A prospective study contrasting the psychiatric outcome in drug-resistant epilepsy between patients who underwent surgery and a control group

AbstractIt has been suggested that children undergoing tonsillectomy would benefit from an intravenous infusion, to counteract the period of pre-operativefasting combined with the blood loss at operation.A prospective study of 50 children undergoing tonsillectomy was undertaken. The children were randomly allocated into two groups, one to receive an infusion and a control group.There were no significant differences between the two groups, although the children with an infusion had a longer mean post-operative stay.There would seem to be no role for routine intravenous fluid replacement in children undergoing uncomplicated tonsillectomy.

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How to Inject Ictal SPECT? From Manual to Automated Injection

10.21203/rs.3.rs-255385/v1 ◽

2021 ◽

Author(s):

Xavier Setoain ◽

Francisco Campos ◽

Antonio Donaire ◽

Maria Mayoral ◽

Andres Perissinotti ◽

...

Keyword(s):

Injection System ◽

Control Group ◽

Epileptogenic Zone ◽

Drug Resistant ◽

Injection Time ◽

Tracer Injection ◽

Ictal Spect ◽

Seizure Focus ◽

Drug Resistant Epilepsy ◽

Automated Injection

Abstract BackgroundSuccessful surgery depends on the accurate localization of epileptogenic zone before surgery. Ictal SPECT is the only imaging modality that allows identification of the ictal onset zone by measuring the regional cerebral blood flow at the time of injection. The main limitations of ictal SPECT in epilepsy are the complex methodology of the tracer injection during a seizure. To overcome these limitations, we present the main features of the first automated injector for ictal SPECT (epijet, LemerPax; La Chapelle -sur-Erdre; France). In this study we compared traditional manual injection with automated injection for ictal SPECT in122 patients with drug-resistant epilepsy. MethodsThe study included 55 consecutive prospective patients with drug-resistant epilepsy undergoing injection with the automated injector. The control group was our retrospective database of a historic pool of 67 patients, injected manually from 2014-2016. Calculated annual exposure/radioactive dose for operators was measured. Injection time, seizure focus localization with ictal SPECT, as well as repeated hospitalizations related to fails injections were compared in these two groups of patients. ResultsThere were no differences in the average injection time with epijet (13 s) compared with the traditional manual injection (14s). The seizure focus was successfully localized with ictal SPECT with epijet in 44/55 (80%) patients and with manual injection in 46/67 (68%) patients (p=0.694). Repeated studies were required in 16/67 (23%) patients in the manual injection group compared to 4 patients (7%) in the epijet group (p=0.022). Calculated annual exposure/dose for operators of 0.39 mSv/year and administered dose error inferior to 5% are other advantages of epijet. ConclusionThe first results using epijet are promising in adjustment of the injection dose, reducing the rate of radiation exposure for patients and nurses, maintaining the same injection time and allowing high SPECT accuracy. These preliminary results support the use of an automated injection system to inject radioactive ictal SPECT doses in epilepsy units.

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Epistaxis as a marker for severe acute respiratory syndrome coronavirus-2 status – a prospective study

The Journal of Laryngology & Otology ◽

10.1017/s0022215120001863 ◽

2020 ◽

Vol 134 (8) ◽

pp. 717-720 ◽

Cited By ~ 1

Author(s):

MH Hussain ◽

M Mair ◽

P Rea

Keyword(s):

Severe Acute Respiratory Syndrome ◽

Prospective Study ◽

Control Group ◽

Study Group ◽

Chain Reaction ◽

Polymerase Chain Reaction Testing ◽

The Mean ◽

Polymerase Chain ◽

The Difference ◽

A Prospective Study

AbstractObjectiveTo evaluate the prevalence of severe acute respiratory syndrome coronavirus-2 infection in patients presenting with epistaxis to a tertiary otolaryngology unit.MethodsA prospective study was conducted of 40 consecutive patients presenting with epistaxis referred to our tertiary otolaryngology unit. A group of 40 age-matched controls were also included. All patients underwent real-time reverse transcriptase polymerase chain reaction testing for severe acute respiratory syndrome coronavirus-2. Symptoms of fever, cough and anosmia were noted in the study group.ResultsThe mean age was 66.5 ± 22.4 years in the study group. There were 22 males (55 per cent) and 18 females (45 per cent). The mean age in the control group was 66.3 ± 22.4 years (p = 0.935). There were six positive cases for severe acute respiratory syndrome coronavirus-2 (15 per cent) in the epistaxis group and one case (2.5 per cent) in the control group. The difference was statistically significant (p = 0.05).ConclusionEpistaxis may represent a presenting symptom of severe acute respiratory syndrome coronavirus-2 infection. This may serve as a useful additional criterion for screening patients.

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Do Statins Affect Thyroid Volume and Nodule Size in Patients with Hyperlipidemia in a Region with Mild-to-Moderate Iodine Deficiency? A Prospective Study

Medical Principles and Practice ◽

10.1159/000486748 ◽

2018 ◽

Vol 27 (1) ◽

pp. 1-7

Author(s):

Canan Demir ◽

Cuneyd Anil ◽

Yusuf Bozkus ◽

Umut Mousa ◽

Altug Kut ◽

...

Keyword(s):

Prospective Study ◽

Thyroid Function ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Thyroid Volume ◽

Lifestyle Changes ◽

Control Group ◽

Nodule Size ◽

A Prospective Study ◽

And Control

Objective: The objective of this study was to assess the antiproliferative pleiotropic effects of statins on thyroid function, volume, and nodularity. Subjects and Methods: One hundred and six hyperlipidemic patients were included in this prospective study. The 69 patients in the statin groups received atorvastatin (16 received 10 mg and 18 received 20 mg) or rosuvastatin (20 received 10 mg and 15 received 20 mg). The 37 patients in the control group, assessed as not requiring drugs, made only lifestyle changes. Upon admission and after 6 months, all patients were evaluated by ultrasonography as well as for lipid variables (total cholesterol, high- and low-density lipoprotein cholesterol, and triglycerides) and thyroid function and structure. Results: After 6 months, no differences in thyroid function, thyroid volume, the number of thyroid nodules, or nodule size were observed in the statin and control groups. In a subgroup analysis, total thyroid volume had decreased more in patients receiving 20 mg of rosuvastatin than that in the control group (p < 0.05). Maximum nodule size had decreased more in those receiving 10 mg of rosuvastatin (p < 0.05). Conclusions: Our results suggest an association between rosuvastatin treatment and smaller thyroid volume and maximum nodule diameter; this could be attributable to the antiproliferative effects of statin therapy on the thyroid.

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Detection and characterization of drug-resistant conferring genes in Mycobacterium tuberculosis complex strains: A prospective study in two distant regions of Ghana

Tuberculosis ◽

10.1016/j.tube.2016.05.014 ◽

2016 ◽

Vol 99 ◽

pp. 147-154 ◽

Cited By ~ 17

Author(s):

I.D. Otchere ◽

A. Asante-Poku ◽

S. Osei-Wusu ◽

A. Baddoo ◽

E. Sarpong ◽

...

Keyword(s):

Mycobacterium Tuberculosis ◽

Prospective Study ◽

Mycobacterium Tuberculosis Complex ◽

Drug Resistant ◽

Tuberculosis Complex ◽

A Prospective Study

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Risk Factors for Development of Coronary Artery Disease in Women with Systemic Lupus Erythematosus

The Journal of Rheumatology ◽

10.3899/jrheum.090011 ◽

2009 ◽

Vol 36 (11) ◽

pp. 2454-2461 ◽

Cited By ~ 49

Author(s):

ROBERT J. GOLDBERG ◽

MURRAY B. UROWITZ ◽

DOMINIQUE IBAÑEZ ◽

MANDANA NIKPOUR ◽

DAFNA D. GLADMAN

Keyword(s):

Risk Factors ◽

Systemic Lupus Erythematosus ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Prospective Study ◽

Lupus Erythematosus ◽

Control Group ◽

Systemic Lupus ◽

Artery Disease ◽

A Prospective Study

Objective.To ascertain coronary artery disease (CAD) outcomes and predictive factors in a prospective study of patients with systemic lupus erythematosus (SLE) and matched healthy controls.Methods.SLE patients and non-SLE age-matched controls without a history of CAD were recruited into a prospective study between 1997 and 1999. CAD events were assessed at clinic visit for SLE patients and through telephone interview and chart review for controls. All events were verified with patient medical records.Results.Followup information was available on 237 controls and 241 SLE patients. The mean followup time was 7.2 years. Univariate analyses identified age and postmenopausal status as predictors of CAD in both the groups. Sedentary lifestyle, hypertension, the presence of metabolic syndrome, and the number of Framingham risk factors were predictive in the control group only. The 10-year risk of CAD score was predictive in both groups but was not as marked in the SLE group as in the controls. None of the lipid subfractions were predictive for CAD in the SLE group, whereas in the controls, a high triglyceride level ≥ 2.8 was predictive. Time-to-event multivariate analysis for CAD in all subjects revealed SLE itself, older age, and triglycerides ≥ 2.8 to be highly predictive for CAD.Conclusion.In a prospective study of patients with SLE and matched controls followed over a median of 8 years, patients with SLE developed significantly more CAD events than controls. Accounting for demographic variability, CAD risk factors, and lipid factors, SLE is an independent risk factor for the development of CAD.

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Rufinamide efficacy and safety as adjunctive treatment in children with focal drug resistant epilepsy: The first Italian prospective study

Epilepsy Research ◽

10.1016/j.eplepsyres.2012.05.004 ◽

2012 ◽

Vol 102 (1-2) ◽

pp. 94-99 ◽

Cited By ~ 9

Author(s):

Romina Moavero ◽

Raffaella Cusmai ◽

Nicola Specchio ◽

Lucia Fusco ◽

Alessandro Capuano ◽

...

Keyword(s):

Prospective Study ◽

Adjunctive Treatment ◽

Drug Resistant ◽

Efficacy And Safety ◽

Drug Resistant Epilepsy

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The effect of diabetes mellitus on evolution and outcome of tuberculosis in a prospective study

The Moldovan Medical Journal ◽

10.52418/moldovan-med-j.64-5.21.03 ◽

2021 ◽

Vol 64 (5) ◽

pp. 16-20

Author(s):

Alina Malic ◽

◽

Evelina Lesnic ◽

Keyword(s):

Diabetes Mellitus ◽

Prospective Study ◽

Treatment Effectiveness ◽

Similar Rate ◽

Control Group ◽

Diabetic Patients ◽

A Prospective Study ◽

Prospective Longitudinal ◽

The Impact

Background: In the Republic of Moldova almost 5% of the cases with tuberculosis are diagnosed annually among diabetic patients. The aim of this study was to assess the impact of diabetes mellitus on the evolution and anti-tuberculosis treatment effectiveness in a prospective study. Material and methods: A prospective, longitudinal and case-control study, which included a total number of 252 patients diagnosed with pulmonary tuberculosis and distributed in a study group, consisting of 93 patients diagnosed with diabetes mellitus and a control group, consisting of 159 patients without glycemic disorders, was performed. Results: This study identified that one half of the group with diabetes was detected by active screening and one third received anti-tuberculous treatment before actual episode. A similar rate of diabetic and non-diabetic patients was microbiologically positive, as well confirmed with drug-resistance. The anti-tuberculous treatment effectiveness was lower in diabetic patients, the death rate and the low treatment outcome (lost to follow-up and failed) were higher than in non-diabetic patients. The main causes of unfavorable evolution were: glycemic disorders (hyperglycemia), diabetes complications and the history of the anti-tuberculous treatment in the anamnesis. Conclusions: The individualized approach and a tight follow-up should be performed regularly in all patients with glycemic disorders and tuberculosis for the improvement of the disease outcome.

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