Anti-Inflammatory Activities of R ubus Fruit Anthocyanins in Inflamed Human Intestinal Epithelial Cells

2015 ◽  
Vol 39 (3) ◽  
pp. 300-309 ◽  
Author(s):  
Hana Jung ◽  
Hee Jae Lee ◽  
Hyunnho Cho ◽  
Keum Taek Hwang
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Human Intestinal Epithelial Cells ◽  
Anti Inflammatory

scholarly journals Nonsteroidal Anti-Inflammatory Drug-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells

2017 ◽  
Vol 4 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Aadra P. Bhatt ◽  
Dulan B. Gunasekara ◽  
Jennifer Speer ◽  
Mark I. Reed ◽  
Alexis N. Peña ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Leaky Gut ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Human Intestinal Epithelial Cells ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory effect of Lycium barbarum on polarized human intestinal epithelial cells

2019 ◽  
Vol 13 (2) ◽  
pp. 95 ◽  
Author(s):  
So-Rok Lee ◽  
Hye-Jeong Hwang ◽  
Ju-Gyeong Yoon ◽  
Eun Young Bae ◽  
Kyo-Suk Goo ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Lycium Barbarum ◽  
Human Intestinal Epithelial Cells ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells.

2006 ◽  
Vol 176 (6) ◽  
pp. 3841.3-3841 ◽  
Author(s):  
M.-T. Tien ◽  
S. E. Girardin ◽  
B. Regnault ◽  
L. Le Bourhis ◽  
M.-A. Dillies ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Lactobacillus Casei ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Human Intestinal Epithelial Cells ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Anti-Inflammatory Effect ofLactobacillus caseionShigella-Infected Human Intestinal Epithelial Cells

2006 ◽  
Vol 176 (2) ◽  
pp. 1228-1237 ◽  
Author(s):  
Meng-Tsung Tien ◽  
Stephen E. Girardin ◽  
Béatrice Regnault ◽  
Lionel Le Bourhis ◽  
Marie-Agnès Dillies ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Human Intestinal Epithelial Cells ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Anti-Inflammatory Effects of the Nicotinergic Peptides SLURP-1 and SLURP-2 on Human Intestinal Epithelial Cells and Immunocytes

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Alex I. Chernyavsky ◽  
Valentin Galitovskiy ◽  
Igor B. Shchepotin ◽  
Sergei A. Grando
Keyword(s):  
T Cells ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Therapeutic Modalities ◽  
Human Intestinal Epithelial Cells ◽  
Inflammatory Bowel ◽  
Anti Inflammatory ◽  
Contemporary Medicine ◽  
Inflammatory Action

A search for novel and more efficient therapeutic modalities of inflammatory bowel disease (IBD) is one of the most important tasks of contemporary medicine. The anti-inflammatory action of nicotine in IBD might be therapeutic, but its toxicity due to off-target and nonreceptor effects limited its use and prompted a search for nontoxic nicotinergic drugs. We tested the hypothesis that SLURP-1 and -2—the physiological nicotinergic substances produced by the human intestinal epithelial cells (IEC) and immunocytes—can mimic the anti-inflammatory effects of nicotine. We used human CCL-241 enterocytes, CCL-248 colonocytes, CCRF-CEM T-cells, and U937 macrophages. SLURP-1 diminished the TLR9-dependent secretion of IL-8 by CCL-241, and IFNγ-induced upregulation of ICAM-1 in both IEC types. rSLURP-2 inhibited IL-1β-induced secretion of IL-6 and TLR4- and TLR9-dependent induction of CXCL10 and IL-8, respectively, in CCL-241. rSLURP-1 decreased production of TNFαby T-cells, downregulated IL-1βand IL-6 secretion by macrophages, and moderately upregulated IL-10 production by both types of immunocytes. SLURP-2 downregulated TNFαand IFNγR in T-cells and reduced IL-6 production by macrophages. Combining both SLURPs amplified their anti-inflammatory effects. Learning the pharmacology of SLURP-1 and -2 actions on enterocytes, colonocytes, T cells, and macrophages may help develop novel effective treatments of IBD.

Antioxidant and anti-inflammatory potential of Aloe vera and Punica granatum: onconutraceutical potential in intestinal epithelial cells

2019 ◽  
Author(s):  
SF Rapa ◽  
G Pepe ◽  
D Cianciarulo ◽  
F Merciai ◽  
E Salviati ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Aloe Vera ◽  
Punica Granatum ◽  
Intestinal Epithelial ◽  
Anti Inflammatory

Bifidobacterium infantis Modulates Pathogen-Induced CCL20 Secretion by Human Intestinal Epithelial Cells

Endoscopy ◽  
2006 ◽  
Vol 38 (11) ◽  
Author(s):  
AM O'Hara ◽  
J Ryan ◽  
B Sheil ◽  
A Fanning ◽  
L O'Mahony ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Bifidobacterium Infantis ◽  
Human Intestinal Epithelial Cells

scholarly journals Protective Effects of Lactoferrin against SARS-CoV-2 Infection In Vitro

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 328 ◽  
Author(s):  
Claudio Salaris ◽  
Melania Scarpa ◽  
Marina Elli ◽  
Alice Bertolini ◽  
Simone Guglielmetti ◽  
...  
Keyword(s):  
Immune Response ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Plaque Assay ◽  
Immune Response Gene ◽  
Intestinal Epithelial ◽  
Antiviral Immune Response ◽  
Qrt Pcr ◽  
Anti Inflammatory

SARS-CoV-2 is a newly emerging virus that currently lacks curative treatments. Lactoferrin (LF) is a naturally occurring non-toxic glycoprotein with broad-spectrum antiviral, immunomodulatory and anti-inflammatory effects. In this study, we assessed the potential of LF in the prevention of SARS-CoV-2 infection in vitro. Antiviral immune response gene expression was analyzed by qRT-PCR in uninfected Caco-2 intestinal epithelial cells treated with LF. An infection assay for SARS-CoV-2 was performed in Caco-2 cells treated or not with LF. SARS-CoV-2 titer was determined by qRT-PCR, plaque assay and immunostaining. Inflammatory and anti-inflammatory cytokine production was determined by qRT-PCR. LF significantly induced the expression of IFNA1, IFNB1, TLR3, TLR7, IRF3, IRF7 and MAVS genes. Furthermore, LF partially inhibited SARS-CoV-2 infection and replication in Caco-2 intestinal epithelial cells. Our in vitro data support LF as an immune modulator of the antiviral immune response with moderate effects against SARS-CoV-2 infection.

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