Rosmarinic Acid: A Naturally Occurring Plant Based Agent Prevents Impaired Mitochondrial Dynamics and Apoptosis in Ultraviolet‐B ‐Irradiated Human Skin Cells

2021 ◽  
Author(s):  
Divya Gupta ◽  
Archoo Sajida ◽  
Naikoo Hussain Shahid ◽  
Sheikh Abdullah Tasduq
Keyword(s):  
Human Skin ◽  
Rosmarinic Acid ◽  
Mitochondrial Dynamics ◽  
Ultraviolet B ◽  
Skin Cells ◽  
Naturally Occurring ◽  
Human Skin Cells

scholarly journals Baicalein Protects Human Skin Cells against Ultraviolet B-Induced Oxidative Stress

2016 ◽  
Vol 24 (6) ◽  
pp. 616-622 ◽  
Author(s):  
Min Chang Oh ◽  
Mei Jing Piao ◽  
Pattage Madushan Dilhara Jayatissa Fernando ◽  
Xia Han ◽  
Susara Ruwan Kumara Madduma Hewage ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Skin ◽  
Ultraviolet B ◽  
Skin Cells ◽  
Human Skin Cells

scholarly journals Exogenous Antioxidants Impact on UV-Induced Changes in Membrane Phospholipids and the Effectiveness of the Endocannabinoid System in Human Skin Cells

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1260
Author(s):  
Agnieszka Gęgotek ◽  
Anna Jastrząb ◽  
Marta Dobrzyńska ◽  
Michał Biernacki ◽  
Elżbieta Skrzydlewska
Keyword(s):  
Ascorbic Acid ◽  
Cell Viability ◽  
Human Skin ◽  
Phospholipid Fatty Acid ◽  
Antioxidant Properties ◽  
Endocannabinoid System ◽  
Membrane Phospholipids ◽  
Skin Cells ◽  
Human Skin Cells ◽  
Induced Changes

Natural antioxidants effectively counteract changes caused by UV radiation in human skin cells. However, their action is limited due to their lipo/hydrophilicity. Therefore, the aim of this study was to analyze the mutual protective action of hydrophilic ascorbic acid and partially lipophilic rutin against UVA/UVB-induced changes in membranes phospholipid and endocannabinoid system in keratinocytes and fibroblasts. Obtained results clearly showed that, despite the stronger antioxidant properties of ascorbic acid, the lipid membranes were more effectively protected against UV-induced oxidation by rutin, including changes in phospholipid fatty acid levels, prevention against reactive aldehydes formation and endocannabinoids degradation. Ascorbic acid more strongly prevented UV-induced endocannabinoid receptors expression in fibroblasts, especially CB1. However, the combined action of used antioxidants resulted in the greatest cytoprotective effect, which was evident in the inflammatory marker TNFα down-regulation and increased cell viability following cell irradiation. The applied mixture of antioxidants showed a stronger protective in relation to membrane phospholipids in keratinocytes and in the endocannabinoid system in fibroblasts. In conclusion, it can be suggested that combined antioxidant capacities of ascorbic acid and rutin protects against lipid peroxidation but also decreases the UV-induced inflammation by direct interaction with the endocannabinoid system, thus increasing skin cell viability.

Basic Red 51, a permitted semi-permanent hair dye, is cytotoxic to human skin cells: Studies in monolayer and 3D skin model using human keratinocytes (HaCaT)

2014 ◽  
Vol 227 (2) ◽  
pp. 139-149 ◽  
Author(s):  
Thalita B. Zanoni ◽  
Manoela Tiago ◽  
Fernanda Faião-Flores ◽  
Silvia B. de Moraes Barros ◽  
Aalt Bast ◽  
...  
Keyword(s):  
Human Skin ◽  
Human Keratinocytes ◽  
Skin Model ◽  
Hair Dye ◽  
Skin Cells ◽  
Human Skin Cells ◽  
3D Skin

scholarly journals Effects of a complex mixture prepared from agrimonia, houttuynia, licorice, peony, and phellodendron on human skin cells

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kyung-Ha Lee ◽  
Jeong Pyo Lee ◽  
Wanil Kim
Keyword(s):  
Human Skin ◽  
Complex Mixture ◽  
Skin Barrier ◽  
Aging Effect ◽  
Human Keratinocytes ◽  
Skin Barrier Function ◽  
Active Ingredients ◽  
Γ Irradiation ◽  
Skin Cells ◽  
Human Skin Cells

AbstractActive ingredients derived from natural sources are widely utilized in many industries. Cosmetic active ingredients are largely derived from various plants. In this study, we examined whether a mixture of plant extracts obtained from agrimonia, houttuynia, licorice, peony, and phellodendron (hereafter AHLPP), which are well-known for their effects on skin, could affect skin barrier function, inflammation, and aging in human skin cells. We also determined whether AHLPP extracts sterilized using γ-irradiation (to avoid preservatives) retained their skin cell regulating activity. The AHLPP mixture could downregulate representative pro-inflammatory cytokines including IL 1-β and IL 7. Procollagen peptide synthesis was also increased by AHLPP treatment along with mRNA upregulation of barrier proteins such as filaggrin and desmoplakin. The AHLPP mixture showed an anti-aging effect by significantly upregulating telomerase activity in human keratinocytes. We further observed TERT upregulation and CDKN1B downregulation, implying a weakening of pro-aging signal transduction. Co-cultivation of a hydrogel polymer containing the AHLPP mixture with human skin cells showed an alteration in skin-significant genes such as FLG, which encodes filaggrin. Thus, the AHLPP mixture with or without γ-irradiation can be utilized for skin protection as it alters the expression of some significant genes in human skin cells.

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