scholarly journals Ammonium regulates the development of pine roots through hormonal crosstalk and differential expression of transcription factors in the apex

2021 ◽  
Author(s):  
Francisco Ortigosa ◽  
César Lobato‐Fernández ◽  
Hitomi Shikano ◽  
Concepción Ávila ◽  
Shu Taira ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Differential Expression ◽  
Hormonal Crosstalk

scholarly journals Differential Expression of Heat Shock Transcription Factors and Heat Shock Proteins after Acute and Chronic Heat Stress in Laying Chickens (Gallus gallus)

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e102204 ◽  
Author(s):  
Jingjing Xie ◽  
Li Tang ◽  
Lin Lu ◽  
Liyang Zhang ◽  
Lin Xi ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Heat Stress ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Differential Expression ◽  
Gallus Gallus ◽  
Heat Shock Transcription Factors ◽  
Shock Proteins

scholarly journals Differential Expression of Members of SOX Family of Transcription Factors in Failing Human Hearts

2020 ◽  
Author(s):  
Chia-Feng Liu ◽  
Ying Ng ◽  
Varun Thachil ◽  
Michael Morley ◽  
Christine S Moravec ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Differential Expression ◽  
Cardiac Fibrosis ◽  
Meta Analysis ◽  
High Mobility ◽  
Human Myocardium ◽  
Cardiac Tissues ◽  
Protein Levels ◽  
Sox Genes ◽  
Rna Levels

Abstract Background: The Sry-related high-mobility-group box (SOX) gene family, with 20 known transcription factors in humans, plays essential roles during development and in many disease processes. Several SOX proteins, e.g., SOX4, SOX11, and SOX9, are required for normal heart morphogenesis. SOX9 was shown to contribute to cardiac fibrosis in animal models. However, differential expression of other SOX transcription factors and their functional roles in the failing human myocardium have not been explored.Methods and Findings: All 20 SOX genes from RNA-seq data were extracted, and their RNA levels were compared to the NF, DCM, and hypertrophic cardiomyopathy (HCM) groups. The protein levels of the differential expressed SOX genes were confirmed by Western blot. Four SOX genes whose RNA levels were significantly upregulated in DCM or HCM compared to NF. However, only SOX4 and SOX8 proteins were markedly increased in the heart failure groups. Gene co-expression network analysis identified genes associated and respond similarly to perturbations with SOX4 in cardiac tissues. Using a meta-analysis combining epigenetics and genome-wide association data, we reported several genomic variants associated with HF phenotype linked to SOX4 or SOX8.Conclusions: Elevation of SOX8 and SOX4 are observed in the failing human myocardium. The molecular mechanism associated with them in HF warrants further investigation.

Differential expression of transcription factors in the accumbens of an animal model of ADHD

Neuroreport ◽  
1997 ◽  
Vol 8 (7) ◽  
pp. 1607-1612 ◽  
Author(s):  
Michele Papa ◽  
Joseph A. Sergeant ◽  
Adolfo G. Sadile
Keyword(s):  
Animal Model ◽  
Transcription Factors ◽  
Differential Expression

scholarly journals The Western Diet Regulates Hippocampal Microvascular Gene Expression: An Integrated Genomic Analyses in Female Mice

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Saivageethi Nuthikattu ◽  
Dragan Milenkovic ◽  
John Rutledge ◽  
Amparo Villablanca
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Differential Expression ◽  
Differential Gene Expression ◽  
Gene Networks ◽  
Molecular Mechanisms ◽  
Western Diet ◽  
Protein Coding ◽  
Female Mice ◽  
Differential Gene

AbstractHyperlipidemia is a risk factor for dementia, and chronic consumption of a Western Diet (WD) is associated with cognitive impairment. However, the molecular mechanisms underlying the development of microvascular disease in the memory centers of the brain are poorly understood. This pilot study investigated the nutrigenomic pathways by which the WD regulates gene expression in hippocampal brain microvessels of female mice. Five-week-old female low-density lipoprotein receptor deficient (LDL-R−/−) and C57BL/6J wild type (WT) mice were fed a chow or WD for 8 weeks. Metabolics for lipids, glucose and insulin were determined. Differential gene expression, gene networks and pathways, transcription factors, and non-protein coding RNAs were evaluated by genome-wide microarray and bioinformatics analysis of laser captured hippocampal microvessels. The WD resulted in differential expression of 2,412 genes. The majority of differential gene expression was attributable to differential regulation of cell signaling proteins and their transcription factors, approximately 7% was attributable to differential expression of miRNAs, and a lesser proportion was due to other non-protein coding RNAs, primarily long non-coding RNAs (lncRNAs) and small nucleolar RNAs (snoRNAs) not previously described to be modified by the WD in females. Our findings revealed that chronic consumption of the WD resulted in integrated multilevel molecular regulation of the hippocampal microvasculature of female mice and may provide one of the mechanisms underlying vascular dementia.

scholarly journals Differential expression of AP-1 transcription factors in human prostate LNCaP and PC-3 cells: role of Fra-1 in transition to CRPC status

2017 ◽  
Vol 433 (1-2) ◽  
pp. 13-26 ◽  
Author(s):  
K. Kavya ◽  
M. Naveen Kumar ◽  
Rajeshwari H. Patil ◽  
Shubha M. Hegde ◽  
K. M. Kiran Kumar ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Differential Expression ◽  
Human Prostate

scholarly journals Differential Expression of Peptidoglycan Recognition Protein 2 in the Skin and Liver Requires Different Transcription Factors

2006 ◽  
Vol 281 (30) ◽  
pp. 20738-20748 ◽  
Author(s):  
Xinna Li ◽  
Shiyong Wang ◽  
Haitao Wang ◽  
Dipika Gupta
Keyword(s):  
Transcription Factors ◽  
Differential Expression ◽  
Peptidoglycan Recognition Protein ◽  
Recognition Protein

scholarly journals Differential expression of members of the E2F family of transcription factors in rodent testes

2006 ◽  
Vol 4 (1) ◽  
Author(s):  
Kame S El-Darwish ◽  
Martti Parvinen ◽  
Jorma Toppari
Keyword(s):  
Transcription Factors ◽  
Differential Expression

Differential expression of the transcription factors MarA, Rob, and SoxS of Salmonella Typhimurium in response to sodium hypochlorite: down-regulation of rob by MarA and SoxS

2012 ◽  
Vol 194 (11) ◽  
pp. 933-942 ◽  
Author(s):  
B. Collao ◽  
E. H. Morales ◽  
F. Gil ◽  
R. Polanco ◽  
I. L. Calderón ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Salmonella Typhimurium ◽  
Differential Expression ◽  
Sodium Hypochlorite ◽  
Down Regulation

scholarly journals FKBP-related ncRNA-mRNA axis in breast cancer

2020 ◽  
Author(s):  
Hanchu Xiong ◽  
Zihan Chen ◽  
Wenwen Zheng ◽  
Jing Sun ◽  
Qingshuang Fu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factors ◽  
Differential Expression ◽  
Pathway Analysis ◽  
Kegg Pathway ◽  
Ppi Network ◽  
Hub Genes ◽  
Go Annotation ◽  
Prognostic Analysis ◽  
Kegg Pathway Analysis

Abstract Background Breast cancer (BC) is a disease with morbidity ranking the first of women worldwidely. FK506-binding protein (FKBP) family has been demonstrated to possess various functions by interacting with different molecular targets in BC. However, a comprehensive ncRNA-mRNA regulatory axis of FKBP has not yet been reported. Methods FKBP related miRNAs were obtained from miRWalk database. Then, potential lncRNAs, transcription factors as well as mRNAs of screened differentially expressed miRNAs (DE-miRNAs) were analysed by using LncBase v.2, miRGen v3 and miRWalk database. Additionally, differential expression and prognostic analysis of lncRNAs were evaluated using TANRIC database. Next, GO annotation and KEGG pathway analysis were processed using DAVID database. Protein-Protein Interaction (PPI) network was established and hub genes were identified using STRING database. Finally, differential expression and prognostic analysis of hub genes were further conducted using UALCAN and bc-GenExMiner v4.2 database, respectively. Results Eleven DE-miRNAs, consisting of four FKBP4 related DE-miRNAs and seven FKBP5 related DE-miRNAs, were screened. 482 predicted lncRNAs were found for DE-miRNAs. Then, expression and prognostic results of nine of top twenty lncRNAs of BC were significantly identified. LINC00662 and LINC00963 expression were significantly associated with patients’ overall survival (OS). Then, nine potential upstream transcription factors were identified in motifs of DE-miRNAs. 320 target genes were identified for GO annotation and KEGG pathway analysis, which were mainly enriched in cysteine-type endopeptidase activity involved in apoptotic process. Construction and analysis in PPI network showed that RAB7A was selected as a hub gene with the toppest connectivity scores. Differential expression analysis of nine in top ten hub genes of BC were significantly identified. RAB7A and ARRB1 expression were significantly related with BC patients’ OS. Conclusions In current study, we firstly established a predicted FKBP-related ncRNA-mRNA regulatory network, thus exploring a comprehensive interpretation of molecular mechanisms and providing potential clues in seeking novel therapeutics for BC. In the future, much more experiments should be conducted to verify our findings.

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