive effect of its drug compensation on the parameters of hormonal and metabolic status and PA in D-deficient men with PA were shown (p &lt; 0.05). Conclusion: The results of the study confirm an important role of the studied systemic hormonal and metabolic disorders in the pathogenesis of PA and the need for their diagnosis and pharmacotherapeutic correction in all patients with PA on the basis of an integrative approach, according to the proposed algorithms.

scholarly journals Training of Respiratory Muscles in Motion in the Physical Rehabilitation of Patients with Chronic Cerebral Ischem

2020 ◽  
Vol 100 (6) ◽  
pp. 19-24
Author(s):  
V.V. Ezhov ◽  
V.I. Mizin ◽  
A.Yu. Tsarev ◽  
T.E. Platunova
Keyword(s):  
Cerebral Ischemia ◽  
Respiratory Muscles ◽  
Physical Rehabilitation ◽  
Medical Rehabilitation ◽  
Control Group ◽  
Physical Endurance ◽  
External Respiration ◽  
Chronic Cerebral Ischemia ◽  
State Reduction ◽  
Therapeutic Exercises

The aim of the study was to evaluate the effectiveness of respiratory muscles training in patients with chronic cerebral ischemia at thehealth resort stage of medical rehabilitation. Materials and methods. An open randomized controlled clinical trial was conducted in 60 patients with chronic cerebral ischemia,who underwent a course of sanatorium-resort rehabilitation treatment on the southern coast of Crimea (Yalta, Republic of Crimea). Men - 11.0%, women - 89.0%, age - 62.3 ± 2.3 years, disease duration - 4.5 ± 1.2 years. In control group 1 (n = 30), climatotherapy, physical training (morning exercises, remedial gymnastics, health path), massage, hardware physiotherapy and medications were carried out. In the main group 2 (n = 30), a similar basic complex was used, but therapeutic exercises were carried out with a breathing simulator and included walking, exercises for diaphragm training, general motor skills, coordination, dexterity, mobility, and joint flexibility. Number 10–12. Before and after the treatment, clinical, laboratory, biochemical, functional (spirography, electrocardiography, fitness test), psychological (Reeder and Back tests) studies were carried out; the indicators of the quality of life were studied; the state of 23 selected domains of the “International classification of functioning, disabilities and health”, included in the section “Body functions”, was assessed. Results. During the sanatorium-resort stage of medical rehabilitation, significant systemic effects were noted in the form of a decrease in clinical manifestations of the disease, an improvement in physical performance indicators and an increase in reserves for overcoming psychological stress. In patients, there was an improvement in static-coordination and psycho emotional state, reduction of dizziness and cephalgia, fatigue, increase in exercise tolerance, general physical endurance, normalization of carbohydrate metabolism indicators and blood lipids.Conclusion. A method of physical rehabilitation based on the principle of external respiration modification by using a breathing trainer with vibration function has been developed. The study allows us to recommend the inclusion in the complex of medical rehabilitation of patients with chronic cerebral ischemia, physical exercises with a breathing simulator, focused on increasing the functional body reserves.

scholarly journals The role of α-tocopherol and ɷ-3 polyunsaturated fatty acids in miscarriage at early stages of pregnancy with cytomegalovirus infection

2021 ◽  
pp. 98-104
Author(s):  
N. A. Ishutina ◽  
I. А. Andrievskaya ◽  
I. V. Dovzhikova ◽  
N. N. Dorofienko
Keyword(s):  
Peripheral Blood ◽  
Cytomegalovirus Infection ◽  
First Trimester ◽  
Main Group ◽  
Control Group ◽  
Gas Liquid Chromatography ◽  
Epa And Dha ◽  
Group A ◽  
Therapeutic Measures

Introduction. It is now generally acknowledged that cytomegalovirus infection (CMVI) is one of the main causes of miscarriage. However, the mechanism of this effect has not been sufficiently studied. At the same time, the influence of acids of the ɷ-3 family and α-tocopherol (αTP) on the placentation process through a pro-angiogenic action is shown.Aim. To study the concentration of αTP and ɷ-3 family acids in the peripheral blood and establish their role in miscarriage in CMV-seropositive women with CMVI reactivation.Materials and methods. A case-control study included 64 women in the first trimester of pregnancy (7-10 weeks), of which 36 were CMV-seropositive with CMVI reactivation (main group) and 28 were CMV-seronegative (control group). CMVI was diagnosed by the determination of class M and G antibodies by ELISA, as well as CMV DNA detected by PCR. The concentration of ɷ-3 acids of the family (eicosapentaenoic – EPA, docosahexaenoic – DHA) in blood serum was studied by capillary gas-liquid chromatography (J.P.Carreau, J.P.Dubacq). The αTP concentration was determined by the fluorometric method (L.G.Hansen, W.I.Warwich).Results. In women of the main group, a significant (p<0.001) decrease in the concentration of αTP to 1.32±0.025 μg/mL was observed in the peripheral blood compared to the same indicator in the control group (1.49±0.029 μg/mL). At the same time, the levels of EPA and DHA were also statistically significant (p<0.001) lower than the same indicator in the control group and amounted to 1.09±0.012 and 6.09±0.015%, respectively (in the control, 1.29±0.071 and 8.80±0.071%, respectively). Conclusion. The obtained results of the study allow us to establish the important role of disorders in the content of α-TF, EPA and DHA in the pathogenesis of miscarriage during reactivation of CMVI in the early periods of gestation, which can serve as a basis for expanding diagnostic and therapeutic measures in this pathology of pregnant women.

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