PERIPHERAL BLOOD BASOPHILS PREDICT ASTHMA CONTROL: A ONE‐MONTH PROSPECTIVE COHORT STUDY

Aims:To test the hypothesis that compliance with a hospital protocol on peripheral blood culture (PBC) collection in adults is associated with a reduction in PBC contamination, and to investigate likely contributing factors for contamination.Methods:A prospective cohort study was conducted, utilising data collection by participant questionnaire completion, and utilising bacteriology laboratory results on PBCs. Participants were all healthcare workers involved in obtaining PBCs from adults.Results:1460 PBCs with questionnaires were received. Contamination among the 1460 PBCs as a whole was 8.8%. 766 of the questionnaires were sufficiently complete to allow analysis of blood culture contamination in relation to protocol compliance. Among these, protocol compliance was 30% and contamination was 8.0%. When the protocol was complied with, 2.6% of PBCs were contaminated, but when the protocol was not followed, contamination was significantly higher at 10.3% (OR 4.35, 95% CI 1.84 to 12.54). Univariate analysis on all 1460 PBCs suggested that the site for blood collection, and disinfection of the venepuncture site were important factors in PBC contamination: when no venepuncture site disinfection was performed, contamination was significantly higher than when alcohol was used (5.1% versus 15.8%, OR 3.46, 95% CI 2.01 to 5.97); when a PBC collection site other than a fresh peripheral vein was used, contamination was significantly higher (7.3% versus 12.0%, OR 1.75, 95% CI 1.03 to 2.96).Conclusions:Compliance with a hospital protocol on PBC collection technique in adults significantly reduces blood culture contamination.

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Comparison of fractional exhaled nitric oxide, spirometry, and Asthma Control Test, in predicting asthma exacerbations: A prospective cohort study

Lung India ◽

10.4103/lungindia.lungindia_546_19 ◽

2020 ◽

Vol 37 (5) ◽

pp. 394

Author(s):

MohanK Manu ◽

ChandrashekarY Kriti ◽

AswiniK Mohapatra ◽

Asha Kamath

Keyword(s):

Nitric Oxide ◽

Cohort Study ◽

Asthma Control ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Exhaled Nitric Oxide ◽

Control Test ◽

Fractional Exhaled Nitric Oxide ◽

Asthma Control Test ◽

Asthma Exacerbations

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The Relationship of the Test for Respiratory and Asthma Control in Kids Initial Score on the Prognosis of Pre-school Children With Asthma: A Prospective Cohort Study

Frontiers in Pediatrics ◽

10.3389/fped.2021.690333 ◽

2021 ◽

Vol 9 ◽

Author(s):

Lu Liu ◽

Jing Zhang ◽

Lei Zhang ◽

Shu-Hua Yuan ◽

Jin-Hong Wu ◽

...

Keyword(s):

Cohort Study ◽

Asthma Control ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Respiratory Infections ◽

Clinical Manifestations ◽

Ed Visits ◽

Initial Score ◽

The Relationship

Objective: The test for respiratory and asthma control in kids (TRACK) is currently the only standard follow-up tool for children under 5 years of age with asthma. The purpose of this study was to investigate the relationship between the TRACK initial score (Ti) and their prognosis after 6 months of follow-up in pre-schoolers with asthma.Design: A prospective cohort study.Methods: The study included pre-schoolers diagnosed with asthma at the Shanghai Children's Medical Center between January 2019 and June 2020, and follow-up for 6 months. TRACK scores, frequency of wheezing and respiratory infections, number of Emergency Department (ED) visits and treatment regimen were collected. According to the TRACK initial score, the children were divided into “Ti < 60 group” and “Ti ≥ 60 group,” and the two groups were compared in terms of TRACK score related indicators, clinical manifestations and treatment.Results: There are 102 pre-schoolers included in the analysis [78 boys (76.5%) and 24 girls (23.5%); mean (SD) age, 28.05 (11.63) months]. After 6 months of follow-up, the TRACK score was improved in both groups, and the “Ti ≥ 60 group” had a higher score, lower rate of uncontrolled asthma and fewer reassessments were required. There was no difference in the number of wheezing attacks between the two groups in terms of clinical presentation, but the “Ti < 60 group” had more respiratory infections and ED visits. Regarding the use of ICSs, in the “Ti < 60 groups,” the dose of ICSs was higher and reduced slowly, and the dose difference between the two groups began to appear after 5 months of follow-up.Conclusion: TRACK is essential for pre-schoolers with asthma at the time they are diagnosed. In addition, if the TRACK initial score is < 60, the probability of poor prognosis is higher.

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Prospective cohort study of pregnancy complications and birth outcomes in women with asthma

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-018-4800-y ◽

2018 ◽

Vol 298 (2) ◽

pp. 279-287

Author(s):

Nasrin Fazel ◽

Michael Kundi ◽

Erika Jensen-Jarolim ◽

Isabella Pali-Schöll ◽

Asghar Kazemzadeh ◽

...

Keyword(s):

Cohort Study ◽

Gestational Diabetes ◽

Asthma Control ◽

Birth Outcomes ◽

Prospective Cohort Study ◽

Pregnancy Complications ◽

Prospective Cohort ◽

Maternal Outcomes ◽

Total Ige ◽

In Pregnancy

AbstractBackgroundAsthma is the most common potentially serious medical complication in pregnancy. The purpose of this study was to determine the association between maternal asthma and a spectrum of adverse neonatal and maternal outcomes.MethodsEvents during pregnancy and birth outcome were evaluated in 34 asthmatic as well as 1569 non-asthmatic pregnant women who were enrolled in a prospective cohort study undertaken at the antenatal clinics of Mobini Hospital in Iran. The women were interviewed and classified according to clinical severity and asthma control as per GINA guidelines. Information on asthma symptoms was collected by a questionnaire as well as by spirometry and physical examination. All subjects were followed until delivery, and postpartum charts were reviewed to assess neonatal and maternal outcomes. Eosinophil cells counts were obtained and total IgE was measured by ELISA. Results were assessed by multivariate logistic regression adjusting for maternal age and parity, and for birth outcomes, for gestational diabetes, and hypertension/pre-eclampsia.ResultsThe well-known relationship between family history of asthma and asthma in pregnancy was again supported (p < 0.001). Women with asthma had more bleeding events 3 weeks or more before delivery (OR 3.30, 95% CI 1.41–7.26), more often placenta problems (OR 6.86, 95% CI 1.42–33.02), and gestational diabetes mellitus (OR 3.82, 95% CI 1.06–13.75). No significant differences between asthmatic and non-asthmatic mothers regarding duration of gestation, birthweight, low Apgar scores, or neonatal respiratory difficulties were found. Total IgE antibody levels and eosinophil counts did not differ by asthma control and severity.ConclusionsAsthma in pregnancy poses some risk for pregnancy complications and adverse perinatal outcomes. Managing asthma effectively throughout pregnancy could benefit women and their babies and help to reduce the health burden associated with asthma during pregnancy.

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Detection of mammaglobin mRNA in peripheral blood is associated with high grade breast cancer: Interim results of a prospective cohort study

BMC Cancer ◽

10.1186/1471-2407-8-55 ◽

2008 ◽

Vol 8 (1) ◽

Cited By ~ 27

Author(s):

Kaidi Mikhitarian ◽

Renee Hebert Martin ◽

Megan Baker Ruppel ◽

William E Gillanders ◽

Rana Hoda ◽

...

Keyword(s):

Breast Cancer ◽

Cohort Study ◽

Prospective Cohort Study ◽

Peripheral Blood ◽

Prospective Cohort ◽

High Grade

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Association Between Sleep Characteristics and Asthma Control in Middle-Aged and Older Adults: A Prospective Cohort Study

Journal of Asthma and Allergy ◽

10.2147/jaa.s301444 ◽

2021 ◽

Vol Volume 14 ◽

pp. 325-334

Author(s):

Suguru Sato ◽

Junpei Saito ◽

Atsuro Fukuhara ◽

Manabu Uematsu ◽

Yasuhito Suzuki ◽

...

Keyword(s):

Older Adults ◽

Cohort Study ◽

Asthma Control ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Middle Aged

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SARS-CoV-2 responsive T cell numbers are associated with protection from COVID-19: A prospective cohort study in keyworkers

10.1101/2020.11.02.20222778 ◽

2020 ◽

Cited By ~ 5

Author(s):

David Wyllie ◽

Ranya Mulchandani ◽

Hayley E Jones ◽

Sian Taylor-Phillips ◽

Tim Brooks ◽

...

Keyword(s):

T Cells ◽

Cohort Study ◽

T Cell ◽

Prospective Cohort Study ◽

Peripheral Blood ◽

Prospective Cohort ◽

T Cell Responses ◽

Cell Numbers ◽

Cell Responses ◽

Immune Correlates

AbstractBackgroundImmune correlates of protection from COVID-19 are important, but incompletely understood.MethodsWe conducted a prospective cohort study in 2,826 participants working in hospitals and Fire and Police services in England, UK during the pandemic(ISRCTN5660922). Of these, 2,672 were unselected volunteers recruited irrespective of previous SARS-CoV-2 RT-PCR test results, and 154 others were recruited separately specifically because they previously tested positive. At recruitment in June 2020, we measured numbers of interferon-γ secreting, SARS-CoV-2 responsive T cells using T-SPOT®Discovery SARS-CoV-2 kits (Oxford Immunotec Ltd), and antibodies to SARS-CoV-2 proteins using commercial immunoassays. We then described time to microbiologically confirmed SARS-CoV-2 infection, stratified by immunological parameters.ResultsT cells responsive to the spike (S), nuclear (N) and membrane proteins (M) dominated the responses measured. Using the sum of the spots (responsive cells within each well of 250,000 peripheral blood mononuclear cells) for S, N and M antigens minus the control, the 2,672 unselected participants were divided into those with higher responses (n=669, 25.4%; median 30 spots (IQR 18,54)) and those with low responses (n=2016, 76.7%, median 3 (IQR 1,6)), the cutoff we derived being 12 spots. Of the participants with higher T cell responses, 367 (53%) had detectable antibodies against the N or S proteins. During a median of 118 days follow-up, 20 participants with lower T cell responses developed COVID-19, compared with none in the population with high T cell responses (log-rank test, p=6×10−3).ConclusionsPeripheral blood SARS-CoV-2 responsive T cell numbers are associated with risk of developing COVID-19.

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