Perphenazine Decanoate in sesame oil vs. Perphenazine Enanthate in sesame oil: A comparative study of pharmakokinetic properties and some clinical implications

A comparative study of fluphénazine enanthate, a long-acting neuroleptic, fluphénazine bichlorhydrate and placebo was made on 28 chronic schizophrenics. The double-blind technique was possible by giving to the patients one of the three following treatments: the long-acting neuroleptic by injection every fortnight and placebo tablets daily, the standard neuroleptic (tablets) daily and regular injection of sesame oil or the two inactive substances in a similar way. Dosage of fluphénazine enanthate was 25, 50 or 75 mg every fortnight and of bichlorhydrate 10, 20 or 30 mg. daily after a fixed schedule. Antipsychotic action of the drugs was evaluated according to three types of measures: 1) IMPS; 2) NOSIE and 3) need for chlorpromazine given p.r.n. (indirect measure). Results of this study indicate that both fluphénazine salts are superior to placebo and possess significant antipsychotic properties as demonstrated by the indirect measure. No significant difference was found between enanthate and bichlorhydrate of fluphénazine. Some methodological aspects of psychopharmacological research are also discussed.

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Comparative study of the thermal properties of Sesame oil and two mineral oils of different viscosity

Inge CUC ◽

10.17981/ingecuc.15.2.2019.10 ◽

2019 ◽

Vol 15 (2) ◽

pp. 99-109

Author(s):

Anny Astrid Espitia Cubillos ◽

Arnoldo Emilio Delgado-Tobón ◽

William Arnulfo Aperador Chaparro

Keyword(s):

Fatty Acids ◽

Thermal Properties ◽

Comparative Study ◽

Unsaturated Fatty Acids ◽

Saturated Hydrocarbon ◽

High Viscosity ◽

Sesame Oil ◽

Antioxidant Additive ◽

Mineral Oils ◽

The Impact

Introduction: In recent years the research and development of biolubricants from vegetable oils has increased to minimize the impact on the environment of petroleum derivatives. Objective: In this work, there was realized a comparative study of the thermal properties of the oil of Sesame with those of two mineral oils, of medium and high viscosity (360 and 255), which were free of additives. Method: The characterization of the three oils was performed using the technique of infrared spectroscopy (FT-IR) and physical properties such as kinematic viscosity, density, thermal and oxidative properties were determined by the analysis of Differential Calorimetry Scanning (DSC). Results: The sesame oil had a pour point of – 14.67 ° C, lower temperature than for mineral oils of 255 and 360, (– 4.29 ° C and – 6.89 ° C, respectively). The high content of unsaturated fatty acids (84.86%) could be responsible for this behavior. The oils were stable to temperatures near to 250 °C and with nitrogen atmosphere. Mineral oils were more stable to oxidation because of their high content of fatty acids with saturated hydrocarbon chains which it had no oxidizable sites. Conclusions: Nevertheless, the low stability of sesame oil is due to the high content of unsaturated fatty acids, the use of antioxidant, additive or a chemical modification of the unsaturated chains, this property might be improved to use the oil as a lubricant.

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