Etiopatogenesis dan terapi kasus multipel sialolithiasis kelenjar submandibulaEtiopathogenesis and treatment of multiple cases of submandibular gland sialolithiasis

Pendahuluan: Sialolithiasis adalah penyakit umum kelenjar saliva. Gejalanya termasuk pembengkakan kelenjar yang terlibat, terutama selama makan, dan nyeri tekan, yang mungkin mereda tetapi dapat kambuh kembali. Sialolith terjadi terutama di kelenjar submandibula (80-90%) dan pada tingkat yang lebih rendah di kelenjar parotid (5-20%). Sialolith bisa tunggal atau jamak. Multipel sialolith di kelenjar submandibula jarang terjadi. Tujuh puluh dari delapan puluh persen kasus memiliki sialolith tunggal, hanya sekitar 5% pasien yang memiliki tiga atau lebih sialolith. Faktor etiopatogenesis terkait dengan pembentukan sialolith adalah obstruksi, penurunan laju aliran saliva, dehidrasi, infeksi kelenjar saliva, dan terganggunya kelarutan kristaloid. Tujuan penulisan laporan kasus ini untuk menjelaskan etiopatogenesis dan terapi kasus multipel sialolithiasis kelenjar submandibula. Laporan kasus: Seorang wanita 24 tahun datang dengan pembengkakkan dan nyeri pada submandibula kanan. Radiografi panoramik menunjukkan massa radiopak terdefinisi dengan baik dalam submandibula kanan. Interpretasi ultrasonografi menunjukkan massa tak homogen hypoechoic dengan kalsifikasi ganda. Pengangkatan kelenjar submandibula dilakukan dengan pendekatan ekstraoral. Laporan kasus ini menunjukkan Gambaran sebanyak sembilan sialolith di kelenjar submandibula, yang dihilangkan dengan pendekatan ekstraoral. Simpulan: Etiopatogenesis dari pembentukan multipel sialolithiasis pada duktus kelenjar, yaitu faktor mekanis, inflamasi, kimiawi, dan infeksi. Diperkirakan bahwa alkalin serta saliva kental yang mengandung banyak sel mukus, memiliki persentase kalsium fosfat lebih tinggi seperti pada kelenjar saliva submandibula yang mendukung pembentukan sialolith. Pengangkatan kelenjar submandibula beserta sialolith dilakukan sebagai standar baku perawatan dan dapat menghindari kekambuhan. Pasien kontrol kembali satu minggu pasca operasi dengan kondisi baik dan dijadwalkan untuk pemeriksaan radiografis ulang enam bulan kemudian untuk memastikan tidak terjadinya pembentukan sialolith baru di saluran kelenjar saliva.Kata kunci: Multipel, sialolithiasis, kelenjar submandibula. ABSTRACTIntroduction: Sialolithiasis is a common disease of the salivary glands. Symptoms include the glands inflammation, especially during eating, and tenderness, which may subside but may recur. Sialoliths occur mainly in the submandibular glands (80-90%) and to a lesser extent in the parotid glands (5-20%). Sialolith can be singular or plural. Multiple sialoliths in the submandibular gland rarely occur. Seventy out of eighty per cent of cases have a single sialolith. Only about 5% of patients have three or more sialoliths. The etiopathogenetic factors associated with sialolith formation are obstruction, decreasing salivary flow rate, dehydration, salivary gland infection, and impaired crystalloid solubility. The purpose of this case report was to describe the etiopathogenesis and treatment of multiple cases of submandibular gland sialolithiasis. Case report: A 24-year-old woman presented with inflammation and pain in the right submandibular. Panoramic radiograph shows a well-defined radiopaque mass in the right submandibular. Ultrasound interpretation revealed a hypoechoic homogeneous mass with multiple calcifications. Removal of the submandibular gland was carried out with an extraoral approach. This case report showed the appearance of as many as nine sialoliths in the sub-mandibular gland, removed by an extraoral approach. Conclusion: Etiopathogenesis of the formation of multiple sialolithiasis in the glandular duct are mechanical, inflammatory, chemical, and infectious factors. It is thought that alkaline and thick saliva, which contains many mucus cells, has a higher percentage of calcium phosphate than in the submandibular salivary glands, which support the formation of sialoliths. Submandibular gland removal along with the sialoliths is performed as the treatment standard, which can avoid recurrence. The control visit is carried out one week postoperatively in good condition, and the patient is scheduled for another radiographic examination six months after to ensure that no new sialoliths occurred in the salivary gland.Keywords: Multiple, sialolithiasis, submandibular gland.

MORPHOMETRIC STUDY OF ARTERIES OF THE LOWER JAW REORGANIZATION ASPECTS IN THE SIMULATED POST-RESECTION ARTERIAL PULMONARY HYPERTENSION

Summary. The salivary glands are a special group of secretory organs that play a significant role in dental health of the population, as well as one of the vital functions of the whole human body. With the development of modern medical science, clinicians have often diagnosed salivary gland pathology. One of the most important problems of these pathologies is the study of direct and reverse effects of organs on each other, the principles of their correlations and methods of morphological expression. In recent decades, there has also been an increase of pulmonary lesions, which are accompanied by hypertension in the small circulation and lead to the development of pulmonary heart disease and its decompensation. There are isolated studies on the features of the involvement of the mandibular gland in the pathological process, and only some works reflect the structural changes of the submandibular gland in hemodynamic disorders. The aim of the work – to study morphometric aspects of mandibular arteries reorganization in simulated post-resection arterial pulmonary hypertension. Material and Methods. The arteries of medium (51–125) μm and small (26–50) μm calibers [16] of the mandibular salivary gland of 27 Vietnamese pigs, which were divided into 3 groups, were studied by a complex of histological and morphometric methods. Group 1 included 9 intact animals aged 6.5–7 months, group 2 – 12 pigs of the same age with post-resection pulmonary hypertension and compensated pulmonary heart, group 3 – 6 animals 6.5–7 months with pulmonary hypertension and decompensated pulmonary heart. Results and Discussion. Hypertension (one-month term) in the small circle of blood circulation, which occurred after right-sided pulmonectomy led to the development of pulmonary heart and venous stasis in the organs of the large circle of blood circulation, including in the mandibular gland. At arterial hypertension in a small circle of blood circulation essential structural reorganization of arteries of a mandibular gland is revealed. Although morphological changes were found in the arteries of small caliber of the studied organ and in the decompensation of the pulmonary heart. Conclusions. Our morphological study provided comprehensive information on the features of remodeling of the mandibular arteries in postresection arterial pulmonary hypertension. Prolonged pulmonary hypertension leads to structural rearrangement of the arteries of the middle and small caliber of the mandible, which is characterized by thickening of the membrane, narrowing their lumen and endothelial cells damage, impaired blood supply and hypoxia in the body. The biggest changes are in the arteries of the small caliber of the mandibular gland and in the decompensation of the pulmonary heart in 6.5–7 month old male pigs of the Vietnamese breed.

Influence of Different Feed Physical Forms on Mandibular Gland in Growing Pigs

A study was performed on the mandibular gland obtained from growing pigs enrolled in a wide research project aiming to test the effects of different feed physical forms on animal health, production and welfare. We used 48 pigs fed for four weeks with different dietary treatments based on different grinding intensities and compactions of the same diet, namely coarsely ground meal (CM), finely ground pelleted (FP) and coarsely ground pelleted (CP) diets. Samples were analyzed by conventional histochemistry to identify the glycohistochemical profile and by immunohistochemistry to localize aquaporin 5, apelin and apelin receptor. Statistical elaborations were performed using the Stats R-package, version 3.5.3. Pig mandibular gland adenomere increased both the quantity and acidity of produced glycoconjugates from CM to FP and CP diets. This probably calls forth higher watery saliva, thus promoting a better feed softening facilitating the amalgamation of the bolus. Mandibular gland increased aquaporin 5 positivity in the CP diet, supporting the hypothesis of an augmented demand for water. Based on apelin/receptor localization, it was hypothesized that in pig mandibular gland the apelinergic system likely performs an endocrine control on the demilunes activity and a paracrine control on ducts, facilitating the production of a more fluid saliva.

Anatomical characteristics of the major salivary glands of puma (Puma concolor Linnaeus, 1771)

The morphological knowledge of the salivary glands in wild species is fundamental, since these studiescan be used as conservation strategies, clinical treatments and the preservation of species threatened with extinction. Thus, the aim of the study was to anatomically describe the larger salivary glands: parotid, mandibular, sublingual and molar of the jaguar. For this, two specimens of puma (Puma concolor) were used, after death by road traffic accident, donated by the Clinical Surgical Service Department of the Veterinary Hospital “Dr. Halim Atique “(UNIRP). The animals were fixed with 10% aqueous formaldehyde solution, dissected, descriptively analyzed and photographed. Morphologically, the parotid gland is grayish-yellow in color, distinctly lobulated, and has a semilunar shape. This gland is located in the posterolateral region of the face and at its ventral end we observe the parotid duct. The mandibular gland presents a slightly rounded outline, a grayish color and its surface is covered by a capsule of connective tissue. This gland is located in the posterolateral region of the face and we find the mandibular duct at its ventral end. The monostomatic sublingual gland is located on the rostral border of the mandibular gland and it is covered by the mandibular lymph nodes. The molar gland is a yellowish-gray membranous protuberance, elongated, with rectangular shape and it lies dorsally to the labial commissure. Based on the dissections, we conclude that the morphological and topographic characteristics of salivary glands of puma follow the same structural pattern described for other species of carnivorous mammals (domestic and wild).

Volatiles from the Mandibular Gland Reservoir Content of Colobopsis explodens Laciny and Zettel, 2018, Worker Ants (Hymenoptera: Formicidae)

Forty-five volatile organic compounds (VOCs) were identified or annotated in the mandibular gland reservoir content (MGRC) of the Southeast Asian ant Colobopsis explodens Laciny and Zettel, 2018 (Hymenoptera: Formicidae), using headspace solid-phase microextraction (HS-SPME) coupled to gas chromatography mass spectrometry (GC-MS) and liquid extraction combined with GC-MS. In extension of previous reports on VOCs of C. explodens, members of different compound classes, such as alkanes, aliphatic and aromatic carboxylic acids, and phenolics, were detected. The ketone 2-heptanone and the biochemically related phenolics benzene-1,3,5-triol (phloroglucinol, PG), 1-(2,4,6-trihydroxyphenyl)ethanone (monoacetylphloroglucinol, MAPG), 5,7-dihydroxy-2-methylchromen-4-one (noreugenin), and 1-(3-Acetyl-2,4,6-trihydroxyphenyl)ethanone (2,4-diacetylphloroglucinol, DAPG) dominated the GC-MS chromatograms. The identities of the main phenolics MAPG and noreugenin were further verified by liquid chromatography-high resolution-tandem mass spectrometry (LC-HRMS/MS). A comparative study of MGRC samples originating from three distinct field expeditions revealed differences in the VOC profiles, but the presence and relative abundances of the dominating constituents were largely consistent in all samples. Our study considerably extends the knowledge about the number and type of VOCs occurring in the MGRC of C. explodens. Based on the type of the detected compounds, we propose that the likely irritant and antibiotic phenolic constituents play a role in defense against arthropod opponents or in protection against microbial pathogens.