scholarly journals The Relationship of Three-Dimensional Human Skull Motion to Brain Tissue Deformation in Magnetic Resonance Elastography Studies

2017 ◽  
Vol 139 (5) ◽  
Author(s):  
Andrew A. Badachhape ◽  
Ruth J. Okamoto ◽  
Ramona S. Durham ◽  
Brent D. Efron ◽  
Sam J. Nadell ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Brain Tissue ◽  
Human Subjects ◽  
Three Dimensional ◽  
Vital Role ◽  
Magnetic Resonance Elastography ◽  
Phase Lag ◽  
Accelerometer Data ◽  
Pia Mater ◽  
Brain Interface

In traumatic brain injury (TBI), membranes such as the dura mater, arachnoid mater, and pia mater play a vital role in transmitting motion from the skull to brain tissue. Magnetic resonance elastography (MRE) is an imaging technique developed for noninvasive estimation of soft tissue material parameters. In MRE, dynamic deformation of brain tissue is induced by skull vibrations during magnetic resonance imaging (MRI); however, skull motion and its mode of transmission to the brain remain largely uncharacterized. In this study, displacements of points in the skull, reconstructed using data from an array of MRI-safe accelerometers, were compared to displacements of neighboring material points in brain tissue, estimated from MRE measurements. Comparison of the relative amplitudes, directions, and temporal phases of harmonic motion in the skulls and brains of six human subjects shows that the skull–brain interface significantly attenuates and delays transmission of motion from skull to brain. In contrast, in a cylindrical gelatin “phantom,” displacements of the rigid case (reconstructed from accelerometer data) were transmitted to the gelatin inside (estimated from MRE data) with little attenuation or phase lag. This quantitative characterization of the skull–brain interface will be valuable in the parameterization and validation of computer models of TBI.

scholarly journals The Role of Three‐Dimensional Magnetic Resonance Elastography in the Diagnosis of Nonalcoholic Steatohepatitis in Obese Patients Undergoing Bariatric Surgery

Hepatology ◽  
2019 ◽  
Vol 71 (2) ◽  
pp. 510-521 ◽  
Author(s):  
Alina M. Allen ◽  
Vijay H. Shah ◽  
Terry M. Therneau ◽  
Sudhakar K. Venkatesh ◽  
Taofic Mounajjed ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Magnetic Resonance ◽  
Nonalcoholic Steatohepatitis ◽  
Three Dimensional ◽  
Magnetic Resonance Elastography ◽  
Obese Patients

High-resolution mechanical imaging of the human brain by three-dimensional multifrequency magnetic resonance elastography at 7T

NeuroImage ◽  
2014 ◽  
Vol 90 ◽  
pp. 308-314 ◽  
Author(s):  
Jürgen Braun ◽  
Jing Guo ◽  
Ralf Lützkendorf ◽  
Jörg Stadler ◽  
Sebastian Papazoglou ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
High Resolution ◽  
Human Brain ◽  
Three Dimensional ◽  
Magnetic Resonance Elastography ◽  
Mechanical Imaging

scholarly journals Brain tissue viscoelasticity in chronically shunted patients with headaches using Magnetic Resonance Elastography

2015 ◽  
Vol 12 (Suppl 1) ◽  
pp. O30
Author(s):  
Kristy Tan ◽  
Adam L Sandler ◽  
Avital Meiri ◽  
Rick Abbott ◽  
James T Goodrich ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Brain Tissue ◽  
Magnetic Resonance Elastography

Brain magnetic resonance elastography on healthy volunteers: A safety study

2009 ◽  
Vol 50 (4) ◽  
pp. 423-429 ◽  
Author(s):  
Guang-Rui Liu ◽  
Pei-Yi Gao ◽  
Yan Lin ◽  
Jing Xue ◽  
Xiao-Chun Wang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Magnetic Resonance ◽  
Healthy Volunteers ◽  
Human Subjects ◽  
Magnetic Resonance Elastography ◽  
Tissue Elasticity ◽  
Study Results ◽  
Significant Difference ◽  
The Right

Background: Magnetic resonance elastography (MRE) is a recently developed imaging technique that can directly visualize and quantitatively measure tissue elasticity. Purpose: To evaluate the safety of brain MRE on human subjects. Material and Methods: The study included 20 healthy volunteers. MRE sequence scan (drive signal not applied to external force actuator) and MRE study were separately performed on each volunteer at an interval of more than 24 hours. The heart rate and blood pressure of each volunteer were measured immediately before and after MRE sequence scan and MRE study. Electroencephalography (EEG) was also performed within 2 hours after each scan. The volunteers were asked about their experience of the two scans. Randomized-block analysis of variance (ANOVA) was used to analyze the data of blood pressure and heart rate. Paired t test was used to analyze the data of the two EEG examinations. The volunteers were followed up 1 week after the examination. Results: All procedures were performed on each volunteer, and no one complained of obvious discomfort. No related adverse events were reported during follow-up. There was no statistically significant difference in heart rate or blood pressure. There was a statistically significant difference ( P<0.05) in EEG results in the right temporoparietal region. Increased power was found in the theta, delta, alpha, and beta2 bands. No brain injury was detected by the EEG examinations. Conclusion: Based on the study results, brain MRE examinations are safe to perform on human subjects.

scholarly journals Altered brain tissue viscoelasticity in pediatric cerebral palsy measured by magnetic resonance elastography

2019 ◽  
Vol 22 ◽  
pp. 101750 ◽  
Author(s):  
Charlotte A. Chaze ◽  
Grace McIlvain ◽  
Daniel R. Smith ◽  
Gabrielle M. Villermaux ◽  
Peyton L. Delgorio ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Magnetic Resonance ◽  
Brain Tissue ◽  
Magnetic Resonance Elastography ◽  
Pediatric Cerebral Palsy

Diffusion-Weighted and Diffusion Tensor Magnetic Resonance Brain Imaging: Principles and Applications

2003 ◽  
Vol 16 (2) ◽  
pp. 207-220 ◽  
Author(s):  
F. Pizzini ◽  
A. Beltramello ◽  
E. Piovan ◽  
F. Alessandrini
Keyword(s):  
White Matter ◽  
Magnetic Resonance ◽  
Brain Tissue ◽  
Diffusion Weighted Imaging ◽  
Diffusion Tensor ◽  
Three Dimensional ◽  
Functional Studies ◽  
Fiber Tracts ◽  
Normal Appearing White Matter ◽  
Diffusion Weighted

Diffusion Weighted Imaging (DWI) is one of the most recent products of Magnetic Resonance (MR) technology evolution. DWI has been proposed as a noninvasive tool for evaluating structural and physiologic states in biologic tissues as hyperacute ischemic changes within brain tissue. Recently, its more complex and detailed evolution, Diffusion Tensor Imaging (DTI), has been introduced and its clinical applications are the evaluation of anatomical structures and pathologic processes in white matter. White matter quantitative maps that indicate the integrity of brain tissue, color map, and tractography that identifies macroscopic three-dimensional architecture of fiber tracts (e.g., projections and association pathways) can be obtained with DTI. Diffusion weighted imaging visualization techniques (ADC and Trace) are applied for the study of stroke, in the differential diagnosis of expansive lesions (e.g. epidermoid vs. arachnoid cyst) and in detecting traumatic and other lesions associated with restricted diffusion (e.g. MS plaques). On the other hand, DTI provides the identification of abnormalities in the otherwise normal appearing white matter with the understanding of the organization of the fibers, both in tumors and in other cortical or white matter diseases (including stroke, dementias, demyelinating-dismyelinating diseases, epilepsy, schizophrenia). Furthermore, in combination with functional MR, DTI might contribute to the comprehension of brain development, aging and connectivity, thus having a significant impact on brain functional studies.

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