Difference in outcome between curative intent vs marginal excision as a first treatment in dogs with oral malignant melanoma and the impact of adjuvant CSPG4‐DNA electrovaccination: a retrospective study on 155 cases

Medical records were searched for dogs that had received curative intent surgery for oral malignant melanoma and ipsilateral excisional regional lymph node biopsy. Twenty-seven dogs were operated on and 25 dogs of these dogs met the inclusion criteria of signalment, post-excision margin status, presence of metastasis for each biopsied lymphocentrum, survival time post-excision, presence of recurrence or metastasis at follow-up or at death/euthanasia, location of the primary tumor, and any postoperative adjuvant treatment. These 25 dogs had complete tumor excision with tumor-free margins and 19 (76%) had postoperative adjuvant therapy. Median survival time after excision for the dogs in this study was 335.5 days. Results of this study support previous work that documents prolonged survival time following complete excision of oral malignant melanoma with tumor-free surgical margins in dogs. Additionally, 4 dogs (16%) had histologically confirmed regional lymph node metastasis at the time of definitive surgery.

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Multiple Primary Tumours, How Frequent we can Offer Curative Therapy?

Asian Pacific Journal of Cancer Care ◽

10.31557/apjcc.2020.5.2.71-78 ◽

2020 ◽

Vol 5 (2) ◽

pp. 71-78

Author(s):

Omima Elemam ◽

Seham Abdelkhalek ◽

Doaa Abdelmoety ◽

Reem Baraka ◽

Mervat Yousef

Keyword(s):

Retrospective Study ◽

Primary Tumour ◽

Response To Therapy ◽

Response To Treatment ◽

Curative Treatment ◽

Second Primary ◽

Curative Intent ◽

Multiple Primary Malignancies ◽

Multiple Primary ◽

The Impact

Background: Patients with Multiple-primary Malignancies are usually excluded from clinical trials. Clinical information re-distribution, associations, response to treatment and prognosis are scared. Collecting information will help us to expect the impact of prior therapies and to teach us how to best treat them. This study aims to report cases in our society and to see if we have a special predilection of certain Multiple-primary Malignancies in our region based on different geographic and environmental risk factors. Our retrospective study aims to collect these cases and follow their prognosis and treatment response as well as looking for any relation to cancer therapy. Methods: A retrospective study included patients who have two or more histologically diverse primary malignancy, either as synchronous or metachronous malignancy. The study was conducted in King Abdullah Medical City, Saudi Arabia over 7 years period from 2012 to 2019. We collected all patient’s clinicopathological information, treatment, and modalities. Results: We collected 53 cases of multiple primary malignancies 26were synchronous (48%) and 27 were metachronous (52%). Out of 53 patients, 29 (60 %) were females and 14 (40 %) were males. The most common sites for synchronous are breast and endometrial cancer. Curative treatment could be offered in 19 patients (73%). For metachronous tumours, the most common primary tumour was breast cancer, while the most common second malignancy was colorectal cancer. Curative treatment could be offered in 15 patients (53%). Conclusion: Multiple primary malignancies represent a small proportion of our cases, with no special predilection in our society. Multiple primary malignancies did not signify a poor prognosis; besides nonmetastatic cases showed a good response to therapy. We should not forget the possibility of a second primary tumour as these cases can be reasonably treated with curative intent.

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Positron emission tomography and ultrasonography. A comparative retrospective study assessing the diagnostic validity in lymph node metastases of malignant melanoma

Archives of Dermatology ◽

10.1001/archderm.131.12.1394 ◽

1995 ◽

Vol 131 (12) ◽

pp. 1394-1398 ◽

Cited By ~ 17

Author(s):

C. Blessing

Keyword(s):

Positron Emission Tomography ◽

Lymph Node ◽

Retrospective Study ◽

Malignant Melanoma ◽

Lymph Node Metastases ◽

Emission Tomography ◽

Diagnostic Validity ◽

Positron Emission ◽

Node Metastases

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Faculty Opinions recommendation of The impact of curative intent surgery on the survival of pancreatic cancer patients: a U.S. Population-based study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1088860.541976 ◽

2007 ◽

Author(s):

Waqar Qureshi

Keyword(s):

Pancreatic Cancer ◽

Cancer Patients ◽

Population Based ◽

Curative Intent ◽

Population Based Study ◽

The Impact

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Pleural Solitary Fibrous Tumors—A Retrospective Study on 45 Patients

Medicina ◽

10.3390/medicina56040185 ◽

2020 ◽

Vol 56 (4) ◽

pp. 185 ◽

Cited By ~ 1

Author(s):

Cornel Savu ◽

Alexandru Melinte ◽

Radu Posea ◽

Niculae Galie ◽

Irina Balescu ◽

...

Keyword(s):

Retrospective Study ◽

Ct Scan ◽

Single Case ◽

Postoperative Mortality ◽

Diagnostic Methods ◽

Chest Wall Resection ◽

En Bloc ◽

Curative Intent ◽

Solitary Fibrous Tumors ◽

Thoracic Ct

Introduction: The purpose of this paper is to study the type, the clinical presentation, and the best diagnostic methods for pleural solitary fibrous tumors (PSFTs), as well as to evaluate which is the most appropriate treatment, especially as PSFTs represent a rare occurrence in the thoracic pathology. Material and Method: A retrospective study was conducted on a group of 45 patients submitted to surgery between January 2015 and December 2019. In most cases, the diagnosis was established through imaging studies—thoracic computed tomography (CT) scan with or without contrast—but also using magnetic resonance imaging (MRI) or positron emission tomography (PET) scans when data from CT scans were scarce. All patients were submitted to surgery with curative intent. Results: Most patients included in this study were asymptomatic, with this pathology being more common in patients over 60 years of age, and more common in women. The occurrence of malignant PSFT in our study was 17.77% (8 cases). All cases were submitted to surgery with curative intent, with a single case developing further recurrence. In order to achieve complete resection en bloc resection of the tumor with the chest wall, resection was performed in two cases, while lower lobectomy, pneumectomy, and hemidiaphragm resection, respectively, were needed in each case. Postoperative mortality was null. Conclusion: Thoracic CT scan remains the most important imagistic investigation in diagnosing. MRI is superior to thoracic CT, especially in cases that involved the larger blood vessels within the thorax, spinal column, or diaphragm. Complete surgical resection is the gold standard in treatment of PSFT, and the prognosis in benign cases is very good.

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Diagnosis and treatment delay of head and neck cancers during COVID-19 era in a tertiary care academic hospital: what should we expect?

European Archives of Oto-Rhino-Laryngology ◽

10.1007/s00405-021-06834-1 ◽

2021 ◽

Author(s):

Pietro De Luca ◽

Antonella Bisogno ◽

Vito Colacurcio ◽

Pasquale Marra ◽

Claudia Cassandro ◽

...

Keyword(s):

Retrospective Study ◽

Head And Neck ◽

Retrospective Analysis ◽

Tertiary Care ◽

Diagnostic Delay ◽

Treatment Delay ◽

Head And Neck Cancers ◽

Control Measures ◽

Academic Hospital ◽

The Impact

Abstract Background Since the spreading of SARS-CoV-2 from China, all deferrable medical activities have been suspended, to redirect resources for the management of COVID patients. The goal of this retrospective study was to investigate the impact of COVID-19 on head and neck cancers’ diagnosis in our Academic Hospital. Methods A retrospective analysis of patients treated for head and neck cancers between March 12 and November 1, 2020 was carried out, and we compared these data with the diagnoses of the same periods of the 5 previous years. Results 47 patients were included in this study. We observed a significative reduction in comparison with the same period of the previous 5 years. Conclusions Our findings suggest that the COVID-19 pandemic is associated with a decrease in the number of new H&N cancers diagnoses, and a substantial diagnostic delay can be attributable to COVID-19 control measures.

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Increased Emergency Calls during the COVID-19 Pandemic in Saudi Arabia: A National Retrospective Study

Healthcare ◽

10.3390/healthcare9010014 ◽

2020 ◽

Vol 9 (1) ◽

pp. 14

Author(s):

Ahmed Al-Wathinani ◽

Attila J. Hertelendy ◽

Sultana Alhurishi ◽

Abdulmajeed Mobrad ◽

Riyadh Alhazmi ◽

...

Keyword(s):

Saudi Arabia ◽

Retrospective Study ◽

Emergency Medical Services ◽

Indirect Effect ◽

Mobile Application ◽

Healthcare Systems ◽

Emergency Calls ◽

The World ◽

Staffing Patterns ◽

The Impact

The coronavirus 2019 (COVID-19) pandemic has a direct and indirect effect on the different healthcare systems around the world. In this study, we aim to describe the impact on the utilization of emergency medical services (EMS) in Saudi Arabia during the COVID-19 pandemic. We studied cumulative data from emergency calls collected from the SRCA. Data were separated into three periods: before COVID-19 (1 January–29 February 2020), during COVID-19 (1 March–23 April 2020), and during the Holy Month of Ramadan (24 April–23 May 2020). A marked increase of cases was handled during the COVID-19 period compared to the number before pandemic. Increases in all types of cases, except for those related to trauma, occurred during COVID-19, with all regions experiencing increased call volumes during COVID-19 compared with before pandemic. Demand for EMS significantly increased throughout Saudi Arabia during the pandemic period. Use of the mobile application ASAFNY to request an ambulance almost doubled during the pandemic but remained a small fraction of total calls. Altered weekly call patterns and increased call volume during the pandemic indicated not only a need for increased staff but an alteration in staffing patterns.

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