Male-specific risk of first and recurrent venous thrombosis: a phylogenetic analysis of the Y chromosome

SummaryAntithrombin-III activity was determined in 752 patients with a history of venous thrombosis and/or pulmonary embolism. 54 patients (7.18%) had an antithrombin-III activity below the normal range. Among these were 13 patients (1.73%) with proven hereditary deficiency. 14 patients were judged to have probable hereditary antithrombin-III deficiency, because they had a positive family history, but antithrombin-III deficiency could not be verified in other members of the family. In the 27 remaining patients (most of them with only slight deficiency) hereditary antithrombin-III deficiency was unlikely. The prevalence of hereditary antithrombin-III deficiency was higher in patients with recurrent venous thrombosis.

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Clinical Utility of Real-Time Compression Ultrasonography for Diagnostic Management of Patients with Recurrent Venous Thrombosis

Acta Radiologica ◽

10.3109/02841859209173182 ◽

1992 ◽

Vol 33 (4) ◽

pp. 297-300 ◽

Cited By ~ 47

Author(s):

H. Heijboer ◽

L. M. M. Jongbloets ◽

H. R. Buller ◽

A. W. A. Lensing ◽

J. W. Ten Cate

Keyword(s):

Venous Thrombosis ◽

Real Time ◽

Clinical Utility ◽

Time Compression ◽

Diagnostic Management ◽

Recurrent Venous Thrombosis ◽

Compression Ultrasonography

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Statin use and risk of recurrent venous thrombosis: results from the MEGA follow-up study

Research and Practice in Thrombosis and Haemostasis ◽

10.1002/rth2.12003 ◽

2017 ◽

Vol 1 (1) ◽

pp. 112-119 ◽

Cited By ~ 3

Author(s):

Sigrid K. Braekkan ◽

Camila Caram-Deelder ◽

Bob Siegerink ◽

Astrid van Hylckama Vlieg ◽

Saskia le Cessie ◽

...

Keyword(s):

Venous Thrombosis ◽

Follow Up Study ◽

Recurrent Venous Thrombosis ◽

Statin Use

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A Female with Recurrent Venous Thrombosis

Journal of Medicine ◽

10.3329/jom.v13i1.10085 ◽

1970 ◽

Vol 13 (1) ◽

pp. 100-102

Author(s):

Aparna Das ◽

AKM Aminul Hoque ◽

Ratan Dasgupta ◽

Ahmedul Kabir ◽

Gobinda Banik ◽

...

Keyword(s):

Ischemic Stroke ◽

Venous Thrombosis ◽

Protein S ◽

Protein S Deficiency ◽

Low Level ◽

S Deficiency ◽

Thrombophilia Screening ◽

Recurrent Venous Thrombosis

A 50- year-old female was presented with recurrent venous thrombosis with ischemic stroke due to protein S deficiency. Other causes of recurrent venous thrombosis were excluded by different investigations. We only found low level of protein S. In most of the cases, thrombophilia screening is not usaally done. So, this report will illustrate the importance of thrombophlia screening in patient having recurrent venous thrombosis. DOI: http://dx.doi.org/10.3329/jom.v13i1.10085 JOM 2012; 13(1): 100-102

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Risk assessment for recurrent venous thrombosis

The Lancet ◽

10.1016/s0140-6736(10)60962-2 ◽

2010 ◽

Vol 376 (9757) ◽

pp. 2032-2039 ◽

Cited By ~ 159

Author(s):

Paul Alexander Kyrle ◽

Frits R Rosendaal ◽

Sabine Eichinger

Keyword(s):

Risk Assessment ◽

Venous Thrombosis ◽

Recurrent Venous Thrombosis

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Recurrent Venous Thrombosis and Markers of Inflammation

Thrombosis and Haemostasis ◽

10.1055/s-0037-1613858 ◽

2000 ◽

Vol 83 (04) ◽

pp. 536-539 ◽

Cited By ~ 84

Author(s):

Benien van Aken ◽

Martin den Heijer ◽

Gerard Bos ◽

Sander van Deventer ◽

Pieter Reitsma

Keyword(s):

Venous Thrombosis ◽

Inflammatory Mediators ◽

Odds Ratio ◽

Plasma Concentrations ◽

Control Group ◽

Cytokines And Chemokines ◽

Markers Of Inflammation ◽

Causal Nature ◽

Recurrent Venous Thrombosis ◽

Definition Of

SummaryInflammatory processes may play a key role in venous thrombosis, by inducing a procoagulant state through the action of cytokines and chemokines on monocytes and endothelial cells. Plasma concentrations of three inflammatory mediators, interleukin 6 (IL-6), interleukin 8 (IL-8) and monocyte chemotactic protein 1 (MCP-1), that mediate the cross-talk between inflammation and coagulation, were measured in 182 subjects with recurrent venous thrombosis and 350 healthy subjects recruited through a general practice. Elevated levels of IL-6 (>90th percentile of the control group) were detected in 25.8% of the patients with venous thrombosis in comparison with 10% (by definition) of the controls [odds ratio 2.4 (95%CI 1.5-3.8)]. In 21.5% of the patients elevated plasma levels of IL-8 (>90th percentile) were determined [odds ratio 2.0 (95%CI 1.2-3.5)]. Elevated levels of MCP-1 (>90th percentile) were detected in 24.1% of the patients [odds ratio 1.9 (95%CI 1.2-3.2)]. This is the first large clinical study showing that an increase in inflammatory mediators is associated with venous thrombosis. Future prospective studies are necessary to clarify the causal nature of the inflammatory process with respect to venous thrombosis.

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Venous Thromboembolism

10.2310/fm.1102 ◽

2020 ◽

Author(s):

Samuel Z. Goldhaber

Keyword(s):

Risk Factors ◽

Pulmonary Embolism ◽

Venous Thromboembolism ◽

Venous Thrombosis ◽

Antithrombotic Agents ◽

Vein Thrombosis ◽

Recurrent Venous Thrombosis ◽

Deep Vein ◽

D Dimer ◽

In Pregnancy

Venous thromboembolism, which involves venous thrombosis and pulmonary embolism, is a leading cause of morbidity and mortality in hospitalized patients and is being seen with increasing frequency in outpatients. This chapter discusses the risk factors, etiology, classification, pathophysiology, natural history, prognosis, diagnosis (including venous thrombosis, recurrent venous thrombosis, and pulmonary embolism), prophylaxis, and treatment of venous thromboembolism (including the pharmacology of antithrombotic agents), as well as venous thromboembolism in pregnancy and miscellaneous thromboembolic disorders (including thrombosis of unusual sites). This review contains 8 figures, 16 tables, and 79 references. Keywords: Venous thromboembolism, pulmonary embolism, deep vein thrombosis, embolectomy, thrombolysis, hypercoagulability, duplex ultrasonography, D-dimer, anticoagulation

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