Mitochondrial polymorphisms as risk factors for endometrial cancer in southwest China

2006 ◽  
Vol 16 (4) ◽  
pp. 1661-1667 ◽  
Author(s):  
L. XU ◽  
Y. HU ◽  
B. CHEN ◽  
W. TANG ◽  
X. HAN ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endometrial Cancer ◽  
Southwest China

scholarly journals Survival in endometrial cancer in relation to minimally invasive surgery or open surgery – a Swedish Gynecologic Cancer Group (SweGCG) study

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Christer Borgfeldt ◽  
Erik Holmberg ◽  
Janusz Marcickiewicz ◽  
Karin Stålberg ◽  
Bengt Tholander ◽  
...  
Keyword(s):  
Risk Factors ◽  
Overall Survival ◽  
Endometrial Cancer ◽  
Minimally Invasive ◽  
Cancer Patients ◽  
Surgical Approach ◽  
Open Surgery ◽  
Gynecologic Cancer ◽  
Multivariable Analysis ◽  
Figo Stage

Abstract Background The aim of this study was to analyze overall survival in endometrial cancer patients’ FIGO stages I-III in relation to surgical approach; minimally invasive (MIS) or open surgery (laparotomy). Methods A population-based retrospective study of 7275 endometrial cancer patients included in the Swedish Quality Registry for Gynecologic Cancer diagnosed from 2010 to 2018. Cox proportional hazard models were used in univariable and multivariable survival analyses. Results In univariable analysis open surgery was associated with worse overall survival compared with MIS hazard ratio, HR, 1.39 (95% CI 1.18–1.63) while in the multivariable analysis, surgical approach (MIS vs open surgery) was not associated with overall survival after adjustment for known risk factors (HR 1.12, 95% CI 0.95–1.32). Higher FIGO stage, non-endometrioid histology, non-diploid tumors, lymphovascular space invasion and increasing age were independent risk factors for overall survival. Conclusion The minimal invasive or open surgical approach did not show any impact on survival for patients with endometrial cancer stages I-III when known prognostic risk factors were included in the multivariable analyses.

Risk Factors for Young Premenopausal Women With Endometrial Cancer

2005 ◽  
Vol 105 (3) ◽  
pp. 575-580 ◽  
Author(s):  
Pamela T. Soliman ◽  
Jonathan C. Oh ◽  
Kathleen M. Schmeler ◽  
Charlotte C. Sun ◽  
Brian M. Slomovitz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endometrial Cancer ◽  
Premenopausal Women

scholarly journals Clinicopathological Characteristics and Prognosis in Endometrial Cancer With Bone Metastasis: A SEER-Based Study of 584 Women

2021 ◽  
Vol 11 ◽  
Author(s):  
Hejia Hu ◽  
Zhan Wang ◽  
Miaofeng Zhang ◽  
Feng Niu ◽  
Qunfei Yu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endometrial Cancer ◽  
Bone Metastasis ◽  
Brain Metastases ◽  
Systemic Chemotherapy ◽  
Tumor Grade ◽  
Seer Database ◽  
Tumor Subtype ◽  
Local Surgery ◽  
Independent Risk Factors

PurposeBone metastasis from endometrial cancer (EC) is rare and poorly described. The purpose of the present study was to investigate the correlation between the clinically accessible factors and survival time among EC patients with bone metastasis.Patients and MethodsWe retrospectively identified and reviewed EC patients with bone metastasis from 2010 to 2016, based on the Surveillance, Epidemiology and End Results (SEER) database. Univariable and multivariable Cox regressions were applied to evaluate the effects of clinical variables on survival. Kaplan–Meier plots were used to visually demonstrate the correlation between independent risk factors and survival.ResultsClinical data of 584 EC patients with bone metastasis from the SEER database were analyzed. EC patients with bone metastasis experienced extremely poor survival, with 1-year overall survival (OS) and cancer-specific survival (CSS) rates 33.8 and 35.8%, respectively. Variables associated with OS and CSS in the univariable analysis included race, tumor grade, tumor subtype, tumor size, lung, liver and brain metastases, surgery, radiotherapy, and chemotherapy. In the multivariable analysis, tumor grade, tumor subtype, liver and brain metastases, local surgery, and systemic chemotherapy remained independent risk factors for OS and CSS. However, local radiotherapy was an independent predictor of OS, not CSS.ConclusionsWe identified several factors affect the survival of EC patients with bone metastasis, which is useful for clinicians to assess patients’ outcomes. Our study supports surgery and radiotherapy of primary EC, and systemic chemotherapy for prolonging survival among EC patients with bone metastasis, which lays a solid foundation for defining optimal treatment strategy in this specific cohort.

scholarly journals Multi-trait genome-wide association study identifies novel endometrial cancer risk loci that are associated with obesity or female testosterone levels

2021 ◽  
Author(s):  
Xuemin Wang ◽  
Pik Fang Kho ◽  
Dhanya Ramachandran ◽  
Cemsel Bafligil ◽  
Frederic Amant ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Genome Wide Association ◽  
Endometrial Cancer Risk ◽  
Cancer Risk Factors ◽  
Genome Wide

We have performed genetic correlation and Mendelian randomization analyses using publicly available genome-wide association study (GWAS) data to identify endometrial cancer risk factors. These and previously established risk factors of endometrial cancer were then included in a multi-trait Bayesian GWAS analysis to detect endometrial cancer susceptibility variants, identifying three novel loci (7q22.1, 8q24.3 and 16q12.2); two of which were replicated in an independent endometrial cancer GWAS dataset. These loci are hypothesized to affect endometrial cancer risk through altered sex-hormone levels or through effects on obesity. Consistent with this hypothesis, several genes with established roles in these pathways (CYP11B1, CYP3A7, IRX3 and IRX5) were prioritized as candidate endometrial cancer risk genes by interrogation of quantitative trait loci data and chromatin capture assays in endometrial cell lines. The findings of this study identify additional opportunities for hormone treatment and further support weight loss to reduce the risk of developing endometrial cancer.

Symptoms of Posttraumatic Stress Disorder among Health Care Workers in Earthquake-Affected Areas in Southwest China

2010 ◽  
Vol 106 (2) ◽  
pp. 555-561 ◽  
Author(s):  
Li Wang ◽  
Jianxin Zhang ◽  
Mingjie Zhou ◽  
Zhanbiao Shi ◽  
Ping Liu
Keyword(s):  
Mental Health ◽  
Risk Factors ◽  
Health Care ◽  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Health Care Workers ◽  
Southwest China ◽  
Stress Disorder ◽  
Care Workers ◽  
The Impact

The symptoms of posttraumatic stress disorder and associated risk factors were investigated among health care workers in earthquake-affected areas in southwest China. 343 health care workers completed the Chinese version of the Impact of Event Scale–Revised 3 mo. after the Wenchuan Earthquake. The prevalence of probable PTSD was 19%. The significant risk factors identified for PTSD severity included being female, being bereaved, being injured, and higher intensity of initial fear. These findings suggest that PTSD is a common mental health problem among health care workers in earthquake-affected areas. The present information can be useful in directing, strengthening, and evaluating disaster-related mental health needs and interventions after an earthquake.

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