Effect of a Loading Dose of Vitamin D3 in Frail Elderly Patients with Insufficient 25-Hydroxyvitamin D Serum Levels

2009 ◽  
Vol 57 (11) ◽  
pp. 2155-2157 ◽  
Author(s):  
Guillaume Deschasse ◽  
Dominique Chavanne ◽  
Véronique Dardaine-Giraud ◽  
Thierry Constans
Keyword(s):  
Elderly Patients ◽  
Vitamin D3 ◽  
Frail Elderly ◽  
Serum Levels ◽  
Loading Dose ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Effect of smoking on the serum levels of 25-hydroxyvitamin D depends on the assay employed

2010 ◽  
Vol 163 (6) ◽  
pp. 965 ◽  
Author(s):  
Guri Grimnes ◽  
Bjørg Almaas ◽  
Anne Elise Eggen ◽  
Nina Emaus ◽  
Yngve Figenschau ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Serum Levels ◽  
Ultraviolet B ◽  
Vitamin D2 ◽  
Related Article ◽  
Hydroxyvitamin D ◽  
Article Type ◽  
25 Hydroxyvitamin D ◽  
Uvb Exposure

The authors and the journal apologise for errors in the Introduction section of this paper published in the European Journal of Endocrinology 2010 vol 163 pp 339–348. Lines 11–14 of the Introduction section should read as follows:This reflects the amount of vitamin D ingested from food (ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3)) and the amount of vitamin D produced in the skin during ultraviolet B (UVB) exposure (vitamin D3)and not as published.

scholarly journals Differential Responses to Vitamin D2 and Vitamin D3 Are Associated With Variations in Free 25-Hydroxyvitamin D

Endocrinology ◽  
2016 ◽  
Vol 157 (9) ◽  
pp. 3420-3430 ◽  
Author(s):  
Rene F. Chun ◽  
Ivan Hernandez ◽  
Renata Pereira ◽  
Leon Swinkles ◽  
Tonnie Huijs ◽  
...  
Keyword(s):  
Vitamin D3 ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Mineral Apposition Rate ◽  
Vitamin D2 ◽  
Bone Surface ◽  
Functional Responses ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
25 Hydroxyvitamin D

25-Hydroxyvitamin D (25D) circulates bound primarily to serum vitamin D binding protein (DBP), with DBP showing higher binding affinity for 25D3 than 25D2. We therefore hypothesized that vitamin D2 (D2) promotes higher serum levels of unbound 25D (free 25D), with different functional responses, relative to vitamin D3 (D3). Week 3 C56BL/6 mice were placed on diets containing either D2 or D3 alone (both 1000 IU/kg). At week 8 and week 16, D2 mice had only 25D2 in circulation (26.6 ± 1.9 and 33.3 ± 4.4 ng/mL), and D3 mice had only 25D3 (28.3 ± 2.0 and 31.7 ± 2.1 ng/mL). At week 8 (44.5 ± 6.4 vs 62.4 ± 11.6 pg/mL, P < .05) and week 16 (78.4 ± 12.6 vs 95.5 ± 11.6), D2 mice had lower serum 1,25-dihydroxyvitamin D relative to D3 mice. By contrast, measured free 25D was significantly higher in D2 mice at week 8 (16.8 ± 0.65 vs 8.4 ± 0.63 pg/mL, P < .001) and week 16 (17.4 ± 0.43 vs 8.4 ± 0.44, P < .001). A two-way ANOVA of bone histomorphometry showed that week 8 D2 mice had significantly higher osteoclast surface/bone surface, eroded surface/bone surface, and mineral apposition rate compared with D3 mice. Osteoblast surface/bone surface was higher in week 8 D2 females but not week 8 D2 males. At week 16, D2 mice had significantly higher bone volume/total volume and trabecular number compared with D3 mice. Differences in bone phenotype were observed despite D2 mice reaching similar serum 25D levels and lower 1,25D levels compared with D3 mice. These data indicate that 25D2 binds less well to DBP than 25D3, with resulting higher levels of free 25D promoting differential effects on bone in mice exposed to D2 alone.

scholarly journals The ADeViD Study: Alzheimer’s Dementia and Vitamin D Study

2020 ◽  
pp. 1-4
Author(s):  
Alberto Castagna ◽  
Alberto Castagna ◽  
Carmen Ruberto ◽  
Giovanni Ruotolo ◽  
Giuseppe Attisani ◽  
...  
Keyword(s):  
Vitamin D ◽  
Elderly Patients ◽  
Cognitive Functions ◽  
Cognitive Disorders ◽  
Hypovitaminosis D ◽  
Serum Levels ◽  
The Elderly ◽  
Cognitive Status ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Introduction: Aging is associated with a large increase in the prevalence of hypovitaminosis D. 25- Hydroxyvitamin D, 25(OH)D, is the best indicator for vitamin D status. Its possible role in the pathogenesis of Alzheimer’s disease (AD), the leading cause of dementia in the elderly, is particularly important. The aim of the present study was to examine the association between 25-hydroxyvitamin D (25(OH)D) and cognitive functions in a group of Italian elderly patients affected with AD. Methods: We studied the relationship between 25(OH)D and cognitive functions assessed by MMSE (Mini Mental State Examination) in 150 consecutive elderly patients (F 76 %, age 78,66+ 6,05 years old) attending our Geriatric ambulatory for cognitive disorders with diagnosis of AD. Results: In our sample hypovitaminosis D was present in 100% of the screened patients; 111 patients (74%) had 25(OH)D serum levels inferior to 20 ng/ml; 39 (26%) patients had serum levels included between 20 and 30 ng/ml. After adjustment for age, gender, systolic blood pressure, education, cardiovascular diseases and antihypertensive treatment, a significant relationship was observed between 25(OH)D and cognitive status. MMSE appeared significantly higher in subjects with 25(OH)D serum levels ≥ 20 ng/ml than in those with 25(OH)D < 20 ng/ml (18,42+4,33 vs 12,22+4,44; p=0,000). Conclusion: Our results showed a relationship between 25(OH)D and cognitive impairment in patients with AD, suggesting that 25(OH)D could be involved in the onset of dementia.

Correlations between serum levels of 25-hydroxyvitamin D and carotid atherosclerosis in patients with type 2 diabetes in Shanghai

2014 ◽  
Vol 75 (4) ◽  
pp. 206-212 ◽  
Author(s):  
Rui-hua Chen ◽  
Xiao-zhen Jiang ◽  
Quan Jiang ◽  
Zhe Gu ◽  
Pei-li Gu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Carotid Atherosclerosis ◽  
Serum Levels ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Using Activities of Daily Living Assessments to Measure the Effectiveness of Vitamin D Supplements in Elderly Long-Stay Patients

1987 ◽  
Vol 50 (2) ◽  
pp. 60-62 ◽  
Author(s):  
D Corless ◽  
M Ellis ◽  
E Dawson ◽  
F Fraser ◽  
S Evans ◽  
...  
Keyword(s):  
Vitamin D ◽  
Elderly Patients ◽  
Activities Of Daily Living ◽  
Daily Living ◽  
Controlled Trial ◽  
Double Blind ◽  
Hydroxyvitamin D ◽  
Low Concentrations ◽  
25 Hydroxyvitamin D ◽  
Vitamin D Supplements

Selected activities of daily living were used to measure improvement in independence of long-stay elderly patients known to have low concentrations of plasma 25-hydroxyvitamin D. This was a double-blind random controlled trial lasting between 8 and 40 weeks. No significant changes were found in either group.

AB0800 CLINICAL ASSOCIATION BETWEEN URIC ACID/25-HYDROXYVITAMIN D SERUM LEVELS RATIO IN PATIENTS WITH PSORIATIC ARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1699.1-1700
Author(s):  
F. Masini ◽  
K. Gjeloshi ◽  
E. Pinotti ◽  
F. Danzo ◽  
F. Guarino ◽  
...  
Keyword(s):  
Vitamin D ◽  
Uric Acid ◽  
Psoriatic Arthritis ◽  
Disease Activity ◽  
Activity Index ◽  
Univariate Analysis ◽  
Disease Activity Index ◽  
Serum Levels ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Background:The association between hyperuricemia and psoriatic arthritis (PsA) is actually generally accepted. Previous studies have demonstrated that uric acid suppress 25(OH)D metabolism [1]. More evidence is required to demonstrate the immune modulatory effects in psoriasis, psoriatic arthritis and other autoimmune diseases. In particular, the potential association between 25-hydroxyvitamin D serum levels and PsA still remains unknown.Objectives:To assess a clinical association between uric acid/25(OH)D serum levels ratio related to PASI, BASDAI and DAPSA, if any, in patients with psoriatic arthritis.Methods:We retrospectively observed 61 patients with psoriatic arthritis referred to our outpatients clinic, independently from already being on therapy or naïve. All selected patients underwent only conventional non-biological therapy at baseline and none received vitamin D supplementation and either allopurinol or febuxostat previously. Blood samples were drawn from all participants for assessment of 25-hydroxyvitamin D and uric acid serum levels. Disease activity of psoriasis and psoriatic arthritis were assessed by the Psoriasis Area and Severity Index (PASI), the Disease Activity Index for Psoriatic Arthritis (DAPSA) and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). We assessed the covariates of interest by the Wilcoxon non parametric test, through the SPSS 24 Software.Results:We observed 61 patients, mainly females (83.6%). At the univariate analysis, the uric acid/25(OH)D serum levels ratio revealed significantly associated with DAPSA and BASDAI indexes (p<0.001 and p<0.001, respectively), whilst no significant association emerged with the PASI index (p=0.462).Conclusion:Data in the literature about these associations in the context of psoriatic arthritis are really poor. As a consequence, our findings, though preliminary, suggest us to hypothesize a potential role of uric acid/25(OH)D serum levels ratio as potential inflammation marker in order to better assess the disease activity. However, future larger studies are needed to investigate more in depth this association.[1]Charoenngam N, Ponvilawan B, Ungprasert P. Vitamin D insufficiency and deficiency are associated with a higher level of serum uric acid: A systematic review and meta-analysis. Mod Rheumatol. 2019 Mar 4:1-6.Disclosure of Interests:None declared

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