Therapeutic Arthritis Research and Gastrointestinal Event Trial of lumiracoxib - study design and patient demographics

Background: Congenital foot anomalies affect a large number of childrenthroughout the world. Rehabilitation of these anomalies is expensive and time consuming.There are many factors responsible for these anomalies. Incidence of these anomalies variesin different areas of the world. The aim of this study is to determine the frequency of congenitalfoot anomalies among children reporting at Chal foundation, Swabi, Pakistan. Study Design: Across sectional descriptive study. Setting: Chal Foundation, Swabi, Pakistan. Period: October2012 – October 2014. Methodology: Sample was selected using the convenience samplingtechnique. A total of 1141 patients visited the center, out of which 408 cases of congenitalfoot anomalies. Patient demographics including name, age, gender and district along withdiagnosis and side involvement was noted, and analyzed on SPSS v21.0. Results: A sampleof 408 patients was taken from which 70.3% were males and 29.7% were females. The meanage of the patients was 4.47 years at the time of visit. Only 5.9% cases were reported within thefirst year after birth. Right side foot anomaly was observed in 23.8% cases and 20.3% caseshad left side foot anomaly. Bilateral anomaly was observed in 55.9% cases. Among the 408cases, the most often reported was CTEV, observed in 79.7% cases. The second most commonanomaly was pes planus, observed in 8.8% cases. Conclusion: Congenital foot anomalies arecommon musculoskeletal anomalies affecting a large number of children, the most prevalentof which is CTEV. Unfortunately few people seek management in time either due to lack offacilities or awareness. Prevalent cousin marriages in the society may also play an influentialrole in increased risk of such anomalies to occur. Many of these anomalies can be managedconservatively with physical therapy and orthotics if reported in due time. Attention should bepaid on educating people regarding identification and timely management of such conditions.

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Review of Available and Investigational Biologics and Non-Biologic Small Molecules for the Treatment of Plaque Psoriasis

Journal of Psoriasis and Psoriatic Arthritis ◽

10.1177/247553031600200103 ◽

2016 ◽

Vol 2 (1) ◽

pp. 11-21 ◽

Cited By ~ 1

Author(s):

Yasmin Amir ◽

Mark G. Lebwohl

Keyword(s):

Clinical Trials ◽

Small Molecules ◽

Study Design ◽

Primary Endpoint ◽

Plaque Psoriasis ◽

Patient Demographics ◽

Accurate Comparison ◽

Investigational Agents

Background In recent years, the number of agents for treatment of plaque psoriasis has increased rapidly. Objective To compare available and investigational agents for treatment of psoriasis. Methods Pivotal clinical trials for infliximab, etanercept, adalimumab, ustekinumab, secukinumab, ixekizumab, brodalumab, guselkumab, tildrakizumab, methotrexate, tofacitinib, and apremilast in plaque psoriasis were identified. Percentages of patients achieving PASI 75, 90, and 100 were extracted. Results Seventeen publications, including data from 21 trials, were reviewed. All medications were more efficacious in achieving PASI 75 compared to placebo. Ixekizumab exhibited the greatest difference in PASI 75 and PASI 90, while brodalumab showed the greatest difference in PASI 100. Limitations Heterogeneity existed in patient demographics and study design including primary endpoint weeks between trials. Data included were only from the primary endpoint week. Conclusions All biologics exhibited greater PASI improvement than placebo, with newer agents more capable of achieving PASI 90 and PASI 100. Head-to-head comparator trials are needed for more accurate comparison.

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EMPIRE-CF: A phase II randomized placebo-controlled trial of once-daily, oral acebilustat in adult patients with cystic fibrosis – Study design and patient demographics

Contemporary Clinical Trials ◽

10.1016/j.cct.2018.07.014 ◽

2018 ◽

Vol 72 ◽

pp. 86-94 ◽

Cited By ~ 17

Author(s):

J. Stuart Elborn ◽

Sanjeev Ahuja ◽

Eric Springman ◽

John Mershon ◽

Ralph Grosswald ◽

...

Keyword(s):

Cystic Fibrosis ◽

Phase Ii ◽

Study Design ◽

Controlled Trial ◽

Adult Patients ◽

Once Daily ◽

Patient Demographics

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Study Design Factors and Patient Demographics and Their Effect on the Decline of Placebo-Treated Subjects in Randomized Clinical Trials in Alzheimer's Disease

The Journal of Clinical Psychiatry ◽

10.4088/jcp.v68n0313 ◽

2007 ◽

Vol 68 (03) ◽

pp. 430-438 ◽

Cited By ~ 11

Author(s):

Michael Gold

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trials ◽

Study Design ◽

Randomized Clinical Trials ◽

Patient Demographics ◽

Design Factors

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Vygotskian Theory and Case Study Design: A Fit of Theory and Methodology

Perspectives on Language Learning and Education ◽

10.1044/lle4.1.32 ◽

1997 ◽

Vol 4 (1) ◽

pp. 32-34

Author(s):

Anne van Kleeck

Keyword(s):

Study Design ◽

Case Study Design ◽

Vygotskian Theory

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Interferon beta-1b therapy in relapsing-remitting multiple sclerosis: Study design and preliminary results

Electroencephalography and Clinical Neurophysiology ◽

10.1016/s0013-4694(97)88414-7 ◽

1997 ◽

Vol 103 (1) ◽

pp. 99

Author(s):

G Salemi

Keyword(s):

Multiple Sclerosis ◽

Study Design ◽

Interferon Beta ◽

Preliminary Results ◽

Relapsing Remitting ◽

Remitting Multiple Sclerosis ◽

Relapsing Remitting Multiple Sclerosis

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Dark and Peculiar

Journal of Individual Differences ◽

10.1027/1614-0001/a000280 ◽

2019 ◽

Vol 40 (2) ◽

pp. 92-103 ◽

Cited By ~ 7

Author(s):

Janko Međedović ◽

Goran Knežević

Keyword(s):

Undergraduate Students ◽

Study Design ◽

Personal Characteristics ◽

Emotional Reaction ◽

Current Understanding ◽

Male Students ◽

Psychosis Proneness ◽

Negative Emotional Reaction ◽

Mind Set ◽

Psychopathic Tendencies

Abstract. Earlier research suggested that militant extremists could have certain aspects of psychopathic and psychotic characteristics. Relying on these studies, we investigated whether the Militant Extremist Mind-Set (MEM) could be explained by psychopathy, sadism, and Disintegration (psychosis proneness), as subclinical manifestations of amoral, antisocial, and psychotic-like traits. In Study 1 (306 undergraduate students), it was shown that sadistic and psychopathic tendencies were related to Proviolence (advocating violence as a means for achieving a goal); psychopathic and disintegrative tendencies were associated to the Vile World (belief in a world as a corrupted and vile place), while Disintegration was the best predictor of Divine Power (relying on supernatural forces as a rationale for extremist acts). In Study 2 (147 male convicts), these relations were largely replicated and broadened by including implicit emotional associations to violence in the study design. Thus, while Proviolence was found to be related to a weakened negative emotional reaction to violent pictures, Vile World was found to be associated with stronger negative emotions as a response to violence. Furthermore, Proviolence was the only MEM factor clearly differentiating the sample of convicts from male students who participated in Study 1. Results help extend current understanding about personal characteristics related to militant extremism.

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