Increased short‐ and long‐term mortality following infections in dementia: a nationwide registry‐based cohort study

2020 ◽  
Author(s):  
J. Janbek ◽  
L. Taudorf ◽  
C. S. Musaeus ◽  
N. Frimodt‐Møller ◽  
T. M. Laursen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Nationwide Registry ◽  
Short And Long Term ◽  
Long Term Mortality

scholarly journals Lower short- and long-term mortality associated with overweight and obesity in a large cohort study of adult intensive care unit patients

Critical Care ◽  
2012 ◽  
Vol 16 (6) ◽  
pp. R235 ◽  
Author(s):  
Swapna Abhyankar ◽  
Kira Leishear ◽  
Fiona M Callaghan ◽  
Dina Demner-Fushman ◽  
Clement J McDonald
Keyword(s):  
Intensive Care Unit ◽  
Cohort Study ◽  
Intensive Care ◽  
Overweight And Obesity ◽  
Large Cohort ◽  
Adult Intensive Care Unit ◽  
Large Cohort Study ◽  
Short And Long Term ◽  
Long Term Mortality

Impact Of Comorbidity and Performance Status On Treatment Intent and Outcome In AML Patients. A Danish Population-Based Cohort Study

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 3879-3879 ◽  
Author(s):  
Lene S.G. Østgård ◽  
Mette Nørgaard ◽  
Henrik Sengeløv ◽  
Jan M. Nørgaard
Keyword(s):  
Cohort Study ◽  
Complete Remission ◽  
Performance Status ◽  
Population Based ◽  
Comorbid Disease ◽  
Curative Intent ◽  
Short And Long Term ◽  
And Performance ◽  
Long Term Mortality

Abstract Background With an aging population, the burden of comorbidity in AML patients is expected to increase. Evidence on how to integrate comorbidity and functional status into clinical decision making is sparse and prior studies have been predictive and limited by single center study design, and small sample sizes. Objectives To examine the impact of comorbidity and WHO Performance Status (PS) on intent of treatment in Danish AML patients. Secondary, to determine the prognostic impact of comorbidity and PS on achievement of complete remission, short- and long-term mortality in AML patients treated with curative intent. Methods In a nationwide cohort study, we identified all AML (non-promyelocytic leukemia) patients diagnosed in Denmark from 2000-2013 using a population-based leukemia registry (n=2785) which prospectively collects clinical data. We excluded patients with unknown intent of treatment (n=25). We identified comorbid conditions through the Danish National Registry of Patients. Comorbidity was evaluated according to presence of 17 of the 19 chronic diseases (HIV and leukemia excluded) in the Charlson Comorbidity Index with separate adjustment for all diseases associated with secondary AML (modified CCI (mCCI)). Crude and adjusted odds ratios (OR) and corresponding 95% confidence intervals (CI) for receiving treatment with curative intent were estimated. We used Cox proportional hazards regression to assess the influence of comorbidity and performance status on 90-day and 90-day to 3-year mortality in patients treated with curative intent (n=1444) by estimating crude and adjusted mortality ratios (MRs) and corresponding 95% CIs. We adjusted for age, gender, leukocyte count, prior chemo-/radiotherapy, and prior hematological diseases. Results Of 2760 patients 52% were treated with curative intent. Median age was 69 years (palliative intent: 78 vs. curative intent: 58). Overall, 60% of patients did not have any comorbidity, 26% had 1 comorbid disease, and 13% had 2 or more comorbidities. In patients treated with curative intent, the corresponding prevalences were 76%, 19%, and 6%. Overall, 26% of patients had PS=0, 42% had PS=1, and 32% had PS ≥2. The corresponding figures in patients treated with curative intent were 33%, 47%, and 20%. Dementia and heart failure were the two individual comorbid diseases most strongly associated with opting-out of intensive treatment (prevalence ratio 0.11 (95%CI 0.01-0.67) and 0.24 (95%CI 0.15-0.37). In patients treated with curative intent, those with comorbidity had lower complete remission rate than those without comorbidity, 66% (95%CI 60.7-70.7) vs. 74% (95%CI 70.8-76.9) whereas choice of chemotherapy regimen and dose did not differ. Compared to patients without comorbidity (mCCI=0), the adjusted ORs for treatment with curative intent were 0.57 (95%CI 0.41-0.73) for patients with 1 comorbid disease and 0.32 (95%CI 0.22-0.47) for 2 or more. Compared to patients with PS=0, the adjusted ORs of treatment with curative intent were 0.80 (95%CI 0.58-1.09) for PS 1, 0.45 (95%CI 0.31-0.65) for PS 2, and 0.09 (95%CI 0.05-0.14) for PS≥3. Crude survival curves according to comorbidity and PS are shown below. Crude and adjusted MRs are listed in table 1. Conclusions The chance of being allocated to intensive chemotherapy decreased dramatically with increasing number of comorbid diseases and increasing PS. Surprisingly, among patients treated with curative intent presence of comorbidity was not associated with an increase in short-term mortality, and if any, only a slight increase in long-term mortality. High PS was strongly associated with both short- and long-term mortality. Our findings may be explained by the selection process before treatment with curative intent and raises the question whether more patients with comorbidity and low PS at time of diagnosis may benefit from intensive treatment. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Short and Long-Term Mortality Trends for Cancer Patients with Septic Shock Stratified by Cancer Type from 2009 to 2017: A Population-Based Cohort Study

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 657
Author(s):  
Youn-Jung Kim ◽  
Min-Ju Kim ◽  
Ye-Jee Kim ◽  
Won Young Kim
Keyword(s):  
Septic Shock ◽  
Cohort Study ◽  
Cancer Patients ◽  
Population Based ◽  
Cancer Type ◽  
Mortality Trends ◽  
Sepsis Management ◽  
Short And Long Term ◽  
Long Term Mortality

There have been recent advances in both cancer and sepsis management. This study aimed to assess short and long-term mortality trends in cancer patients with septic shock from 2009 to 2017 by cancer type. This nationwide population-based cohort study using data from the National Health Insurance Service of Korea included adult cancer patients who presented to an emergency department (ED) with septic shock from 2009 to 2017. Among 43,466 adult cancer patients with septic shock (90% solid and 10% hematologic cancer cases), the 30-day and 1-year mortality rates were 52.1% and 81.3%, respectively. The overall 30-day mortality showed a marked decrease of 4.8% annually from 2013 to 2017, but the annual decrease in the 1-year mortality over the same period was only 1.9%. Pancreatic cancer cases showed the most significant improvement in 30-day mortality between 2014 and 2019 (11.0% decrease/year). Lung and stomach cancers showed a sustained decrease in 30-day mortality during the whole study period (1.7% and 2.0% decrease/year, respectively). The outcomes of cancer patients with septic shock have improved in recent years across most cancer types. Physicians should have expectations of an improved prognosis in cancer patients admitted to the ED with septic shock.

scholarly journals Increased excess short‐ and long‐term mortality following infections in dementia: A prospective nationwide and registry‐based cohort study

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Janet Janbek ◽  
Lærke Taudorf ◽  
Christian Sandøe Musaeus ◽  
Niels Frimodt‐Møller ◽  
Thomas Munk Laursen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Short And Long Term ◽  
Long Term Mortality

scholarly journals Impact of preoperative serum creatinine on short- and long-term mortality after cardiac surgery: a cohort study

2015 ◽  
Vol 114 (1) ◽  
pp. 53-62 ◽  
Author(s):  
M.H. Bernardi ◽  
D. Schmidlin ◽  
A. Schiferer ◽  
R. Ristl ◽  
T. Neugebauer ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Cohort Study ◽  
Serum Creatinine ◽  
Preoperative Serum ◽  
Short And Long Term ◽  
Long Term Mortality

scholarly journals Predictors of Short- and Long-Term Mortality in Males and Females with Hip Fracture - A Prospective Observational Cohort Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e78169 ◽  
Author(s):  
Andreas P. Diamantopoulos ◽  
Mari Hoff ◽  
Marc Hochberg ◽  
Glenn Haugeberg
Keyword(s):  
Cohort Study ◽  
Hip Fracture ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Observational Cohort ◽  
Short And Long Term ◽  
Males And Females ◽  
Long Term Mortality

scholarly journals 25 year trends in first time hospitalisation for acute myocardial infarction, subsequent short and long term mortality, and the prognostic impact of sex and comorbidity: a Danish nationwide cohort study

BMJ ◽  
2012 ◽  
Vol 344 (jan25 2) ◽  
pp. e356-e356 ◽  
Author(s):  
M. Schmidt ◽  
J. B. Jacobsen ◽  
T. L. Lash ◽  
H. E. Botker ◽  
H. T. Sorensen
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cohort Study ◽  
Prognostic Impact ◽  
Short And Long Term ◽  
First Time ◽  
Long Term Mortality
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