Antiproliferative effects of mealworm larvae ( Tenebrio molitor ) aqueous extract on human colorectal adenocarcinoma (Caco‐2) and hepatocellular carcinoma (HepG2) cancer cell lines

2021 ◽  
Author(s):  
Qingzhi Ding ◽  
Ricardo A. Wu ◽  
Tingting Shi ◽  
Yanhua Yu ◽  
Yilin Yan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Lines ◽  
Cancer Cell ◽  
Aqueous Extract ◽  
Colorectal Adenocarcinoma ◽  
Tenebrio Molitor ◽  
Cancer Cell Lines ◽  
Antiproliferative Effects ◽  
Mealworm Larvae

Ellagic Acid: Cytodifferentiating and Antiproliferative Effects In Human Prostatic Cancer Cell Lines

2013 ◽  
Vol 19 (15) ◽  
pp. 2728-2736 ◽  
Author(s):  
Luca Vanella ◽  
Ignazio Barbagallo ◽  
Rosaria Acquaviva ◽  
Claudia Di Giacomo ◽  
Venera Cardile ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Ellagic Acid ◽  
Prostatic Cancer ◽  
Cancer Cell Lines ◽  
Antiproliferative Effects

scholarly journals Anti-Proliferative Effects of an Extra-Virgin Olive Oil Extract Enriched in Ligstroside Aglycone and Oleocanthal on Human Liver Cancer Cell Lines

Cancers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1640 ◽  
Author(s):  
De Stefanis ◽  
Scimè ◽  
Accomazzo ◽  
Catti ◽  
Occhipinti ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Olive Oil ◽  
Cell Lines ◽  
Cancer Cell ◽  
Virgin Olive Oil ◽  
Cancer Cell Lines ◽  
Liver Cancer Cell ◽  
Antioxidant Power ◽  
Polyphenolic Extract

Oleocanthal and ligstroside aglycone are olive oil-derived polyphenols. The former interferes with tumor growth with minor or no cytotoxicity on non-tumorigenic primary cell lines. The information about the bioactivity of ligstroside aglycone are scanty, with the exception of a known antioxidant power. Hepatocellular carcinoma is a malignant tumor with high mortality rates. Systemic chemotherapy is only marginally effective and is frequently complicated by toxicity. Previous observations have shown that hepatocellular carcinoma cell lines become more sensitive to taxol when it is combined with Tumor Necrosis Factor α (TNFα). The present work aimed to assess the effects of a polyphenolic extract containing both oleocanthal and ligstroside aglycone on proliferation and/or death in three liver cancer cell lines (HepG2, Huh7 and Hep3B). The possibility to enhance such effect by the addition of TNFα was also investigated. Both cell proliferation and death were enhanced by the exposure to the polyphenolic extract. Such effect was associated with induction of autophagy and could be potentiated by TNFα. The presence of ligstroside aglycone in the extract lowered the oleocanthal concentration required for cytotoxicity. These results show for the first time that the effects of a polyphenol extract can be potentiated by TNFα and that modulation of autophagy likely account for these effects.

scholarly journals Epigenetic Regulation of Pluripotent Genes Mediates Stem Cell Features in Human Hepatocellular Carcinoma and Cancer Cell Lines

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e72435 ◽  
Author(s):  
Xiao Qi Wang ◽  
Ray Kit Ng ◽  
Xiaoyan Ming ◽  
Wu Zhang ◽  
Lin Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cell ◽  
Cell Lines ◽  
Cancer Cell ◽  
Epigenetic Regulation ◽  
Cancer Cell Lines ◽  
Human Hepatocellular Carcinoma

scholarly journals Synthesis, Anticancer Activity, and Molecular Modeling of New Halogenated Spiro[pyrrolidine-thiazolo-oxindoles] Derivatives

2020 ◽  
Vol 10 (6) ◽  
pp. 2170 ◽  
Author(s):  
Mohammad Shahidul Islam ◽  
Abdullah Mohammed Al-Majid ◽  
Fardous F. El-Senduny ◽  
Farid A. Badria ◽  
A. F. M. Motiur Rahman ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Single Step ◽  
One Pot ◽  
Antiproliferative Effects ◽  
Physiochemical Parameters ◽  
Hct 116 ◽  
Mcf 7

A one-pot, single-step, and an atom-economical process towards the synthesis of highly functionalized spirooxindoles analogues was efficiently conducted to produce a satisfactory chemical yields (70–93%) with excellent relative diastereo-, and regio-selectivity. An in vitro antiproliferative assay was carried out on different cancer cell lines to evaluate the biological activity of the synthesized tetrahydro-1’H-spiro[indoline-3,5’-pyrrolo[1,2-c]thiazol]-2-one 5a–n. The prepared hybrids were then tested in vitro for their antiproliferative effects against three cancer cell lines, namely, HepG2 (liver cancer), MCF-7 (breast cancer), and HCT-116 (colon cancer). The spirooxindole analogue 5g exhibited a broad activity against HepG2, MCF-7, and HCT-116 cell lines of liver, breast, and colorectal cancers when compared to cisplatin. Modeling studies including shape similarity, lipophilicity scores, and physicochemical parameters were calculated. The results of this study indicated that spirooxindole analogue 5g retained a good physiochemical parameters with acceptable lipophilicity scores.

scholarly journals A Chromone from Seseli praecox (Apiaceae)

2010 ◽  
Vol 5 (4) ◽  
pp. 1934578X1000500
Author(s):  
Marco Leonti ◽  
Laura Casu ◽  
Maria Novella Solinas ◽  
Filippo Cottiglia ◽  
Pierluigi Caboni ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Chemical Investigation ◽  
Adherent Cells ◽  
Biological Characterization ◽  
Antiproliferative Effects ◽  
Natural Precursor

Chemical investigation of the stems of Seseli praecox (Gamisans) Gamisans, an endemic Apiaceae from Sardinia, afforded an isopropenylated chromone (5-hydroxy-6-(2- Z-butenyl-3-hydroxymethyl)-7-methoxy-2-methylchromone), along with four known linear furocoumarins and their natural precursor. For biological characterization the new compound was screened against four cancer cell lines in vitro and showed differential μM antiproliferative effects between suspension and adherent cells.

Antiproliferative effects of rapamycin as a single agent and in combination with carboplatin and paclitaxel in head and neck cancer cell lines

2007 ◽  
Vol 62 (2) ◽  
pp. 305-313 ◽  
Author(s):  
Nasredine Aissat ◽  
Christophe Le Tourneau ◽  
Aïda Ghoul ◽  
Maria Serova ◽  
Ivan Bieche ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cell Lines ◽  
Cancer Cell ◽  
Neck Cancer ◽  
Single Agent ◽  
Cancer Cell Lines ◽  
Antiproliferative Effects

scholarly journals Comparative antiproliferative effects of iniparib and olaparib on a panel of triple-negative and non-triple-negative breast cancer cell lines

2013 ◽  
Vol 14 (6) ◽  
pp. 537-545 ◽  
Author(s):  
Aisling Pierce ◽  
Patricia M. McGowan ◽  
Maura Cotter ◽  
Maeve Mullooly ◽  
Norma O’Donovan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Antiproliferative Effects

Preliminary antiproliferative effects of some species of Terminalia, Combretum and Pteleopsis collected in Tanzania on some human cancer cell lines

Fitoterapia ◽  
2006 ◽  
Vol 77 (5) ◽  
pp. 358-366 ◽  
Author(s):  
P. Fyhrquist ◽  
L. Mwasumbi ◽  
P. Vuorela ◽  
H. Vuorela ◽  
R. Hiltunen ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Antiproliferative Effects ◽  
Human Cancer Cell Lines
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