Enhancing Mimetic Three-Dimensional Modeling and Printing for Presurgical Planning Applications: Improved Soft Tissue Assesments, Analyses and Consolidation Strategies

2020 ◽  
Author(s):  
Jorge A. Vergen ◽  
Tinen L. Iles ◽  
Paul A. Iaizzo
Keyword(s):  
Soft Tissue ◽  
3D Printing ◽  
Soft Tissues ◽  
Management Strategies ◽  
Three Dimensional ◽  
University Of Minnesota ◽  
Biaxial Testing ◽  
Presurgical Planning ◽  
Three Dimensional Modeling ◽  
Planning Models

Abstract Mimetic three-dimensional (3D) printing has been shown to enhance presurgical planning and improve patient outcomes. However, data inconsistencies and non-optimized soft tissue data management strategies have impaired efforts to characterize soft tissues and translate biophysical values to 3D printing media durometers and shore values. As a result, finished models are inconsistent and exhibit reduced mimetic qualities. Improving biophysical characterizations of soft tissues, analysis strategies, and consolidation infrastructures are important factors that will improve 3D modeling in a presurgical planning setting. In our ongoing associated studies, both physiologically viable and formalin fixed large mammalian tissues (including human) were assessed using uniaxial and biaxial testing strategies. Biophysical datasets were analyzed using a gated analysis strategy, tailored to data acquisition methods developed within the University of Minnesota Visible Heart® Labs (VHL). A SQL database was then constructed to consolidate analyzed data for future retrieval. This strong preliminary data is a foundation for further development and refinement of future studies. It is our long-term goal that these strategies be improved and adopted to enhance the mimetic qualities of 3D presurgical planning models.

scholarly journals Accuracy and Reliability of Soft Tissue Landmarks Using Three-Dimensional Imaging in Comparison With Two-Dimensional Cephalometrics: A Systematic Review

2020 ◽  
Vol 54 (4) ◽  
pp. 289-296
Author(s):  
Adeeba Ali ◽  
Anil K. Chandna ◽  
Anshul Munjal
Keyword(s):  
Systematic Review ◽  
Soft Tissue ◽  
3D Imaging ◽  
Soft Tissues ◽  
Three Dimensional ◽  
Database Search ◽  
Cochrane Library ◽  
Two Dimensional ◽  
Imaging Tool ◽  
Electronic Database Search

Background: Concerns about the accuracy and reliability of soft tissue landmarks using two-dimensional (2D) and three-dimensional (3D) imaging. Objective: The aim of the systematic review is to estimate accuracy and reliability of soft tissue landmarks with 2D imaging and 3D imaging for orthodontic diagnosis planning and treatment planning purposes. Data Sources: Electronic database search was performed in MEDLINE via PubMed, Embase via embase.com, and the Cochrane library website. Selection Criteria: The data were extracted according to two protocols based on Centre for Evidence-Based Medicine (CEBM) critical appraisal tools. Next, levels of evidence were categorized into three groups: low, medium, and high. Data Synthesis: Fifty-five publications were found through database search strategies. A total of nine publications were included in this review. Conclusion According to the available literature, 3D imaging modalities were more accurate and reliable as compared to 2D modalities. Cone beam computed tomography (CBCT) was considered the most reliable imaging tool for soft tissues.

scholarly journals Polymeric Bioinks for 3D Hepatic Printing

Chemistry ◽  
2021 ◽  
Vol 3 (1) ◽  
pp. 164-181
Author(s):  
Joyita Sarkar ◽  
Swapnil C. Kamble ◽  
Nilambari C. Kashikar
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Soft Tissues ◽  
Three Dimensional ◽  
Stem Cell Differentiation ◽  
Synthetic Polymers ◽  
Bioactive Molecules ◽  
Complex Geometries ◽  
Printing Techniques ◽  
Natural And Synthetic

Three-dimensional (3D) printing techniques have revolutionized the field of tissue engineering. This is especially favorable to construct intricate tissues such as liver, as 3D printing allows for the precise delivery of biomaterials, cells and bioactive molecules in complex geometries. Bioinks made of polymers, of both natural and synthetic origin, have been very beneficial to printing soft tissues such as liver. Using polymeric bioinks, 3D hepatic structures are printed with or without cells and biomolecules, and have been used for different tissue engineering applications. In this review, with the introduction to basic 3D printing techniques, we discuss different natural and synthetic polymers including decellularized matrices that have been employed for the 3D bioprinting of hepatic structures. Finally, we focus on recent advances in polymeric bioinks for 3D hepatic printing and their applications. The studies indicate that much work has been devoted to improvising the design, stability and longevity of the printed structures. Others focus on the printing of tissue engineered hepatic structures for applications in drug screening, regenerative medicine and disease models. More attention must now be diverted to developing personalized structures and stem cell differentiation to hepatic lineage.

A Quantitative Three-Dimensional Assessment of Abnormal Variations in Facial Soft Tissues of Adult Patients with Cleft Lip and Palate

2003 ◽  
Vol 40 (5) ◽  
pp. 544-549 ◽  
Author(s):  
Virgilio F. Ferrario ◽  
Chiarella Sforza ◽  
Claudia Dellavia ◽  
Gianluca M. Tartaglia ◽  
Davide Sozzi ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Cleft Lip ◽  
Soft Tissues ◽  
Cleft Lip And Palate ◽  
Three Dimensional ◽  
Z Score ◽  
Soft Tissue Profile ◽  
Variability Index ◽  
The Mean ◽  
Facial Soft Tissues

Objective To supply quantitative information about the facial soft tissues of adult operated patients with cleft lip and palate (CLP). Design, Setting, and Patients The three-dimensional coordinates of soft tissue facial landmarks were obtained using an electromagnetic digitizer in 18 Caucasian patients with CLP (11 males and 7 females aged 19 to 27 years) and 162 healthy controls (73 females and 89 males aged 18 to 30 years). From the landmarks, 15 facial dimensions and two angles were calculated. Data were compared with those collected in healthy individuals by computing z-scores. Two summary anthropometric measurements for quantifying craniofacial variations were assessed in both the patients and reference subjects: the mean z-score (an index of overall facial size), and its SD, called the craniofacial variability index (an index of facial harmony). Results In treated patients with CLP, facial size was somewhat smaller than in normal individuals, but in all occasions the mean z-score fell inside the normal interval (mean ± 2 SD). Almost all patients had a craniofacial variability index larger than the normal interval, indicating a global disharmonious appearance. Overall, in patients pronasale, subnasale, and pogonion were more posterior, the nose was shorter and larger, the face was narrower, and the soft tissue profile and upper lip were flatter than in the reference population. Conclusions The facial soft tissue structures of adult operated patients with CLP differed from those of normal controls of the same age, sex, and ethnic group. In this patient group, surgical corrections of CLP failed to provide a completely harmonious appearance, even if the deviations from the reference were limited. Further analyses of larger groups of patients are needed.

3D Printed Glitches

2019 ◽  
pp. 70-93
Author(s):  
James F. Kerestes
Keyword(s):  
Higher Education ◽  
3D Printing ◽  
Three Dimensional ◽  
The United States ◽  
Three Dimensional Modeling ◽  
Modeling Software ◽  
Common Resource ◽  
Education Design ◽  
3D Printed ◽  
Architecture And Design

3D printing is a common resource within the architecture and design disciplines in higher education. As is the case with all tools, there is a predetermined functionality and expected outcome when using additive manufacturing technology. There are also learning opportunities rooted in unforeseen equipment errors. The following chapter outlines alternate approaches for the use of 3D printing beyond mere representation and utilization in higher education design environments. Manufactured glitches enable students to analyze the predetermined functionality of the tools they engage with, and enter into a dialogue with technology as a medium for exploration and authorial exchange. To explore these concepts, a series of case studies that tested the parameters of glitches in both digital (three-dimensional modeling software) and physical mediums (rapid prototyping) was completed by a group of architecture and design students at a Midwestern University in the United States.

scholarly journals A Perioral Soft Tissue evaluation after Orthognathic Surgery Using Three-Dimensional Computed Tomography Scan

2018 ◽  
Vol 12 (1) ◽  
pp. 366-376
Author(s):  
Rahul Tiwari ◽  
P. Srinivas Chakravarthi ◽  
Vivekanand S. Kattimani ◽  
Krishna Prasad Lingamaneni
Keyword(s):  
Computed Tomography ◽  
Soft Tissue ◽  
Orthognathic Surgery ◽  
Soft Tissues ◽  
Three Dimensional ◽  
Computed Tomography Scan ◽  
Nasolabial Angle ◽  
Tissue Changes ◽  
Soft Tissue Changes ◽  
Tomography Scan

Background: Facial appearance is an important factor, affects social and psychological well-being. The ideal positioning of jaws and soft tissues is crucial during orthognathic surgery for a better outcome, but the response of facial soft tissues does not always reflect the exact movements of the underlying jaws in 1:1 ratio. So, soft tissue changes following orthognathic surgery require utmost attention during surgical correction to make successful treatment. Aims and Objectives: Evaluation of perioral soft tissue changes after orthognathic surgical procedures. The objectives of the study were to assess and compare pre and post-operative perioral soft tissue changes of lip width, nasolabial and mentolabial angle using Three Dimensional Computed Tomography scan (3DCT). Patient and Methods: The study involved ten patients for evaluation requiring orthognathic surgical procedures (maxillary or mandibular anteroposterior excess or deficiency, transverse deformities, vertical maxillary excess and facial asymmetry) presented to the department of oral and maxillofacial surgery during 2014-2016. Pre and post-operative 3DCT scan were taken after 12 months using iCT 256 slice whole body CT scanner and evaluated for changes using Dicom PMS D view. Results: Significant changes were observed in nasolabial angle after maxillary advancement (1.81°) and maxillary setback procedure (2.73°). The mentolabial angle was significantly increased with mandibular setback procedures (3.27°). Mandibular advancement procedures showed both increase (3.6°) and decrease (7.6°) in mentolabial angle. Conclusion: 3DCT showed a significant difference in perioral soft tissue changes in nasolabial and mentolabial angle but no significant change was observed in lip width. 3DCT is a reliable tool for 3D assessment. The conventional thought of changes in Nasolabial angle after surgery is changing due to the underlying factors which should be considered for prediction.

Three-Dimensional Analysis Techniques—Part 3: Color-Coded System for Three-Dimensional Measurement of Bone and Ratio of Soft Tissue to Bone: The Analysis

1997 ◽  
Vol 34 (1) ◽  
pp. 52-57 ◽  
Author(s):  
Andrew M. Mccance ◽  
James P. Moss ◽  
W. Rick Fright ◽  
Alf D. Linney
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Three Dimensional ◽  
Ct Scans ◽  
Dimensional Changes ◽  
Analysis Techniques ◽  
Dimensional Measurement ◽  
Three Dimensional Measurement ◽  
The Face ◽  
Bimaxillary Surgery

A new color-coded method of illustrating three-dimensional changes in the bone and the ratio of soft tissue to bone movement is described. The technique is illustrated by superimposing preoperative and 1-year postoperative CT scans of three patients following bimaxillary surgery. The method has proved to be a very simple, effective, and readily interpreted method of quantifying both bone and the ratio of movement of the overlying soft tissues across the face following surgery.

scholarly journals Three-dimensional cone beam computed tomographic image reorientation using soft tissues as reference for facial asymmetry diagnosis

2013 ◽  
Vol 84 (1) ◽  
pp. 38-47 ◽  
Author(s):  
Jae-Kyu Lee ◽  
Pil-Kyo Jung ◽  
Cheol-Hyun Moon
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Three Dimensional ◽  
Facial Asymmetry ◽  
Cone Beam ◽  
Expert Group ◽  
Computed Tomographic ◽  
Asymmetry Analysis ◽  
Cbct Image ◽  
Facial Midline

ABSTRACT Objective: To investigate discrepancies in results of facial asymmetry analysis using different cone beam computed tomography (CBCT) image reorientation methods and the effectiveness of soft tissue as a reorientation reference for analysis of facial asymmetry. Materials and Methods: An asymmetric group of 30 patients with 4 mm or more of chin point (menton [Me]) deviation and a symmetric group of 30 patients with less than 4 mm of deviation of Me were chosen as study subjects. Three orientation methods were used to calculate and compare Me deviation values of the 60 subjects. Two methods used only skeletal landmarks for reference, and one method included the soft tissue landmarks around the eye. Preferences of an expert group for the facial midline as determined by each reorientation method were also examined. Results: The examinations showed significant discrepancies in Me deviation values between the three reorientation methods. The expert group showed the greatest preference for the facial midline reorientation method that incorporated soft tissue landmarks of the eye. Conclusions: These study findings suggest that the inclusion of soft tissue landmarks, especially those around the eyes, is effective for three-dimensional CBCT image reorientation for facial asymmetry analysis.

Simultaneous, laser-sintered, three-dimensional modelling of bony structures and soft tissue for surgical navigation of extended cholesteatoma

2009 ◽  
Vol 124 (5) ◽  
pp. 564-568 ◽  
Author(s):  
M Suzuki ◽  
Y Ogawa ◽  
T Hasegawa ◽  
S Kawaguchi ◽  
K Yukawa ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Soft Tissue ◽  
Soft Tissues ◽  
Surgical Navigation ◽  
Selective Laser Sintering ◽  
Three Dimensional ◽  
Styloid Process ◽  
Dimensional Structure ◽  
Dimensional Model ◽  
Three Dimensional Model

AbstractAim:To examine the usefulness of a three-dimensional model for surgical navigation of cholesteatoma.Materials and method:A three-dimensional model was prototyped using selective laser sintering. Based on detailed computed tomography data, powder layers were laser-fused and accumulated to create a three-dimensional structure. The computed tomography threshold was adjusted to simultaneously replicate bony structures and soft tissues.Results:The cholesteatoma, major vessels and bony structures were well replicated. This laser-sintered model was used to aid surgery for recurrent cholesteatoma. The cholesteatoma, which extended from the hypotympanum through the styloid process sheath and the internal carotid artery sheath, was removed safely via a minimal skin incision.Conclusion:The laser-sintered model was useful for surgical planning and navigation in a cholesteatoma case involving complex bony structures and soft tissue.

3D Printing Technologies for Tissue Engineering

2014 ◽  
Author(s):  
Weibin Lin ◽  
Qingjin Peng
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
3D Printing ◽  
Soft Tissues ◽  
Theoretical Research ◽  
Tissue Structure ◽  
3D Printer ◽  
Human Tissues ◽  
Biological Functions ◽  
Preliminary Trial

Tissue engineering (TE) integrates methods of cells, engineering and materials to improve or replace biological functions of native tissues or organs. 3D printing technologies have been used in TE to produce different kinds of tissues. Human tissues have intricate structures with the distribution of a variety of cells. For this reason, existing methods in the construction of artificial tissues use universal 3D printing equipment or some simple devices, which is hard to meet requirements of the tissue structure in accuracy and diversity. Especially for soft tissue organs, a professional bio-3D printer is required for theoretical research and preliminary trial. Based on review of the exiting 3D printing technologies used in TE, special requirements of fabricating soft tissues are identified in this research. The need of a proposed bio-3D printer for producing artificial soft tissues is discussed. The bio-3D printer suggested consists of a pneumatic dispenser, a temperature controller and a multi-nozzle changing system.

Soft-tissue-mimicking using silicones for the manufacturing of soft phantoms by fresh 3D printing

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Aitor Tejo-Otero ◽  
Arthur Colly ◽  
Edwin-Joffrey Courtial ◽  
Felip Fenollosa-Artés ◽  
Irene Buj-Corral ◽  
...  
Keyword(s):  
Soft Tissue ◽  
3D Printing ◽  
Three Dimensional ◽  
Mechanical Analysis ◽  
Living Tissue ◽  
Scanning Calorimetry ◽  
Content Type ◽  
Microscopy Analysis ◽  
3D Printed ◽  
Liver Phantom

Purpose The purpose of this study is to use the Freeform Reversible Embedding of Suspended Hydrogels (FRESH) additive manufacturing (AM) technique for manufacturing a liver phantom which can mimic the corresponding soft living tissue. One of the possible applications is surgical planning. Design/methodology/approach A thermo-reversible Pluronic® F-127-based support bath is used for the FRESH technique. To verify how three-dimensional (3D)-printed new materials can mimic liver tissue, dynamic mechanical analysis and oscillation shear rheometry tests are carried out to identify mechanical characteristics of different 3D printed silicone samples. Additionally, the differential scanning calorimetry was done on the silicone samples. Then, a validation of a 3D printed silicone liver phantom is performed with a 3D scanner. Finally, the surface topography of the 3D printed liver phantom was fulfiled and microscopy analysis of its surface. Findings Silicone samples were able to mimic the liver, therefore obtaining the first soft phantom of the liver using the FRESH technique. Practical implications Because of the use of soft silicones, surgeons could practice over these improved phantoms which have an unprecedented degree of living tissue mimicking, enhancing their rehearsal experience before surgery. Social implications An improvement in surgeons surgery skills would lead to a bettering in the patient outcome. Originality/value The first research study was carried out to mimic soft tissue and apply it to the 3D printing of organ phantoms using AM FRESH technique.

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