scholarly journals Intracellular Signaling Mechanisms Involved in the Biological Effects of the Xanthophyll Carotenoid Astaxanthin to Prevent the Photo‐aging of the Skin in a Reactive Oxygen Species Depletion‐independent Manner: The Key Role of Mitogen and Stress‐activated Protein Kinase 1

2018 ◽  
Vol 95 (2) ◽  
pp. 480-489 ◽  
Author(s):  
Genji Imokawa
Keyword(s):  
Reactive Oxygen Species ◽  
Protein Kinase ◽  
Intracellular Signaling ◽  
Biological Effects ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Independent Manner ◽  
Signaling Mechanisms

The role of nitric oxide, reactive oxygen species, and protein kinase C in oxytocin-induced cardioprotection in ischemic rat heart

Peptides ◽  
2012 ◽  
Vol 37 (2) ◽  
pp. 314-319 ◽  
Author(s):  
Mahdieh Faghihi ◽  
Ali Mohammad Alizadeh ◽  
Vahid Khori ◽  
Mostafa Latifpour ◽  
Saeed Khodayari
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Rat Heart ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Kinase C

scholarly journals NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species

2015 ◽  
Vol 2015 ◽  
pp. 1-25 ◽  
Author(s):  
Rajeshwary Ghosh ◽  
Azra Alajbegovic ◽  
Aldrin V. Gomes
Keyword(s):  
Reactive Oxygen Species ◽  
Cardiovascular Diseases ◽  
Side Effects ◽  
Intracellular Signaling ◽  
Reactive Oxygen ◽  
Cell Types ◽  
Oxygen Species ◽  
Beneficial Effects ◽  
Increased Risk

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs worldwide. NSAIDs are used for a variety of conditions including pain, rheumatoid arthritis, and musculoskeletal disorders. The beneficial effects of NSAIDs in reducing or relieving pain are well established, and other benefits such as reducing inflammation and anticancer effects are also documented. The undesirable side effects of NSAIDs include ulcers, internal bleeding, kidney failure, and increased risk of heart attack and stroke. Some of these side effects may be due to the oxidative stress induced by NSAIDs in different tissues. NSAIDs have been shown to induce reactive oxygen species (ROS) in different cell types including cardiac and cardiovascular related cells. Increases in ROS result in increased levels of oxidized proteins which alters key intracellular signaling pathways. One of these key pathways is apoptosis which causes cell death when significantly activated. This review discusses the relationship between NSAIDs and cardiovascular diseases (CVD) and the role of NSAID-induced ROS in CVD.

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