scholarly journals Effects of Acupoint Application Therapy with TianGui Powder on Osteoporosis in Ovariectomized Rats through TGF-β1 and Smad2/3 Signaling Pathway

2019 ◽  
Vol 11 (1) ◽  
pp. 143-150 ◽  
Author(s):  
Xiao-Sheng Lin ◽  
Hai-yan Wang ◽  
Zhen Zhang ◽  
Han-Jiao Liu ◽  
Zhen Qu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Ovariectomized Rats ◽  
Application Therapy ◽  
Tgf Β1

Adrenomedullin Rescues Testicular Steroidogenesis of Leydig Cells by Suppressing TGF-β1 via PI3K/Akt-Dependent Activation of GSK-3β/β-Catenin Signaling Pathway

2020 ◽  
Author(s):  
Wei Hu ◽  
Xia-lian Zhu ◽  
Chang-geng Xu ◽  
Ming-yong Li ◽  
Wei Wang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Leydig Cells ◽  
Testicular Steroidogenesis ◽  
Gsk 3Β ◽  
Tgf Β1

TGF‐β1/Smad2/3 signaling pathway modulates octreotide antisecretory and antiproliferative effects in pituitary somatotroph tumor cells

2021 ◽  
Author(s):  
Florencia Picech ◽  
Liliana DV. Sosa ◽  
Pablo A. Perez ◽  
Laura Cecenarro ◽  
Sergio R. Oms ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Tumor Cells ◽  
Antiproliferative Effects ◽  
Tgf Β1

scholarly journals Regorafenib-Attenuated, Bleomycin-Induced Pulmonary Fibrosis by Inhibiting the TGF-β1 Signaling Pathway

2021 ◽  
Vol 22 (4) ◽  
pp. 1985
Author(s):  
Xiaohe Li ◽  
Ling Ma ◽  
Kai Huang ◽  
Yuli Wei ◽  
Shida Long ◽  
...  
Keyword(s):  
Pulmonary Fibrosis ◽  
Signaling Pathway ◽  
Transforming Growth Factor ◽  
Kinase Inhibitor ◽  
In Vivo Experiments ◽  
Age Related ◽  
And Migration ◽  
Tgf Β1

Idiopathic pulmonary fibrosis (IPF) is a fatal and age-related pulmonary disease. Nintedanib is a receptor tyrosine kinase inhibitor, and one of the only two listed drugs against IPF. Regorafenib is a novel, orally active, multi-kinase inhibitor that has similar targets to nintedanib and is applied to treat colorectal cancer and gastrointestinal stromal tumors in patients. In this study, we first identified that regorafenib could alleviate bleomycin-induced pulmonary fibrosis in mice. The in vivo experiments indicated that regorafenib suppresses collagen accumulation and myofibroblast activation. Further in vitro mechanism studies showed that regorafenib inhibits the activation and migration of myofibroblasts and extracellular matrix production, mainly through suppressing the transforming growth factor (TGF)-β1/Smad and non-Smad signaling pathways. In vitro studies have also indicated that regorafenib could augment autophagy in myofibroblasts by suppressing TGF-β1/mTOR (mechanistic target of rapamycin) signaling, and could promote apoptosis in myofibroblasts. In conclusion, regorafenib attenuates bleomycin-induced pulmonary fibrosis by suppressing the TGF-β1 signaling pathway.

scholarly journals Probiotic Propionibacterium freudenreichii MJ2 Enhances Osteoblast Differentiation and Mineralization by Increasing the OPG/RANKL Ratio

2021 ◽  
Vol 9 (4) ◽  
pp. 673
Author(s):  
Jiah Yeom ◽  
Seongho Ma ◽  
Young-Hee Lim
Keyword(s):  
Signaling Pathway ◽  
Osteoblast Differentiation ◽  
Surface Proteins ◽  
Bone Morphogenetic Protein 2 ◽  
Ovariectomized Rats ◽  
Osteoblastic Cell ◽  
Enhancement Effect ◽  
Propionibacterium Freudenreichii ◽  
Alizarin Red ◽  
Osteoblastic Cell Line

Osteoblast differentiation is important for the development of bone and the maintenance of bone density. Propionibacterium freudenreichii is a probiotic with an anti-inflammatory property. The aim of this study was to investigate the enhancement effect of P. freudenreichii MJ2 (MJ2) isolated from raw milk on osteoblast differentiation, mineralization, and its signaling pathway. For in vitro and in vivo experiments, human fetal osteoblastic cell line hFOB 1.19 and an ovariectomized rat model were used, respectively. Expression levels of genes and proteins related to osteoblast differentiation and mineralization were measured by real-time polymerase chain reaction (qPCR) and Western blotting, respectively. Alizarin red S staining was performed to measure osteoblast mineralization. Heat-killed MJ2 (hkMJ2)-treated cells showed significantly increased osteoblast differentiation via an increase in the osteoprotegerin (OPG)/receptor activator of nuclear factor-κB ligand (RANKL) ratio and significantly increased osteoblast mineralization by stimulating the expression of bone morphogenetic protein 2 and runt-related transcription factor 2. Additionally, oral administration of live or heat-killed MJ2 to ovariectomized rats inhibited osteoporosis-induced bone loss. Specifically, surface proteins isolated from MJ2 promoted osteoblast differentiation and mineralization. In conclusion, MJ2 enhanced osteoblast differentiation and mineralization through the OPG/RANKL signaling pathway and the effective component of MJ2 might be its surface proteins.

scholarly journals The effect of propofol on the proliferation and apoptosis of hepatocellular carcinoma cells through TGF-Β1/Smad2 signaling pathway

Bioengineered ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 4581-4592
Author(s):  
Zongchao Li ◽  
Honglei Liu ◽  
Yunxiao Zhang ◽  
Hongyu Tan
Keyword(s):  
Hepatocellular Carcinoma ◽  
Signaling Pathway ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells ◽  
Proliferation And Apoptosis ◽  
Tgf Β1

Silencing circ_0062389 alleviates cardiomyocyte apoptosis in heart failure rats via modulating TGF-β1/Smad3 signaling pathway

Gene ◽  
2021 ◽  
Vol 766 ◽  
pp. 145154
Author(s):  
Yongjun Zhang ◽  
Bin Chen
Keyword(s):  
Heart Failure ◽  
Signaling Pathway ◽  
Cardiomyocyte Apoptosis ◽  
Tgf Β1

scholarly journals Interleukin-22 attenuates renal tubular cells inflammation and fibrosis induced by TGF-β1 through Notch1 signaling pathway

Renal Failure ◽  
2020 ◽  
Vol 42 (1) ◽  
pp. 381-390 ◽  
Author(s):  
Rong Tang ◽  
Xiangcheng Xiao ◽  
Yang Lu ◽  
Huihui Li ◽  
Qiaoling Zhou ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Tubular Cells ◽  
Interleukin 22 ◽  
Renal Tubular Cells ◽  
Notch1 Signaling ◽  
Renal Tubular ◽  
Notch1 Signaling Pathway ◽  
Tgf Β1

scholarly journals FGF-2– and TGF-β1–Induced Downregulation of Lumican and Keratocan in Activated Corneal Keratocytes by JNK Signaling Pathway

2011 ◽  
Vol 52 (12) ◽  
pp. 8957 ◽  
Author(s):  
Jian Chen ◽  
Julie Wong-Chong ◽  
Nirmala SundarRaj
Keyword(s):  
Signaling Pathway ◽  
Jnk Signaling ◽  
Jnk Signaling Pathway ◽  
Corneal Keratocytes ◽  
Tgf Β1

Effect of MiR-34a on hypertension-induced hypertrophic cardiomyopathy in rats via the TGF-β1/Smads signaling pathway

2021 ◽  
Vol 112 (3) ◽  
Author(s):  
Ying SUN ◽  
Jian REN ◽  
Wen Zhen WU
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Signaling Pathway ◽  
Tgf Β1
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