The Relationship of Microglial Cells to Dying Neurons During Natural Neuronal Cell Death and Axotomy-induced Degeneration of the Rat Retina

1991 ◽  
Vol 3 (12) ◽  
pp. 1189-1207 ◽  
Author(s):  
Solon Thanos
Keyword(s):  
Cell Death ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Microglial Cells ◽  
Rat Retina ◽  
Relationship Of ◽  
The Relationship

Activation of microglial cells via protease-activated receptor 2 mediates neuronal cell death in cultured rat primary neuron

Nitric Oxide ◽  
2010 ◽  
Vol 22 (1) ◽  
pp. 18-29 ◽  
Author(s):  
Gyu Hwan Park ◽  
Se Jin Jeon ◽  
Hyun Myung Ko ◽  
Jae Ryun Ryu ◽  
Jong Min Lee ◽  
...  
Keyword(s):  
Cell Death ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Microglial Cells ◽  
Primary Neuron ◽  
Protease Activated Receptor 2

scholarly journals Investigating the Relationship Between Neuronal Cell Death and Early DNA Methylation After Ischemic Injury

2020 ◽  
Vol 14 ◽  
Author(s):  
Mayumi Asada ◽  
Hideki Hayashi ◽  
Kenjiro Murakami ◽  
Kento Kikuiri ◽  
Ryotaro Kaneko ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cell Death ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Ischemic Injury ◽  
The Relationship

scholarly journals Autophagy down regulates pro-inflammatory mediators in BV2 microglial cells and rescues both LPS and alpha-synuclein induced neuronal cell death

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Claudio Bussi ◽  
Javier Maria Peralta Ramos ◽  
Daniela S. Arroyo ◽  
Emilia A. Gaviglio ◽  
Jose Ignacio Gallea ◽  
...  
Keyword(s):  
Cell Death ◽  
Inflammatory Mediators ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Alpha Synuclein ◽  
Microglial Cells ◽  
Bv2 Microglial Cells

Protective effect of all-trans retinoic acid on NMDA-induced neuronal cell death in rat retina

2010 ◽  
Vol 635 (1-3) ◽  
pp. 56-61 ◽  
Author(s):  
Kenji Sakamoto ◽  
Masahide Hiraiwa ◽  
Maki Saito ◽  
Tsutomu Nakahara ◽  
Yoji Sato ◽  
...  
Keyword(s):  
Cell Death ◽  
Retinoic Acid ◽  
Protective Effect ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Rat Retina ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Zhenzhen Liu ◽  
Tao Li ◽  
Ping Li ◽  
Nannan Wei ◽  
Zhiquan Zhao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Early Event ◽  
Tau Hyperphosphorylation ◽  
Pathological Conditions ◽  
Relationship Of ◽  
The Relationship

Alzheimer’s disease (AD) is the most common form of dementia. The pathological hallmarks of AD are amyloid plaques [aggregates of amyloid-beta (Aβ)] and neurofibrillary tangles (aggregates of tau). Growing evidence suggests that tau accumulation is pathologically more relevant to the development of neurodegeneration and cognitive decline in AD patients than Aβplaques. Oxidative stress is a prominent early event in the pathogenesis of AD and is therefore believed to contribute to tau hyperphosphorylation. Several studies have shown that the autophagic pathway in neurons is important under physiological and pathological conditions. Therefore, this pathway plays a crucial role for the degradation of endogenous soluble tau. However, the relationship between oxidative stress, tau protein hyperphosphorylation, autophagy dysregulation, and neuronal cell death in AD remains unclear. Here, we review the latest progress in AD, with a special emphasis on oxidative stress, tau hyperphosphorylation, and autophagy. We also discuss the relationship of these three factors in AD.

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