scholarly journals A COMPARATIVE STUDY OF ANTIBACTERIAL AND ANTI-INFLAMMATORY EFFECTS OF MOUTHRINSE CONTAINING TEA TREE OIL

2017 ◽  
Vol 10 (1) ◽  
pp. 59 ◽  
Author(s):  
C Salvatori
Keyword(s):  
Comparative Study ◽  
Tea Tree Oil ◽  
Tea Tree ◽  
Anti Inflammatory

scholarly journals INHIBITORY EFFECTS ON TUMOR NECROSIS FACTOR ALPHA AND INTERLEUKIN 12 USING CLOBETASOL PROPIONATE LOADED TEA TREE OIL NANOEMULSION GEL ON ANIMAL MODEL

2018 ◽  
Vol 11 (6) ◽  
pp. 182
Author(s):  
Md Sarfaraz Alam ◽  
Mohamammad Daud Ali ◽  
Md Salahuddin Ansari ◽  
Pankaj Sharma
Keyword(s):  
Clobetasol Propionate ◽  
Interleukin 12 ◽  
Tea Tree Oil ◽  
Necrosis Factor Alpha ◽  
Tea Tree ◽  
Tnf Α ◽  
Nanoemulsion Gel ◽  
Factor Alpha ◽  
Anti Inflammatory ◽  
Necrosis Factor

Objective: The main objective of our study is to explore anti-inflammatory activity at its molecular level like tumor necrosis factor alpha (TNF-α), interleukin 12 (IL-12) expression, and histopathological study.Methods: As per solubility/miscibility of clobetasol propionate (CP) with tea tree oil (TTO), surfactant and cosurfactant (Smix), and water in a ratio of oil:Smix:water (15:35:50) taken in milliliter for the preparation of nanoemulsion. Induced allergic contact dermatitis (ACD) with dinitrofluorobenzene (DNFB) was used for the study. TNF-α and interleukin 12 (IL-12) were estimated with rabbit antimouse TNF-α and rat antimouse IL-12 antibodies in 1% of bovine serum albumin in phosphate buffer.Results: Topical application of CP loaded nanoemulsion gel inhibits ear inflammation and erythema in DNFB-induced ACD in mice and significantly reduces the intracellular edema and infiltration with inflammatory mediator cells involving of mononuclear cells and neutrophils. CP loaded nanoemulsion gel reduces expression of protein level of TNF-α and IL-12.Conclusion: CP loaded nanoemulsion gel confirmed that anti-inflammatory effects showed more rapidly than the placebo and marketed gel preparation. However, the animals treated with placebo nanoemulsion gel showed a somehow comparable reduction of their inflammation during treatment compared with the marketed gel. This effect may be due to anti-inflammatory effect of TTO. This result suggested that anti-inflammatory activity of placebo nanoemulsion gel may be due to TTO present in nanoemulsion as vehicle.

Comparison of the efficacy of tea tree (Melaleuca alternifolia) oil with other current pharmacological management in human demodicosis: A Systematic Review

Parasitology ◽  
2020 ◽  
Vol 147 (14) ◽  
pp. 1587-1613
Author(s):  
Nelson Siu Kei Lam ◽  
Xin Xin Long ◽  
Xuegang Li ◽  
Li Yang ◽  
Robert C Griffin ◽  
...  
Keyword(s):  
Side Effects ◽  
Cost Effective ◽  
Research Needs ◽  
Tea Tree Oil ◽  
Melaleuca Alternifolia ◽  
Pharmacological Management ◽  
Tea Tree ◽  
Anti Inflammatory ◽  
Anti Fungal ◽  
Delivery Technology

AbstractVarious treatments are found to be moderately effective in managing Demodex-related diseases except tea tree oil (TTO) and terpinen-4-ol (T4O), which showed superior miticidal and anti-inflammatory effects in numerous clinical studies. Their possible effects include lowering mite counts, relieving Demodex-related symptoms, and modulating the immune system. This review summarizes the current clinical topical and oral treatments in human demodicosis, their possible mechanisms of action, side-effects and resistance in treating this condition. TTO (especially T4O) is found to be the most effective followed by metronidazole, ivermectin and permethrin in managing the disease. This is because TTO has anti-parasitic, anti-bacterial, anti-fungal, anti-inflammatory and wound-healing effects. Furthermore, nanoTTO can even release its contents into fungus and Pseudomonas biofilms. Combinations of different treatments are occasionally needed for refractory cases, especially for individuals with underlying genetic predisposal or are immuno-compromised. Although the current treatments show efficacy in controlling the Demodex mite population and the related symptoms, further research needs to be focused on the efficacy and drug delivery technology in order to develop alternative treatments with better side-effects profiles, less toxicity, lower risk of resistance and are more cost-effective.

A comparative study of tea‐tree oil versus benzoylperoxide in the treatment of acne

1990 ◽  
Vol 153 (8) ◽  
pp. 455-458 ◽  
Author(s):  
Ingrid B Bassett ◽  
Ross St C Barnetson ◽  
Debra L Pannowitz
Keyword(s):  
Comparative Study ◽  
Tea Tree Oil ◽  
Tea Tree

scholarly journals Intracellular Replication Inhibitory Effects of Tea Tree Oil on Vesicular Stomatitis Virus and Anti-inflammatory Activities in Vero Cells

2021 ◽  
Vol 8 ◽  
Author(s):  
Qi Shao ◽  
Junjie Huang ◽  
Jingui Li
Keyword(s):  
Viral Infection ◽  
Vesicular Stomatitis Virus ◽  
Skin Diseases ◽  
Quantitative Polymerase Chain Reaction ◽  
Vero Cells ◽  
Tea Tree Oil ◽  
Tea Tree ◽  
Vesicular Stomatitis ◽  
Anti Inflammatory ◽  
In Cells

Viral disease management has been proven difficult, and there are no broadly licensed vaccines or therapeutics. Vesicular stomatitis virus (VSV) is an active pathogen of wild ungulates and livestock; its infection frequently caused irreversible vesicles on the tongue or other positions, leading to enormous economic loss. Tea tree oil (TTO) has been shown to be a popular remedy for many skin diseases owing to its antibacterial, antipruritic, and anti-inflammatory effects. However, the potential effect of TTO on VSV proliferation and the corresponding inflammatory response in cells remain unclear. In this study, methyl thiazolyl tetrazolium assay was used to evaluate the cell viability of TTO, and cytotoxic concentration 50 (CC50) was calculated. Then, fluorescence observation, reverse transcription–quantitative polymerase chain reaction, Western blot (WB), and flow cytometry (FCM) assay were used to evaluate the antiviral effect of TTO against VSV under three manners of pre-infection before medication, co-administration, pretreatment before infection at safe doses to Vero cells. Meanwhile, the mRNA expressions of interleukin 8, tumor necrosis factor α, and ISG56 in cells were also detected. The results showed that the maximum safe concentration of TTO to Vero cells was 0.063% and the CC50 is 0.32%. Most notably, TTO dose-dependently inhibited the VSV GFP fluorescence generation and restrained the replication of VSV in gene and protein levels regardless of the treatment modes. Based on the results of the FCM, effective concentration 50 of TTO against VSV is 0.019%. Similarly, the mRNA expression of the above cytokines induced by viral infection was also remarkably curbed. These findings suggest that TTO emerged blocking, prophylaxis, and treatment action against VSV replication and suppressed the related inflammation in Vero cells. This study provides a novel potential for TTO fighting against viral infection and anti-inflammatory activities in Vero cells.

scholarly journals Tea-tree oil – a naturally occurring biocide

2010 ◽  
Vol 31 (4) ◽  
pp. 182
Author(s):  
Natalie Thomson ◽  
Katherine Hammer ◽  
Thomas Riley
Keyword(s):  
Essential Oil ◽  
Native Plant ◽  
Tea Tree Oil ◽  
Tea Tree ◽  
Resistance To Antibiotics ◽  
Naturally Occurring ◽  
Australian Native Plant ◽  
Anti Inflammatory

Tea-tree oil (TTO) is the essential oil derived from an Australian native plant that has been used for hundreds of years, mainly for its antimicrobial and anti-inflammatory properties. With the advent of ever-increasing resistance to antibiotics and biocides amongst organisms, TTO may play an important role in the health industry in the fight against resistance.

scholarly journals Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

2006 ◽  
Vol 19 (1) ◽  
pp. 50-62 ◽  
Author(s):  
C. F. Carson ◽  
K. A. Hammer ◽  
T. V. Riley
Keyword(s):  
Essential Oil ◽  
Active Component ◽  
Tea Tree Oil ◽  
Melaleuca Alternifolia ◽  
Tea Tree ◽  
Alternative Medicines ◽  
Recent Developments ◽  
Medicinal Properties ◽  
Anti Inflammatory ◽  
Inflammatory Action

SUMMARY Complementary and alternative medicines such as tea tree (melaleuca) oil have become increasingly popular in recent decades. This essential oil has been used for almost 100 years in Australia but is now available worldwide both as neat oil and as an active component in an array of products. The primary uses of tea tree oil have historically capitalized on the antiseptic and anti-inflammatory actions of the oil. This review summarizes recent developments in our understanding of the antimicrobial and anti-inflammatory activities of the oil and its components, as well as clinical efficacy. Specific mechanisms of antimicrobial and anti-inflammatory action are reviewed, and the toxicity of the oil is briefly discussed.

scholarly journals In-Vivo assessment of glucocorticoid loaded tea tree oil nanoemulsion gel

2019 ◽  
Vol 9 (1) ◽  
pp. 108-113
Author(s):  
Md. Sarfaraz Alam ◽  
Rohit Saraswat ◽  
Pankaj Sharma ◽  
Md. Salahuddin Ansari
Keyword(s):  
Aqueous Phase ◽  
Clobetasol Propionate ◽  
Inflammatory Activity ◽  
In Vivo Study ◽  
Nucleoside Triphosphate ◽  
Tea Tree Oil ◽  
Tea Tree ◽  
Nanoemulsion Gel ◽  
Anti Inflammatory

Optimized formulations were subjected to various in vivo studies like anti-inflammatory activity, Nickel induced dermatitis, irritation study and Acute and repeated dose dermal toxicity studies. Clobetasol propionate (CP) has anti-inflammatory, immunomodulatory, and antiproliferative activity. The aim of the present work was to test the hypothesis that the addition CP in nanoemulsions would result in enhancement CP delivery and leading to better antipsoriatic activity. Nanoemulsions were prepared by aqueous phase titration method, using Tea Tree oil, Tween 20, Transcutol P, and distilled water as the oil phase, surfactant, co-surfactant and aqueous phase, respectively.We developed a topical O/W nanoemulsion in which drug is incorporated in disperse phase of oil and evaluated its efficacy against different types of in vivostudies. It was also found that the significantly increased their anti-inflammatory activity. It was reported that CP-loaded nanoemulsion significantly increased NTPDase (Nucleoside triphosphate diphosphohydrolases) activity in lymphocytes. This membrane protein is responsible for the hydrolysis of extracellular ATP (Adenosine triphosphate) which is responsible for cell proliferation, differentiation and inflammatory processes. In vivoirritation studies did not show any irritation in spite of having high amount of surfactant. Group treated with CP loaded nanoemulsion gel showed no evident toxicity even on repeated exposure. On the basis of above in vivo study we conclude that developed nanoemulsion is safe for human. Keywords: Clobetasol propionate, In-vivo study, Nanoemulsion, Anti-inflammatory study, Toxicity study

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