Transcriptional regulation of ZIP genes is independent of local zinc status in Brachypodium shoots upon zinc deficiency and resupply

Objective: The purpose of this study was to evaluate serum zinc status of pregnant women in the China Adult Chronic Disease and Nutrition Surveillance (CACDNS) in 2015–2016. Methods: A total of 7147 apparently healthy pregnant women were randomly selected in 302 national monitoring sites. Information on age, race, residence region, education, pregnancy, and family income per annum was collected, and the concentration of serum zinc was determined. The evaluation of serum zinc status was further performed according to the recommendations by the International Zinc Nutrition Consultative Group (IZiNCG). Results: The median concentration of serum zinc was 858.9 μg/L with an interquartile range (IQR) of 712.9 μg/L and 1048.9 μg/L, while the overall prevalence of zinc deficiency was 3.5% with a 95% confidence interval (CI) of 3.0% and 3.9%. Serum zinc status of pregnant women changed greatly in the different categories, particular in pregnancy and family income per annum (p < 0.05), but no significant difference was observed in the prevalence of zinc deficiency (p > 0.05). Conclusions: The lower prevalence of zinc deficiency generally indicated a better zinc status for pregnant women in the CACDNS in 2015–2016. However, a well-designed evaluation system of zinc status for pregnant women should be continually optimized and improved by inducing more parameters such as biochemical, dietary, or functional indicators.

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Factors Attenuating Zinc Deficiency Improvement in Direct-Acting Antiviral Agent-Treated Chronic Hepatitis C Virus Infection

Nutrients ◽

10.3390/nu10111620 ◽

2018 ◽

Vol 10 (11) ◽

pp. 1620 ◽

Cited By ~ 5

Author(s):

Yi-Ling Ko ◽

Daisuke Morihara ◽

Kumiko Shibata ◽

Ryo Yamauchi ◽

Hiromi Fukuda ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Zinc Deficiency ◽

Dietary Habits ◽

Serum Zinc ◽

Antiviral Agent ◽

Zinc Status ◽

Direct Acting Antiviral ◽

Direct Acting

Zinc deficiency is frequently observed in chronic liver diseases. However, no studies have focused on the zinc status in chronic hepatitis C (HCV)-infected patients receiving direct-acting antiviral agents (DAAs). In this retrospective study, we assessed the serum zinc status in DAA-treated HCV patients with sustained virologic response for over two years (Zn-2y). Ninety-five patients were enrolled, whose baseline characteristics and blood parameters at DAA therapy initiation were collected. Baseline Zn < 65 µg/dL (odds ratio (OR) = 10.56, p < 0.001) and baseline uric acid (UA) > 5.5 mg/dL (OR = 9.99, p = 0.001) were independent risk factors for Zn-2y deficiency. A decision-tree algorithm classified low-baseline Zn and high-baseline UA as the first two variables, suggesting that baseline hypozincemia and hyperuricemia are prognosticators for long-term zinc deficiency. Baseline Zn was negatively correlated with the Fibrosis-4 (FIB-4) index, while baseline UA was significantly higher in habitual alcohol drinkers. In conclusion, serum zinc levels should be closely monitored, considering that zinc status improvement is related to liver fibrosis regression. Hyperuricemia indicates risks of developing metabolic disorders and subsequent zinc deficiency, for which an adjustment of personal lifestyle or dietary habits should be recommended clinically.

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Influence of Marginal Maternal Zinc Deficiency on Pregnancy Outcome and Infant Zinc Status in Rhesus Monkeys

Pediatric Research ◽

10.1203/00006450-198911000-00022 ◽

1989 ◽

Vol 26 (5) ◽

pp. 470-477 ◽

Cited By ~ 21

Author(s):

Carl L Keen ◽

B O Lönnerdal ◽

Mari S Golub ◽

Janet Y Uriu-Hare ◽

Katherine L Olin ◽

...

Keyword(s):

Pregnancy Outcome ◽

Zinc Deficiency ◽

Rhesus Monkeys ◽

Zinc Status

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Dietary zinc deficiency affects blood linoleic acid:dihomo‐γ‐linolenic acid ratio: a sensitive physiological marker of zinc status in vivo ( Gallus gallus ) (1043.2)

The FASEB Journal ◽

10.1096/fasebj.28.1_supplement.1043.2 ◽

2014 ◽

Vol 28 (S1) ◽

Author(s):

Spenser Reed ◽

Xia Qin ◽

Rinat Ran‐Ressler ◽

J Brenna ◽

Raymond Glahn ◽

...

Keyword(s):

Linolenic Acid ◽

Zinc Deficiency ◽

Gallus Gallus ◽

Zinc Status ◽

Dietary Zinc ◽

Acid Ratio

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CHARD (BETA VULGARIS VAR. CICLA) EXTRACT MODULATES ZINC STATUS, GLUCOSE LEVEL AND ANTIOXYDANT VALUES IN DIABETIC RATS FED ZINC DEFICIENCY DIET

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2017v9i10.19315 ◽

2017 ◽

Vol 9 (10) ◽

pp. 297 ◽

Cited By ~ 1

Author(s):

Malika Hamdiken ◽

Zine Kechrid

Keyword(s):

Oxidative Stress ◽

Body Weight ◽

Weight Gain ◽

Beta Vulgaris ◽

Zinc Deficiency ◽

Body Weight Gain ◽

Diabetic Rats ◽

The Other ◽

Zinc Status ◽

Deficient Diet

Objective: Oxidative stress which comes from hyperglycemia, it accelerates the development of cellular and vascular damage complications in diabetes, but the antioxidants may play a beneficial role in its prevention. Several plants extracts have an antioxidant activity and the ability to reduce oxidative stress in diabetes. Thus this study was conducted to investigate the effect of Beta vulgaris var cicla extract on zinc status, glucose concentration and antioxidant parameters in streptozotocin-diabetic rats fed zinc deficiency diet.Methods: Twenty-eight male albino (Wistar) rats were divided into four groups: two groups fed a zinc-sufficient diet one non-diabetic and the other diabetic, while the others two diabetic groups were fed a zinc-deficient diet, one non-treated group and the other treated with the extract of Beta vulgaris var cicla. After 21 d of dietary manipulation, fasting animals were scarified. Blood glucose, tissues zinc (femur, liver, kidney), malondialdehyde (MDA), reduced glutathione (GSH), glutathione peroxidase (GSH-Px) and glutathione-S-transferase (GST) were evaluated.Results: Body weight gain of zinc-deficient diabetic animals was lower than that of zinc-adequate diabetic animals. It was noticed also that inadequate dietary zinc intake increased glucose and MDA levels. In addition, zinc deficiency diet led to a decrease in zinc tissues, GSH concentration both GST and GSH-Px activities. However, Oral administration of Beta vulgaris extract significantly decreased both serum glucose and MDA (p<0.001) levels, with a significant increase in body weight gain (p<0.001), GSH concentration (p<0.05, P<0.001), GST (p<0.05, p<0.001) and GSH-Px (p<0.001) activities.Conclusion: The present study showed that Beta vulgaris var cicla supplementation presumably acting as an antioxidant, and it can be a natural source for the reduction of diabetes development caused by zinc deficiency.

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Serum zinc status is a matter of concern among children and non-pregnant women in a nationwide survey of Nepal

Scientific Reports ◽

10.1038/s41598-021-94344-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Suresh Mehata ◽

Man Kumar Tamang ◽

Kedar Raj Parajuli ◽

Binod Rayamajhee ◽

Uday Narayan Yadav ◽

...

Keyword(s):

Vitamin A ◽

Pregnant Women ◽

Zinc Deficiency ◽

Serum Zinc ◽

Wealth Quintile ◽

Household Wealth ◽

Intervention Programs ◽

Zinc Status ◽

Micronutrient Status ◽

Prevalence Of Anemia

AbstractNationally representative population data on zinc status in Nepal is lacking at present. This study analyzed data from the recent Nepal National Micronutrient status survey 2016 to determine the prevalence of zinc deficiency and associated risk factors among children aged 6–59 months (n = 1462) and non-pregnant women aged 15–49 years (n = 1923). Venous blood was collected from the participants to measure micronutrients such as zinc, markers of anemia, RBP (vitamin A), and markers of inflammation. Stool samples were collected to assess soil-transmitted helminths and Helicobacter pylori infection. Socio-demographic, household, and other relevant factors were collected by a structured questionnaire. Serum zinc concentration was measured by Microwave Plasma Atomic Emission Spectrometry, and zinc deficiency was defined according to the International Zinc Nutrition Consultative Group’s guidelines. Logistic regression was used to examine the predictors of zinc deficiency among the participants. The overall zinc deficiency in children was 22.9%, while it was higher in non-pregnant women (24.7%). The prevalence of anemia among zinc-deficient children was higher (21.3%) than the zinc non-deficit children (18.7%). The prevalence of anemia was 18% among zinc-deficient non-pregnant women compared to 22% non-deficit non-pregnant women. Predictors associated with zinc deficiency among the study children were living in rural areas (AOR = 2.25, 95% CI, [1.13, 4.49]), the occurrence of diarrhea during the two weeks preceding the survey (AOR = 1.57, 95% CI, [1.07, 2.30]), lowest household wealth quintile (AOR = 0.48, 95% CI, [0.25, 0.92]) and lower vitamin A status (AOR = 0.49, 95% CI, [0.28, 0.85]. The predictors associated with zinc deficiency among non-pregnant women were: being underweight (AOR = 1.55, 95% CI, [1.12, 2.15]), fever occurrence during two weeks preceding the survey (AOR = 1.43, 95% CI, [1.04, 1.98]), H. pylori in the stool (AOR = 1.33, 95% CI, [1.04, 1.71]), lowest household wealth quintile (AOR = 0.62, 95% CI,[0.40, 0.94]) and being at risk of folate deficiency (AOR = 0.58, 95% CI,[0.36, 0.94]). We conclude that community-level intervention programs focused on rural children and women to prevent diarrhea, improve nutrition counseling, and provide economic opportunities in rural communities may help to lower zinc deficiency and other micronutrient deficiencies in the Nepalese population. We believe that intervention programs to address zinc deficiency should not be isolated. Instead, integrated approaches are beneficial to improve overall micronutrient status, such as encouraging dietary diversity, providing livelihood opportunities to the unemployed, micronutrient supplementation to vulnerable populations, and consumption of zinc-rich animal-based foods.

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Zinc Status Elicits Age-Dependent Effects in the Gut Microbiome

Current Developments in Nutrition ◽

10.1093/cdn/nzaa062_009 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 1552-1552

Author(s):

Edward Davis ◽

Carmen Wong ◽

John Bouranis ◽

Thomas Sharpton ◽

Emily Ho

Keyword(s):

Zinc Deficiency ◽

Gut Microbiome ◽

Permutation Test ◽

Sampling Site ◽

Zinc Status ◽

Microbial Composition ◽

Age Related ◽

Marginal Zinc Deficiency ◽

Older Populations ◽

Old Mice

Abstract Objectives Zinc is an essential micronutrient critical for a variety of cellular processes, including immune function. In US, 12% of the population do not consume the EAR for zinc. In older populations the prevalence of inadequate zinc intake increases to ∼40%. Moreover, zinc levels are also often depressed in aged individuals, even when consuming a zinc-adequate diet. Thus, older populations can be highly susceptible to zinc deficiency. Both zinc deficiency and aging are associated with progressive immune dysfunction and chronic inflammation that could be correlated with the promotion of many age-related diseases. Increasing evidence indicates that the interaction among gut microbiota, the immune system, and diet contributes to age-related inflammation. Objectives: The goal of this study is to determine the importance of zinc status and age with respect to composition of the gut microbiome. We hypothesize that age and zinc status are correlated with specific taxa in the gut microbiome. Further, we expect to see additional correlations, both positive and negative, between these significant taxa and markers of host inflammation. Methods We studied the effects of dietary zinc supplementation and marginal zinc deficiency on changes in microbial communities in young and old mice. Young (2 mo) and old (24 mo) C57Bl/6 mice were fed a zinc adequate (30ppm Zn), zinc supplemented (300ppm Zn), or marginal zinc deficient (6 ppm Zn) diet for six weeks. 16S rRNA amplicon sequencing was performed on fecal samples at study start and end; cecal and colon samples at study end. Results Age correlated with overall microbial composition in the gut, according to a PERMANOVA test and a permutation test, regardless of zinc status. Gut microbiome content of young mice had significant overall correlation with zinc status, while the gut microbiome of old mice was not significantly affected by zinc status. Conclusions Age effects on the microbiome are significant and must be considered when studying effects of diet on the host gut microbiome. Zinc status, especially deficiency, elicits a varied effect on the microbiome that is dependent upon host age. Sampling site (i.e., colon, cecum, feces) had a small but significant effect on specific microbial taxa. Funding Sources NIFA, USDA.

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Assessment of zinc deficiency and effect of dietary carrot, amchur and onion on zinc status during repletion in zinc-deficient rats

Journal of the Science of Food and Agriculture ◽

10.1002/jsfa.4558 ◽

2011 ◽

Vol 92 (1) ◽

pp. 165-170 ◽

Cited By ~ 4

Author(s):

Smita Gautam ◽

Kalpana Platel ◽

Krishnapura Srinivasan

Keyword(s):

Zinc Deficiency ◽

Zinc Status

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Dietary Zinc Deficiency Affects Blood Linoleic Acid: Dihomo-γ-linolenic Acid (LA:DGLA) Ratio; a Sensitive Physiological Marker of Zinc Status in Vivo (Gallus gallus)

Nutrients ◽

10.3390/nu6031164 ◽

2014 ◽

Vol 6 (3) ◽

pp. 1164-1180 ◽

Cited By ~ 36

Author(s):

Spenser Reed ◽

Xia Qin ◽

Rinat Ran-Ressler ◽

James Brenna ◽

Raymond Glahn ◽

...

Keyword(s):

Linoleic Acid ◽

Linolenic Acid ◽

Zinc Deficiency ◽

Gallus Gallus ◽

Zinc Status ◽

Dietary Zinc

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The effect of 2-(4-2′,4′-dichlorophenoxy-phenoxy)-methyl propanoate on the uptake and utilization of zinc by wheat

Australian Journal of Agricultural Research ◽

10.1071/ar9890981 ◽

1989 ◽

Vol 40 (5) ◽

pp. 981 ◽

Cited By ~ 5

Author(s):

AD Robson ◽

K Snowball

Keyword(s):

Plant Growth ◽

Zinc Deficiency ◽

Zinc Uptake ◽

Root Weight ◽

Zinc Status ◽

Herbicide Application ◽

Field Crops ◽

Zinc Concentrations ◽

Plant Effects ◽

Methyl Propanoate

The effect of the herbicide diclofop-methyl on the uptake and utilization of zinc by wheat was examined in a series of glasshouse experiments. Application of diclofop-methyl to soil induced symptoms of zinc deficiency and decreased zinc concentrations within shoots. Effects of the herbicide application in decreasing plant growth were more marked at marginal levels of zinc than at adequate levels. The application of diclofop-methyl to the soil induced zinc deficiency by decreasing the uptake of zinc from soil rather than by effects on the utilization of zinc within the plant. The application of diclofop-methyl to leaves with no contamination of the soil did not affect the zinc status of the plant. Effects of diclofopmethyl in decreasing zinc uptake did not appear to be due to effects of the herbicide on root weight or root length.In the field, diclofop-methyl is sprayed on crops with low leaf areas, hence a high proportion of the herbicide will reach the soil. It is thus likely that in field crops application of diclofop-methyl will induce zinc deficiency where the supply of zinc for the crop is marginal.

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