Clinical Trial of Hyposensitisation in Hay Fever: Two Methods of Relating Symptom Scores to Daily Pollen Counts

Allergy ◽  
1984 ◽  
Vol 39 (6) ◽  
pp. 463-468 ◽  
Author(s):  
P. Wilkinson ◽  
E. Taudorf
Keyword(s):  
Clinical Trial ◽  
Hay Fever ◽  
Pollen Counts ◽  
Symptom Scores

Xylometazoline hydrochloride 0.1 per cent versus physiological saline in nasal surgical aftercare: a randomised, single-blinded, comparative clinical trial

2008 ◽  
Vol 123 (1) ◽  
pp. 85-90 ◽  
Author(s):  
M R Humphreys ◽  
D Grant ◽  
S A McKean ◽  
C Y Eng ◽  
J Townend ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Nasal Spray ◽  
Physiological Saline ◽  
Nasal Surgery ◽  
Chi Square ◽  
Comparative Clinical Trial ◽  
Pain Scores ◽  
Symptom Scores ◽  
Chi Square Test ◽  
Median Pain

AbstractObjectives:A variety of topical preparations are used for symptomatic relief following nasal surgery. The aim of this study was to compare the effect of two commonly used products on patient symptom scores following nasal surgery.Design:Randomised, single-blinded, comparative clinical trial.Setting:A single, secondary otorhinolaryngology centre.Participants:One hundred and twenty patients undergoing septoplasty or functional endoscopic sinus surgery as an isolated procedure between November 2003 and January 2006. Patients undergoing additional nasal procedures were excluded, as were those requiring additional post-operative medications other than standardised analgesia.Methods:Following nasal surgery, patients were randomised to receive either xylometazoline hydrochloride 0.1 per cent nasal spray or a sterile physiological saline aerosol.Main outcome measures:Visual analogue scale symptom scores for nasal obstruction, rhinorrhoea, pain, loss of sense of smell and bleeding were assessed at day 10 post-operatively.Results:Post-operative symptom scores were compared between treatment groups. Overall, median pain scores were significantly higher in the xylometazoline group (p = 0.03, chi-square test). When analysed by procedure, median pain scores were significantly higher in septoplasty patients using xylometazoline (p = 0.019, chi-square test).Conclusion:There is no evidence to support the use of xylometazoline hydrochloride 0.1 per cent nasal spray over aerosolised physiological saline alone, following nasal surgery. Furthermore, there may be more pain associated with the post-operative use of xylometazoline.

scholarly journals Personalized Pollen Monitoring and Symptom Scores: A Feasibility Study in Grass Pollen Allergic Patients

2021 ◽  
Vol 2 ◽  
Author(s):  
Letty A. de Weger ◽  
Peter Th. W. van Hal ◽  
Bernadette Bos ◽  
Frank Molster ◽  
Marijke Mostert ◽  
...  
Keyword(s):  
Feasibility Study ◽  
Grass Pollen ◽  
Airborne Pollen ◽  
Mobile App ◽  
Pollen Monitoring ◽  
Pollen Counts ◽  
Pollen Concentrations ◽  
Symptom Scores ◽  
Pollen Exposure ◽  
Grass Pollen Counts

Background: Pollen is a major trigger for allergic symptoms in sensitized individuals. Airborne pollen is usually monitored by Hirst type pollen samplers located at rooftop level, providing a general overview of the pollen distribution in the larger surroundings. In this feasibility study, grass pollen-sensitized subjects monitored the pollen in their direct environment using a portable pollen sampler (Pollensniffer) and scored their symptoms, to study the relation between symptom severity and personal grass pollen exposure. For comparison the symptoms were also correlated with pollen collected by the rooftop sampler.Methods: After recruitment 18 participants were screened for grass pollen specific (GP-sIgE) of which 12 were eligible. Nine participants completed the study (May, 2018). They were asked to monitor personal pollen exposure using a Pollensniffer on their way to school, work or other destination, and to score their symptoms via a mobile app on a scale from 0 to 10. Daily pollen concentrations were collected by a Hirst type sampler at rooftop level. Pollen grains were analyzed using a microscope.Results: Three of the four participants with high GP-sIgE (≥9.6 kU/l) reported high symptom scores (>4) and an analysis showed a significant correlation (CC) between eye, nose, and lung symptoms and the grass pollen counts collected by the Pollensniffer, as well as the daily grass pollen concentrations monitored by the rooftop sampler (CC≥0.54). In contrast, the participants with low GP-sIgE levels (<9.6 kU/l) reported low symptom scores (≤4) and often other sensitizations were present. For these subjects, no significant positive correlations (CC<0.3) of symptoms with either grass pollen collected by the personal or the rooftop sampler were found.Conclusion: The results of this feasibility study suggest that correlations between the severity of clinical symptoms of grass pollen allergic patients, and grass pollen counts as determined by the Pollensniffer or a rooftop sampler, is restricted to patients with high GP-sIgE levels, high symptom scores, and no relevant other sensitizations. Based on the low numbers of subjects with severe symptoms included in this feasibility study, no conclusions can be drawn on the performance of the Pollensniffer in relating symptoms and pollen exposure in comparison with the rooftop sampler.Trial Registration: The study was approved by the Committee Medical Ethics of the LUMC (approval numbers: NL63953.058.17/ P17.304).

Citizen science based symptom scores of allergic rhinitis to validate the grass pollen hay fever forecast

2015 ◽  
Author(s):  
Letty A. De Weger ◽  
H. Bas Hofstee ◽  
Arnold J.H. Van Vliet ◽  
Pieter S. Hiemstra ◽  
Jacob K. Sont
Keyword(s):  
Allergic Rhinitis ◽  
Citizen Science ◽  
Grass Pollen ◽  
Hay Fever ◽  
Symptom Scores

Nasal decongestant effect of oxymetazoline in the common cold: An objective dose-response study in 106 patients

1989 ◽  
Vol 103 (8) ◽  
pp. 743-746 ◽  
Author(s):  
Anders Åkerland ◽  
Thorsten Klint ◽  
Lars Olén ◽  
Hans Rundcrantz
Keyword(s):  
Clinical Trial ◽  
Dose Response ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Double Blind ◽  
Nasal Decongestant ◽  
Double Blind Clinical Trial ◽  
Symptom Scores ◽  
The Common ◽  
Dose Response Study

AbstractOxymetazoline has been used as decongesting nosedrops for more than 25 years but so far no objective does-response study of the drug has been published. In this double-blind clinical trial the decongestant effect on the nasal mucosa by the doses and concentrations traditionally used of oxymetazoline were studied.In 106 men with acute infectious rhinitis, a significant dose-response relationship was found when the decongestant effect was measured objectively by anterior rhinomanometry and subjectively by symptom scores.The concentration and volumes of the drug recommended from clinical experience seem to be adequate.

Hay Fever Treatment in General Practice: A Randomised Controlled Trial Comparing Standardised Western Acupuncture with Sham Acupuncture

1996 ◽  
Vol 14 (1) ◽  
pp. 6-10 ◽  
Author(s):  
L Williamson ◽  
P Yudkin ◽  
R Livingstone ◽  
K Prasad ◽  
A Fuller ◽  
...  
Keyword(s):  
Treatment Group ◽  
Active Treatment ◽  
Sham Group ◽  
Controlled Trial ◽  
Active Treatment Group ◽  
Sham Acupuncture ◽  
Hay Fever ◽  
Good Effect ◽  
Symptom Scores ◽  
Randomised Controlled

The effect of standardised, Western acupuncture on hay fever symptoms was investigated in a randomised, controlled, single-blind trial in comparison with “sham” acupuncture. Three general practices, in Oxfordshire (rural), Lincolnshire (semi-rural), and Peterborough (urban), recruited 102 patients aged 16 or over with long-standing, moderate or severe hay fever symptoms that had required continuous therapy for at least one month of the year for three or more consecutive years. The patients were asked to keep a diary to record: the amount of medication used daily; a daily symptom score (using a ten-point scale), from which was derived a weekly remission of symptoms score; and their assessment of the effect of acupuncture on the hay fever symptoms. Symptom scores and use of medication were similar in the two groups. In the four-week period following each patient's first treatment, remission of symptoms was reported by 39.0% in the active treatment group and 45.2% in the sham group; mean weekly symptom scores were 18.4 and 17.6 respectively; and mean units of medication used were 4.1 and 5.0 respectively. Sixteen out of 43 patients in the active treatment group and 14 out of 43 in the sham group felt that the acupuncture had had an excellent or very good effect on their hay fever. The treatments were simple, safe, reproducible and perceived as equally effective. Whether this represented an acupuncture effect, a placebo effect, or natural variation in a fluctuating condition, is not clear.

scholarly journals Novel insights into irritability: the relationship between subjective experience, age and mood

BJPsych Open ◽  
2021 ◽  
Vol 7 (6) ◽  
Author(s):  
Erica Bell ◽  
Gin S. Malhi ◽  
Zola Mannie ◽  
Philip Boyce ◽  
Richard Bryant ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Depressive Symptoms ◽  
Subjective Experience ◽  
Psychological Intervention ◽  
Mood Symptoms ◽  
Symptom Scores ◽  
Previous Clinical Trial ◽  
The Relationship ◽  
Over Time ◽  
Temper Outbursts

Background The relationship between irritability as a subjective experience and the behavioural indicators typically used to measure the construct are not known. Its links to mood, and contextual relationships, vary with age and are yet to be thoroughly examined. Aims First, to interrogate the relationship between the subjective experience of irritability and mood, and that with its behavioural indicators. Second, to determine how these relationships vary with age and over time. Method This study examined data from a previous clinical trial of adolescents and young adults (N = 82) with bipolar disorder, who received a psychological intervention over 18 months. Participants completed a battery of questionnaires, which included assessments of irritability. Analyses of covariance were conducted to examine the interaction between mood symptoms, subjective measures of irritability, behavioural measures of irritability and age over time. Results Subjective irritability scores differed significantly over time when controlling for manic, but not depressive, symptom scores. Further, subjective irritability significantly differed when controlling for behavioural measures of irritability (temper outbursts and argumentativeness). There were significant interactions between scores of depressive symptoms, temper outbursts and subjective irritability with age, wherein younger participants showed no correlation between depressive symptoms and temper outbursts. In addition, younger participants showed lower correlations between subjective irritability and both depressive and temper outburst scores, than older participants. Conclusions Subjective irritability is linked to mood morbidity and behavioural outbursts, and these relationships are contingent on age. Our novel findings suggest that subjective irritability should be assessed in greater detail in patients with mood disorders.

Hay fever symptoms compared to atmospheric pollen counts and floral phenology within Paris suburban area in 1987 and 1988

Aerobiologia ◽  
1989 ◽  
Vol 5 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Marie Roger Ickovic ◽  
Françoise Boussioud-Corbieres ◽  
Jean Pierre Sutra ◽  
Michel Thibaudon
Keyword(s):  
Hay Fever ◽  
Suburban Area ◽  
Pollen Counts ◽  
Floral Phenology ◽  
Atmospheric Pollen

scholarly journals Pharmacokinetic-based failure of a detergent virucidal for SARS-COV-2 nasal infections

2021 ◽  
Author(s):  
Charles R. Esther ◽  
Kyle S. Kimura ◽  
Yu Mikami ◽  
Caitlin E. Edwards ◽  
Suman R. Das ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Hypertonic Saline ◽  
Airway Epithelia ◽  
Antiviral Therapies ◽  
Human Airway ◽  
Symptom Scores ◽  
Human Airway Epithelia ◽  
Viral Titers

Abstract The nose is the portal for SARS-CoV-2 infection, suggesting the nose as a target for topical antiviral therapies. Because detergents are virucidal, Johnson and Johnson’s Baby Shampoo (J&J) was tested as a topical virucidal agent in SARS-CoV-2 infected subjects. Twice daily irrigation of J&J in hypertonic saline, hypertonic saline alone, or no intervention were compared (n = 24/group). Despite demonstrated safety and robust efficacy in in vitro virucidal assays, J&J irrigations had no impact on viral titers or symptom scores in treated subjects relative to controls. Similar findings were observed administering J&J to infected cultured human airway epithelia using protocols mimicking the clinical trial regimen. Additional studies of cultured human nasal epithelia demonstrated that lack of efficacy reflected pharmacokinetic failure, with the most virucidal J&J detergent components rapidly absorbed from nasal surfaces. This study emphasizes the need to assess the pharmacokinetic characteristics of virucidal agents on airway surfaces to guide clinical trials.

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