Interaction networks between the Fallopian tubes and the embryo in human tubal pregnancy: Current knowledge and perspectives

2021 ◽  
Author(s):  
Huan Jiang ◽  
Jian‐Xiong Li
Keyword(s):  
Current Knowledge ◽  
Tubal Pregnancy ◽  
Interaction Networks ◽  
Fallopian Tubes

Ribosomally synthesized peptides, foreground players in microbial interactions: recent developments and unanswered questions

2021 ◽  
Author(s):  
Sylvie Rebuffat
Keyword(s):  
Current Knowledge ◽  
Complex Interaction ◽  
Microbial Interactions ◽  
Interaction Networks ◽  
Recent Developments

This review unveils current knowledge on the complex interaction networks involving ribosomally synthesized peptides, either modified or not, being at play in microbial interactions and symbioses.

scholarly journals Ectopic Pregnancy in Two Cats

2018 ◽  
Vol 46 ◽  
pp. 5
Author(s):  
Jia-San Zheng ◽  
Zheng Wang ◽  
Jia-Ren Zhang ◽  
Shuang Qiu ◽  
Ren-Yue Wei ◽  
...  
Keyword(s):  
Ectopic Pregnancy ◽  
Fallopian Tube ◽  
Clinical Symptoms ◽  
Abdominal Cavity ◽  
Scar Tissue ◽  
Tubal Pregnancy ◽  
Abdominal Pregnancy ◽  
Fallopian Tubes ◽  
Gestational Sac ◽  
Ectopic Pregnancies

Background: Ectopic pregnancy mainly refers to tubal pregnancy and abdominal pregnancy. Tubal pregnancy presents as an implanted embryo that develops in the fallopian tubes, and is relatively common in humans. In animals, tubal pregnancy occurs primarily in primates, for example monkeys. The probability of a tubal pregnancy in non-primate animals is extremely low. Abdominal pregnancy is a type of ectopic pregnancy that occurs outside of the uterus, fallopian tube, ovary, and ligament(broad ligament, ovarian ligament, suspensory ligament).This paper describes two cases of ectopic pregnancy in cats.Cases: Cat 1. The presenting sign was a significant increase in abdominal circumference. The age and immune and sterilization status of the cat were unknown. On palpation, a 4 cm, rough, oval-shaped, hard mass was found in the posterior abdomen. Radiographic examination showed three high-density images in the posterior abdomen. The fetus was significantlycalcified and some feces was evident in the colon. The condition was preliminarily diagnosed as ectopic pregnancy. Cat 2. The owner of a 2-year-old British shorthair cat visited us because of a hard lump in the cat’s abdomen. The cat had a normal diet and was drinking normally. Routine immunization and insect repulsion had been implemented. The cat had naturally delivered five healthy kittens two months previous. Radiographs showed an oval-shaped mass with a clear edge in the middle abdominal cavity. Other examinations were normal. The case was preliminarily diagnosed as ectopic pregnancy, and the pregnancy was surgically terminated. The ectopic pregnancies were surgically terminated. During surgery, the structures of the uterus and ovary of cat 1 were found to be intact and the organs were in a normal physiological position.Cat 1 was diagnosed with primary abdominal pregnancy. In cat 2, the uterus left side was small and the fallopian tube on the same side was both enlarged and longer than normal. Immature fetuses were found in the gestational sac. Thus, cat 2 was diagnosed with tubal ectopic pregnancy based on the presenting pathology.Discussion: Cats with ectopic pregnancies generally show no obvious clinical symptoms. The ectopic fetus can remain within the body for several months or even years. Occasionally, necrotic ectopic tissues or mechanical stimulation of the ectopic fetus can lead to a systemic inflammatory response, loss of appetite, and apathy. The two cats in our reportshowed no significant clinical symptoms. To our knowledge, there have been no previous reports of the development of an ectopic fetus to maturity, within the abdominal cavity of felines, because the placenta of cats cannot support the growth and development of the fetus outside of the uterus. Secondary abdominal ectopic pregnancy, lacking any signs of uterine rupture is likely associated with the strong regenerative ability of uterine muscles. A damaged uterus or fallopian tube can quickly recover and rarely leaves scar tissue. In the present report, cat 1 showed no apparent scar tissue, nor signs of a ruptured ovary or fallopian tubes. It was diagnosed with primary ectopic abdominal pregnancy, which could arise from the descent of the fertilized egg from the fallopian tube into the abdominal cavity. There was an abnormal protrusion in left of the fallopian tubes in cat 2, to which the gestational sac was directly connected. Based on pathological examination of the uterus, fallopian tubes, and gestational sac, the cat was diagnosed with a tubal pregnancy. Placental tissues and signs of fetal calcification were observed in both the fallopian tube and gestational sac.Keywords: tubal pregnancy, abdominal pregnancy, feline, ectopic fetus, fallopian tube, gestational sac.

Ectopic tubal pregnancy without fallopian tubes—an (im)possible diagnosis?

2005 ◽  
Vol 118 (1) ◽  
pp. 109-110 ◽  
Author(s):  
Alexander Strauss ◽  
Carolin Kuemper
Keyword(s):  
Tubal Pregnancy ◽  
Fallopian Tubes

scholarly journals Personalized Medicine and Molecular Interaction Networks in Amyotrophic Lateral Sclerosis (ALS): Current Knowledge

2018 ◽  
Vol 8 (4) ◽  
pp. 44 ◽  
Author(s):  
Stephen Morgan ◽  
Stephanie Duguez ◽  
William Duddy
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Personalized Medicine ◽  
Molecular Interaction ◽  
Current Knowledge ◽  
Systemic Disease ◽  
Neuromuscular Disorder ◽  
Interaction Networks ◽  
Molecular Interaction Networks ◽  
Analytical Approaches ◽  
Lateral Sclerosis

Multiple genes and mechanisms of pathophysiology have been implicated in amyotrophic lateral sclerosis (ALS), suggesting it is a complex systemic disease. With this in mind, applying personalized medicine (PM) approaches to tailor treatment pipelines for ALS patients may be necessary. The modelling and analysis of molecular interaction networks could represent valuable resources in defining ALS-associated pathways and discovering novel therapeutic targets. Here we review existing omics datasets and analytical approaches, in order to consider how molecular interaction networks could improve our understanding of the molecular pathophysiology of this fatal neuromuscular disorder.

scholarly journals CASE OF TUBAL PREGNANCY AND RUPTURE OF THE FALLOPIAN TUBES.

The Lancet ◽  
1840 ◽  
Vol 35 (894) ◽  
pp. 135
Author(s):  
Hector Gavin
Keyword(s):  
Tubal Pregnancy ◽  
Fallopian Tubes

scholarly journals Structural Changes in the Fallopian Tubes in Patients With Ectopic Pregnancy

2021 ◽  
Vol 9 (4) ◽  
pp. 598-605
Author(s):  
G. P. Titova ◽  
M. M. Damirov ◽  
I. V. Anchabadze ◽  
A. A. Medvedev
Keyword(s):  
Ectopic Pregnancy ◽  
Fallopian Tube ◽  
Structural Changes ◽  
Tube Wall ◽  
First Trimester ◽  
Tubal Pregnancy ◽  
Fallopian Tubes ◽  
Depth Of Penetration ◽  
Morphological Examination ◽  
Surgical Interventions

Relevance.Ectopic (extrauterine) pregnancy (EP) occupies a leading place in the structure of urgent gynecological morbidity. This pathology poses a threat to the health and life of a woman, being one of the leading causes of maternal mortality during pregnancy during the first trimester. Among emergency gynecological operations, surgical interventions for EP make up about 50%, and in recent years, most operations have been performed by the laparoscopic method. However, up to now, the pathomorphological changes in the fallopian tubes in patients with EP remain poorly understood.Purpose of the study. To study the features of pathomorphological changes in the fallopian tubes in women with tubal pregnancy, operated on by the laparoscopic method, to substantiate the volume of surgery in patients with this pathology.Material and methods. Morphological examination was performed in 100 women operated on for tubal pregnancy using the laparoscopic method. A comprehensive morphological study of the fallopian tubes removed during the operation was carried out.Results and discussion. The implantation of the ovum in the fallopian tube led to significant changes in its macro- and microstructure, which were caused by the invasion of chorionic villi and involved all layers of the tube wall, differing only in the depth of penetration and prevalence. The anatomical features of the structure of the fallopian tubes contributed to the deep invasion of the ovum into the myosalpinx and subserous parts of the tube, creating the possibility of wall rupture in this area.Conclusions. 1. In all cases of ectopic pregnancy, implantation of the ovum was accompanied by invasion of cytotrophoblast and syncytiotrophoblast, and it involved all layers of the tube wall, differing only in depth and prevalence. The invasive properties of the cytotrophoblast lead to the development of pronounced degenerative changes in the tube wall, which leads to functional inferiority of the tube after the onset of tubal pregnancy in it.2. The chronic productive endomyosalpingitis diagnosed in most patients with ectopic pregnancy with deformation of the tube lumen against the background of changes in the tube wall caused by cytotrophoblastic invasion is an indication for tubectomy. Performing organ-preserving operations on an anatomically and functionally altered fallopian tube is impractical, since it is a high risk factor for recurrent tubal pregnancy in this tube.

scholarly journals Florid Cystic Endosalpingiosis (Müllerianosis) in Pregnancy

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
José Morales-Roselló ◽  
Loida Pamplona-Bueno ◽  
Beatriz Montero-Balaguer ◽  
Domingo Desantes-Real ◽  
Alfredo Perales-Marín
Keyword(s):  
Cesarean Section ◽  
Current Knowledge ◽  
Progesterone Receptors ◽  
Breech Presentation ◽  
The Body ◽  
Fallopian Tubes ◽  
Immunohistochemistry Analysis ◽  
Positive Expression ◽  
Uterine Fundus ◽  
In Pregnancy

Cystic endosalpingiosis refers to the existence of heterotopic cystic müllerian tissue resembling structures of the fallopian tubes. We report a case of florid cystic endosalpingiosis discovered in a pregnant woman during a scheduled cesarean section and review the current knowledge of this disease. A 30-year-old woman with a twin pregnancy attended the hospital day unit at term. The first twin was in a breech presentation and a cesarean section was scheduled. During the procedure the uterine fundus and part of the body were seen completely seeded with multitude of cyst-like structures resembling hydatids of Morgagni. The immunohistochemistry analysis showed a positive expression for PAX8 (Box-8), CK7, and estrogen and progesterone receptors. The lesions did not disappear after pregnancy. Cystic endosalpingiosis should be always borne in mind, even in pregnancy, when it comes to making the differential diagnosis of a pelvic or systemic multicystic mass.

scholarly journals Exosomal Long Non-Coding RNAs in Lung Diseases

2020 ◽  
Vol 21 (10) ◽  
pp. 3580 ◽  
Author(s):  
Christophe Poulet ◽  
Makon-Sébastien Njock ◽  
Catherine Moermans ◽  
Edouard Louis ◽  
Renaud Louis ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Lung Diseases ◽  
Current Knowledge ◽  
Mechanisms Of Action ◽  
Interaction Networks ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Lung Cancers ◽  
Diagnosis And Prognosis ◽  
Non Coding Rnas

Within the non-coding genome landscape, long non-coding RNAs (lncRNAs) and their secretion within exosomes are a window that could further explain the regulation, the sustaining, and the spread of lung diseases. We present here a compilation of the current knowledge on lncRNAs commonly found in Chronic Obstructive Pulmonary Disease (COPD), asthma, Idiopathic Pulmonary Fibrosis (IPF), or lung cancers. We built interaction networks describing the mechanisms of action for COPD, asthma, and IPF, as well as private networks for H19, MALAT1, MEG3, FENDRR, CDKN2B-AS1, TUG1, HOTAIR, and GAS5 lncRNAs in lung cancers. We identified five signaling pathways targeted by these eight lncRNAs over the lung diseases mentioned above. These lncRNAs were involved in ten treatment resistances in lung cancers, with HOTAIR being itself described in seven resistances. Besides, five of them were previously described as promising biomarkers for the diagnosis and prognosis of asthma, COPD, and lung cancers. Additionally, we describe the exosomal-based studies on H19, MALAT1, HOTAIR, GAS5, UCA1, lnc-MMP2-2, GAPLINC, TBILA, AGAP2-AS1, and SOX2-OT. This review concludes on the need for additional studies describing the lncRNA mechanisms of action and confirming their potential as biomarkers, as well as their involvement in resistance to treatment, especially in non-cancerous lung diseases.

scholarly journals Surgical Diseases of the Ovaries and Fallopian Tubes, Including Tubal Pregnancy,

JAMA ◽  
1892 ◽  
Vol XVIII (18) ◽  
pp. 567
Keyword(s):  
Tubal Pregnancy ◽  
Fallopian Tubes
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