Contribution of the Mutation T865G in TPH1 Gene to the Genetic Potentiality of Housed Mongolian Sheep to Year‐round Breeding

2021 ◽  
Author(s):  
Chenhui Liu ◽  
Xunping Jiang ◽  
Shaxuan Chi ◽  
Dongdong Bo ◽  
Guiqiong Liu
Keyword(s):  
Mongolian Sheep

scholarly journals Whole Genome Sequencing Reveals the Effects of Recent Artificial Selection on Litter Size of Bamei Mutton Sheep

Animals ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 157
Author(s):  
Yaxin Yao ◽  
Zhangyuan Pan ◽  
Ran Di ◽  
Qiuyue Liu ◽  
Wenping Hu ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Litter Size ◽  
Artificial Selection ◽  
Estrogen Signaling ◽  
Meat Production ◽  
Domestic Sheep ◽  
Whole Genome ◽  
Nonsynonymous Mutation ◽  
Demethylase Activity ◽  
Mongolian Sheep

Bamei mutton sheep is a Chinese domestic sheep breed developed by crossing German Mutton Merino sheep and indigenous Mongolian sheep for meat production. Here, we focused on detecting candidate genes associated with the increasing of the litter size in this breeds under recent artificial selection to improve the efficiency of mutton production. We selected five high- and five low-fecundity Bamei mutton sheep for whole-genome resequencing to identify candidate genes for sheep prolificacy. We used the FST and XP-EHH statistical approach to detect the selective sweeps between these two groups. Combining the two selective sweep methods, the reproduction-related genes JUN, ITPR3, PLCB2, HERC5, and KDM4B were detected. JUN, ITPR3, and PLCB2 play vital roles in GnRH (gonadotropin-releasing hormone), oxytocin, and estrogen signaling pathway. Moreover, KDM4B, which had the highest FST value, exhibits demethylase activity. It can affect reproduction by binding the promoters of estrogen-regulated genes, such as FOXA1 (forkhead box A1) and ESR1 (estrogen receptor 1). Notably, one nonsynonymous mutation (p.S936A) specific to the high-prolificacy group was identified at the TUDOR domain of KDM4B. These observations provide a new opportunity to research the genetic variation influencing fecundity traits within a population evolving under artificial selection. The identified genomic regions that are responsible for litter size can in turn be used for further selection.

Isolation, culture, and induced multiple differentiation of Mongolian sheep bone marrow-derived mesenchymal stem cells

2014 ◽  
Vol 50 (5) ◽  
pp. 464-474 ◽  
Author(s):  
Zongzheng Liu ◽  
Wei Wang ◽  
Jinfang Gao ◽  
Huanmin Zhou ◽  
Yanru Zhang
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Multiple Differentiation ◽  
Mongolian Sheep

scholarly journals Amino Acid Polymorphisms of PrP Gene in Mongolian Sheep

2003 ◽  
Vol 65 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Altangerel GOMBOJAV ◽  
Naotaka ISHIGURO ◽  
Motohiro HORIUCHI ◽  
Dorj SERJMYADAG ◽  
Badarch BYAMBAA ◽  
...  
Keyword(s):  
Amino Acid ◽  
Mongolian Sheep ◽  
Prp Gene

THE SEASONAL EFFECTS ON IMF CONTENT OF FAS mRNA EXPRESION IN MUSCLES OF MONGOLIAN SHEEP

2018 ◽  
Vol 21 (02) ◽  
pp. 43-48 ◽  
Author(s):  
Erkigul B ◽  
Gerelt B ◽  
Damdinsuren L
Keyword(s):  
Gene Expression ◽  
Mrna Expression ◽  
Expression Level ◽  
Seasonal Effects ◽  
Seasonal Effect ◽  
Triceps Brachii ◽  
Significant Difference ◽  
Fas Mrna ◽  
Mongolian Sheep ◽  
Imf Content

This survey’s aim was to investigate the seasonal effect of Fatty acid synthesis (FAS) expression on intramuscular fat (IMF) content in grazing Mongolian, Ujumqin and grain-fed Ujumqin sheep. Different skeletal muscles of sheep (biceps femoris, longissimus dorsi and triceps brachii) were sampled to measure IMF content and total RNA was extracted to determine FAS mRNA expression levels by real-time PCR. The result revealed that: (1) The difference in IMF content in the muscles of Mongolian sheep grazed in summer was observed to be much higher than sheep grazed in winter (p<0.01). Also there was significant difference in IMF content in the muscles of Ujumqin sheep grazed in summer than winter (p<0.05). The mRNA expression level of FAS in muscles of winter grazing Mongolian sheep was significantly higher than summer (p<0.05). The seasonal effects on IMF content in the muscles and it’s FAS mRNA gene expression was all negative correlated between the sheep breeds. Accordingly, grazing Mongolian sheep’s FAS gene expression level was very high negatively correlated (r=-0.964). This study suggested that grazing Mongolian and Ujumqin sheep able to store large amount of IMF under depends on seasonal effects.

The result of in vitro fertilazation of Mongolian sheep oocytes

2019 ◽  
Vol 28 (03) ◽  
pp. 9-14
Author(s):  
Erdenetogtoh P ◽  
Otgonjargal S ◽  
Ganbat S
Keyword(s):  
In Vitro Culture ◽  
Fertilization Rate ◽  
Development Stage ◽  
Developmental Competence ◽  
Mongolian Sheep

The effects of astaxanthin (Ax) were tested in ovine oocytes during the maturational culture. Oocytes were cultured for 22 hours in with or without 500 ng/ml Ax. Oocytes and embryos were cultured in the multi-incubator with 39°C till the development stage of blastocysts during 7 days. After maturational culture, the embryos transferred to the synchronized recipients. Fertilization rate was similar in Ax-treated oocytes and in non-treated oocytes. The development of blastocysts in the Ax-treated oocytes tended to be higher than in non-treated oocytes (P=0.06). These results indicate that Ax treatment improves the developmental competence of ovine oocytes. The first lamps were born in Mongolia using the method of in vitro culture. Монгол хонины өндгөн эсийг in vitro орчинд үр тогтоосон дүн Бид хонины өндгөн эсийг in vitro орчинд үр тогтооход астаксантин бодис хэрхэн нөлөөлөхийг судлав. Өндгөн эсийг 22 цагийн турш 500 ng/ml астаксантин (Ax) агуулсан болон агуулаагүй орчинд бойжуулж үр тогтоолыг хийв. Үр тогтсон хөврөлийн 39оС мульт-инкубаторт 7 хоног байлгаж бластоцист шат хүртэл нь өсгөвөрлөсний дараа тээгч хээлтэгчид шилжүүлэн суулгав. Астаксантин агуулсан болон агуулаагүй орчинд үр тогтолтын үр дүн бодитой ялгаа байхгүй байв. Харин бластоцистийн шат хүртэл хөгжих үед астаксантин бүхий орчинд өсгөвөрлөсөн хөврөлийн хөгжил астаксингүй орчныхоос илүү байв (P=0.06). Энэ нь үр тогтсоны дараа хөврөлийн цаашдын хөгжилд астаксантин эерэг нөлөөтэй болохыг илэрхийлж байна. Монгол орны нөхцөлд анх удаа in vitro орчинд өсгөвөрлөсөн хөврөлийн гаралтай хурга гаргаж авав. Түлхүүр үг: өндгөн эс, морул, бластоцист, хөврөл, антиоксидант

The Effects of Elimination of Fungi on Microbial Population and Fiber Degradation in Sheep Rumen

2013 ◽  
Vol 295-298 ◽  
pp. 224-231 ◽  
Author(s):  
Ai Wu Gao ◽  
Hai Rong Wang ◽  
Jin Li Yang ◽  
Cai Xia Shi
Keyword(s):  
Real Time ◽  
Real Time Pcr ◽  
Culture Method ◽  
Control Group ◽  
Cellulolytic Bacteria ◽  
Fiber Degradation ◽  
Sheep Rumen ◽  
Bacteria And Fungi ◽  
Mongolian Sheep

The role of microbes in fiber degradation and the relations among the microbes in sheep rumen were explored by in vivo elimination of fungi. The experiment was conducted on 6 Mongolian sheep with fistulae approximately 1.5 years old (35kg). The sheep were randomly divided into two groups, treatment group (n=3) and control group (n=3). The rumen fluids were collected from the rumen though fistulae. The results showed that the total numbers of bacteria, cellulolytic bacteria and protozoa in the rumen were significantly increased (P<0.05) after fungus elimination. Among the three main cellulolytic bacteria, the number of R.flavefaciens and F.succinogenes increased significant (P<0.05). Elimination of fungi significantly reduced the degradation of DM, NDF and ADF, and the activity of CMCase in sheep rumen (P<0.05). The number of total rumen bacteria and fungi detected by real-time PCR were about 10 times and 1,000 times higher than that of the traditional anaerobic culture method, suggesting that real-time PCR is superior to the traditional roller tube culture method.

scholarly journals Origin-related study of genetic diversity and heteroplasmy of Mongolian sheep (Ovis arie) using mitochondrial DNA

2020 ◽  
Vol 35 (2) ◽  
pp. 198-206
Author(s):  
Yi Seul Kim ◽  
Khaliunaa Tseveen ◽  
Badamsuren Batsukh ◽  
Jiyeon Seong ◽  
Hong Sik Kong
Keyword(s):  
Genetic Diversity ◽  
Mitochondrial Dna ◽  
Mongolian Sheep

scholarly journals Effect of Progesterone on the β-Defensin Expression in Epithelial Cells of Mongolian Sheep Fallopian Tubes

2010 ◽  
Vol 30 (5) ◽  
pp. 497-502
Author(s):  
Bo TANG ◽  
Gao-wa XILIN ◽  
Ben-dong FU ◽  
Chen-guang DU ◽  
Gui-fang CAO
Keyword(s):  
Epithelial Cells ◽  
Fallopian Tubes ◽  
Mongolian Sheep

DNA methylation analysis of exon-1 of the ovine HOXC-8 gene in Mongolian sheep using bisulphite sequencing

2012 ◽  
Vol 40 (3) ◽  
pp. 198-202 ◽  
Author(s):  
Qi Chen ◽  
Liling Zhang ◽  
Jing Zhao ◽  
Yuehui Ma
Keyword(s):  
Dna Methylation ◽  
Methylation Analysis ◽  
Bisulphite Sequencing ◽  
Exon 1 ◽  
Mongolian Sheep ◽  
Dna Methylation Analysis

Histological study of germ cells development and apoptosis in mongolian sheep fetal ovaries

2008 ◽  
Vol 103 (1-2) ◽  
pp. 179-186 ◽  
Author(s):  
Aladaer Qi ◽  
ZP Zhang ◽  
GF Cao ◽  
Y. Zhang
Keyword(s):  
Germ Cells ◽  
Histological Study ◽  
Mongolian Sheep
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