Mitochondrial DNA haplogroups affect physical performances in Han older adults: an 8‐year follow‐up prospective cohort study

Ultra-processed food (UPF) consumption has been associated with increased risk of cardiovascular risk factors and mortality. However, little is known on the UPF effect on renal function. The aim of this study is to assess prospectively the association between consumption of UPF and renal function decline. This is a prospective cohort study of 1312 community-dwelling individuals aged 60 and older recruited during 2008–2010 and followed up to December 2015. At baseline, a validated dietary history was obtained. UPF was identified according to NOVA classification. At baseline and at follow-up, serum creatinine (SCr) and estimated glomerular filtration rate (eGFR) levels were ascertained and changes were calculated. A combined end-point of renal decline was considered: SCr increase or eGFR decreased beyond that expected for age. Logistic regression with adjustment for potential confounders was performed. During follow-up, 183 cases of renal function decline occurred. The fully adjusted odds ratios (95% CI) of renal function decline across terciles of percentage of total energy intake from UPF were 1.56 (1.02–2.38) for the second tercile, and 1.74 (1.14–2.66) for the highest tercile; p-trend was 0.026. High UPF consumption is independently associated with an increase higher than 50% in the risk of renal function decline in Spanish older adults.

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Effects of health literacy on frailty status at two-year follow-up in older adults: A prospective cohort study

Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics ◽

10.3143/geriatrics.58.101 ◽

2021 ◽

Vol 58 (1) ◽

pp. 101-110

Author(s):

Kazuki Uemura ◽

Minoru Yamada ◽

Tsukasa Kamitani ◽

Atsuya Watanabe ◽

Hiroshi Okamoto

Keyword(s):

Older Adults ◽

Cohort Study ◽

Health Literacy ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Frailty Status

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Potentially serious alcohol–medication interactions and falls in community-dwelling older adults: a prospective cohort study

Age and Ageing ◽

10.1093/ageing/afz112 ◽

2019 ◽

Vol 48 (6) ◽

pp. 824-831 ◽

Cited By ~ 1

Author(s):

Alice Holton ◽

Fiona Boland ◽

Paul Gallagher ◽

Tom Fahey ◽

Frank Moriarty ◽

...

Keyword(s):

Older Adults ◽

Cohort Study ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Community Dwelling ◽

Adjusted Relative Risk ◽

Injurious Falls ◽

Risk Of Falls ◽

Community Dwelling Older Adults

Abstract Objective To investigate the association between potentially serious alcohol–medication interactions (POSAMINO criteria), hypothesised to increase the risk of falls in older adults, and falls in community-dwelling older adults at two and 4 years follow-up. Design A prospective cohort study. Setting The Irish Longitudinal Study on Ageing. Subjects A total of 1,457 community-dwelling older adults aged ≥65 years, with a complete alcohol and regular medication data to allow for the application of the POSAMINO criteria. Outcomes Self-reported falls at 2 and 4 years follow-up, any falls (yes/no), injurious falls (yes/no) and number of falls (count variable). Results The number of participants who reported falling since their baseline interview at 2 and 4 years were 357 (24%) and 608 (41.8%), respectively; 145 (10%) reported an injurious fall at 2 years and 268 (18%) at 4 years. Median (IQR) number of falls was 1 (1–2) at 2 years and 2 (1–3) at 4 years. Exposure to CNS POSAMINO criteria, hypothesised to increase the risk of falls due primarily to increased sedation, was associated with a significantly increased risk for falling (adjusted relative risk (RR) 1.50, 95% confidence interval (CI) 1.21–1.88) and for injurious falls (adjusted RR 1.62, 95% CI: 1.03–2.55) at 4 years. These equate to an absolute risk of 19% for falling (95% CI: 5–33%) and 8% for injurious falls (95% CI, 4–20%) at 4 years. Conclusions Assessment and management strategies to prevent falls in community-dwelling older adults should consider patients’ alcohol consumption alongside their assessment of patient medications, particularly among those receiving CNS agents.

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Systemic immune-inflammation index independently predicts poor survival of older adults with hip fracture: a prospective cohort study

BMC Geriatrics ◽

10.1186/s12877-021-02102-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Zhi-Cong Wang ◽

Wei Jiang ◽

Xi Chen ◽

Ling Yang ◽

Hong Wang ◽

...

Keyword(s):

Older Adults ◽

Cohort Study ◽

Hip Fracture ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Public Health Problem ◽

Global Public Health ◽

All Cause Mortality ◽

Immune Inflammation

Abstract Background The systemic immune-inflammation index (SII), based on peripheral platelet, neutrophil and lymphocyte counts, has been proven to be a promising prognostic indicator in various diseases. Hip fracture is a common injury among the older adults, and has become a global public health problem with high mortality and disability rates. However, the relationship between SII and the prognosis of hip fracture is not yet well-known. The aim of the this study was to explore the predictive value of SII in older adults with hip fracture undergoing surgery. Methods This was a prospective cohort study performed from January 2014 to December 2018 at a orthopaedic center, China. The SII was calculated as platelet×neutrophil/lymphocyte counts. Univariable and multivariable Cox proportional hazard models were used to assess the association between SII and all-cause mortality. Results A total of 290 older adults with hip fracture were included, and the mean (SD) age was 77.6 (8.6) years, and 189 (65.2%) were female. The median (IQR) SII was 759.4 (519.0–1128.7) × 109/L. After a median follow-up time of 33.4 months, 13 (4.5%), 26 (9.0%) and 54 (18.6%) patients died within the 30-day, 1-year and last follow-up, respectively. Multivariable Cox analysis revealed that each increase of 100 units of SII was associated with a 8% increased hazard of death at 1-year follow-up (HR = 1.08, 95% CI: 1.01–1.17, p = 0.033), and 9% increased hazard of death at last follow-up (HR = 1.09, 95% CI: 1.03–1.15, p = 0.003). Conclusions SII is associated with poor all-cause mortality in older adults with hip fracture undergoing surgery, and deserves further investigation and application in clinical practice.

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