scholarly journals Serum Gamma-Glutamyl Transferase Is Associated with Epicardial Fat Thickness in Middle Aged Women

2020 ◽  
Vol 71 (1) ◽  
pp. 430-435
Author(s):  
Adriana Albu ◽  
Anca Moldovan ◽  
Cristian Petra ◽  
Ioana Para
Keyword(s):  
Visceral Adiposity ◽  
Skewed Distribution ◽  
Epicardial Fat ◽  
Abdominal Circumference ◽  
Gamma Glutamyl Transferase ◽  
Middle Aged ◽  
Cross Sectional ◽  
Gamma Glutamyl ◽  
Cardiovascular Morbidity And Mortality ◽  
Glutamyl Transferase

Accumulating data indicate that gamma-glutamyl transferase (GGT) is associated with cardiovascular morbidity and mortality. A positive correlation between GGT levels and various cardiometabolic risk factors has been previously found. The aim of this study was to investigate the relationship between GGT and epicardial fat tissue thickness (EFTT) a marker of visceral adiposity. A total of one hundred five middle-aged (40-60 years) women were included in this cross-sectional study. EFTT was measured using 2-dimensional echocardiography, on the free wall of the right ventricle perpendicularly to the aortic annulus. Biochemical parameters were determined with an automated biochemical analyzer. Values of GGT were logarithmically transformed (log-GGT) because of their skewed distribution. We found that log-GGT correlated with age, body mass index, abdominal circumference, EFTT, triglycerides, fasting plasma glucose and uric acid. In multivariate regression analysis, log-GGT levels were independently associated with EFTT (�=0.27, p=0.004), postmenopausal status (�=0.25, p=0.008) and triglycerides (�=0.23, p=0.01). In conclusion, in middle-aged women, GGT independently correlated with EFTT and may be a marker of visceral adiposity and increased cardiovascular risk.

STUDY ON EVALUATION OF SERUM GAMMA-GLUTAMYL TRANSFERASE (GGT) LEVELS IN ACUTE CORONARY SYNDROME

2021 ◽  
pp. 39-40
Author(s):  
Avtar Singh Dhanju ◽  
Deepshikha Singla ◽  
Pashaura Singh ◽  
Ajay Chhabra ◽  
Sukhraj Kaur
Keyword(s):  
Acute Coronary Syndrome ◽  
Cross Sectional Study ◽  
Gamma Glutamyl Transferase ◽  
Cross Sectional ◽  
Gamma Glutamyl ◽  
Coronary Syndrome ◽  
Healthy Control ◽  
Group A ◽  
Group B ◽  
Glutamyl Transferase

Aim: The present study was undertaken with the aim to evaluate serum Gamma Glutamyl Transferase (GGT) levels in patients of acute coronary syndrome. Methodology: This cross-sectional study was conducted on 50 cases with acute coronary syndrome (Group A) and 50 healthy control subjects (Group B) meeting inclusion and exclusion criteria. Results: There is signicant rise in serum GGT levels in patients presenting with ACS in Group A as compared to Group B. Conclusion: Higher levels of GGT in ACS patients with risk factors such as hypertension, dyslipidemia and smoking may serve as biomarker to predict the occurrence of ACS.

scholarly journals Elevated gamma glutamyl transferase levels are associated with the location of acute pulmonary embolism. Cross-sectional evaluation in hospital setting

2015 ◽  
Vol 133 (6) ◽  
pp. 488-494 ◽  
Author(s):  
Ozge Korkmaz ◽  
Hasan Yucel ◽  
Ali Zorlu ◽  
Ocal Berkan ◽  
Hakki Kaya ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Pulmonary Artery ◽  
Acute Pulmonary Embolism ◽  
Main Pulmonary Artery ◽  
Systolic Pressure ◽  
Pulmonary Artery Systolic Pressure ◽  
Gamma Glutamyl Transferase ◽  
Cross Sectional ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

ABSTRACT CONTEXT AND OBJECTIVE: The location of embolism is associated with clinical findings and disease severity in cases of acute pulmonary embolism. The level of gamma-glutamyl transferase increases under oxidative stress-related conditions. In this study, we investigated whether gamma-glutamyl transferase levels could predict the location of pulmonary embolism. DESIGN AND SETTING: Hospital-based cross-sectional study at Cumhuriyet University, Sivas, Turkey. METHODS : 120 patients who were diagnosed with acute pulmonary embolism through computed tomography-assisted pulmonary angiography were evaluated. They were divided into two main groups (proximally and distally located), and subsequently into subgroups according to thrombus localization as follows: first group (thrombus in main pulmonary artery; n = 9); second group (thrombus in main pulmonary artery branches; n = 71); third group (thrombus in pulmonary artery segmental branches; n = 34); and fourth group (thrombus in pulmonary artery subsegmental branches; n = 8). RESULTS : Gamma-glutamyl transferase levels on admission, heart rate, oxygen saturation, right ventricular dilatation/hypokinesia, pulmonary artery systolic pressure and cardiopulmonary resuscitation requirement showed prognostic significance in univariate analysis. The multivariate logistic regression model showed that gamma-glutamyl transferase level on admission (odds ratio, OR = 1.044; 95% confidence interval, CI: 1.011-1.079; P = 0.009) and pulmonary artery systolic pressure (OR = 1.063; 95% CI: 1.005-1.124; P = 0.033) remained independently associated with proximally localized thrombus in pulmonary artery. CONCLUSIONS : The findings revealed a significant association between increased existing embolism load in the pulmonary artery and increased serum gamma-glutamyl transferase levels.

scholarly journals DIFFERENCES OF GAMMA GLUTAMYL TRANSFERASE IN CORONARY HEART DISEASE PATIENTS WITH MORE THAN EQUAL 70% OCCLUSION AND LESS THAN 70% OCCLUSION

2020 ◽  
pp. 1-3
Author(s):  
Dahlan Siahaan ◽  
Burhanuddin Nasution ◽  
Nizam Zikri Akbar
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Causes Of Death ◽  
Gamma Glutamyl Transferase ◽  
Cross Sectional ◽  
Heart Attacks ◽  
Gamma Glutamyl ◽  
Artery Disease ◽  
Glutamyl Transferase ◽  
Relationship Of

Background: Coronary heart disease (CHD) is a cumulation of plaque in the heart arteries that can cause heart attacks. CHD is one of the main and rst causes of death in developed and developing countries, including Indonesia. It is estimated that throughout the world, CHD in 2020 became the rst most frequent killer of 36% of all deaths, twice as high as cancer deaths. Currently Gamma Glutamyl Transferase (GGT) is a prognostic marker of death and reinfarction in patients with patients Coronary Artery Disease (CAD) and there is a relationship of GGT with the prognosis of CAD patients undergoing angiography. Methods: The study was conducted by cross sectional method. The study subjects were 60 male and female CHD patients who were treated and treated at the hospital in the Department of Cardiology FK-USU / H. Adam Malik Hospital Medan, which was enforced by history, physical examination, angiography and laboratory and underwent coronary angiography. GGT examination uses Architect c8000. Results: A total of 60 CHD patients in this study found that GGT values were greater in the ≥70% group compared with occlusions <70% with p = 0.003. Conclusions: This study showed a signicant difference in the values of GGT with occlusion ≥70% and <70% occlusion.

Serum Gamma-Glutamyl Transferase and a Somatic Health Score in Middle-Aged Men

1980 ◽  
Vol 17 (3) ◽  
pp. 134-139 ◽  
Author(s):  
E Trell ◽  
B Petersson ◽  
H Kristenson ◽  
G Fex ◽  
P Larme ◽  
...  
Keyword(s):  
Health Screening ◽  
Screening Tests ◽  
Gamma Glutamyl Transferase ◽  
Hepatic Enzyme ◽  
Middle Aged ◽  
Normal Distributions ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase ◽  
Descriptive Method ◽  
Score Index

In an ongoing population investigation of middle-aged men in Malmö, Sweden, several health screening variables showed strong but crude individual covariations with the level of the hepatic enzyme, serum gamma-glutamyl transferase (GGT). These variables were combined, according to an analysis of their normal distributions, into a score index which exhibited a much smoother correlation with low, normal, and elevated levels of GGT when tested in a random population subsample. It is concluded that this scoring system may find further utilisation as a general descriptive method of recording statistical covariations between health screening tests and sum them up.

scholarly journals Utility of serum gamma glutamyl transferase activity among hypertensive patients

2019 ◽  
Vol 6 (1) ◽  
pp. 21
Author(s):  
Saroj Kunwar ◽  
Luniva Maharjan ◽  
Bimal Chaulaigai ◽  
Sanjay Kumar Sah
Keyword(s):  
Potential Role ◽  
Medical Condition ◽  
Cross Sectional Study ◽  
Chronic Medical Condition ◽  
Transferase Activity ◽  
Gamma Glutamyl Transferase ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

<p class="abstract"><strong>Background:</strong> Hypertension, a chronic medical condition of elevated blood pressure in the arteries. It is an emerging problem worldwide and one of the identifiable cause of kidney disease. Gamma glutamyl transferase (GGT) plays essential role in the metabolism of glutathione which is reported as major antioxidant. More recently increased GGT is associated with pathogenesis of hypertension. This study was aimed to determine activity of gamma glutamyl transferase in hypertensive patients.</p><p class="abstract"><strong>Methods:</strong> All together 150 participants were recruited from Department of Medicine, Star Hospital for this hospital based cross-sectional study. Among which 50 were normotensive, 50 were pre-hypertensive and 50 were hypertensive. Blood sample were collected and analyzed in autoanalyser by enzymatic method.  </p><p class="abstract"><strong>Results:</strong> Mean serum gamma glutamyl transferase activity is significantly different among normotensive, prehypertensive and hypertensive groups (i.e., 10.3 IU/l, 26.8IU/l and 37.2 IU/l respectively). Serum gamma glutamyl transferase activity is significantly higher in prehypertensive patients than normotensive group (p=0.001). Similarly GGT activity is significantly increased in hypertensive patients than prehypertensive patients (p=0.001).</p><p class="abstract"><strong>Conclusions:</strong> Serum gamma glutamyl transferase activity is raised in prehypertensive and hypertensive participants as compared to normotensive. Thus Serum gamma glutamyl transferase level can have potential role on management of hypertension.</p>

Sign in / Sign up

Export Citation Format

Share Document