Lack of prognostic significance of T-lymphocyte subset counts in B-cell chronic lyrnphocytic leukaemia

2009 ◽  
Vol 38 (1) ◽  
pp. 67-74 ◽  
Author(s):  
Christian H. Geisler ◽  
Jørgen K. Larsen ◽  
Torben Plesner ◽  
Mads Hansen ◽  
Mogens Mørk Hansen
Keyword(s):  
B Cell ◽  
T Lymphocyte ◽  
Prognostic Significance ◽  
Lymphocyte Subset ◽  
T Lymphocyte Subset

scholarly journals Baseline T-lymphocyte subset absolute counts can predict both outcome and severity in SARS-CoV-2 infected patients: a single center study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marco Iannetta ◽  
Francesco Buccisano ◽  
Daniela Fraboni ◽  
Vincenzo Malagnino ◽  
Laura Campogiani ◽  
...  
Keyword(s):  
Hospital Mortality ◽  
T Lymphocyte ◽  
Lymphocyte Subsets ◽  
Severe Disease ◽  
Laboratory Data ◽  
Lymphocyte Subset ◽  
Multivariable Logistic Regression Analysis ◽  
Double Positive ◽  
Increased Risk ◽  
T Lymphocyte Subset

AbstractThe aim of this study was to evaluate the role of baseline lymphocyte subset counts in predicting the outcome and severity of COVID-19 patients. Hospitalized patients confirmed to be infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were included and classified according to in-hospital mortality (survivors/nonsurvivors) and the maximal oxygen support/ventilation supply required (nonsevere/severe). Demographics, clinical and laboratory data, and peripheral blood lymphocyte subsets were retrospectively analyzed. Overall, 160 patients were retrospectively included in the study. T-lymphocyte subset (total CD3+, CD3+ CD4+, CD3+ CD8+, CD3+ CD4+ CD8+ double positive [DP] and CD3+ CD4− CD8− double negative [DN]) absolute counts were decreased in nonsurvivors and in patients with severe disease compared to survivors and nonsevere patients (p < 0.001). Multivariable logistic regression analysis showed that absolute counts of CD3+ T-lymphocytes < 524 cells/µl, CD3+ CD4+ < 369 cells/µl, and the number of T-lymphocyte subsets below the cutoff (T-lymphocyte subset index [TLSI]) were independent predictors of in-hospital mortality. Baseline T-lymphocyte subset counts and TLSI were also predictive of disease severity (CD3+  < 733 cells/µl; CD3+ CD4+ < 426 cells/µl; CD3+ CD8+ < 262 cells/µl; CD3+ DP < 4.5 cells/µl; CD3+ DN < 18.5 cells/µl). The evaluation of peripheral T-lymphocyte absolute counts in the early stages of COVID-19 might represent a useful tool for identifying patients at increased risk of unfavorable outcomes.

T cell receptor Vβ repertoire of the antigen specific CD8 T lymphocyte subset of HIV infected children

AIDS ◽  
2002 ◽  
Vol 16 (11) ◽  
pp. 1459-1465 ◽  
Author(s):  
Thomas W. McCloskey ◽  
Viraga Haridas ◽  
Rajendra Pahwa ◽  
Savita Pahwa
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
T Lymphocyte ◽  
Cell Receptor ◽  
Lymphocyte Subset ◽  
Cd8 T Lymphocyte ◽  
T Cell Receptor Vβ ◽  
T Lymphocyte Subset

scholarly journals Isolation and initial characterization of multiple species of T-lymphocyte subset cDNA clones.

1987 ◽  
Vol 84 (9) ◽  
pp. 2896-2900 ◽  
Author(s):  
B. S. Kwon ◽  
G. S. Kim ◽  
M. B. Prystowsky ◽  
D. W. Lancki ◽  
D. E. Sabath ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Subset ◽  
Cdna Clones ◽  
Initial Characterization ◽  
Multiple Species ◽  
T Lymphocyte Subset

scholarly journals Clinical usefulness of multivariate autoregressive (AR) modeling as a tool for analyzing T-lymphocyte subset fluctuations

1990 ◽  
Vol 14 ◽  
pp. 610-613 ◽  
Author(s):  
Takao Wada ◽  
Haruyasu Yamada ◽  
Hiroshi Inoue ◽  
Takenobu Iso ◽  
Eiichi Udagawa ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Subset ◽  
Clinical Usefulness ◽  
Ar Modeling ◽  
T Lymphocyte Subset ◽  
Multivariate Autoregressive
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