Exogenous progesterone short‐termly affects the periodontal environment in perimenopausal women

Oral Diseases ◽  
2022 ◽  
Author(s):  
Ying Man ◽  
Lu Sun ◽  
Jianyong Qin ◽  
Xinyue Zhang ◽  
Shengjie Yan ◽  
...  
Keyword(s):  
Perimenopausal Women ◽  
Exogenous Progesterone

STEROID FORMATION IN PORCINE OVARIAN TISSUE IN VITRO

1970 ◽  
Vol 63 (3) ◽  
pp. 441-453 ◽  
Author(s):  
Asbjørn Aakvaag
Keyword(s):  
Liquid Scintillation ◽  
Specific Activity ◽  
Ovarian Tissue ◽  
Gas Liquid Chromatography ◽  
Similar Concentration ◽  
Endogenous Substrates ◽  
Exogenous Progesterone ◽  
Relative Utilization ◽  
Radioactive Substrate

ABSTRACT Slices of non-luteinized porcine ovaries have been incubated in the presence or absence of human chorionic gonadotrophin (HCG) and exogenous radioactive substrates. Progesterone, 17α-hydroxyprogesterone and androstenedione were isolated in a radiochemically pure form. The chemical mass and the specific activity were determined by gas liquid chromatography and liquid scintillation spectrometry. HCG stimulated the rate of formation of androstenedione in the absence of exogenous substrates with a factor of 4–8. In the presence of pregnenolone or progesterone at a concentration of about 2 × 10−6 mol/l the stimulatory effect of HCG was either abolished or markedly reduced. The conversion of exogenous progesterone to androstenedione was reduced in response to HCG indicating that the capacity of the tissue to convert progesterone to androstenedione was limited, and that the limit was reached at this rather low substrate concentration. These findings furthermore suggest that the endogenous rather than the exogenous radioactive substrate will be »preferred« by the tissue. The observations demonstrate the necessity of measuring both the radioactivity and the chemical mass of the products in investigations of this type using radioactive substrates. The formation of progesterone from endogenous substrates was also stimulated by HCG. [1-14C] acetate and [7α-3H]cholesterol were not utilized by the tissue for steroid formation. Exogenous [4-14C] pregnenolone and [7α-3H] progesterone in similar concentration were both utilized for production of 17α-hydroxyprogesterone and androstenedione. HCG had no effect on the relative utilization of the radioactive substrates.

Correlative Study of Bone-Related Biochemicals and Endocrine Changes in Perimenopausal Women in Enugu, Nigeria.

2020 ◽  
Vol 23 ◽  
Author(s):  
Chinwe Ifeoma Ikegwuonu ◽  
Ikenna Kingsley Uchendu ◽  
Chukwudi Ignatius Maduka
Keyword(s):  
Inorganic Phosphate ◽  
Premenopausal Women ◽  
Positive Association ◽  
Biochemical Changes ◽  
Health Conditions ◽  
Hormonal Changes ◽  
Negatively Associated ◽  
Perimenopausal Women ◽  
Endocrine Parameters ◽  
Apparently Healthy

Background and Objective: Perimenopause is a physiological occurrence in women, and is characterized by endocrine and biochemical changes. During perimenopause phase, many derangements or abnormal health conditions start developing as a result of hormonal changes. These derangements in health conditions and biochemical changes lead to higher incidence of metabolic syndrome (MetS) occurrence with or without bone involvement. There is scarcity of information on MetS in Enugu, Southern Nigeria and there is no available data on the correlation of selected bone-related biochemicals with endocrine parameters and MetS in perimenopausal women from the region. Material and Methods: We consecutively sampled 200 apparently healthy women, and categorized them into 120 perimenopausal women (age ( Results: Calcium was predominantly high in the three criteria (p<0.05). LH and FSH showed positive correlation with FPG while E2 was negatively associated with FPG. Similarly LH showed positive association with inorganic phosphate while E2 was negatively associated with alkaline phosphatase (p<0.05). Conclusion: Perimenopausal women are at higher risk for developing osteoporosis than premenopausal women. This emphasizes the need for timely diagnosis of osteoporosis in perimenopausal women.

Cardiovascular Risk in Perimenopausal Women

2019 ◽  
Vol 17 (6) ◽  
pp. 591-594 ◽  
Author(s):  
John C. Stevenson ◽  
Sophia Tsiligiannis ◽  
Nick Panay
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Ovarian Function ◽  
Density Lipoprotein ◽  
Premenopausal Women ◽  
Therapeutic Interventions ◽  
Additional Risk Factor ◽  
Chd Risk ◽  
Perimenopausal Women ◽  
Chd Risk Factors

Cardiovascular disease, and particularly coronary heart disease (CHD), has a low incidence in premenopausal women. Loss of ovarian hormones during the perimenopause and menopause leads to a sharp increase in incidence. Although most CHD risk factors are common to both men and women, the menopause is a unique additional risk factor for women. Sex steroids have profound effects on many CHD risk factors. Their loss leads to adverse changes in lipids and lipoproteins, with increases being seen in low density lipoprotein (LDL) cholesterol and triglycerides, and decreases in high density lipoprotein (HDL) cholesterol. There is a reduction in insulin secretion and elimination, but increases in insulin resistance eventually result in increasing circulating insulin levels. There are changes in body fat distribution with accumulation in central and visceral fat which links to the other adverse metabolic changes. There is an increase in the incidence of hypertension and of type 2 diabetes mellitus, both major risk factors for CHD. Oestrogens have potent effects on blood vessels and their loss leads to dysfunction of the vascular endothelium. All of these changes result from loss of ovarian function contributing to the increased development of CHD. Risk factor assessment in perimenopausal women is recommended, thereby permitting the timely introduction of lifestyle, hormonal and therapeutic interventions to modify or reverse these adverse changes.

Estrogen Supplementation Decreases Norepinephrine-Induced Vasoconstriction and Total Body Norepinephrine Spillover in Perimenopausal Women

Hypertension ◽  
1997 ◽  
Vol 30 (6) ◽  
pp. 1538-1543 ◽  
Author(s):  
Krishnankutty Sudhir ◽  
Murray D. Esler ◽  
Garry L. Jennings ◽  
Paul A. Komesaroff
Keyword(s):  
Perimenopausal Women ◽  
Total Body ◽  
Norepinephrine Spillover

scholarly journals Using a short questionnaire of the perimenopausal fatigue scale to evaluate perimenopausal women prone to fatigue syndrome

2021 ◽  
Vol 60 (4) ◽  
pp. 734-738
Author(s):  
Hsiao-Hui Chiu ◽  
Lee-Ing Tsao ◽  
Chieh-Yu Liu ◽  
Yu-Ying Lu ◽  
Whei-Mei Shih ◽  
...  
Keyword(s):  
Short Questionnaire ◽  
Fatigue Syndrome ◽  
Perimenopausal Women

scholarly journals Predictors of irritability symptoms in mildly depressed perimenopausal women

2021 ◽  
pp. 105128
Author(s):  
Anouk E. de Wit ◽  
Erik J. Giltay ◽  
Marrit K. Boer ◽  
Margo Nathan ◽  
Aleta Wiley ◽  
...  
Keyword(s):  
Perimenopausal Women

scholarly journals Urinary phthalate metabolite concentrations and serum hormone levels in pre- and perimenopausal women from the Midlife Women’s Health Study

2021 ◽  
Vol 156 ◽  
pp. 106633
Author(s):  
Catheryne Chiang ◽  
Diana C. Pacyga ◽  
Rita S. Strakovsky ◽  
Rebecca L. Smith ◽  
Tamarra James-Todd ◽  
...  
Keyword(s):  
Women’S Health ◽  
Women's Health ◽  
Health Study ◽  
Hormone Levels ◽  
Perimenopausal Women ◽  
Metabolite Concentrations ◽  
Serum Hormone ◽  
Phthalate Metabolite
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