Myxoid Fibrolipoma: Case series of a lipoma variant with myxoid stroma and dense fibrous tissue

Thrombocytopenia (platelet count less than 150 × 109/L) is a frequent complication of decompensate cirrhosis and is considered as an indicator of advanced disease. Carica papaya leaf juice has beneficial effect in thrombocytopenia associated with dengue. Tinospora cordifolia has been shown to prevent the fibrous tissue deposition of liver by modulation of kupffer cell activation. An attempt was taken to observe the usefulness of extract Carica papaya and Tinospora cordifolia in alcoholic decompensate cirrhosis. A market available product Cariden is easily available to the patients which contains Phyto extracts of Carica papaya 1100mg and Tinospora cordifolia 500mg. Phyto extracts of Carica papaya and Tinospora cordifolia can enhance the platelet count within 15 days and it can normalise the platelet within 90 days of therapy in all three cases. Further randomised control trial is suggested.

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The cardiac conduction system in Hurler syndrome: pathological features and clinical implications

Cardiology in the Young ◽

10.1017/s1047951100000858 ◽

1992 ◽

Vol 2 (2) ◽

pp. 196-199

Author(s):

Louis Tsun-cheung Chow ◽

Wing-Hing Chow

Keyword(s):

Sinus Node ◽

Fibrous Tissue ◽

Conduction System ◽

Cardiac Conduction ◽

Cardiac Conduction System ◽

Clinical Implications ◽

Hurler Syndrome ◽

Pathological Features ◽

Hydropic Degeneration ◽

Dense Fibrous Tissue

SummaryWe studied the cardiac conduction system in a case of Hurler syndrome. There was dense fibrosis of the supporting matrix of the sinus node and accumulation of mucopolysaccharide in the nodal cells. The bundle branches showed prominent hydropic degeneration, being encased and punctuated by dense fibrous tissue. These changes in the conduction system may predispose to the development of arrhythmias, accounting for the sudden deaths in Hurler syndrome.

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Foreign Body Reaction Associated With Artificial LARS Ligaments: A Retrieval Study

Orthopaedic Journal of Sports Medicine ◽

10.1177/2325967118811604 ◽

2018 ◽

Vol 6 (12) ◽

pp. 232596711881160 ◽

Cited By ~ 5

Author(s):

Zachary Paul Sinagra ◽

Alan Kop ◽

Moreica Pabbruwe ◽

Jeremy Parry ◽

Gavin Clark

Keyword(s):

Foreign Body ◽

Foreign Body Reaction ◽

Fibrous Tissue ◽

Case Series ◽

Significant Degree ◽

Level Of Evidence ◽

Tissue Ingrowth ◽

Artificial Ligaments ◽

Clinically Significant ◽

Improved Design

Background: Artificial ligaments have been developed and used in the treatment of ligamentous injuries since the 1970s. The early generation of artificial ligaments showed promising short-term results but resulted in high rates of rupture and inflammatory reaction in the surrounding tissues. Purpose: To determine whether the use of Ligament Augmentation and Reconstruction System (LARS) ligaments is associated with the development of intra-articular foreign body reaction. Study Design: Case series; Level of evidence, 4. Methods: LARS ligaments were explanted from 15 patients under 6 consultant orthopaedic surgeons at 8 surgical centers. Of these, 14 explanted samples were sent for macroscopic and histological analysis, with the 1 remaining sample sent for scanning electron microscopy, to assess for inflammatory change as well as the degree of fibrous tissue ingrowth. Results: We observed a foreign body reaction in 10 of 14 explanted LARS ligaments. Seven samples demonstrated fibrous tissue ingrowth, with 5 producing only focal or incomplete ingrowth. The 2 samples with extensive fibrous coverage were completely free of any foreign body reaction, while all 5 remaining samples with only focal or partial fibrous ingrowth were associated with at least some degree of harmful immune response. Conclusion: The LARS ligament is still associated with a clinically significant degree of foreign body reaction despite the LARS Company’s efforts to reduce complications through improved design. The development and completion of fibrous tissue ingrowth may work to reduce the occurrence of a foreign body reaction.

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Labyrinthitis ossificans: How accurate is MRI in predicting cochlear obstruction?

Otolaryngology ◽

10.1016/j.otohns.2008.12.029 ◽

2009 ◽

Vol 140 (5) ◽

pp. 692-696 ◽

Cited By ~ 59

Author(s):

Brandon Isaacson ◽

Timothy Booth ◽

Joe W. Kutz ◽

Kenneth H. Lee ◽

Peter S. Roland

Keyword(s):

High Resolution ◽

Bacterial Meningitis ◽

Cochlear Implant ◽

Tertiary Care ◽

Fibrous Tissue ◽

Case Series ◽

Prior History ◽

Basal Turn ◽

Labyrinthitis Ossificans ◽

History Of

Objective: To determine the accuracy of preoperative MRI in predicting cochlear obstruction in pediatric patients with a history of bacterial meningitis. Methods: A case series with chart review was performed at a tertiary care multidisciplinary cochlear implant program. Forty-five children with hearing loss that resulted from bacterial meningitis were implanted from 1991 to 2006. Twenty-five children had preoperative MRI with high-resolution axial T2-weighted images to assess for cochlear patency. Results: Seventeen of 25 patients (68%) had surgical evidence of cochlear obstruction. Six patients (37.5%) required circummodiolar drill-outs, and one patient (6.25%) underwent placement of a double array cochlear implant. The nine remaining patients (56%) with cochlear obstruction required removal of fibrous tissue or drilling of the inferior basal turn, but did not require manipulation of the ascending basal turn to achieve full electrode insertion. The sensitivity, specificity, and positive and negative predictive value of MRI predicting intraoperative cochlear obstruction with 95 percent confidence intervals was 94.1 percent (71–99), 87.5 percent (47–99), 94.1 percent (71–99) and 87.5 percent (47–99), respectively. Conclusion: Preoperative high-resolution T2 MRI may be useful in predicting cochlear obstruction in patients with a prior history of bacterial meningitis.

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Posterolateral Elbow Impingement in Professional Boxers

The American Journal of Sports Medicine ◽

10.1177/0363546507308937 ◽

2007 ◽

Vol 36 (2) ◽

pp. 328-332 ◽

Cited By ~ 17

Author(s):

Kars P. Valkering ◽

Henk van der Hoeven ◽

Bas C. M. Pijnenburg

Keyword(s):

Fibrous Tissue ◽

Case Series ◽

Normal Function ◽

Ligament Injury ◽

Arthroscopic Debridement ◽

Extension Deficit ◽

Level Of Evidence ◽

Elbow Injury ◽

Special Surgery ◽

Hospital For Special Surgery

Background Elbow injury is common in boxing, but it has not been reported in the literature. The onset is often a hyperextension trauma caused by a missed hit. Clinically the boxers complain of pain, stiffness, and an extension deficit. Purpose To evaluate the pathogenesis, diagnostic approach, and arthroscopic treatment of elbow injury in boxers, and to compare these with other sports-related elbow injuries. Study Design Case series; Level of evidence, 4. Methods Between 2003 and 2005, a group of 5 professional boxers received a diagnosis of posterior elbow impingement. An arthroscopic debridement was performed. All patients were evaluated preoperatively and 1 year postoperatively with the Hospital for Special Surgery Elbow Assessment Scale. Results An arthroscopic partial resection of the posterior olecranon tip was performed, and osteophytes and fibrous tissue were removed in this area. Loose bodies were removed from the elbow in 3 patients. They were present in the posterior compartment in 2 patients and the anterior compartment in 1. The Hospital for Special Surgery score showed satisfactory to good improvement after 1 year in all 5 cases. They all showed a normal function at follow-up and had a full return to their sports activities. In contrast with the valgus extension overload syndrome, our patients did not show any signs of concomitant ulnar collateral ligament injury. Conclusion Posterolateral elbow impingement in boxers is caused by hyperextension trauma. Concomitant medial elbow instability was not present. Standard arthroscopic debridement showed good results.

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Simulating orientation and polarization characteristics of dense fibrous tissue by electrostatic spinning of polymeric fibers

Biomedical Optics Express ◽

10.1364/boe.10.000571 ◽

2019 ◽

Vol 10 (2) ◽

pp. 571 ◽

Cited By ~ 1

Author(s):

Shuwei Shen ◽

Haili Wang ◽

Yingjie Qu ◽

Kuiming Huang ◽

Guangli Liu ◽

...

Keyword(s):

Fibrous Tissue ◽

Polymeric Fibers ◽

Electrostatic Spinning ◽

Dense Fibrous Tissue ◽

Polarization Characteristics

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Surgical Management for Refractory Bleb Dysesthesia

Journal of Ophthalmology ◽

10.1155/2020/7570454 ◽

2020 ◽

Vol 2020 ◽

pp. 1-7

Author(s):

Agnieszka Dyrda ◽

Alfonso Anton ◽

Juan Pablo Figueroa-Vercellino ◽

Marta Pazos

Keyword(s):

Surgical Treatment ◽

Literature Review ◽

Surgical Management ◽

Rare Complication ◽

Fibrous Tissue ◽

Case Series ◽

Long Term Results ◽

Radial Incision ◽

First Choice ◽

Ocular Discomfort

Purpose. To present long-term results of modified bleb-limiting conjunctivoplasty as a successful treatment for intractable bleb dysesthesia and to review the literature on the surgical management of dysesthetic bleb. Methods. Consecutive case series and literature review. We present four cases of surgically reduced painful blebs. Our technique consisted of the following steps: (1) conjunctival, radial incision to the bare sclera in the desired limit of the bleb; (2) suturing with buried, interrupted sutures at the nearest edge of the filtering bleb; (3) lower limbal peritomy including unwanted area of the extended bleb; (4) dissection and removal of the underlying fibrous tissue when present; (5) conjunctival and resorbable sutures. In addition, a systematic literature review was performed. Only reports presenting outcomes of surgical treatment of bleb dysesthesia after filtering procedure were included in review. Results. Four eyes were included consecutively in the study in a period of 4 years. On average, they developed circumferential bleb dysesthesia 9.3 ± 4.7 months after uneventful combined phacotrabeculectomy with Mitomycin C as primary procedure. Surgical reduction was decided after failure of lubricants in controlling ocular discomfort. Two cases showed a dense fibrous tissue beneath the conjunctiva that was excised to ensure filtration. In all cases, a rapid disappearance of symptoms with very good aesthetic and functional outcome was observed. After 12-month follow-up, patients remained asymptomatic and maintained intraocular pressure of 10.7 ± 1.2 mmHg without treatment. A systematic review of the literature obtained 15 eligible case series (n = 123) with rates of success within 46–100%, favoring less aggressive approaches to reduce bleb size. Conclusion. Bleb dysesthesia is a rare complication of filtering glaucoma surgery. This modified bleb-limiting conjunctivoplasty technique (with removal of subjacent fibrous tissue if present) is able to target the underlying etiology providing ocular discomfort relief while maintaining bleb function and may be considered as first-choice surgical treatment.

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Experimental Modelling of the Processes for Connective Tissue Reparative Regeneration under Unfavorable Conditions

N.N. Priorov Journal of Traumatology and Orthopedics ◽

10.17816/vto201522118-22 ◽

2015 ◽

Vol 22 (1) ◽

pp. 18-22

Author(s):

M. V Vlasov ◽

S. N Bugrov ◽

A. B Bogos’yan ◽

I. V Musukhina

Keyword(s):

Connective Tissue ◽

Fibrous Tissue ◽

Reparative Regeneration ◽

Lymphoid Cells ◽

Fatty Tissue ◽

Experimental Modelling ◽

Defect Zone ◽

Dense Fibrous Tissue ◽

Mesenteric Vessels ◽

Reverse Development

The purpose of the work was to elaborate experimental model for transverse tenotomy with intersection of facial membranes and mesenteric vessels as well as to study the process of connective tissue reparative regeneration under created conditions. Experiment was performed on 25 chinchilla rabbits of both sexes, aged 1 month with weight 1376 ± 124.8 g. Processes of Achilles tendon reparative regeneration was studied on days 15, 21, 30, 60 and 90 after operation. Histomorphologic study showed that within 30 days after tenotomy the substitution of defect zone with friable, reach in cells and gradually maturating fibrous tissue took place. By the end of day 60 a considerable part of the defect was substituted by dense fibrous connective tissue assumed a scar pattern. On day 90 after tenotomy a reverse development of the defect zone with focal substitution of dense fibrous tissue by friable unformed connective tissue containing histiocytes, lymphoid cells and inclusions of fatty tissue foci was observed. At that term histologic structure of the specimen showed its relatively low mechanical strength. The achieved data enabled to demonstrate that performance of tenotomy with traumatization of peritendinous tissues adversely affected the dynamics and pattern of reparative processes in the tendinosus defect zone.

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Experimental Modelling of the Processes for Connective Tissue Reparative Regeneration under Unfavorable Conditions

N N Priorov Journal of Traumatology and Orthopedics ◽

10.32414/0869-8678-2015-1-18-22 ◽

2015 ◽

pp. 18-22

Author(s):

M. V. Vlasov ◽

S. N. Bugrov ◽

A. B. Bogos’Yan ◽

I. V. Musukhina

Keyword(s):

Connective Tissue ◽

Fibrous Tissue ◽

Reparative Regeneration ◽

Lymphoid Cells ◽

Fatty Tissue ◽

Experimental Modelling ◽

Defect Zone ◽

Dense Fibrous Tissue ◽

Mesenteric Vessels ◽

Reverse Development

The purpose of the work was to elaborate experimental model for transverse tenotomy with intersection of facial membranes and mesenteric vessels as well as to study the process of connective tissue reparative regeneration under created conditions. Experiment was performed on 25 chinchilla rabbits of both sexes, aged 1 month with weight 1376 ± 124.8 g. Processes of Achilles tendon reparative regeneration was studied on days 15, 21, 30, 60 and 90 after operation. Histomorphologic study showed that within 30 days after tenotomy the substitution of defect zone with friable, reach in cells and gradually maturating fibrous tissue took place. By the end of day 60 a considerable part of the defect was substituted by dense fibrous connective tissue assumed a scar pattern. On day 90 after tenotomy a reverse development of the defect zone with focal substitution of dense fibrous tissue by friable unformed connective tissue containing histiocytes, lymphoid cells and inclusions of fatty tissue foci was observed. At that term histologic structure of the specimen showed its relatively low mechanical strength. The achieved data enabled to demonstrate that performance of tenotomy with traumatization of peritendinous tissues adversely affected the dynamics and pattern of reparative processes in the tendinosus defect zone.

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Diffuse Fibrous Pseudotumor of the Testicular Tunics Associated With an Inflamed Hydrocele

Archives of Pathology & Laboratory Medicine ◽

10.5858/2003-127-742-dfpott ◽

2003 ◽

Vol 127 (6) ◽

pp. 742-744 ◽

Cited By ~ 3

Author(s):

Raja R. Seethala ◽

A. Temel Tirkes ◽

Susan Weinstein ◽

John E. Tomaszewski ◽

S. Bruce Malkowicz ◽

...

Keyword(s):

Soft Tissue ◽

Fibrous Tissue ◽

Malignant Neoplasm ◽

Inflammatory Cells ◽

Close Apposition ◽

Left Testis ◽

Dense Fibrous Tissue ◽

History Of ◽

Or History

Abstract Fibrous pseudotumors of the testicular tunics and paratesticular soft tissue are uncommon lesions. They typically arise as painless scrotal masses that may be associated with a hydrocele or history of trauma or infection. Although these lesions are clinically worrisome for a malignant neoplasm, they are thought to be reactive in nature, since they are composed of dense fibrous tissue with interspersed bland fibroblasts and myofibroblasts and mixed inflammatory cells. Once excised, these lesions behave in a benign fashion. Typically, these masses are multinodular, but in rare cases they are diffuse, bandlike myofibroblastic proliferations that encase the testis and are termed fibromatous periorchitis. Herein, we describe a 57-year-old man with a diffuse fibrous pseudotumor/fibromatous periorchitis that encased the left testis and adnexa and arose in close apposition to an inflamed hydrocele.

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