<b>Objective: </b>Obesity and type 2
diabetes are risk factors for cardiovascular diseases and mortality, and that commonly
result in weight variabilities. We aimed to investigate the association between
body weight variability and risk of major cardiovascular outcomes and mortality
in individuals with type 2 diabetes using large-scale, nationwide cohort data on
the Korean population.
<div><p><b>Research Design
and Methods: </b>We
enrolled 624,237 individuals with type 2 diabetes who underwent health
examinations provided by the Korean National Health Insurance System between
2009 and 2010, with ≥3 body weight measurements within 5 years since enrollment
and followed up until the end of 2017. We assessed body weight variability
using four indices, including variability independent of the mean (VIM). Multivariable-adjusted
Cox proportional hazards regression analysis was performed.</p>
<p><b>Results: </b>During the follow-up,
15,832, 25,038, and 44,716 cases of myocardial infarction (MI), stroke, and
all-cause mortality, respectively, were recorded. Body weight variability was
associated with increased risks of major cardiovascular outcomes after
adjusting for confounding variables. Compared with the hazard ratios (HRs) of the
lowest quartile group, the HRs (95% CIs) of the highest quartile group of VIM
for body weight were 1.15 (1.10–1.20), 1.22 (1.18–1.26), and 1.58 (1.53–1.62)
for MI, stroke, and all-cause mortality, respectively.</p>
<p><b>Conclusions: </b>Body weight variability
was associated with increased risks of MI, stroke, and all-cause mortality in type
2 diabetes patients and may be a predictor of cardiovascular outcomes in such patients.
Appropriate interventions to maintain stable weight could positively influence health
outcomes in type 2 diabetes patients.</p>
</div>
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Association of renal arteriosclerosis and hypertension with renal and cardiovascular outcomes in Japanese type 2 diabetes patients with diabetic nephropathy
