Simulating orientation and polarization characteristics of dense fibrous tissue by electrostatic spinning of polymeric fibers

SummaryWe studied the cardiac conduction system in a case of Hurler syndrome. There was dense fibrosis of the supporting matrix of the sinus node and accumulation of mucopolysaccharide in the nodal cells. The bundle branches showed prominent hydropic degeneration, being encased and punctuated by dense fibrous tissue. These changes in the conduction system may predispose to the development of arrhythmias, accounting for the sudden deaths in Hurler syndrome.

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Experimental Modelling of the Processes for Connective Tissue Reparative Regeneration under Unfavorable Conditions

N.N. Priorov Journal of Traumatology and Orthopedics ◽

10.17816/vto201522118-22 ◽

2015 ◽

Vol 22 (1) ◽

pp. 18-22

Author(s):

M. V Vlasov ◽

S. N Bugrov ◽

A. B Bogos’yan ◽

I. V Musukhina

Keyword(s):

Connective Tissue ◽

Fibrous Tissue ◽

Reparative Regeneration ◽

Lymphoid Cells ◽

Fatty Tissue ◽

Experimental Modelling ◽

Defect Zone ◽

Dense Fibrous Tissue ◽

Mesenteric Vessels ◽

Reverse Development

The purpose of the work was to elaborate experimental model for transverse tenotomy with intersection of facial membranes and mesenteric vessels as well as to study the process of connective tissue reparative regeneration under created conditions. Experiment was performed on 25 chinchilla rabbits of both sexes, aged 1 month with weight 1376 ± 124.8 g. Processes of Achilles tendon reparative regeneration was studied on days 15, 21, 30, 60 and 90 after operation. Histomorphologic study showed that within 30 days after tenotomy the substitution of defect zone with friable, reach in cells and gradually maturating fibrous tissue took place. By the end of day 60 a considerable part of the defect was substituted by dense fibrous connective tissue assumed a scar pattern. On day 90 after tenotomy a reverse development of the defect zone with focal substitution of dense fibrous tissue by friable unformed connective tissue containing histiocytes, lymphoid cells and inclusions of fatty tissue foci was observed. At that term histologic structure of the specimen showed its relatively low mechanical strength. The achieved data enabled to demonstrate that performance of tenotomy with traumatization of peritendinous tissues adversely affected the dynamics and pattern of reparative processes in the tendinosus defect zone.

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Experimental Modelling of the Processes for Connective Tissue Reparative Regeneration under Unfavorable Conditions

N N Priorov Journal of Traumatology and Orthopedics ◽

10.32414/0869-8678-2015-1-18-22 ◽

2015 ◽

pp. 18-22

Author(s):

M. V. Vlasov ◽

S. N. Bugrov ◽

A. B. Bogos’Yan ◽

I. V. Musukhina

Keyword(s):

Connective Tissue ◽

Fibrous Tissue ◽

Reparative Regeneration ◽

Lymphoid Cells ◽

Fatty Tissue ◽

Experimental Modelling ◽

Defect Zone ◽

Dense Fibrous Tissue ◽

Mesenteric Vessels ◽

Reverse Development

The purpose of the work was to elaborate experimental model for transverse tenotomy with intersection of facial membranes and mesenteric vessels as well as to study the process of connective tissue reparative regeneration under created conditions. Experiment was performed on 25 chinchilla rabbits of both sexes, aged 1 month with weight 1376 ± 124.8 g. Processes of Achilles tendon reparative regeneration was studied on days 15, 21, 30, 60 and 90 after operation. Histomorphologic study showed that within 30 days after tenotomy the substitution of defect zone with friable, reach in cells and gradually maturating fibrous tissue took place. By the end of day 60 a considerable part of the defect was substituted by dense fibrous connective tissue assumed a scar pattern. On day 90 after tenotomy a reverse development of the defect zone with focal substitution of dense fibrous tissue by friable unformed connective tissue containing histiocytes, lymphoid cells and inclusions of fatty tissue foci was observed. At that term histologic structure of the specimen showed its relatively low mechanical strength. The achieved data enabled to demonstrate that performance of tenotomy with traumatization of peritendinous tissues adversely affected the dynamics and pattern of reparative processes in the tendinosus defect zone.

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Diffuse Fibrous Pseudotumor of the Testicular Tunics Associated With an Inflamed Hydrocele

Archives of Pathology & Laboratory Medicine ◽

10.5858/2003-127-742-dfpott ◽

2003 ◽

Vol 127 (6) ◽

pp. 742-744 ◽

Cited By ~ 3

Author(s):

Raja R. Seethala ◽

A. Temel Tirkes ◽

Susan Weinstein ◽

John E. Tomaszewski ◽

S. Bruce Malkowicz ◽

...

Keyword(s):

Soft Tissue ◽

Fibrous Tissue ◽

Malignant Neoplasm ◽

Inflammatory Cells ◽

Close Apposition ◽

Left Testis ◽

Dense Fibrous Tissue ◽

History Of ◽

Or History

Abstract Fibrous pseudotumors of the testicular tunics and paratesticular soft tissue are uncommon lesions. They typically arise as painless scrotal masses that may be associated with a hydrocele or history of trauma or infection. Although these lesions are clinically worrisome for a malignant neoplasm, they are thought to be reactive in nature, since they are composed of dense fibrous tissue with interspersed bland fibroblasts and myofibroblasts and mixed inflammatory cells. Once excised, these lesions behave in a benign fashion. Typically, these masses are multinodular, but in rare cases they are diffuse, bandlike myofibroblastic proliferations that encase the testis and are termed fibromatous periorchitis. Herein, we describe a 57-year-old man with a diffuse fibrous pseudotumor/fibromatous periorchitis that encased the left testis and adnexa and arose in close apposition to an inflamed hydrocele.

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Brenner tumors

British Journal of Radiology ◽

10.1259/bjr.20210687 ◽

2021 ◽

Author(s):

Filipa de Sousa Costeira ◽

Ana Félix ◽

Teresa Margarida Cunha

Keyword(s):

Differential Diagnosis ◽

Ovarian Neoplasms ◽

Fibrous Tissue ◽

Ovarian Neoplasm ◽

Imaging Features ◽

The Past ◽

Dense Fibrous Tissue ◽

Brenner Tumor ◽

Brenner Tumors ◽

Asymptomatic Women

Brenner tumors are rare ovarian neoplasms composed of ovarian transition cells surrounded by dense fibrous tissue. Most of them are small tumors (<2 cm), detected incidentally in asymptomatic women. Its predominantly fibrous content results in relatively low signal on T2 weighted images, establishing differential diagnosis with ovarian fibroma and thecoma. Their imaging features are very similar, the differentiation is based on secondary characteristics, such as signs or symptoms of estrogen excess and the presence of a second ovarian neoplasm, which has been reported in up to 30% of patients with Brenner tumor. Although originally thought to be universally benign, there have been scattered reports in the past decades of borderline and malignant forms of Brenner tumors.

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Hyperplasia of the bile duct in fascioliasis and its relation to the problem of nutrition in the liver-fluke, Fasciola hepatica L.

Parasitology ◽

10.1017/s0031182000072590 ◽

1963 ◽

Vol 53 (1-2) ◽

pp. 123-133 ◽

Cited By ~ 49

Author(s):

Ben Dawes

Keyword(s):

Bile Duct ◽

Connective Tissue ◽

Bile Ducts ◽

Inflammatory Process ◽

Liver Fluke ◽

Fasciola Hepatica ◽

Fibrous Tissue ◽

Feeding Habit ◽

Glandular Tissue ◽

Dense Fibrous Tissue

Histological investigations of the bile ducts of various hosts of F. hepatica during the early stages of infection, when the flukes are burrowing in the liver and have not yet reached the bile ducts, indicate that subtle changes are brought about, probably by chemical agencies and as a result of the inflammatory process, in the bile ducts of the hosts. The transitory appearance of minute cytoplasmic blebs at the free margins of the epithelial cells seems to inaugurate an intense hyperplasia of the epithelium with tubular ingrowths and adenomatous development of glandular tissue, and an associated fibrosis which produces a thick underlying layer of dense fibrous tissue. At the time of entry of the flukes into the biliary system the hyperplastic epithelium is intact, but soon the spines and suckers of the flukes abrade the superficial cells until this part of the duct is completely denuded. It is suggested that as a result of the inflammatory reaction, the fluke has been provided with a ‘pasture’ of hyperplastic epithelium and connective tissue on which it may continue to browse for considerable periods without necessarily affecting the host adversely. Tissue debris is found in the contents of the bile duct and similar homogenized materials occur in the caecal contents of the fluke. Previous researches have shown that the fluke will feed on various tissues, and it is suggested that this tissue-feeding habit persists during its life in the bile duct. These results agree with the findings of Müller (1923) but are at variance with the results obtained by other investigators, as is shown in discussion. The hyperplasia of the bile duct is not characteristic of fascioliasis, occurring also in clonorchiasis, opisthorchiasis and dicrocoeliasis, and in these and possibly other instances it is probably intimately connected with the nutrition of the flukes concerned.

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Craved by heart, carved next to it: Ballistic report of a souvenir bullet casing

Journal of Kathmandu Medical College ◽

10.3126/jkmc.v8i1.25269 ◽

2019 ◽

Vol 8 (1) ◽

pp. 44-48

Author(s):

Jenash Acharya ◽

Geshu Lama ◽

Malshree Ranjitkar ◽

Arbin Shakya

Keyword(s):

Renal Failure ◽

Abdominal Pain ◽

Fibrous Tissue ◽

Late Complications ◽

The Body ◽

Fistula Formation ◽

Medicine Department ◽

Dense Fibrous Tissue ◽

Long Time ◽

Cartridge Case

A bullet which has been lodged in the body encapsulated by dense fibrous tissue for a long time without causing ill effects is a souvenir bullet. The bullet cartridge is divided into 3 parts: bullet, cartridge case holding bullet with gun powder and detonator at the base. Medicolegal consultation was done with Forensic Medicine Department where cartridge case acted as projectile and accidentally got embedded into the chest of the victim. In an attempt of making an ornament from the casing of bullet which was separated from bullet mechanically and gunpowder was partially removed from the bullet case. When he heated the bullet case to melt and mould, the remaining gun powder ignited with release of large amount of gas which resulted in forceful propulsion and acted as the projectile. An oval penetrating keyhole appearance injury measuring 2 cm x 1.5 cm was present on left side of the chest of the victim. The projectile was found just above the 6th rib and was confined within inter-costal muscle. Although late complications may arise from the metallic toxicity from the bullet case showing manifestations like abdominal pain, anorexia, chronic renal failure, abdominal pain, osteomyelitis, and fistula formation in bones, the projectile was left within the body as a souvenir to be intervened in case complications arise during follow-ups, as manipulating it could cause unanticipated therapeutic complications.

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Vas Deferens Obstruction Due to Fibrosis after Plug Hernioplasty

The American Surgeon ◽

10.1177/000313480607200208 ◽

2006 ◽

Vol 72 (2) ◽

pp. 137-138 ◽

Cited By ~ 1

Author(s):

Gabriele Valenti ◽

Emanuele Baldassarre ◽

Giovanni Torino

Keyword(s):

Side Effects ◽

Direct Contact ◽

Vas Deferens ◽

Fibrous Tissue ◽

Recurrent Hernia ◽

Transversalis Fascia ◽

Dense Fibrous Tissue ◽

First Case ◽

Tissue Microscopy

The positioning of mesh and plug is routinely performed in hernioplasty, but knowledge about the long-term side effects of plug-induced fibrosis on the vas is incomplete. This is the first case of a documented fibrotic vas deferens obstruction resulting from compression of the plug that was in direct contact with the vas. During subsequent repair for a recurrent hernia, the cord and the plug appeared enveloped in dense fibrous tissue. Microscopy confirmed gross surgical findings. To reduce this morbidity, we suggest a cremaster sparing surgery, avoiding the positioning of bioprosthesis in direct contact with the vas deferens. We also found that positioning of a flat mesh over the transversalis fascia will avoid the unnecessary contact between mesh and bare vas below the transversalis fascia.

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Transmission Electron Microscopy of the Brenner Tumor. Contribution to the Histopathogenesis

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100115523 ◽

1975 ◽

Vol 33 ◽

pp. 380-381

Author(s):

I.M. B accarini

Keyword(s):

Fibrous Tissue ◽

Uranyl Acetate ◽

Fresh Tissue ◽

Ovarian Cortex ◽

Dense Fibrous Tissue ◽

Brenner Tumor ◽

Transmission Electron ◽

Acetate Lead ◽

Brenner Tumors ◽

The Many

The histogenetic interpretation of the Brenner tumor remains obscure, despite the many contributions that attempts to explain their origin.Six human ovaries containing islands of Brenner tumors were studied by histologic procedures and by the electron microscope; special stains, PAS, Oil red 0, toluidin blue and Wilder reticulum were also used. Fresh tissue was fixed in 3% glutaraldehyde, embedded in Epon, stained with Uranyl-acetate, Lead citrate and viewed in RCA E.M. The islands of tumor were located in the cortex, in the stroma or in the deep medulla; they were classified in developing, well developed, and degenerated one, depending upon the comparison of the histologic findings with the ultrastructure of the cytoplasmic organelles. These islands were set in a dense fibrous tissue in the stroma. In one case, the tumor was in the periphery of an ovarian fibroma developed in the ovarian cortex.The ultrastructure of the cells were identical, except for the different degree of degeneration, noted in some cells.

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THYMECTOMY IN THE RABBIT

Journal of Experimental Medicine ◽

10.1084/jem.43.1.119 ◽

1926 ◽

Vol 43 (1) ◽

pp. 119-125 ◽

Cited By ~ 3

Author(s):

Chester M. Van Allen

Keyword(s):

Physical Condition ◽

Operative Mortality ◽

Simple Procedure ◽

Fibrous Tissue ◽

Aseptic Technique ◽

Secondary Complications ◽

Operative Death ◽

Open Method ◽

Dense Fibrous Tissue ◽

Additional Loss

Thymectomy in the rabbit is a comparatively simple procedure. The open method described above offers many advantages over any of the closed methods and success depends largely upon the observance of a few precautions; chief among these is the avoidance of haste and the observance of aseptic technique. The operative mortality in our series of rabbits was 10 per cent and there was an additional loss of useful animals, due to secondary complications, amounting to 16 per cent. Among the last 29 rabbits, however, there was only 1 operative death, in an old animal, and 2 cases of slight infection. It appears, therefore, that with some experience the operation can be carried out successfully in nearly all animals, especially so if comparatively young rabbits are used. Old rabbits present greater difficulties on account of the presence of dense fibrous tissue within the field of operation. While the animals of this series showed no immediate symptoms or alteration in physical condition that could be referred to thymoprivia, it is not to be assumed that removal of the thymus is entirely without effect even on rabbits of mature age. Our observations on the reaction of thymoprivic rabbits to disease show that this is not the case and that in all probability decided effects can be demonstrated if the problem is approached on another basis. The object of the present investigation was, however, to determine whether the thymus could be completely removed from rabbits of certain ages without producing any serious disturbance of health which would interfere with their use in other experiments or complicate the interpretation of results. It was found that this could be done.

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