scholarly journals Early exposure of interferon-γ inhibits signal transducer and activator of transcription-6 signalling and nuclear factor κB activation in a short-term monocyte-derived dendritic cell culture promoting ‘FAST’ regulatory dendritic cells

2012 ◽  
Vol 167 (3) ◽  
pp. 447-458 ◽  
Author(s):  
D. Rojas-Canales ◽  
R. Krishnan ◽  
C. F. Jessup ◽  
P. T. Coates
Keyword(s):  
Cell Culture ◽  
Dendritic Cells ◽  
Dendritic Cell ◽  
Nuclear Factor Κb ◽  
Interferon Γ ◽  
Nuclear Factor ◽  
Signal Transducer ◽  
Early Exposure ◽  
Short Term ◽  
Regulatory Dendritic Cells

scholarly journals Reprogramming Tumor Associated Macrophage Phenotype by a Polysaccharide from Ilex asprella for Sarcoma Immunotherapy

2018 ◽  
Vol 19 (12) ◽  
pp. 3816 ◽  
Author(s):  
Qiu Li ◽  
Zhihui Hao ◽  
Yeting Hong ◽  
Wei He ◽  
Wenwen Zhao
Keyword(s):  
Survival Rate ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Signal Transducer ◽  
Macrophage Phenotype ◽  
Therapeutic Tool ◽  
Acidic Polysaccharide ◽  
Tumor Associated Macrophage ◽  
Animal Survival ◽  
Anti Tumor Activity

We report here the discovery of an acidic polysaccharide, namely IAPS-2, from the root of Ilex asprella, with anti-tumor activity via a repolarizing tumor associated macrophages (TAMs) phenotype. We obtained IAPS-2 polysaccharide from this herb based on acidity and found that IAPS-2 expressed the activity of promoting the secretion of anti-tumor cytokines in macrophages. Furthermore, we evaluated its anti-tumor effect on TAM cells, through the activation of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription (STAT) signaling. In particular, in the tumor murine model, IAPS-2 demonstrated that it could significantly inhibit the growth of tumors via modulating the function of TAMs and increase the animal survival rate. In summary, IAPS-2, with a clearly illustrated chemical composition, potent anti-tumor activity, and a solid mechanism of action, may be developed into a valuable therapeutic tool for cancer immunotherapy.

scholarly journals Short-Term Zinc Deficiency Affects Nuclear Factor-κB Nuclear Binding Activity in Rat Testes

2001 ◽  
Vol 131 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Patricia I. Oteiza ◽  
Michael S. Clegg ◽  
Carl L. Keen
Keyword(s):  
Zinc Deficiency ◽  
Nuclear Factor Κb ◽  
Binding Activity ◽  
Nuclear Factor ◽  
Short Term ◽  
Nuclear Binding
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